VoI for Paediatric Pain Reduction
This project aims to use Value of Information methods to design and implement a clinical trial. This clinical trial aims to evaluate drugs to reduce anxiety for children undergoing laceration repair in the paediatric emergency department.
Collaborative Network on Value of Information (ConVOI)
ConVOI is an international network working to improve the use of Value of Information methods in clinical and public health research. The IMPaCT team works with the ConVOI network on this goal.
Expediting Drug Approvals in Oncology
Access with Evidence Development schemes (AEDs) can support the timely adoption of novel therapies by allowing patient access to these therapies whilst mandating that additional data be collected. These additional data are analysed to support the revaluation of the therapy and potential reversal of the approval decision. Value of Information methods have been suggested to support the design of AEDs but have rarely been used. This project combines researchers and policymakers to improve the use of VoI in AEDs with the aim of expediting approvals in Canada for promising new drugs.
Trial Design and Expert Elicitation for the BIPED Study
The BIPED study aims to compare the combination of epinephrine and dexamethasone to placebo for infants presenting with bronchiolitis to the emergency department. The IMPaCT team is working with the BIPED team to understand what clinicians currently believe about the effectiveness of epinephrine and dexamethasone and use this information to design the BIPED study.
Learn more about the Trial Design and Expert Elicitation for the BIPED Study
VoI Calculation Methods
ATTACC/ACTIV-4 Trials
The ATTACC and ACTIV-4 trials evaluated the efficacy of therapeutic-dose parenteral heparin versus usual care in hospitalized COVID-19 using a Bayesian response adaptive design. The IMPaCT team are working to analyze these data and understand more about the efficacy and safety of therapeutic-dose parenteral heparin.