2024:

  1. Baba A, Smith M, Potter BK, Chan AW, Moher D, Offringa M. Guidelines for reporting pediatric and child health clinical trial protocols and reports: study protocol for SPIRIT-Children and CONSORT-Children. Trials. 2024 Jan 30;25(1):96. 

  2. Iverson R, Taljaard M, Geraghty MT, Pugliese M, Tingley K, Coyle D, Kronick JB, Wilson K, Austin V, Brunel-Guitton C, Buhas D, Butcher NJ, Chan AKJ, Dyack S, Goobie S, Greenberg CR, Jain-Ghai S, Inbar-Feigenberg M, Karp N, Kozenko M, Langley E, Lines M, Little J, MacKenzie J, Maranda B, Mercimek-Andrews S, Mhanni A, Mitchell JJ, Nagy L, Offringa M, Pender A, Potter M, Prasad C, Ratko S, Salvarinova R, Schulze A, Siriwardena K, Sondheimer N, Sparkes R, Stockler-Ipsiroglu S, Tapscott K, Trakadis Y, Turner L, Van Karnebeek C, Vandersteen A, Walia JS, Wilson BJ, Yu AC, Potter BK, Chakraborty P. Assessing the quality and value of metabolic chart data for capturing core outcomes for pediatric medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. BMC Pediatr. 2024 Jan 13;24(1):37. 

2023: 

  1. Baba A, Offringa M. Transparent Reporting-SPIRIT-C/CONSORT-C Pediatric Updates. JAMA Pediatr. 2023 Dec 26. Epub ahead of print. 

  2. Maat SC, Gorter RR, van Heurn ELW, Rippen H, Butcher NJ, Offringa M, Derikx JPM. Development of an international core outcome set for treatment trials in paediatric inguinal hernia: Protocol for a three-phase study including a systematic review and Delphi survey. BMJ Open. 2023 Dec 13; 13(12)e077452. 

  3. Baba A, Offringa M, Butcher NJ. Sharing Pediatric Trial Results With Youth and Families: From Why to How. Pediatrics. 2023 Dec 1;152(6):e2023063436. 

  4. Sayfi S, Charide R, Elliott SA, Hartling L, Munan M, Stallwood L, Butcher NJ, Richards DP, Mathew JL, Suvada J, Akl EA, Kredo T, Mbuagbaw L, Motilall A, Baba A, Scott SD, Falavigna M, Klugar M, Friessová T, Lotfi T, Stevens A, Offringa M, Schünemann HJ, Pottie K. A multimethods randomized trial found that plain language versions improved adults understanding of health recommendations. J Clin Epidemiol. 2023 Nov 25;165:111219. 

  5. Sammy A, Baba A, Klassen TP, Moher D, Offringa M. A Decade of Efforts to Add Value to Child Health Research Practices. J Pediatr. 2023 Nov 23;265:113840.  Epub ahead of print. 

  6. Ciani O, Manyara AM, Davies P, Stewart D, Weir CJ, Young AE, Blazeby J, Butcher NJ, Bujkiewicz S, Chan AW, Dawoud D, Offringa M, Ouwens M, Hróbjartssson A, Amstutz A, Bertolaccini L, Bruno VD, Devane D, Faria CDCM, Gilbert PB, Harris R, Lassere M, Marinelli L, Markham S, Powers JH, Rezaei Y, Richert L, Schwendicke F, Tereshchenko LG, Thoma A, Turan A, Worrall A, Christensen R, Collins GS, Ross JS, Taylor RS. A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials. EClinicalMedicine. 2023 Oct 17;65:102283.  

  7. Baba A, Richards DP, Smith M, Pallone N, Vanderhout S, Prebeg M, Elsman EBM, Potter BK, Offringa M, Butcher NJ. Youth and family involvement in the development of a plain language trial results communication tool: CommuniKIDS. Res Involv Engagem. 2023 Sep 30;9(1):88. 

  8. Webbe J, Baba A, Butcher NJ, Rodrigues C, Stallwood E, Goren K, Monsour A, Chang ASM, Trivedi A, Manley BJ, McCall E, Bogossian F, Namba F, Schmölzer GM, Popat H, Nguyen KA, Doyle LW, Jardine L, Rysavy MA, Konstantinidis M, Muhd Helmi MA, Lai NM, Hay S, Onland W, Choo YM, Gale C, Soll RF, Offringa M; CORE OUTCOME REPORTING IN NEONATAL TRIALS (CORINT) STUDY GROUP. Strengthening Reporting of Neonatal Trials. Pediatrics. 2023 Sep 1;152(3):e2022060765. 

  9. Baba A, Webbe J, Butcher NJ, Rodrigues C, Stallwood E, Goren K, Monsour A, Chang ASM, Trivedi A, Manley BJ, McCall E, Bogossian F, Namba F, Schmölzer GM, Harding J, Nguyen KA, Doyle LW, Jardine L, Rysavy MA, Konstantinidis M, Meyer M, Helmi MAM, Lai NM, Hay S, Onland W, Choo YM, Gale C, Soll RF, Offringa M; Core Outcome Reporting in Neonatal Trials Study Group. Heterogeneity and Gaps in Reporting Primary Outcomes From Neonatal Trials. Pediatrics. 2023 Sep 1;152(3):e2022060751.  PMID: 37641881. 

  10. Stallwood L, Sammy A, Prebeg M, Relihan J, Baba A, Charide R, Sayfi S, Elliott SA, Hartling L, Munan M, Richards DP, Mathew JL, Kredo T, Mbuagbaw L, Motilall A, Scott SD, Klugar M, Lotfi T, Stevens AL, Pottie K, Schünemann HJ, Butcher NJ, Offringa M; RecMap Members. Plain Language vs Standard Format for Youth Understanding of COVID-19 Recommendations: A Randomized Clinical Trial. JAMA Pediatr. 2023 Sep 1;177(9):956-965. 

  11. Elliott SA, Scott SD, Charide R, Patterson-Stallwood L, Sayfi S, Motilall A, Baba A, Lotfi T, Suvada J, Klugar M, Kredo T, Mathew JL, Richards DP, Butcher NJ, Offringa M, Pottie K, Schünemann HJ, Hartling L. A multi-methods randomized trial found that plain language versions improved parents’ understanding of health recommendations. J Clin Epidemiol. 2023 Jul 6:S0895-4356(23)00165-8. 

  12. Stallwood E, Elsman EBM, Monsour A, Baba A, Butcher NJ, Offringa M. Measurement Properties of Patient Reported Outcome Scales: A Systematic Review. Pediatrics. 2023 Aug 1;152(2):e2023061489. 

  13. Manyara AM, Davies P, Stewart D, Weir CJ, Young AE, Wells V, Blazeby J, Butcher NJ, Bujkiewicz S, Chan AW, Collins GS, Dawoud D, Offringa M, Ouwens M, Ross JS, Taylor RS, Ciani O. Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate endpoints in trials: A scoping review. J Clin Epidemiol. 2023 Jun 26:S0895-4356(23)00160-9. 

  14. Klerk DH, van Varsseveld OC, Offringa M, Modi N, Lacher M, Zani A, Pakarinen MP, Koivusalo A, Jester I, Spruce M, Derikx JPM, Bakx R, Ksia A, Vermeulen MJ, Kooi EMW, Hulscher JBF. Development of an international core outcome set for treatment trials in necrotizing enterocolitis-a study protocol. Trials. 2023 May 31;24(1):367. 

  15. Monga S, Desai R, Anthony SJ, Arnold PD, Bagnell A, Birmaher B, Campbell LA, Churchill R, Cleverley K, Courtney DB, Dimitropoulos G, Hetrick SE, Krause KR, Mokkink LB, Patten SB, Patton MC, Prebeg MJ, Potter BK, Romanchych E, Shah JL, Smith M, Stewart SE, Szatmari P, Tricco AC, Tugwell P, Walkup JT, Welch VA, Zima BT, Butcher NJ, Offringa M. Study Preregistration: Measuring What Matters: Development and Dissemination of a Core Outcome Set for Pediatric Anxiety Disorders Clinical Trials. J Am Acad Child Adolesc Psychiatry. 2023 Jun;62(6):696-698. 

