The Enhancing Research Impact in Child Health (EnRICH) lab in Child Health and Evaluative Sciences at the Hospital for Sick Children is seeking a Post-Doctoral Research Fellow. This is a unique opportunity for those who are interested in exploring the unique research environment at The Hospital for Sick Children, affiliated with the University of Toronto. EnRICH’s mission is to ensure the highest quality child and family-centred clinical research is performed to improve the welfare of children by basing health care decisions on the best possible evidence. The successful candidate will be supervised by Dr. Martin Offringa, a paediatric clinical epidemiologist. Our training and mentorship strategy are guided by the SPOR Capacity Development Framework, emphasizing multi-disciplinary mentorship tailored to the diverse needs of patients, clinicians, and methodologists. The ideal candidate possesses and applies highly advanced scientific knowledge of innovative research principles, theories and concepts in the field of rare diseases clinical trial methodology.
The Post-Doctoral Research Fellow will work on the INFORM RARE project, which is an innovative registry-based randomized trial network to support decision-making about rare genetic diseases (RDs) therapies for children. New therapies are appearing at an accelerating pace for many RDs such as phenylketonuria (PKU), mucopolysaccharidoses (MPS), and spinal muscular atrophy (SMA). While many emerging high-cost therapies have demonstrated efficacy in highly controlled settings, to properly inform decisions about their use in real-world health care systems, knowledge users (patients, care providers, payers) need timely and robust evidence regarding comparative effectiveness, safety, and costs relative to existing therapies across patient populations. Such evidence is critical both to improve patient, family, and health system outcomes, and to address inequities in care across jurisdictions. INFORM RARE: (i) is co-designed by patients and families, health care providers, policy-makers, methodologists, and experts in research ethics; (ii) focuses on priority questions regarding comparative effectiveness and cost-effectiveness of new and existing treatments; and (iii) starts with 3 trials and is scalable to address emerging questions thereafter. After a needs-assessment for the new INFORM RARE network to identify key training priorities, a targeted webinar series in collaboration with the SPOR iPCT network to address these needs will be developed.
Here’s What You’ll Get To Do:
- Acquire knowledge in evidence-based research methods for evaluative research in rare diseases.
- Conduct and participate in methodological and hospital research, such as systematic reviews and meta-analysis of both observational and randomized control trials individual patient data and challenges pertaining to both.
- Apply scientific creativity and knowledge of innovative research principles, theories and concepts, notably around registry-based clinical (drug) trials designs for children with rare diseases, the development, testing, and implementation of child health outcome measurement instruments, and N-of-1 trial methodology.
- Independently design and implement research projects which include analyses of feasibility and application of a wide variety of scientific principles and concepts.
- Remain current on research of clinical trial methodologies, principles, and theories.
- Review and prepare peer reviewed scientific manuscripts and grant proposals.
- Disseminate research and clinical findings through publications, presentations, and seminars
- Provide leadership and supervision within the EnRICH team on scientific matters and serve as the spokesperson and authority for internal and external contacts on a wide variety of scientific principles and concepts related to new initiatives to improve how child health trials are designed, conducted, analyzed, and reported.
- Supervise and mentor trainees.
- Assist the PI in preparing reviews of others’ grant application and manuscripts as appropriate.
- Assist the PI in ensuring that fiscal safety and legislative responsibilities are maintained.
Here’s What You’ll Need:
- Ph.D. in Clinical Epidemiology, Statistics, Bioinformatics, Psychology, or related field with relevant experience in clinical trial design, conduct and reporting. (Candidates who have obtained their PhD within the last two years are preferred).
- Experience with programming and analysis of epidemiological data using R, SAS, STATA, SPSS, or other packaged programs is required.
- Demonstrated ability to work independently and collaboratively.
- Demonstrated strong competency in written and verbal communications.
- Previous experience with grant and manuscript writing.
- Experience in child health clinical epidemiology would be an asset.
Employment Type: Temporary, Full-Time (2-year contract)