2024
Argon inhalation attenuates systemic inflammation and rescues lung architecture during experimental neonatal sepsis. Pediatr Surg Int. 40: 1-8. Felicia Balsamo, Bo Li, Sinobol Chusilp, Dorothy Lee, George Biouss, Carol Lee, Jason Maynes, Agostino Pierro. (2024).
Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights. Cell Prolif. 2024;57(7). Chen-Yi Wang, Mu-Yu Li, Si-Ying Li, Xiao-Gao Wei, Nai-Xuan Dong, Shu-Ting Liu, Zheng-Wei Yuan, Bo Li, Agostino Pierro, Xiao-Bing Tang, Yu-Zuo Bai. (2024)
Translating regenerative medicine therapies in neonatal necrotizing enterocolitis Pediatr Surg.1-7. Niloofar Ganji, Brian Kalish, Martin Offringa, Bo Li , James Anderson , Sylvain Baruchel , Martin Blakely , Paolo De Coppi , Simon Eaton , Estelle Gauda , Nigel Hall, Anna Heath, Michael H. Livingston, Carol McNair, Robert Mitchell, Ketan Patel, Petros Pechlivanoglou , Hazel Pleasants-Terashita, Erin Pryor, Milica Radisic, Prakesh S. Shah, Bernard Thébaud, Kasper Wang, Augusto Zani and Agostino Pierro (2024)
Cardiac tissue model of immune-induced dysfunction reveals the role of free mitochondrial DNA and the therapeutic effects of exosomes. Sci Adv. 29;10. Rick X.ing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T. Wagner, Erika L. Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C. Andreazza, Claudia C. dos Santos, Milica Radisic. (2024)
Human milk oligosaccharides promote intestinal epithelium regeneration independent of the microbiota during necrotizing enterocolitis. Pediatr Surg Int. 40:(35) 1-8. Andrea Zito, Richard Y.Wu, Bo Li, Steven R. Botts, Mehrsa Feizi, Dorothy Lee, Carol Lee, Kathene C. Johnson‑Henry, Michael G. Surette, Philip M. Sherman, Agostino Pierro (2024)
2023
Remote ischemic conditioning in necrotizing enterocolitis. Semin Pediatr Surg. 32(3): 1-8. Niloofar Ganji, George Biouss, Stella Sabbatini, Bo Li, Carol Lee, Agostino Pierro. (2023).
Family care reduces the incidence of neonatal sepsis: asystematic review and meta-analysis. Front Pediatr. 11: 1-8. Niloofar Ganji, Mashriq Alganabi, Masaya Yamoto, Sinobol Chusilp, Agostino Pierro, Bo Li. (2023).
Remote ischaemic conditioning in necrotisingenterocolitis: a phase I feasibility and safety study. Arch Dis Child Fetal Neonatal Ed. 108(1): 69-76. Carlos Zozaya, Niloofar Ganji, Bo Li, Maarten Janssen Lok, Carol Lee, Yuhki Koike, Estelle Gauda, Martin Offringa, Simon Eaton, Prakeshkumar S Shah, Agostino Pierro. (2023).
Bovine milk-derived exosomes attenuate NLRP3 inflammasome and NF-κB signaling in the lung during neonatal necrotizing enterocolitis. Pediatr Surg Int. 39: 1-8. Rachel Filler, Mina Yeganeh, Bo Li, Carol Lee, Mashriq Alganabi, Alison Hock, George Biouss, Felicia Balsamo, Dorothy Lee, Hiromu Miyake, Agostino Pierro. (2023).
Elective delivery versus expectant management for gastroschisis: a systematic review and meta-analysis. Eur J Pediatr Surg. 33(1): 2-10. Yong Chen, Jiashen Zhao, Mashriq Alganabi, Carmen Mesas-Burgos, Simon Eaton, Tomas Wester, Agostino Pierro. (2023).