  16. Krause KR, Tay J, Douglas WA, Sammy A, Baba A, Goren K, Thombs BD, Howie AH, Oskoui M, Frøbert O, Trakadis Y, Little J, Potter BK, Butcher NJ, Offringa M. Paper II: thematic framework analysis of registry-based randomized controlled trials provided insights for designing trial ready registries. J Clin Epidemiol. 2023 May 4:S0895-4356(23)00103-8. 

  17. Baba A, Tay J, Sammy A, Douglas WA, Goren K, Krause KR, Howie AH, Little J, Oskoui M, Taljaard M, Thombs BD, Potter BK, Butcher NJ, Offringa M. Paper I: Heterogeneous use of registry data for participant identification and primary outcome ascertainment is found in registry-based randomized controlled trials: a scoping review. J Clin Epidemiol. 2023 May 3:S0895-4356(23)00104-X.

  18. Vanderhout S, Potter BK, Smith M, Butcher NJ, Vaters J, Chakraborty P, Adams J, Inbar-Feigenberg M, Offringa M, Speechley K, Trakadis Y, Binik A. Ethical and practical considerations related to data sharing when collecting patient-reported outcomes in care-based child health research. Qual Life Res. 2023 Aug;32(8):2319-2328.

  19. Onland W, van de Loo M, Offringa M, van Kaam A. Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev. 2023 Mar 13;3(3):CD010941. 

  20. Charide R, Stallwood L, Munan M, Sayfi S, Hartling L, Butcher NJ, Offringa M, Elliott S, Richards DP, Mathew JL, Akl EA, Kredo T, Mbuagbaw L, Motillal A, Baba A, Prebeg M, Relihan J, Scott SD, Suvada J, Falavigna M, Klugar M, Lotfi T, Stevens A, Pottie K, Schünemann HJ. Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for three randomized controlled trials and qualitative user-experience studies. Trials. 2023 Jan 14;24(1):27.

  21. Halbmeijer NM, Onland W, Cools F, Swarte RM, van der Heide-Jalving M, Dijk P, Mulder-de Tollenaer S, Tan RNGB, Mohns T, Bruneel E, van Heijst AFJ, Kramer B, Debeer A, van Weissenbruch MM, Marechal Y, Blom H, Plaskie K, Offringa M, van Wassenaer-Leemhuis AG, van Kaam AH, Aarnoudse-Moens CSH; SToP-BPD study group. Effect of systemic hydrocortisone in ventilated preterm infants on parent-reported behavioural outcomes at 2 years’ corrected age: follow-up of a randomised clinical trial. Arch Dis Child Fetal Neonatal Ed. 2023 Jul;108(4):373-379.

  22. Goren K, Monsour A, Stallwood E, Offringa M, Butcher NJ. Pediatric core outcome sets had deficiencies and lacked child and family input: A methodological review. J Clin Epidemiol. 2023 Mar;155:13-21. 

  23. Zozaya C, Ganji N, Li B, Janssen Lok M, Lee C, Koike Y, Gauda E, Offringa M, Eaton S, Shah PS, Pierro A. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study. Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):69-76. 

     

2022 Publications:

  1. Onland W, Offringa M, van Kaam A. Late (≥ 7 days) inhaled corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. Cochrane Database Syst Rev. 2022 Dec 15;12(12). 
  2. Butcher NJ, Monsour A, Mew EJ, Chan AW, Moher D, Mayo-Wilson E, Terwee CB, Chee-A-Tow A, Baba A, Gavin F, Grimshaw JM, Kelly LE, Saeed L, Thabane L, Askie L, Smith M, Farid-Kapadia M, Williamson PR, Szatmari P, Tugwell P, Golub RM, Monga S, Vohra S, Marlin S, Ungar WJ, Offringa M. Guidelines for Reporting Outcomes in Trial Protocols: The SPIRIT-Outcomes 2022 Extension. JAMA. 2022 Dec 20;328(23):2345-2356.
  3. Butcher NJ, Monsour A, Mew EJ, Chan AW, Moher D, Mayo-Wilson E, Terwee CB, Chee-A-Tow A, Baba A, Gavin F, Grimshaw JM, Kelly LE, Saeed L, Thabane L, Askie L, Smith M, Farid-Kapadia M, Williamson PR, Szatmari P, Tugwell P, Golub RM, Monga S, Vohra S, Marlin S, Ungar WJ, Offringa M. Guidelines for Reporting Outcomes in Trial Reports: The CONSORT-Outcomes 2022 Extension. JAMA. 2022 Dec 13;328(22):2252-2264.
  4. Krause KR, Hetrick SE, Courtney DB, Cost KT, Butcher NJ, Offringa M, Monga S, Henderson J, Szatmari P. How much is enough? Considering minimally important change in youth mental health outcomes. Lancet Psychiatry. 2022 Dec;9(12):992-998. 
  5. Manyara AM, Davies P, Stewart D, Weir CJ, Young A, Butcher NJ, Bujkiewicz S, Chan AW, Collins GS, Dawoud D, Offringa M, Ouwens M, Ross JS, Taylor RS, Ciani O. Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE. BMJ Open. 2022 Oct 11;12(10):e064304. 
  6. Patton MC, Desai R, Noureddine Y, Prebeg MJ, Krause KR, Vohra S, Butcher NJ, Monga S. Outcomes and outcome measurement instruments reported in randomised controlled trials of anxiety disorder treatments in children and adolescents: a scoping review protocol. BMJ Open. 2022 Oct 7;12(10):e063404.
  7. Zozaya C, Ganji N, Li B, Janssen Lok M, Lee C, Koike Y, Gauda E, Offringa M, Eaton S, Shah PS, Pierro A. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study. Arch Dis Child Fetal Neonatal Ed. 2023 Jan;108(1):69-76. 
  8. McAleese CE, Butcher NJ, Minchin RF. Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis. Breast Cancer Res Treat. 2022 Oct;195(3):223-236. 
  9. Pasternak M, Shirzadi Z, Mutsaerts HJMM, Boot E, Butcher NJ, MacIntosh BJ, Heung T, Bassett AS, Masellis M. Elevated regional cerebral blood flow in adults with 22q11.2 deletion syndrome. World J Biol Psychiatry. 2023 Mar;24(3):260-265.
  10. Elsman EBM, Butcher NJ, Mokkink LB, Terwee CB, Tricco A, Gagnier JJ, Aiyegbusi OL, Barnett C, Smith M, Moher D, Offringa M. Study protocol for developing, piloting and disseminating the PRISMA-COSMIN guideline: a new reporting guideline for systematic reviews of outcome measurement instruments. Syst Rev. 2022 Jun 13;11(1):121. 
  11. Halbmeijer NM, Onland W, Cools F, Kroon A, van der Heide-Jalving M, Dijk P, van Straaten HLM, Te Pas AB, Mohns T, Bruneel E, van Heijst AFJ, Kramer B, Debeer A, Zonnenberg IA, Marechal Y, Blom H, Plaskie K, Merkus MP, Offringa M, van Kaam AH; SToP-BPD Study Group; STOP-BPD Study Group. Short-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 
  12. Krause KR, Chung S, Rodak T, Cleverley K, Butcher NJ, Szatmari P. Assessing the impact of mental health difficulties on young people’s daily lives: protocol for a scoping umbrella review of measurement instruments. BMJ Open. 2022 Apr 29;12(4):e054679.
  13. Lan J, Plint AC, Dalziel SR, Klassen TP, Offringa M, Heath A; Pediatric Emergency Research Canada (PERC) KIDSCAN/PREDICT BIPED Study Group. Remote, real-time expert elicitation to determine the prior probability distribution for Bayesian sample size determination in international randomised controlled trials: Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone (BIPED) study. Trials. 2022 Apr 11;23(1):279. 
  14. Ganji N, Li B, Ahmad I, Daneman A, Deshpande P, Dhar V, Eaton S, Faingold R, Gauda EB, Hall N, Helou SE, Kabeer MH, Kim JH, King A, Livingston MH, Ng E, Offringa M, Palleri E, Walton M, Wesson DE, Wester T, Wijnen RMH, Willan A, Yankanah R, Zozaya C, Shah PS, Pierro A. Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial. Pediatr Surg Int. 2022 May;38(5):679-694. 
  15. Lemyre B, Lacaze-Masmonteil T, Shah PS, Bodani J, Doucette S, Dunn M, Louis D, Monterrosa L, Mukerji A, Schmölzer GM, Singh B, Wong J, Ye XY, Offringa M. Poractant alfa versus bovine lipid extract surfactant: prospective comparative effectiveness study. J Perinatol. 2022 Apr;42(4):468-475. doi: 10.1038/s41372-022-01346-0. Epub 2022 Feb 18.

