In the News

Embryonic cardiomyocytes

The people behind the papers: Lijun Chi and Paul Delgado-Olguin

Interview by THE NODE

We wrote about our findings demonstrating that the histone methyltransferase G9a controls a transcriptional pathway that activates Notch signaling to promote maturation of the placental vasculature. Moreover, we found that imbalanced proliferation of placental endothelial cells and trophoblast precedes placental defects caused by abnormal vascular maturation. These findings lay the groundwork to identify early signs and prevent the negative effects of placental dysfunction.

Gene switch ‘key to heart health’

Interview by BBC News

We spoke about our discovery that failing to repress a key transcriptional pathway by the histone methyltransferase Ezh2 in differentiating cardiac progenitor cells during early embryogenesis leads to adult-onset heart disease. These findings lay the groundwork to discover the embryonic determinants of adult-onset heart disease.