Eradicating childhood asthma

Promoting lifelong lung health

Eradicating childhood asthma

Promoting lifelong lung health

Subbarao lab logo of exultant child's sillouhette with lungs visible and rainbow-coloured fingerprint in the background

Welcome to the Subbarao Lab

  • Developing tools to diagnose asthma subtypes from infancy

  • Identifying causal risk factors associated with asthma subtypes

  • Developing subtype-specific prevention strategies

  • Producing lung function tests to monitor the effects of therapies aimed at preserving lung function from infancy

  • Conducting clinical trials to evaluate novel therapeutics

A vision for precision lung health

Through a precision health approach, the Subbarao Lab is radically shifting our understanding of childhood asthma to fundamentally change how we diagnose and manage it.

The Subbarao Lab’s transformative research program, supported in part by a Tier 1 Canada Research Chair in Pediatric Asthma and Lung Health, integrates longitudinal lung function measures from infancy with biological markers and exposure measurement, to transform the standard clinical care of pediatric asthma.

The Subbarao Lab employs multiple machine learning and advanced statistical methods to discover novel/specific asthma subtypes and to discover groups with improved lung function growth from infancy. The lab is integrating these lung growth patterns and asthma subtypes with the rich ‘omics’ dataset of the CHILD Cohort Study to discover novel causal factors associated with optimal lung growth and asthma subtypes.

The lab has established the first infant and preschool asthma lung function assessment platform that can support clinical trials to rapidly evaluate novel asthma precision therapeutics for infant and preschool asthma subtypes.

The Lab’s precision health focus aligns with SickKids Strategic Plan 2020-2025 and the Precision Child Health co-led by Dr. Subbarao.

Our vision

In future children will be diagnosed with specific asthma subtypes using objective tools applicable from infancy; they will be offered biologically driven therapeutics targeted towards their precise asthma subtype; their response to therapy will be measured objectively and adjusted to promote health and lung function growth.

This precision health approach will eradicate childhood asthma and promote lifelong lung health.

Funding

Canada Research Chairs logo

Debbie & Donald H. Morrison
Family Foundation

Schroder Foundation logo
Sickids Research Institute logo