2021 Publications:

  1. Heath A, Rios JD, Pullenayegum E, Pechlivanoglou P, Offringa M, Yaskina M, Watts R, Rimmer S, Klassen TP, Coriolano K, Poonai N; PERC-KIDSCAN Ketodex Study Group. The intranasal dexmedetomidine plus ketamine for procedural sedation in children, adaptive randomized controlled non-inferiority multicenter trial (Ketodex): a statistical analysis plan. Trials. 2021 Jan 6;22(1):15. 
  2. Heath A, Yaskina M, Pechlivanoglou P, Rios D, Offringa M, Klassen TP, Poonai N, Pullenayegum E. A Bayesian response-adaptive dose-finding and comparative effectiveness trial. Clin Trials. 2021 Feb;18(1):61-70.
  3. Offringa M, Newton R, Nevitt SJ, Vraka K. Prophylactic drug management for febrile seizures in children. Cochrane Database of Systematic Reviews 2021; 6: CD003031.
  4. Halbmeijer NM, Onland W, Cools F, Swarte R, van der Heide-Jalving M, Merkus MP, van Kaam AH for the STOP-BPD Trial Collaborators. Effect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age. Follow-up of a Randomized Clinical Trial. 2021;326(4):355-357. 
  5. Pugliese M, Tingley K, Chow A, Pallone N, Smith M, Chakraborty P, Geraghty MT, Irwin JK, Mitchell JJ, Stockler S, Nicholls SG, Offringa M, Rahman A, Tessier LA, Butcher NJ, Iverson R, Lamoureux M, Clifford TJ, Hutton B, Paik K, Tao J, Skidmore B, Coyle D, Duddy K, Dyack S, Greenberg CR, Jain Ghai S, Karp N, Korngut L, Kronick J, MacKenzie A, MacKenzie J, Maranda B, Potter M, Prasad C, Schulze A, Sparkes R, Taljaard M, Trakadis Y, Walia J, Potter BK; Canadian Inherited Metabolic Diseases Research Network. Core Outcome Sets for Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Phenylketonuria. Pediatrics. 2021 Jul 15:e2020037747. 
  6. Algurén B, Ramirez JP, Salt M, Sillett N, Myers SN, Alvarez-Cote A, Butcher NJ, Caneo LF, Cespedes JA, Chaplin JE, Ng KC, García-García JJ, Hazelzet JA, Klassen AF, Turquetto ALR, Mew EJ, Morris M, Offringa M, O’Meara M, Papp JM, Rodrigo C, Switaj TL, Valencia Mayer C, Jenkins KJ. Development of an international standard set of patient-centred outcome measures for overall paediatric health: a consensus process. Arch Dis Child. 2021 Sep;106(9):868-876. 
  7. Courtney DB, Watson P, Chan BW, Bennett K, Krause KR, Offringa M, Butcher NJ, Monga S, Neprily K, Zentner T, Rodak T, Szatmari P. Forks in the road: Definitions of response, remission, recovery, and other dichotomized outcomes in randomized controlled trials for adolescent depression. A scoping review. Depress Anxiety. 2021 Nov;38(11):1152-1168. 
  8. Vanderhout SM, Smith M, Pallone N, Tingley K, Pugliese M, Chakraborty P, Stockler S, Offringa M, Butcher N, Nicholls SG, Potter BK. Patient and family engagement in the development of core outcome sets for two rare chronic diseases in children. Res Involv Engagem. 2021 Sep 14;7(1):66. 
  9. Offringa M, Klassen TP. Deferred Consent in Pediatric Drug Trials: Moving from Why to How. Pediatric Drugs, 23(6), 533-535.
  10. Howie AH, Tingley K, Inbar-Feigenberg M, Mitchell JJ, Butcher NJ, Offringa M, Smith M, Angel K, Gentle J, Wyatt A, Campeau PM, Chan A, Chakraborty P, El Turk F, Mamak E, Mhanni A, Skidmore B, Sparkes R, Stockler S, Potter BK; INFORM RARE Network. Establishing a core outcome set for mucopolysaccharidoses (MPS) in children: study protocol for a rapid literature review, candidate outcomes survey, and Delphi surveys. 2021 Nov 17;22(1):816. 
  11. Offringa M, Kalish BT. Subclinical electrographic seizures in the newborn – Is more treatment better? JAMA Network Open. 2021;4(12):e2140677. 

