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Our Research

Our Researchaheath2022-02-17T16:35:03+00:00

VoI for Paediatric Pain Reduction

This project aims to use Value of Information methods to design and implement a clinical trial. This clinical trial aims to evaluate drugs to reduce anxiety for children undergoing laceration repair in the paediatric emergency department.

Learn more about VoI for Paediatric Pain Reduction

Collaborative Network on Value of Information (ConVOI)

ConVOI is an international network working to improve the use of Value of Information methods in clinical and public health research. The IMPaCT team works with the ConVOI network on this goal.

Learn more about ConVOI or visit the ConVOI website

Expediting Drug Approvals in Oncology

Access with Evidence Development schemes (AEDs) can support the timely adoption of novel therapies by allowing patient access to these therapies whilst mandating that additional data be collected. These additional data are analysed to support the revaluation of the therapy and potential reversal of the approval decision. Value of Information methods have been suggested to support the design of AEDs but have rarely been used. This project combines researchers and policymakers to improve the use of VoI in AEDs with the aim of expediting approvals in Canada for promising new drugs.

Learn more about expediting Drug Approvals in Oncology

Trial Design and Expert Elicitation for the BIPED Study

The BIPED study aims to compare the combination of epinephrine and dexamethasone to placebo for infants presenting with bronchiolitis to the emergency department. The IMPaCT team is working with the BIPED team to understand what clinicians currently believe about the effectiveness of epinephrine and dexamethasone and use this information to design the BIPED study.

Learn more about the Trial Design and Expert Elicitation for the BIPED Study

VoI Calculation Methods

VoI measures can be complex to calculate, especially in early phase and adaptive trials. This project aims to address these issues through the development of novel VoI methodology focusing on characterizing uncertainty and calculating VoI in adaptive trials.

Learn more about VoI Calculation Methods

ATTACC/ACTIV-4 Trials

The ATTACC and ACTIV-4 trials evaluated the efficacy of therapeutic-dose parenteral heparin versus usual care in hospitalized COVID-19 using a Bayesian response adaptive design. The IMPaCT team are working to analyze these data and understand more about the efficacy and safety of therapeutic-dose parenteral heparin.

Learn more about the ATTACC/ACTIV-4 Trials

PRACTICAL Randomised Controlled Trial

The PRACTICAL Randomised Controlled Trial is a platform trial that enables phase II and III evaluation of a range of potential interventions and strategies to improve outcomes for patients with acute hypoxemic respiratory failure (AHRF). AHRF is a common, life-threatening condition that leaves patients vulnerable to lung and diaphragm injury associated with mechanical ventilation along with other nosocomial complications of critical care. The platform enrols adult patients with AHRF to evaluate various related interventional strategies.

Learn more about PRACTICAL Randomised Controlled Trial

The IMPaCT team is dedicated to creating a collaborative academic environment of excellence in which we all feel valued, supported and encouraged to grow. We strongly believe that equity, diversity and inclusion are fundamental to this vision and aspire to cherish all irrespective of race, indigenous status, gender, sexual orientation, age, career stage and health status.

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