Balb/C mice are inoculated 3 days postnatally with murine cytomegalovirus in the (right) intra-cerebral with an injection (2000 pfu in 1 ul).

At 4 weeks, auditory function was tested with ABR and OAE measurements.

At 8 weeks, vascular damage was evaluated using partial corrosion cast and SEM microscopy.

Picture of brain showing location of CMV infection

Results

CMV infection causes significant cochlear dysfunction

CMV damages mid to apical turn first

ABR and DPOAE results after CMV infection
difference in cochlea base and apex after CMV infection