The Heart of the Lab

Paul Delgado Olguín, PhD
Paul Delgado Olguín, PhDPrincipal Investigator
Lijun Chi, PhD
Lijun Chi, PhDResearch Associate

Translational Medicine, SickKids Research Institute

Dr. Chi enormously contributes in multiple aspects to all the projects in our lab. In addition, Dr. Chi is investigating the function of histone methyltransferases that form part of epigenetic silencing complexes in the development of cardiovascular precursor cells and their descendants.

Carmina Pérez-Romero, PhD
Carmina Pérez-Romero, PhDResearch Fellow

Translational Medicine, SickKids Research Institute

Dr. Pérez-Romero is delving into the mechanisms of gene expression control that are dysregulated to cause peripartum cardiomyopathy. Dr. Pérez-Romero’s research focuses on uncovering genes and pathways targeted by histone demethylases mediating adaptation of the cardiovascular system to the physiological challenge of pregnancy.

Amalia Caballero
Amalia CaballeroPhD Candidate

Department of Molecular Genetics, U of T

Amalia is investigating how obesity during pregnancy affects gene expression in the early developing embryo. Amalia employs single-cell genome wide approaches to uncover regulatory mechanisms of disease programming.

Jibran Syed
Jibran SyedM.Sc. Student

Department of Molecular Genetics, U of T

Jibran is working on a new project investigating how noncoding RNAs are processed in the heart. Jibran’s research has uncovered a transcriptional repressor that controls cardiomyocyte growth when the heart is challenged by pathological stimuli.

Sofia Wang
Sofia WangResearch Technologist

Translational Medicine, SickKids Research Institute

Sofia investigates the function of a histone methyltransferase as a mediator of the response of cardiomyocytes to pathological stimuli. In addition, Sofia is leading a project that will reveal the dynamic expression of small non-coding RNAs in the developing human heart.

Jielin Yang
Jielin YangResearch Student

Department of Molecular Genetics, U of T

Jielin investigates the dynamics of genome organization in cardiomyocytes to understand the regulatory mechanisms of heart development and regeneration.

Jasmine Li
Jasmine LiResearch Student

Department of Molecular Genetics, U of T

Jasmine is focused on uncovering the function of a histone chaperone in development of cardiac neural crest progenitors and their contribution to formation of the cardiac septum and outflow tract.

Cristina Mate
Cristina MateAdministrative Assistant

Translational Medicine, SickKids Research Institute

Cristina is our point of contact for logistics, onboarding, and navigating the Research Institute’s policy.

Alumni

Research Fellows

Abdalla Ahmed, PhD.

Abdalla discovered a pathway controlled via histone demethylation and that is dysregulated to initiate cardiac deterioration leading to heart failure.

Present position: Consultant, biotech industry.

Graduate Students

Abdalla Ahmed, PhD.

Graduated from the PhD Program in the Department of Molecular Genetics at U of T

Abdalla investigated the earliest effects of obesity during pregnancy on the developing heart and the molecular events that program an increased risk of adult-onset heart disease.

Thesis: Transcriptional Origins of Adult Cardiac Disease in Response to Maternal Obesity

Position after graduation: Research Fellow, The Hospital for Sick Children

Anna Roy

Graduated from the Master of Science program in the Department of Molecular Genetics, U of T.

Thesis: CCCTC-binding Factor (Ctcf) is Required for Mouse Cardiovascular Development.

Position after graduation: Project Coordinator, The Hospital for Sick Children.

Sandra Vuong

Graduated from the Master of Science program in the Department of Molecular Genetics, U of T.

Thesis: Loss of L3mbtl2 in Cardiac Progenitor Cells Causes Subtle Defects in the Developing Heart Leading to Cardiac Dysfunction in Adulthood.

Position after graduation: MD Candidate, Australia.

Undergraduate Research Students

Mabel Yang

Research Student, Special Research Project, Department of Molecular Genetics, University of Toronto

Evonne Anin

Research Student

Etri Kocaqi
Position after graduation: Medical School, McMaster University.

Dorothy Lee
Position after graduation: Student in the PhD program in the Department of Physiology, U of T.

Tao Wang
Position after graduation: Student in the Master of Science program in the Department of Physiology, U of T.

Meaghan Leslie
Position after graduation: Graduate Student in the Master of Science program in the Department of Molecular Genetics, U of T.

Ryan Tracey

Alicia Jarosz
Position after graduation: MD Candidate, University of Alberta.

Evonne Anin

Etri Kocaqi
Position after graduation: Medical School, McMaster University.

Dorothy Lee
Position after graduation: Student in the PhD program in the Department of Physiology, U of T.

Tao Wang
Position after graduation: Student in the Master of Science program in the Department of Physiology, U of T.

Meaghan Leslie
Position after graduation: Graduate Student in the Master of Science program in the Department of Molecular Genetics, U of T.

Ryan Tracey

Alicia Jarosz
Position after graduation: MD Candidate, University of Alberta.

Volunteers

Sina Fatehi Someeh
Position after graduation: Student in the Master of Science program in the Department of Molecular Genetics, U of T.

Angela Chen
Position after graduation: Undergraduate Student, U of T.

Angela An Qi Duan
Position after graduation: Student in the Master of Science program in the Department of Medical Science, U of T.