Change in how the heart produces energy may be key to preventing heart failure
Interview by SICKKIDS NEWSROOM
We spoke with SickKids about our finding that decreased energy production initiates cardiac deterioration toward dilated cardiomyopathy leading to heart failure. We established a new mouse model of heart failure in which disrupting removal of a histone methyl mark in cardiomyocytes decreases mitochondrial function before the heart adversely remodels. A multiomics approach revealed repressed NAD+ synthesis due to abnormal activation of the transcriptional repressor Tbx15 as the underlying pathway. This finding focuses future research toward identification of individuals at a higher risk of heart failure and early its prevention.