  1. Butcher NJ, Tricco AC, Offringa M, Moher D, Galica J. Training researchers in publication science: why, what, and how. J Clin Epidemiol. 2020 Jan;117:165-167
  2. Pugliese M, Tingley K, Chow A, Pallone N, Smith M, Rahman A, Chakraborty P, Geraghty MT, Irwin J, Tessier L, Nicholls SG, Offringa M, Butcher NJ, Iverson R, Clifford TJ, Stockler S, Hutton B, Paik K, Tao J, Skidmore B, Coyle D, Duddy K, Dyack S, Greenberg CR, Ghai SJ, Karp N, Korngut L, Kronick J, MacKenzie A, MacKenzie J, Maranda B, Mitchell JJ, Potter M, Prasad C, Schulze A, Sparkes R, Taljaard M, Trakadis Y, Walia J, Potter BK; Canadian Inherited Metabolic Diseases Research Network. Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review. Orphanet J Rare Dis. 2020 Jan 14;15(1):12. doi: 10.1186/s13023-019-1276-1. C
  3. Ding S, Mew EJ, Chee-A-Tow A, Offringa M, Butcher NJ, Moore GP. Neurodevelopmental outcome descriptions in cohorts of extremely preterm children. Arch Dis Child Fetal Neonatal Ed. 2020 Jan 13. pii: fetalneonatal-2019-318144. doi: 10.1136/archdischild-2019-318144. C
  4. van Kempen AAMW, Eskes PF, Nuytemans DHGM, van der Lee JH, Dijksman LM, van Veenendaal NR, van der Hulst FJPCM, Moonen RMJ, Zimmermann LJI, van ‘t Verlaat EP, van Dongen-van Baal M, Semmekrot BA, Stas HG, van Beek RHT, Vlietman JJ, Dijk PH, Termote JUM, de Jonge RCJ, de Mol AC, Huysman MWA, Kok JH, Offringa M, Boluyt N; HypoEXIT Study Group. Lower versus Traditional Treatment Threshold for Neonatal Hypoglycemia. N Engl J Med. 2020 Feb 6;382(6):534-544. doi: 10.1056/NEJMoa1905593. Co-SRA
  5. Shan F, MacVicar S, Allegaert K, Offringa M, Jansson L, Simpson S, Moulsdale W, Kelly LE. Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review. 2020 Mar 12;21(1):262. doi: 10.1186/s13063-020-4183-9. C
  6. Monga S, Offringa M, Butcher NJ, Szatmari P. From Research to Practice: The Importance of Appropriate Outcome Selection, Measurement, and Reporting in Pediatric Mental Health Research. J Am Acad Child Adolesc Psychiatry. 2020 Apr;59(4):497-500. doi: 10.1016/j.jaac.2019.08.468. Co-PA
  7. Chan W, Thurairajah P, Butcher N, Oosterwijk O, Wever K, Eichler I, Thompson C, Junker A, Offringa M, Preston J. Guidance on development and operation of Young Persons’ Advisory Groups. Archives of Disease in Childhood Online First: 24 March 2020. doi: 10.1136/archdischild-2019-318517. Co-SRA
  8. Heath A, Offringa M, Pechlivanoglou P, Rios JD, Klassen TP, Poonai N, Pullenayegum E. Determining a Bayesian Predictive Power Stopping Rule for Futility in a Non-Inferiority Trial with Binary Outcomes: The INK trial. Contemporary Clinical Trials Volume 18, June 2020, 100561. CPA
  9. Kelly LE, Shan F, MacVicar S, Czaplinksi E, Moulsdale W, Simpson S, Allegaert K, Jansson LM, Offringa M. A Core Outcome Set for Neonatal Opioid Withdrawal Syndrome: NOWS-COS. 2020 Jun 3:e20200018. doi: 10.1542/peds.2020-0018. Online ahead of print. SRA
  10. Brindle ME, McDiarmid C, Short K, Miller K, MacRobie A, Lam JYK, Brockel M, Raval MV, Howlett A, Lee KS, Offringa M, Wong K, de Beer D, Wester T, Skarsgard ED, Wales PW, Fecteau A, Haliburton B, Goobie SM, Nelson G. Consensus Guidelines for Perioperative Care in Neonatal Intestinal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations. World J Surg. 2020 May 8. doi: 10.1007/s00268-020-05530-1. C
  11. Mew EJ, Monsour A, Saeed L, Santos L, Patel S, Courtney DB, Watson PN, Szatmari P, Offringa M, Monga S, Butcher NJ. Systematic scoping review identifies heterogeneity in outcomes measured in adolescent depression clinical trials. J Clin Epidemiol. 2020 Jun 16:S0895-4356(20)30202-X. doi: 10.1016/j.jclinepi.2020.06.013. Co-SRA
  12. Monsour A, Mew E, Patel S, Chee-a-tow A, Santos L, Saeed L, Szatmari P, Offringa M, Butcher NJ. Primary outcome reporting in adolescent depression clinical trials need standardization. BMC Med Res Methodol. 2020 May 25;20(1):129. doi: 10.1186/s12874-020-01019-6. Co-SRA
  13. Ali S, Rajagopal M, Richer L, McCabe C, Willan AR, Yaskina M, Heath A, Drendel AL, Offringa M, Gouin S, Stang AS, Sawyer S, Bhatt M, Hickes S, Poonai N, on behalf of the iPCT-PERC No OUCH Trials Team. A study protocol for two complementary trials of nonsteroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (The No OUCH Study). BMJ Open 2020 Jun 21;10(6):e035177. doi: 10.1136/bmjopen-2019-035177. C
  14. van Kempen AAMW, Boluyt N, Offringa M; HypoExit Study Group. Treatment Threshold for Neonatal Hypoglycemia. Reply. N Engl J Med. 2020 Jun 4;382(23):2273-2274. doi: 10.1056/NEJMc2004233. SRA
  15. Butcher NJ, Mew E, Monsour A, Chan A-W, Moher D, Offringa M. Outcome-reporting recommendations for clinical trial protocols and reports: a scoping review. 2020 Jul 8;21(1):620. doi: 10.1186. SRA
  16. Heath A, Rios JD, Williamson-Urquhart S, Pechlivanoglou P, Offringa M, McCabe C, Hopkin G, Plint AC, Dixon A, Beer D, Gouin S, Joubert G, Klassen TP, Freedman SB; PERC-KIDSCAN DOSE-AGE Study Group. A pragmatic randomized controlled trial of multi-dose oral ondansetron for pediatric gastroenteritis (the DOSE-AGE study): statistical analysis plan. 2020 Aug 24;21(1):735. doi: 10.1186/s13063-020-04651-1. C
  17. Monga S, Monsour A, Stallwood E, Desai R, Cleverley K, Courtney D, Henderson J, Korczak D, Krause K, Smith M, Szatmari P, Offringa M, Butcher N. Core Outcome Set Development for Adolescent Major Depressive Disorder Clinical Trials: A Registered Report. J Am Acad Child Adolesc Psychiatry. 2020 Nov;59(11):1297-1298. doi: 10.1016/j.jaac.2020.07.905. Epub 2020 Aug 24. PMID: 33126995. Co-SRA
  18. Butcher NJ, Mew EJ, Monsour A, Szatmari P, Monga S, Offringa M. Response to “Trials for depressive disorder in adolescents: the emperor’s new clothes,” a letter to the editor by Alain Braillon, MD, PhD. Counting what counts in (mental health) clinical trials 2.0. J Clin Epidemiol. 2020 Aug 26:S0895-4356(20)31059-3. doi: 10.1016/j.jclinepi.2020.08.010. SRA
  19. Heath A, Yaskina M, Hopkin G, Klassen TP, McCabe C, Offringa M, Pechlivanoglou P, Rios JD, Poonai N, Ali S; KidsCAN PERC Innovative Pediatric Clinical Trials No OUCH Study Group.Trials. Non-steroidal or opioid analgesia use for children with musculoskeletal injuries (the No OUCH study): statistical analysis plan. 2020 Sep 3;21(1):759. doi: 10.1186/s13063-020-04503-y.PMID: 32883371 C
  20. Butcher NJ, Monsour A, Mokkink LB, Terwee CB, Tricco AC, Gagnier J, Offringa M. Needed: guidance for reporting knowledge synthesis studies on measurement properties of outcome measurement instruments in health research. BMJ Open 2020; 22 September 2020 SRA
  21. Butcher NJ, Monsour A, Mew EJ, Askie L, Grimshaw J, Moher D, Chan A, Gavin F, Smith M, Offringa M. SPIRIT-Outcomes and CONSORT-Outcomes: Enhanced trial outcome transparency, less bias, improved systematic reviews, better health Advances in Evidence Synthesis: special issue. Cochrane Database of Systematic Reviews 2020;(9 Suppl 1):96. https://doi.org/10.1002/14651858.CD202001 SRA
  22. Offringa M, Farid-Kapadia M, Askie L, Hartling L, Contopoulos-Ioannidis D, Bhutta ZA, Soll R, Moher D. Preferred reporting items for systematic review and meta-analysis protocols and reports: extension for children – _PRISMA-P-C and PRISMA-C 2020. Advances in Evidence Synthesis: special issue. Cochrane Database of Systematic Reviews 2020;(9 Suppl 1):504. https://doi.org/10.1002/14651858.CD202001 PA
  23. Stallwood E, Monsour A, Rodrigues C, Monga S, Terwee C, Offringa M, Butcher NJ. Systematic Review: The Measurement Properties of the Children’s Depression Rating Scale-Revised in Adolescents With Major Depressive Disorder. J Am Acad Child Adolesc Psychiatry. 2020 Oct 29:S0890-8567(20)32050-5. doi: 10.1016/j.jaac.2020.10.009. Online ahead of print.PMID: 33130251. Co-SRA
  24. Heath A, Yaskina M, Pechlivanoglou P, Rios D, Offringa M, Klassen TP, Poonai N, Pullenayegum E. A Bayesian response-adaptive dose-finding and comparative effectiveness trial. Clin Trials. 2020 Nov 24:1740774520965173. doi: 10.1177/1740774520965173. Online ahead of print.PMID: 33231105. C
  25. Algurén B, Ramirez JP, Salt M, Sillett N, Myers SN, Alvarez-Cote A, Butcher NJ, Caneo LF, Cespedes JA, Chaplin JE, Ng KC, García-García JJ, Hazelzet JA, Klassen AF, Turquetto ALR, Mew EJ, Morris M, Offringa M, O’Meara M, Papp JM, Rodrigo C, Switaj TL, Valencia Mayer C, Jenkins KJ. Development of an international standard set of patient-centred outcome measures for overall paediatric health: a consensus process. Arch Dis Child. 2020 Dec 11:archdischild-2020-320345. doi: 10.1136/archdischild-2020-320345. Online ahead of print. PMID: 33310707. C
  26. Poonai N, Coriolano K, Klassen T, Heath A, Yaskina M, Beer D, Sawyer S, Bhatt M, Kam A, Doan Q, Sabhaney V, Offringa M, Pechlivanoglou P, Hickes S, Ali S; KidsCAN PERC iPCT-SPOR (Innovative Paediatric Clinical Trials – Strategy for Patient Oriented Research) Ketodex Study Team. Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol. BMJ Open. 2020 Dec 10;10(12):e041319. doi: 10.1136/bmjopen-2020-041319.PMID: 33303457. C
  27. Groff ML, Offringa M, Emdin A, Mahood Q, Parkin PC, Cohen E. Publication Trends of Pediatric and Adult Randomized Controlled Trials in General Medical Journals, 2005-2018: A Citation Analysis. Children (Basel). 2020 Dec 15;7(12):E293. doi: 10.3390/children7120293. PMID: 33333770. C
  28. Knaapen M, Hall NJ, Moulin D, van der Lee JH, Butcher NJ, Minneci PC, Svensson JF, St Peter SD, Adams S, Nah SA, Skarsgard ED, Zani A, Emil S, Suominen JS, Aziz DA, Rai R, Offringa M, van Heurn EW, Bakx R, Gorter RR; + On behalf of the pediatric appendicitis COS development group. International Core Outcome Set for Acute Simple Appendicitis in Children: Results of A Systematic Review, Delphi Study, and Focus Groups with Young People. Ann Surg. 2020 Dec 29. doi: 10.1097/SLA.0000000000004707. Online ahead of print.PMID: 33630468. C

