The aim of the Strategy for Patient-Oriented Research Innovative Pediatric Clinical Trials Project (SPOR IPCT) is to develop and test innovative statistical and logistical clinical trial methods with a carefully selected set of four pediatric trails, using a centralized trial management structure and recruiting at six pediatric emergency departments in four Canadian provinces. In a partnership with Pediatric Emergency Research Canada (PERC), the EnRICH Lab leads the Methods Core for this CIHR funded four-year project. The four trials, all set in the emergency department, were chosen based on their potential to benefit from innovative methods as well as on the prevalence of the conditions they address.- The No-OUCH trial has been published. It used a patient preference approach to randomization to evaluate the comparative effectiveness of ibuprofen alone, or in combination with acetaminophen or hydromorphone, in clinical pain relief for suspected fractures.
- The DOSE-AGE Study as been published. This pragmatic trial that evaluated both safety and efficacy of multiple doses of ondansetron administered post-discharge to children with acute gastroenteritis
- The BIPED Bronchiolitis trial has been submitted for publication. This trial builds on previous evidence to confirm whether combination therapy with epinephrine and dexamethasone is effective in treating bronchiolitis and reducing infant hospitalizations.
- The INK study – recruitment ongoing – evaluates the use of intranasal versus intravenous ketamine as a less painful experience in procedural sedation as it correlates with child satisfaction and healthcare team morale.
Details on the Innovative pediatric clinical trials (iPCT) can be found here.
Updated February 2026