Welcome to The Hospital for Sick Children’s Structural & Biophysical Core Facility

The Structural & Biophysical Core (SBC) Facility is a shared instrument facility specializing in biophysical methods for investigating biomolecular structure, dynamics, stability, and interactions. The tools are particularly valuable for studying proteins, including folded soluble and membrane proteins and intrinsically disordered proteins; their interactions with binding partners; and their self association, such as in phase-separated states. The facility serves scientists from the Research Institute of The Hospital for Sick Children (SickKids), external academic institutions and industry. The equipment is accessed through pay-per-use fees or yearly membership. Users of the facility are supported by full-time personnel that provide instrument and experimental assistance

Please browse this website to learn about the facility’s instrumentation and capabilities, and how to obtain access to facility resources.