  1. Monsour A, Mew EJ, Szatmari P, Patel S, Saeed L, Offringa M, Butcher NJ. Outcomes reported in randomised clinical trials of major depressive disorder treatments in adolescents: a systematic scoping review protocol. BMJ Open. 2019 Jan 15;9(1):e024191. doi: 10.1136/bmjopen-2018-024191. Co- SRA
  2. Onland W, Cools F, Kroon A, Rademaker K, Merkus MP, Mohns T, Blom H, Marechal Y, Debeer A, Dijk PH, van Heijst AF, Kramer BW, van Straaten HL, Te Pas AB, Theyskens C, Zonnenberg I, Plaskie K, Offringa M, van Kaam AH, on behalf of the SToP-BPD study group. Effect of Hydrocortisone Therapy Initiated 7 to 14 Days After Birth on Mortality or Bronchopulmonary Dysplasia Among Very Preterm Infants Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA. 2019 Jan 29;321(4):354-363. doi: 10.1001/jama.2018.21443. Co- SRA
  3. Butcher NJ, Mew EJ, Saeed L, Monsour A, Chee-a-tow A, Chan A-W, Moher D, Offringa M. Guidance for reporting outcomes in clinical trials: scoping review protocol. BMJ Open. 2019 Feb 19;9(2):e023001. doi: 10.1136/bmjopen-2018-023001 (& Open Science Framework preprint: doi:10.17605/OSF.IO/UGX29). SRA
  4. Butcher NJ, Monsour A, Mew EJ, Szatmari P, Pierro A, Kelly LE, Farid-Kapadia M, Chee-A-Tow A, Saeed L, Monga S, Ungar W, Terwee CB, Vohra S, Fergusson D, Askie LM, Williamson PR, Chan AW, Moher D, Offringa M. Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT). Trials. 2019 Mar 6;20(1):161. doi: 10.1186/s13063-019-3248-0. SRA
  5. van de Loo M, van Kaam A, Offringa M, Doyle LW, Onland W. Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews. Protocol  Cochrane Database of Systematic Reviews 2019, Issue 2. Art. No.: CD013271. DOI: 10.1002/14651858.CD013271. C
  6. Knaapen M, Hall NJ, van der Lee JH, Butcher NJ, Offringa M, Van Heurn EWE, Bakx R, Gorter RR; Paediatric Appendicitis COS development group. Establishing a core outcome set for treatment of uncomplicated appendicitis in children: study protocol for an international Delphi survey. BMJ Open. 2019 May 22;9(5):e028861. doi: 10.1136/bmjopen-2018-028861.
  7. Szatmari P, Offringa M, Butcher NJ, Monga S. Counting what counts: the case for reporting harmonized outcomes in child and youth mental health research. Journal of American Academy of Child and Adolescent Psychiatry. 2019 July, Volume 58(7) : 656-8. CPA
  8. Kelly LE, Richer L, Ali S, Plint AC, Poonai N, Freedman SB, Knisley L, Shimmin C, Hickes S, ‘t Jong GW, Pechlivanoglou P, Offringa M, Lacaze T, Klassen TP, on behalf of KidsCAN Trials and Pediatric Emergency Research Canada (PERC). Innovative approaches to investigator-initiated, multi-centre pediatric clinical trials in Canada. BMJ Open 2019;9:e029024. doi:10.1136/bmjopen-2019-029024. C
  9. Hepburn CM, Gilpin A, Autmizguine J, Denburg A, Dupuis LL, Finkelstein Y, Gruenwoldt E, Ito S, Jong G’, Lacaze-Masmonteil T, Levy D, Macleod S, P Miller S, Offringa M, Pinsk M, Power B, Rieder M, Litalien C. Improving paediatric medications: A prescription for Canadian children and youth. Paediatr Child Health. 2019 Aug;24(5):333-339. doi: 10.1093/pch/pxz079. Epub 2019 Jul 25. C
  10. Hepburn CM, Gilpin A, Autmizguine J, Denburg A, Dupuis LL, Finkelstein Y, Gruenwoldt E, Ito S, Jong G’, Lacaze-Masmonteil T, Levy D, Macleod S, P Miller S, Offringa M, Pinsk M, Power B, Rieder M, Litalien C. L’amélioration des médicaments à usage pédiatrique : une prescription pour les enfants et les adolescents canadiens. Paediatr Child Health. 2019 Aug;24(5):336-339. doi: 10.1093/pch/pxz079. Epub 2019 Jul 25. C
  11. Orkin J, Chan CY, Fayed N, Lin JLL, Major N, Lim A, Peebles ER, Moretti ME, Soscia J, Sultan R, Willan AR, Offringa M, Guttmann A, Bartlett L, Kanani R, Culbert E, Hardy-Brown K, Gordon M, Perlmutar M, Cohen E. Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity. BMJ Open. 2019 Aug 1;9(8):e028121. doi: 10.1136/bmjopen-2018-028121. C
  12. Joachim KC, Farid-Kapadia M, Butcher NJ, Chee-A-Tow A, Monsour A, Cohen E, Mahant S, Guttmann A, Offringa M; Complex Care COS Consensus Meeting Group. Core outcome set for children with neurological impairment and tube feeding. Dev Med Child Neurol. 2019 Aug 1. doi: 10.1111/dmcn.14326. [Epub ahead of print]. SRA
  13. Brigitte Lemyre, MD, Jaya P Bodani, MBBS DCH, Stefani Doucette, MD, Michael S Dunn, MD, Deepak Louis, MD, DM, Luis Monterrosa, MD, Amit Mukerji, MD, Georg M Schmölzer, MD PhD, Prakeshkumar Shah, MD, Balpreet Singh, MD, Jonathan Wong, BSc MD, Thierry Lacaze-Masmonteil, MD PhD, Martin Offringa, MD PhD, A call for a streamlined ethics review process for multijurisdictional, child health research studies. Paediatrics & Child Health. 2019 Dec 19.  SRA
  14. Butcher NJ, Mew E, Saeed L, Monsour A, Chee-a-tow A, Chan A-W, Moher D, Offringa M. Guidance for reporting outcomes in clinical trials: A systematic scoping review protocol.  BMJ Open 2019 ; 9(2):e023001. doi: 10.1136/bmjopen-2018-023001.
  15. Monsour A, Mew E, Szatmari P, Patal S, Saeed L, Offringa M, Butcher NJ. Outcome reporting in randomized controlled trials of major depressive disorder treatment in adolescents: a systematic scoping review protocol. BMJ Open 2019;9:e024191. doi: 10.1136/bmjopen-2018-024191

