CG-MALS works in-line with Wyatt Technology’s miniDAWN TREOS MALS detector and with a choice of either Wyatt Technology’s Optilab TrEX refractive index or Agilent’s UV-VIS diode array detector.
Protein, oligonucleotide, nucleic acid and other biomolecule and polymer applications
Dissociation constant (Kd) determination of label-free and immobilization-free protein-protein and other macromolecular interactions from picomolar to millimolar concentrations.
Stoichiometric determination of reversible self- and hetero-associations.
Weight-average molar mass determination.
Other applications include non-specific interaction parameters and colloidal stability (virial coefficients A2/B22, kD) for concentration dependent determination of protein multimer formation, aggregation rates and dn/dc for polymers and other molecules.