Necrotizing enterocolitis: recent advances in treatment with translational potential. Pediatr Surg Int. 39(1): 1-15. Niloofar Ganji, Bo Li, Carol Lee, Agostino Pierro. (2023).
Development of liver inflammatory injury in biliary atresia: from basic to clinical research. Pediatr Surg Int. 39: 1-9. Sinobol Chusilp, Felicia Balsamo, Bo Li, Paisarn Vejchapipat, Agostino Pierro. (2023).
2022
Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial. Pediatr Surg Int. 38, 679–694. Niloofar Ganji, Bo Li, Irfan Ahmad, Alan Daneman, Poorva Deshpande, Vijay Dhar, Simon Eaton, Ricardo Faingold, Estelle B Gauda, Nigel Hall, Salhab el Helou, Mustafa H Kabeer, Jae H Kim, Alice King, Michael H Livingston, Eugene Ng, Martin Offringa, Elena Palleri, Mark Walton, David E Wesson, Tomas Wester, Rene M H Wijnen, Andrew Willan, Rosanna Yankanah, Carlos Zozaya, Prakesh S Shah, Agostino Pierro. (2022).
Remote ischemic conditioning causes CD4 T cells shift towards reduced cell-mediated inflammation. Pediatr Surg Int 38, 657–664. Mashriq Alganabi, George Biouss, Niloofar Ganji, Masaya Yamoto, Carol Lee, Bo Li, Agostino Pierro. (2022).
Surgical management of pediatric inguinal hernia: a systematic review and guideline from the European Pediatric Surgeons’ Association Evidence and Guideline Committee. Eur J Pediatr Surg. 32(3): 219-232. Francesco Morini, Kelly M A Dreuning, Maarten J H Janssen Lok, Tomas Wester, Joep P M Derikx, Florian Friedmacher, Hiromu Miyake, Haitao Zhu, Luca Pio, Martin Lacher, Stefania Sgró, Augusto Zani, Simon Eaton, L W Ernest van Heurn, Agostino Pierro. (2022).
Extra-pleural pneumonectomy (EPP) in children and adults with locally advanced sarcoma. Curr Oncol. 29(6): 4260-4266. Caroline Rodrigues, Hagit Peretz Soroka, Agostino Pierro, Reto M Baertschiger, Marcelo Cypel, Laura Donahoe, Derek S Tsang, John Cho, Marc De Perrot, Thomas K Waddell, Abha A Gupta. (2022).
Hirschsprung-associated enterocolitis: transformative research from bench to bedside. Eur J Pediatr Surg. 32(5): 383-390. Zhen Zhang, Bo Li, Qian Jiang, Qi Li, Agostino Pierro, Long Li. (2022).
Human breast milk-derived exosomes protect against intestinal ischemia and reperfusion injury in neonatal rats. J Pediatr Surg. 57(7): 1264-1268. Lili Wang, Runnan Gao, Bo Li, Mashriq Alganabi, Weijing He,Chun Shen, Haitao Zhu, Agostino Pierro. (2022).
Structure-function relationships of human milk oligosaccharides on the intestinal epithelial transcriptome in Caco-2 cells and a murine model of necrotizing enterocolitis. Mol Nutr Food Res. 66(4): 1-10. Richard Y Wu, Bo Li, Rachael G Horne, Abdalla Ahmed, Dorothy Lee, Shaiya C Robinson, Haitao Zhu, Marissa Cadete, Mashriq Alganabi, Rachel Filler, Kathene C Johnson-Henry, Paul Delgado-Olguin, Agostino Pierro, Philip M Sherman. (2022).
Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development. Immunity. 55(12): 2300-2317. Ji-Eun Kim, Bo Li, Lijiang Fei, Rachael Horne, Dorothy Lee, Adrian Kwan Loe, Hiromu Miyake, Eda Ayar, Dae-Kyum Kim, Michael G Surette, Dana J Philpott, Philip Sherman, Guoji Guo, Agostino Pierro, Tae-Hee Kim. (2022).