  1. Puligandla PS, Skarsgard ED, Offringa M, for The Canadian CDH Collaborative: The Canadian Congenital Diaphragmatic Hernia Collaborative. Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline. CMAJ January 29, 2018 190 (4) E103-E112; DOI: https://doi.org/10.1503/cmaj.170206
  2. Ardell S, Offringa M, Ovelman C, Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. Cochrane Database of Systematic Reviews 2018, Issue 2. Art. No.: CD008342. DOI: 10.1002/14651858.CD008342.pub2.
  3. Woods H, Oronsaye E, Bali A, Rajakulasingam Y, Lee T, Umali N, Cohen E, Finkelstein Y, Offringa M, Persaud N. Development of a provisional essential medicines list for children in Canada: consensus process. CMAJ Open. 2018 Mar 26;6(1):E146-E150. doi: 10.9778/cmajo.20170129. PMID:29592851.
  4. Barker CIS, Standing JF, Kelly LE, Hanly Faught L, Needham A, Rieder MJ, de Wildt SN, Offringa M. Pharmacokinetic Studies in Children: recommendations for practice and research. Arch Dis Child. 2018 Jul;103(7):695-702. doi: 10.1136/archdischild-2017-314506. PMID:29674514.
  5. Kelly LE, Sinha Y, Barker CIS, Standing JF, Offringa M. Useful Pharmacodynamic Endpoints in Children: Selection, Measurement and Next Steps. Ped Research 2018 Apr 18. doi: 10.1038/pr.2018.38. [Epub ahead of print] PMID:29667952.
  6. Maarten Janssen Lok, Hiromu Miyake, Alison Hock, Alan Daneman, Agostino Pierro, Martin Offringa. Value of abdominal ultrasound in necrotizing enterocolitis management: a systematic review and meta-analysis. Pediatr Surg Int. 2018 May 2. doi: 10.1007/s00383-018-4259-8. [Epub ahead of print] PMID:29721677.
  7. Yu AM, Balasubramanaiam B, Offringa M, Kelly LE. Reporting of interventions and ‘standard of care’ control arms in pediatric clinical trials: a quantitative analysis. Pediatr Res. 2018 Jun 13. doi: 10.1038/s41390-018-0019-7. PMID:29899384.
  8. Galica J, Chee-a-tow A, Gupta S, et al. Learning best-practices in journalology: course description and attendee insights into the inaugural EQUATOR Canada Publication School.  BMC Proceedings. 2018;12(Suppl 10):18. doi:10.1186/s12919-018-0155-4.
  9. Guillot M, Offringa M, Lacaze-Masmonteil T, Thébaud B. Cell-Based Therapy for Bronchopulmonary Dysplasia in Preterm Infants: Workshop report. Can J Physiol Pharmacol. 2018 Oct 5. doi: 10.1139/cjpp-2018-0342. PMID:30290122
  10. Sadeghirad B, Florez ID, Chang Y, Forutan F, Zeraatkar D, Morgan RL, Shahid S, Bala MM, Beyene J, Offringa M, Adams-Webber T, Sherman PM, El-Gouhary E, Guyatt GH, Johnston BC. Comparative Effectiveness of Prophylactic Therapies for Necrotizing Enterocolitis in Preterm Infants: Protocol for a Network Meta-analysis of Randomized Trials. Int J Prev Med. 2018 Sep 17;9:83. doi: 10.4103/ijpvm.IJPVM_328_17. eCollection 2018. PMID: 30283615.
  11. Kelly LE, Dyson MP, Butcher NJ, Balshaw R, London AJ, Neilson CJ, Junker A, Mahmud SM, Driedger SM, Wang X. Considerations for adaptive design in pediatric clinical trials: study protocol for a systematic review, mixed-methods study, and integrated knowledge translation plan. 2018 Oct 19;19(1):572. doi: 10.1186/s13063-018-2934-7. PMID:30340624
  12. Gibb ACN, Crosby MA, McDiarmid C, Urban D, Lam JYK, Wales P, Brockel M, Raval M, Offringa M, Skarsgard E, Wester T, Wong K, de Beer D, Nelson G, Brindle ME. Protocol for Creation of An Enhanced Recovery After Surgery (ERAS®) Guideline for Neonatal Abdominal Surgery Patients: A Knowledge Synthesis and Consensus Generation Approach. BMJ Open.2018 Dec 9;8(12):e023651. doi: 10.1136/bmjopen-2018-023651.
  13. Onland W, Cools F, Kroon A, Rademaker K, Merkus MP, Mohns T, Blom H, Marechal Y, Debeer A, Dijk PH, van Heijst AF, Kramer BW, van Straaten HL, Te Pas AB, Theyskens C, Zonnenberg I, Plaskie K, Offringa M, van Kaam AH, on behalf of the SToP-BPD study group. Targeted Systemic Hydrocortisone for the Prevention of Bronchopulmonary Dysplasia. in press JAMA 2018

