Canada Research Chair in Paediatric Asthma and Lung Health (2020-2027)
PI: Dr. Subbarao
Dr. Subbarao’s world-leading research program, supported by her Tier 1 Canada Research Chair in Paediatric Asthma and Lung Health (2020-2027), aims to disentangle preschool wheeze syndromes, provide tools for use in infants to precisely diagnose asthma subtype, monitor lung growth and response to therapy at the individual level and provide novel insights into the risk and protective factors associated with each asthma subtype. The discovery of novel causal associations will be further explored through targeted translational research collaborations paving the way for novel prevention strategies to eradicate asthma subtypes with precision.
Asthma affects 1 in 7 children leading to poor lung growth, cardiovascular disease and premature death. Current therapies, effective at controlling symptoms, do not prevent the lung function loss associated with asthma. Dr. Subbarao’s program integrates longitudinal lung function measures from infancy, with genetics and exposure measurement to impact standard clinical care of paediatric asthma. Her transformative program will (1) Develop tools to diagnose asthma subtype from infancy. (2) Identify causal risk factors associated with each asthma subtype to develop prevention strategies. (3) Produce lung function tests to monitor therapy aimed at preserving lung function from infancy.