Paediatric appendicitis: international study of management in the COVID-19 pandemic. Br J Surg. 109(11): 1044-1048. Paul van Amstel, Ali El Ghazzaoui, Nigel J Hall, Tomas Wester, Francesco Morini, Johanna H van der Lee, Georg Singer, Agostino Pierro, Augusto Zani, Ramon R Gorter; CONNECT collaborative study group. (2022).
Intestinal atresia and necrotizing enterocolitis: embryology and anatomy. Semin Pediatr Surg. 31(6): 151234. Stella Sabbatini, Niloofar Ganji, Sinobol Chusilp, Felicia Balsamo, Bo Li, Agostino Pierro. (2022).
Amniotic fluid stem cells: A novel treatment for necrotizing enterocolitis. Front Pediatr. 10: 1-10. Felicia Balsamo, Yina Tian, Agostino Pierro, Bo Li. (2022).
2021
Treatment of necrotizing enterocolitis by conditioned medium derived from human amniotic fluid stem cells. PLoS One. 16(12): e0260522. Joshua S O’Connell, Bo Li, Andrea Zito, Abdalla Ahmed, Marissa Cadete, Niloofar Ganji, Ethan Lau, Mashriq Alganabi, Nassim Farhat, Carol Lee, Simon Eaton, Robert Mitchell, Steve Ray, Paolo De Coppi, Ketan Patel, Agostino Pierro. (2021).
Meso-Rex bypass versus portosystemic shunt for the management of extrahepatic portal vein obstruction in children: systematic review and meta-analysis. Pediatr Surg Int. 37, 1699–1710. Masaya Yamoto, Sinobol Chusilp, Mashriq Alganabi, Blayne Amir Sayed, Agostino Pierro. (2021).
Endoplasmic reticulum stress in the acute intestinal epithelial injury of necrotizing enterocolitis. Pediatr Surg Int. 37(9): 1151-1160. Ethan Lau, Carol Lee, Bo Li, Agostino Pierro. (2021).
Live intravital intestine with blood flow visualization in neonatal mice using two-photon laser scanning microscopy. Bio Protoc. 11(5): e3937. Yuhki Koike, Bo Li, Yong Chen, Niloofar Ganji, Mashriq Alganabi, Hiromu Miyake, Carol Lee, Alison Hock, Richard Wu, Keiichi Uchida, Mikihiro Inoue, Paul Delgado-Olguin, Agostino Pierro. (2021).
Surgical site infection after open and laparoscopic surgery in children: a systematic review and meta-analysis. Pediatr Surg Int. 37(8): 973-981. Mashriq Alganabi, George Biouss, Agostino Pierro. (2021).
Doppler ultrasound assessment of splanchnic perfusion and heart rate for the detection of necrotizing enterocolitis. Pediatr Surg Int. 37(3): 347-352. Niloofar Ganji, Yuhki Koike, Bo Li, Haitao Zhu, Ethan Lau, Maarten Janssen Lok, Carol Lee, Agostino Pierro. (2021).
Administration of extracellular vesicles derived from human amniotic fluid stem cells: a new treatment for necrotizing enterocolitis. Pediatr Surg Int. 37(3): 301-309. Joshua S O’Connell, Carol Lee, Nassim Farhat, Lina Antounians, Augusto Zani, Bo Li, Agostino Pierro. (2021).
Nasogastric decompression after intestinal surgery in children: a systematic review and meta-analysis. Pediatr Surg Int. 37(3): 377-388. Sinobol Chusilp, Masaya Yamoto, Paisarn Vejchapipat, Niloofar Ganji, Agostino Pierro. (2021).
Hepatic oxidative injury: role of mitochondrial dysfunction in necrotizing enterocolitis. Pediatr Surg Int. 37(3): 325-332. Bindi E, Alganabi M, Biouss G, Liu J, Li B, Miyake H, Angotti R, Pierro A. (2021).