  1. Kelly LE, Ito S, Woods D, Nunn AJ, Taketomo C, de Hoog M, Offringa M. A Comprehensive List of Items to be Included on a Pediatric Drug Monograph. J Pediatr Pharmacol Ther. 2017 Jan-Feb;22(1):48-59. doi: 10.5863/1551-6776-22.1.48.
  2. Onland W, De Jaegere APMC, Offringa M, van Kaam A. Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants. Cochrane Database of Systematic Reviews 2017, Issue 1. Art. No.: CD010941.
  3. Offringa M, Newton R, Cozijnsen MA, Nevitt SJ. Prophylactic drug management for febrile seizures in children. Cochrane Database of Systematic Reviews 2017, Issue 2. Art. No.: CD003031. DOI: 10.1002/14651858.CD003031.pub3.
  4. Farid-Kapadia M, Askie L, Hartling L, Contopoulos-Ioannidis D, Bhutta ZA, Soll R, Moher D, Offringa M. Do systematic reviews on pediatric topics need special methodological considerations? BMC Pediatr. 2017 Mar 6;17(1):57. doi: 10.1186/s12887-017-0812-1.
  5. Farid-Kapadia M, Joachim KC, Balasingham C, Clyburne-Sherin A, Offringa M. Are child-centric aspects in newborn and child health systematic review and meta-analysis protocols and reports adequately reported? Two systematic reviews. Syst Rev. 2017 Mar 6;6(1):31. doi: 10.1186/s13643-017-0423-9.
  6. Hall NJ, Eaton S, Abbo O, Arnaud A; Beaudin M; Brindle M; Butter A; Davies D; Jancelewicz T; Johnson K; Keijzer R; Lapidus-Kroll E; Nasr A; Offringa M; Piche N; Rintala R; Skarsgard E; Svensson J; Ungar WJ; Wester T; Willan A; Zani A; St Peter SD; Pierro A. Appendectomy versus non-operative treatment for acute uncomplicated appendicitis in children: study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial. BMJ Paediatr Open. 2017 May 18;1(1). pii: bmjpo-2017-000028. doi: 10.1136/bmjpo-2017-000028. eCollection 2017. PMID:29637088.
  7. Onland W, Offringa M, van Kaam A. Late (≥ 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. Cochrane Database of Systematic Reviews 2017, Issue 9. Art. No.: CD002311.
  8. Groothoff JW, Offringa M, Grootenhuis M, Jager KJ. Long-term consequences of renal insufficiency in children: lessons learned from the Dutch LERIC study. Nephrol Dial Transplant. 2017 Jul 7. doi: 10.1093/ndt/gfx190. [Epub ahead of print] PMID: 28992218
  9. Rokhsefat S, Morra DE, Offringa M, Askie LM, Kelly LE. Trial registration in pediatric surgery trials. J Pediatr Surg. 2017 Oct 23. pii: S0022-3468(17)30704-2. doi: 10.1016 / j.jpedsurg 2017.10.049. [Epub ahead of print] PMID: 29150369]
  10. Costain G, Moore AM, Munroe L, Williams A, Zlotnik Shaul R, Rockman-Greenberg C, Offringa M, Kannu P. Enzyme replacement therapy in perinatal hypophosphatasia: Case report of a negative outcome and lessons for clinical practice. Mol Genet Metab Rep. 2017 Nov 7;14:22-26. doi: 10.1016/j.ymgmr.2017.10.006. eCollection 2018 Mar. PMID: 29159075.
  11. Tedesco D, Farid-Kapadia M, Offringa M, Bhutta ZA, Maldonado Y, Ioannidis JPA, Contopoulos-Ioannidis DG. Comparative Evidence on Harms in Pediatric RCTs from Less Developed versus More Developed Countries Is Limited.  J Clin Epidemiol.2017 Nov 27. pii: S0895-4356(17)30240-8. doi: 10.1016/j.jclinepi.2017.11.016. [Epub ahead of print]
  12. Knaapen M, van der Lee JH, Bakx R, The SL, van Heurn EWE, Heij HA, Gorter RR; APAC collaborative study group. Initial non-operative management of uncomplicated appendicitis in children: a protocol for a multicentre randomised controlled trial (APAC trial). BMJ Open. 2017 Nov 15;7(11):e018145. doi: 10.1136/bmjopen-2017-018145. PMID: 2914664
  13. Kelly LE, Caswell K, Short M, Parimi PS, Offringa M, Diacovo T. Response biomarkers in neonatal intervention studies. Pediatr Res. 2017 Aug 21. doi: 10.1038/pr.2017.204. [Epub ahead of print] PMID: 29278643
  14. Potter BK, Hutton B, Clifford TJ, Pallone N, Smith M, Stockler S, Chakraborty P, Barbeau P, Garritty CM, Pugliese M, Rahman A, Skidmore B, Tessier L, Tingley K, Coyle D, Greenberg CR, Korngut L, MacKenzie A, Mitchell JJ, Nicholls S, Offringa M, Schulze A, Taljaard M; Canadian Inherited Metabolic Diseases Research Network. Establishing core outcome sets for phenylketonuria (PKU) and medium-chain Acyl-CoA dehydrogenase (MCAD) deficiency in children: study protocol for systematic reviews and Delphi surveys. 2017 Dec 19;18(1):603. doi: 10.1186/s13063-017-2327-3. PMID: 29258568
  15. Gorter RR, van der Lee JH, Heijsters FACJ, Cense HA, Bakx R, Kneepkens CMF, Wijnen MH, van der Steeg AFW, in ‘t Hof KH, Offringa M, Heij HA, on behalf of the APAC Study Group. Outcome of initially non-operative treatment for acute simple appendicitis in children. J Pediatr Surg.2017 Dec 24. pii: S0022-3468(17)30837-0. doi: 10.1016/j.jpedsurg.2017.12.012. [Epub ahead of print]

  1. Kapadia MZ, Askie L, Hartling L, Contopoulos-Ioannidis D, Bhutta ZA, Soll R, Moher D, Offringa M. PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research. BMJ Open. 2016 Apr 18;6(4):e010270. doi: 10.1136/bmjopen-2015-010270. PMID: 27091820
  2. Kelly LE, Davies EH, Saint-Raymond A, Tomasi P, Offringa M. Important issues in the justification of a control treatment in paediatric drug trials. Arch Dis Child. 2016 Oct;101(10):962-7. doi: 10.1136/archdischild-2016-310644.
  3. De Jaegere AP, Deurloo EE, van Rijn RR, Offringa M, van Kaam AH. Individualized lung recruitment during high-frequency ventilation in preterm infants is not associated with lung hyperinflation and air leaks. Eur J Pediatr. 2016 Aug;175(8):1085-90. doi: 0.1007/s00431-016-2744-4. Epub 2016 Jun 21.
  4. Kapadia MZ, Joachim KC, Balasingham C, Cohen E, Mahant S, Nelson K, Maguire JL, Guttmann A, Offringa M. A Core Outcome Set for Children with Feeding Tubes and Neurologic Impairment: A Systematic Review. 2016 Jul;138(1). pii: e20153967. doi: 10.1542/peds.2015-3967
  5. van der Zanden TM, de Wildt SN, Liem Y, Offringa M, de Hoog M; Developing a Paediatric Drug Formulary for the Netherlands.  Arch Dis Child. 2016 Oct 31. pii: archdischild-2016-311674. PMID: 27799154
  6. Kelly LE, Jansson LM, Moulsdale W, Pereira J, Simpson S, Guttman A, Allegaert K, Askie L, Roukema H, Lacaze T, Davis JM, Finnegan L, Williamson P, Offringa M. A core outcome set for neonatal abstinence syndrome: study protocol for a systematic review, parent interviews and a Delphi survey. Trials. 2016 Nov 8;17(1):536.

  1. Van’t Hoff W, Offringa M; Star Child Health group (http://www.starchildhealth.org). StaR Child Health: developing evidence-based guidance for the design, conduct and reporting of paediatric trials. Arch Dis Child. 2015 Feb;100(2):189-192. doi: 10.1136/archdischild-2012-303094. Epub 2014 Sep 26. PMID: 25260517.
  2. Offringa M, Needham AC. Quality Standards for drug trials with children. Clin. Invest. (Lond.) 2014: 4(11), 997–1000, DOI 10.4155/cli.14.83
  3. Needham AC, Kapadia MZ, Offringa M. Ethics review of pediatric multi-center drug trials. Paediatr Drugs. 2015 Feb;17(1):23-30. doi: 10.1007/s40272-014-0098-9. PMID: 25354988.
  4. Askie L, Offringa M. Systematic reviews and meta-analysis. Semin Fetal Neonatal Med. 2015 Dec;20(6):403-9. doi: 10.1016/j.siny.2015.10.002. Epub 2015 Oct 27. Review. PMID: 26515266
  5. Jansen-van der Weide MC, Caldwell PH, Young B, de Vries MC, Willems DL, Van’t Hoff W, Woolfall K, van der Lee JH, Offringa M. Clinical Trial Decisions in Difficult Circumstances: Parental Consent Under Time Pressure. 2015 Oct;136(4):e983-92. doi: 10.1542/peds.2014-3402. PMID: 26416935
  6. Clyburne-Sherin AV, Thurairajah P, Kapadia MZ, Sampson M, Chan WW, Offringa M. Recommendations and evidence for reporting items in pediatric clinical trial protocols and reports: two systematic reviews. 2015 Sep 18;16:417. doi: 10.1186/s13063-015-0954-0.PMID: 26385379
  7. Pullenayegum EM, Platt RW, Barwick M, Feldman BM, Offringa M, Thabane L. Knowledge translation in biostatistics: a survey of current practices, preferences, and barriers to the dissemination and uptake of new statistical methods. Stat Med. 2015 Aug 25. doi: 10.1002/sim.6633. [Epub ahead of print] PMID: 26307183 C
  8. Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. 2015 Aug 18;351:h4240. doi: 10.1136/bmj.h4240. Review. PMID: 26286537
  9. Hall NJ, Kapadia MZ, Eaton S, Chan WW, Nickel C, Pierro A, Offringa M. Outcome reporting in randomised controlled trials and meta-analyses of appendicitis treatments in children: a systematic review. 2015 Jun 17;16:275. doi: 10.1186/s13063-015-0783-1. PMID: 26081254
  10. Fernandes RM, Plint AC, Terwee CB, Sampaio C, Klassen TP, Offringa M, van der Lee JH. Validity of bronchiolitis outcome measures. 2015 Jun;135(6):e1399-408. doi: 10.1542/peds.2014-3557. Epub 2015 May 18. PMID: 25986025
  11. Gorter RR, van der Lee JH, Cense HA, Kneepkens CM, Wijnen MH, In ‘t Hof KH, Offringa M, Heij HA; APAC Study Group. Initial antibiotic treatment for acute simple appendicitis in children is safe: Short-term results from a multicenter, prospective cohort study. 2015;157(5):916-23. doi: 10.1016/j.surg.2015.01.008. Epub 2015 Mar 16. PMID: 25791031
  12. Cools F, Offringa M, Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev. 2015 Mar 19;3:CD000104. doi: 10.1002/14651858.CD000104.pub4. Review. PMID: 25785789

