Our Paediatric Neuroinflammatory Disorders program, in collaboration with other site investigators across Canada and internationally, are currently recruiting for several studies under the following areas:

Lifestyle Outcomes

Active Teens with Multiple Sclerosis (ATOMIC)

We developed a physical activity intervention using a mobile app tailored for youth with multiple sclerosis (MS). We propose to test the feasibility of implementing this intervention in youth with multiple sclerosis (MS) and to examine the extent to which the intervention can change physical activity levels in this population. We will also evaluate improvement in regional brain volumes, mood, and quality of life in these youth. Learn more.

If interested, please contact Olivia Lau

 

Social Networks Study

The goal of this study is to understand the effects of COVID-19-related societal changes on health behaviours and mental health outcomes in children and adolescents with neuroinflammatory conditions. Learn more.

If interested, please contact Tara Berenbaum (416-813-7654 x328576)

Visual and neuro-cognitive outcomes

Metformin in Children with MS

We want to see if we can repair damaged myelin in children with MS using a drug called metformin. Previous research has shown that metformin helps repair myelin in mice and may associate with decreased relapses in adults with MS and metabolic syndromes. Learn more.

If interested, please contact Tara Berenbaum (416-813-7654 x328576)

 

OMAS Study

The goal of this study is to investigate eye movement outcomes in relation to brain volume, cognitive function, and disease severity in pediatric OMAS. Learn more.

If interested, please contact Tara Berenbaum (416-813-7654 x328576)

Therapies and outcomes in autoimmune encephalopathy

Autoimmune Encephalitis Gene Expression Study

The goal of this study is to identify key molecular and cellular mechanisms of immune responses in childhood autoimmune encephalitides in order to help identify potential disease biomarkers and develop new targeted therapies. Learn more.

If interested, please contact Carmen Yea or Olivia Lau

Other studies

Patient Registry

The purpose of the Registry is to collect information on children with neuroinflammatory disorders for use in research aimed to increase our knowledge of childhood neuroinflammation, and to help doctors develop better ways to diagnose and treat children with this rare condition. Learn more.

 

Acute Flaccid Paralysis in Canadian Children

This study is a national collaborative retrospective evaluation of clinical and MRI outcomes of children presenting with non-polio acute onset flaccid paresis (AFP). Learn more.

If interested, please contact Carmen Yea.

We welcome both patients and healthy volunteers to participate in the studies that our team is currently recruiting for.To learn more about how to participate in our research studies please contact yeh.team@sickkids.ca

To learn more about what our research participants do, please visit the Research Components page.

To view our past publications, please click here.

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