Remote ischemic conditioning avoids the development of intestinal damage after ischemia reperfusion by reducing intestinal inflammation and increasing intestinal regeneration. Zhu H, Li B, Bindi E, Lee C, Alganabi M, Lok MJ, Pierro A. Pediatr Surg Int. 2021 Mar;37(3):333-337. doi: 10.1007/s00383-020-04831-9.
Intestinal epithelial tight junctions and permeability can be rescued through the regulation of endoplasmic reticulum stress by amniotic fluid stem cells during necrotizing enterocolitis. Li B, Lee C, Chuslip S, Lee D, Biouss G, Wu R, Koike Y, Miyake H, Ip W, Gonska T, Pierro A. FASEB Journal. 2021 Jan;35(1):e21265. doi: 10.1096/fj.202001426R.
2020
Human amniotic fluid stem cells attenuate cholangiocyte apoptosis in a bile duct injury model of liver ductal organoids. Chusilp S, Lee C, Li B, Lee D, Yamoto M, Ganji N, Vejchapipat P, Pierro A. Journal of Pediatric Surgery. 2020 Oct 6:S0022-3468(20)30692-8. doi: 10.1016/j.jpedsurg.2020.09.043.
A novel model of injured liver ductal organoids to investigate cholangiocyte apoptosis with relevance to biliary atresia. Chusilp S, Lee C, Li B, Lee D, Yamoto M, Ganji N, Vejchapipat P, Pierro A. Pediatric Surgery International. 2020 Dec;36(12):1471-1479. doi: 10.1007/s00383-020-04765-2.
The effect of pre- and post-remote ischemic conditioning reduces the injury associated with intestinal ischemia/reperfusion. Miyake H, Koike Y, Seo S, Lee C, Li B, Ganji N, Pierro A. Pediatric Surgery International. 2020 Dec;36(12):1437-1442. doi: 10.1007/s00383-020-04762-5.
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation. Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A. Nature Communications. 2020 Oct 2;11(1):4950. doi: 10.1038/s41467-020-18750-9.
Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis. Li B, Lee C, O’Connell JS, Antounians L, Ganji N, Alganabi M, Cadete M, Nascimben F, Koike Y, Hock A, Botts SR, Wu RY, Miyake H, Minich A, Maalouf MF, Zani-Ruttenstock E, Chen Y, Johnson-Henry KC, De Coppi P, Eaton S, Maattanen P, Delgado Olguin P, Zani A, Sherman PM, Pierro A. Cell Death and Disease. 2020 Sep 14;11(9):750. doi: 10.1038/s41419-020-02964-2.
Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Activating Intestinal Cell Differentiation. Li B, Wu RY, Horne RG, Ahmed A, Lee D, Robinson SC, Zhu H, Lee C, Cadete M, Johnson-Henry KC, Landberg E, Alganabi M, Abrahamsson T, Delgado-Olguin P, Pierro A, Sherman PM. Molecular nutrition & food research. 2020 Nov;64(21):e2000519. doi: 10.1002/mnfr.202000519.
Lysosomal overloading and necrotizing enterocolitis. Yamoto M, Alganabi M, Chusilp S, Lee D, Yazaki Y, Lee C, Li B, Pierro A. Pediatric Surgery International. 2020 Oct;36(10):1157-1165. doi: 10.1007/s00383-020-04724-x.
Beneficial effects of butyrate in intestinal injury. Liu J, Zhu H, Li B, Lee C, Alganabi M, Zheng S, Pierro A. Journal of Pediatric Surgery. 2020 Jun;55(6):1088-1093. doi: 10.1016/j.jpedsurg.2020.02.036.
Fecal microbiota transplantation by enema reduces intestinal injury in experimental necrotizing enterocolitis. Liu J, Miyake H, Zhu H, Li B, Alganabi M, Lee C, Pierro A. Journal of Pediatric Surgery. 2020 Jun;55(6):1094-1098. doi: 10.1016/j.jpedsurg.2020.02.035.