  1. Hulzebos CV, Dijk PH, van Imhoff DE, Bos AF, Lopriore E, Offringa M, Ruiter SA, van Braeckel KN, Krabbe PF, Quik EH, van Toledo-Eppinga L, Nuytemans DH, van Wassenaer-Leemhuis AG, Benders MJ, Korbeeck-van Hof KK, van Lingen RA, Groot Jebbink LJ, Liem D, Mansvelt P, Buijs J, Govaert P, van Vliet I, Mulder TL, Wolfs C, Fetter WP, Laarman C; BARTrial Study Group. The bilirubin albumin ratio in the management of hyperbilirubinemia in preterm infants to improve neurodevelopmental outcome: a randomized controlled trial–BARTrial. PLoS One. 2014 Jun 13;9(6):e99466. doi: 10.1371/journal.pone.0099466. eCollection 2014. PMID: 24927259.

  1. van Laerhoven H, de Haan TR, Offringa M, Post B, van der Lee JH Prognostic tests in term neonates with hypoxic-ischemic encephalopathy: a systematic review. Pediatrics. 2013 Jan;131(1):88-98. doi: 10..1542/peds.2012-1297 Epub 2012 Dec 17. PMID: 23248219.
  2. Offringa M, Newton R. Prophylactic drug management for febrile seizures in children (Review). Evid Based Child Health. 2013 Jul;8(4):1376-485. doi: 10.1002/ebch.192. PMID: 23877946.
  3. de Kluiver E, Offringa M, Walther FJ, Duvekot JJ, de Laat MW. Perinatal policy in cases of extreme prematurity; an investigation into the implementation of the guidelines. Ned Tijdschr Geneeskd. 2013;157(38):A6362. Dutch. PMID: 24080448.
  4. Schoenmaker NJ, Tromp WF, van der Lee JH, Offringa M, Craig JC, Groothoff JW. Quality and consistency of clinical practice guidelines for the management of children on chronic dialysis. Nephrol Dial Transplant. 2013 Dec;28(12):3052-61. doi: 10.1093/ndt/gft303. Epub 2013 Oct 3. PMID: 24097802
  5. Offringa M, Needham AC, Chan WW; StaR Child Health group. StaR Child Health: improving global standards for child health research. Early Hum Dev. 2013 Nov;89(11):861-4. doi: 10.1016/j.earlhumdev.2013.09.011. Epub 2013 Oct 7. PMID: 24113210
  6. Schoenmaker NJ, Haverman L, Tromp WF, van der Lee JH, Offringa M, Adams B, Bouts AH, Collard L, Cransberg K, van Dyck M, Godefroid N, van Hoeck K, Koster-Kamphuis L, Lilien MR, Raes A, Taylan C, Grootenhuis MA, Groothoff JW. Children of non-Western origin with end-stage renal disease in the Netherlands, Belgium and a part of Germany have impaired health-related quality of life compared with Western children. Nephrol Dial Transplant. 2014 Feb;29(2):448-57. doi: 10.1093/ndt/gft436. Epub 2013 Nov 13. PMID: 24235076.
  7. Onland W, Debray TP, Laughon MM, Miedema M, Cools F, Askie LM, Asselin JM, Calvert SA, Courtney SE, Dani C, Durand DJ, Marlow N, Peacock JL, Pillow JJ, Soll RF, Thome UH, Truffert P, Schreiber MD, Van Reempts P, Vendettuoli V, Vento G, van Kaam AH, Moons KG, Offringa M. Clinical prediction models for bronchopulmonary dysplasia: a systematic review and external validation study. BMC Pediatr. 2013 Dec 17;13:207. doi: 10.1186/1471-2431-13-207. Review. PMID: 24345305.

  1. Onland W, Offringa M, van Kaam A. Late (≥ 7 days) inhalation corticosteroids to reduce bronchopulmonary dysplasia in preterm infants. Cochrane Database of Systematic Reviews 2012, Issue 4. Art. No.: CD002311. DOI: 10.1002/14651858.CD002311.pub3
  2. Offringa M, Newton R. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2012 Apr 18;4:CD003031. doi: 10.1002/14651858.CD003031.pub2. Review. PMID: 22513908.
  3. de Haan TR, Bijleveld YA, van der Lee JH, Groenendaal F, van den Broek MP, Rademaker CM, van Straaten HL, van Weissenbruch MM, Vermeulen JR, Dijk PH, Dudink J, Rijken M, van Heijst A, Dijkman KP, Gavilanes D, van Kaam AH, Offringa M, Mathôt RA. Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study. BMC Pediatr. 2012 May 22;12:45. doi: 10.1186/1471-2431-12-45. PMID: 22515424.
  4. Wittmeier KD, Craig J, Klassen TP, Offringa M. The mission of StaR Child Health is to improve the quality of the design, conduct, and reporting of pediatric clinical research by promoting the use of modern research standards. Introduction. Pediatrics. 2012 Jun;129 Suppl 3:S111. doi: 10.1542/peds.2012-0055B. No abstract available. PMID: 22661755.
  5. Hartling L, Wittmeier KD, Caldwell P, van der Lee H, Klassen TP, Craig JC, Offringa M; StaR Child Health Group. StaR child health: developing evidence-based guidance for the design, conduct, and reporting of pediatric trials. Pediatrics. 2012 Jun;129 Suppl 3:S112-7. doi: 10.1542/peds.2012-0055C. Review. No abstract available. PMID: 22661756.
  6. Caldwell PH, Dans L, de Vries MC, Newman Ba Hons J, Sammons H, Spriggs M Bioeth M, Tambe P, Van’t Hoff W, Woolfall K, Young B, Offringa M; StaR Child Health Group. Standard 1: consent and recruitment. Pediatrics. 2012 Jun; 129 Suppl 3:S118-23. doi: 10.1542/peds.2012-0055D. PMID: 22661757.
  7. *Hartling L, Hamm M, Klassen T, Chan AW, Meremikwu M, Moyer V, Scott S, Moher D, Offringa M; StaR Child Health Group. Standard 2: containing risk of bias. Pediatrics. 2012 Jun;129 Suppl 3:S124-31. doi: 10.1542/peds.2012-0055E. Review. No abstract available. PMID: 22661758.
  8. Ellenberg S, Fernandes RM, Saloojee H, Bassler D, Askie L, Vandermeer B, Offringa M, Van der Tweel I, Altman DG, van der Lee JH; StaR Child Health Group. Standard 3: data monitoring committees. Pediatrics. 2012 Jun;129 Suppl 3:S132-7. doi: 10.1542/peds.2012-0055F. Review. No abstract available. PMID: 22661759.
  9. van der Tweel I, Askie L, Vandermeer B, Ellenberg S, Fernandes RM, Saloojee H, Bassler D, Altman DG, Offringa M, van der Lee JH; StaR Child Health Group. Standard 4: determining adequate sample sizes. Pediatrics. 2012 Jun;129 Suppl 3:S138-45. doi: 10.1542/peds.2012-0055G. Review. No abstract available. PMID: 22661760.
  10. Sinha IP, Altman DG, Beresford MW, Boers M, Clarke M, Craig J, Alberighi OD, Fernandes RM, Hartling L, Johnston BC, Lux A, Plint A, Tugwell P, Turner M, van der Lee JH, Offringa M, Williamson PR, Smyth RL; StaR Child Health Group. Standard 5: selection, measurement, and reporting of outcomes in clinical trials in children. Pediatrics. 2012 Jun;129 Suppl 3:S146-52. doi: 10.1542/peds.2012-0055H. Review. No abstract available. PMID: 22661761.