The intestinal injury caused by ischemia-reperfusion is attenuated by amniotic fluid stem cells via the release of tumor necrosis factor-stimulated gene 6 protein. Koike, Y., Li, B., Lee, C., Alganabi, M., Zhu, H., Chusilp, S., Lee, D., Cheng, S., Li, Q., & Pierro, A. FASEB journal. 2020 May;34(5):6824-6836. doi: 10.1096/fj.201902892RR.
Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis. Alganabi, M., Zhu, H., O’Connell, J.S., Biouss, G., Zito, A., Li, B., Bindi, E., Pierro, A. Pediatric Surgery International. 2020 Jan 16;10.1007/s00383-019-04615-w.
Human breast milk exosomes attenuate intestinal damage. Miyake, H., Lee, C., Chusilp, S., Bhalla, M., Li, B., Pitino, M., Seo, S., O’Connor, D.L., Pierro, A. Pediatric Surgery International. 2020 Feb;36(2):155-163.
2019
Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis. Chen, Y., Koike, Y., Chi, L., Ahmed, A., Miyake, H., Li, B., Lee, C., Delgado-Olguín, P., Pierro, A.. Disease Models and Mechanisms. 2019 Dec 9;12(12):dmm040998.
Protective effects of lactoferrin on injured intestinal epithelial cells. Liu, J., Li, B., Lee, C., Zhu, H., Zheng, S., Pierro, A. Journal of Pediatric Surgery. 2019 Dec;54(12):2509-2513.
Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. Seo, S., Miyake, H., Alganabi, M., Janssen Lok, M., O’Connell, J.S., Lee, C., Li, B., Pierro, A. Journal of Pediatric Surgery. 2019 Dec;54(12):2520-2523.
Protective effects of vitamin D against injury in intestinal epithelium. Lee, C., Lau, E., Chusilp, S., Filler, R., Li, B., Zhu, H., Yamoto, M., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1395-1401.
Mitochondrial DNA: A Biomarker of Disease Severity in Necrotizing Enterocolitis. Bindi, E., Li, B., Zhou, H., Janssen Lok, M., Alganabi, M., Angotti, R., Pierro, A. European Journal of Pediatric Surgery. 2019 Oct 10;10.1055/s-0039-1697910.
Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis. Li, B., Lee, C., Cadete, M., Zhu, H., Koike, Y., Hock, A., Wu, R.Y., Botts, S.R., Minich, A., Alganabi, M., Chi, L., Zani-Ruttenstock, E., Miyake, H., Chen, Y., Mutanen, A., Ngan, B., Johnson-Henry, K.C., De Coppi, P., Eaton, S., Määttänen, P., Delgado-Olguin, P., Sherman, P.M., Zani, A., Pierro, A. Cell Death and Disease. 2019 Oct 3;10(10):743.
Endothelin receptor B affects the perfusion of newborn intestine: possible mechanism of necrotizing enterocolitis development. Miyake, H., Seo, S., Fujiwara, N., Miyahara, K., Lee, C., Li, B., Chen, Y., Yamataka, A., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1339-1343.
The role of autophagy in intestinal epithelial injury. Yamoto, M., Lee, C., Chusilp, S., Yazaki, Y., Alganabi, M., Li, B., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1389-1394.
Liver Organoids Generated from Mice with Necrotizing Enterocolitis Have Reduced Regenerative Capacity. Miyake, H., Lee, C., Seo, S., Li, B., Pierro, A. European Journal of Pediatric Surgery. 2019 Jul 31;10.
Lactoferrin Reduces Necrotizing Enterocolitis Severity by Upregulating Intestinal Epithelial Proliferation. Liu, J., Zhu, H.T., Li, B., Robinson, S.C., Lee, C., O’Connell, J.S., Bindi, E., Zheng, S., Sherman, P.M., Pierro, A. European Journal of Pediatric Surgery. 2019 Jul 25;10.
Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain. Biouss, G., Antounians, L., Li, B., O’Connell, J.S., Seo, S., Catania, V.D., Guadagno, J., Rahman, A., Zani-Ruttenstock, E., Svergun, N., Pierro, A., Zani, A.. Journal of Neuroinflammation. 2019 May 10;16(1):97.
2018
2017
Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair. Li, B., Lee, C., Filler, T., Hock, A., Wu, R.Y., Li, Q., Chen, S., Koike, Y., Ip, W., Chi, L., Zani-Ruttenstock, E., Määttänen, P., Gonska, T., Delgado-Olguin, P., Zani, A., Sherman, P.M., Pierro, A. Scientific Reports. 2017 May;7:46616.
Gastric emptying is reduced in experimental NEC and correlates with the severity of intestinal damage. Koike, Y., Li, B., Lee, C., Cheng, S., Miyake, H., Welsh, C., Hock, A., Belik, J., Zani, A., Pierro, A. Journal of Pediatric Surgery. 2017 Jan.
Breast milk-derived exosomes promote intestinal epithelial cell growth. Hock, A., Miyake, H., Li, B., Lee, C., Ermini, L., Koike, Y., Chen, Y., Maattanen, P., Zani, A., Pierro, A. Journal of Pediatric Surgery. 2017 Jan.
Intestinal epithelial injury induced by maternal separation is protected by hydrogen sulfide. Li, B., Lee, C., Martin, Z., Li, X., Koike, Y., Hock, A., Zani-Ruttenstock, E., Zani, A., Pierro, A. Journal of Pediatric Surgery. 2017 Jan;52(1):40-4.
2016
Osmolality of enteral formula and severity of experimental necrotizing enterocolitis. Miyake, H., Chen, Y., Koike, Y., Hock, A., Li, B., Lee, C., Zani, A., Pierro, A. Pediatric Surgery International. 2016 Dec;32(12):1153-6.
Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Chen, Y., Koike, Y., Miyake, H., Li, B., Lee, C., Hock, A., Zani, A., Pierro, A. Pediatric Surgery International. 2016 Dec;32(12):1115-9.
Endoplasmic reticulum stress is involved in the colonic epithelium damage induced by maternal separation. Li, B., Zani, A., Lee, C., Zani-Ruttenstock, E., Zhang, Z., Li, X., Ip, W., Gonska, T., Pierro, A. Journal of Pediatric Surgery. 2016 Jun;51(6):1001-4.
Intestinal epithelial cell injury is rescued by hydrogen sulfide. Li, B., Zani, A., Martin, Z., Lee, C., Zani-Ruttenstock, E., Eaton, S., Pierro, A. Journal of Pediatric Surgery. 2016 May;51(5):775-8.
A spectrum of intestinal injury models in neonatal mice. Zani, A., Zani-Ruttenstock, E., Peyvandi, F., Lee, C., Li, B., Pierro, A. Pediatric Surgery International. 2016 January;32(1):65-70.
2015
Necrotizing enterocolitis: controversies and challenges. Zani A , Pierro A. (2015).
2014
Early maternal separation induces alterations of colonic epithelial permeability and morphology. Li, B., Lee, C., Zani, A., Zani-Rutterstock, E., Ip, W., Chi, L., Delgado Olguin, P., Gonska, T., Pierro, A. Pediatric Surgery International. 2014 Dec;30(12):1217-22.
Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Zani, A., Cananzi, M., Fascetti-Leon, F., Lauriti, G., Smith, V.V., Bollini, S., Ghionzoli, M., D’Arrigo, A., Pozzobon, M., Piccoli, M., Hicks, A., Wells, J., Siow, B., Sebire, N.J., Bishop, C., Leon, A., Atala, A., Lythgoe, M.F., Pierro, A., Eaton, S., De Coppi, P. Gut. 2014 Feb;63(2):300-9.