Recent publications

Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis. Alganabi, M., Zhu, H., O’Connell, J.S., Biouss, G., Zito, A., Li, B., Bindi, E., Pierro, A. Pediatric Surgery International. 2020 Jan 16;10.1007/s00383-019-04615-w.

Human breast milk exosomes attenuate intestinal damage. Miyake, H., Lee, C., Chusilp, S., Bhalla, M., Li, B., Pitino, M., Seo, S., O’Connor, D.L., Pierro, A. Pediatric Surgery International. 2020 Feb;36(2):155-163.

Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis. Chen, Y., Koike, Y., Chi, L., Ahmed, A., Miyake, H., Li, B., Lee, C., Delgado-Olguín, P., Pierro, A.. Disease Models and Mechanisms. 2019 Dec 9;12(12):dmm040998.

Protective effects of lactoferrin on injured intestinal epithelial cells. Liu, J., Li, B., Lee, C., Zhu, H., Zheng, S., Pierro, A. Journal of Pediatric Surgery. 2019 Dec;54(12):2509-2513.

Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis. Seo, S., Miyake, H., Alganabi, M., Janssen Lok, M., O’Connell, J.S., Lee, C., Li, B., Pierro, A. Journal of Pediatric Surgery. 2019 Dec;54(12):2520-2523.

Protective effects of vitamin D against injury in intestinal epithelium. Lee, C., Lau, E., Chusilp, S., Filler, R., Li, B., Zhu, H., Yamoto, M., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1395-1401.

Mitochondrial DNA: A Biomarker of Disease Severity in Necrotizing Enterocolitis. Bindi, E., Li, B., Zhou, H., Janssen Lok, M., Alganabi, M., Angotti, R., Pierro, A. European Journal of Pediatric Surgery. 2019 Oct 10;10.1055/s-0039-1697910.

Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis. Li, B., Lee, C., Cadete, M., Zhu, H., Koike, Y., Hock, A., Wu, R.Y., Botts, S.R., Minich, A., Alganabi, M., Chi, L., Zani-Ruttenstock, E., Miyake, H., Chen, Y., Mutanen, A., Ngan, B., Johnson-Henry, K.C., De Coppi, P., Eaton, S., Määttänen, P., Delgado-Olguin, P., Sherman, P.M., Zani, A., Pierro, A. Cell Death and Disease. 2019 Oct 3;10(10):743.

Endothelin receptor B affects the perfusion of newborn intestine: possible mechanism of necrotizing enterocolitis development. Miyake, H., Seo, S., Fujiwara, N., Miyahara, K., Lee, C., Li, B., Chen, Y., Yamataka, A., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1339-1343.

The role of autophagy in intestinal epithelial injury. Yamoto, M., Lee, C., Chusilp, S., Yazaki, Y., Alganabi, M., Li, B., Pierro, A. Pediatric Surgery International. 2019 Dec;35(12):1389-1394.

Liver Organoids Generated from Mice with Necrotizing Enterocolitis Have Reduced Regenerative Capacity. Miyake, H., Lee, C., Seo, S., Li, B., Pierro, A. European Journal of Pediatric Surgery. 2019 Jul 31;10.

Lactoferrin Reduces Necrotizing Enterocolitis Severity by Upregulating Intestinal Epithelial Proliferation. Liu, J., Zhu, H.T., Li, B., Robinson, S.C., Lee, C., O’Connell, J.S., Bindi, E., Zheng, S., Sherman, P.M., Pierro, A. European Journal of Pediatric Surgery. 2019 Jul 25;10.

Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain. Biouss, G., Antounians, L., Li, B., O’Connell, J.S., Seo, S., Catania, V.D., Guadagno, J., Rahman, A., Zani-Ruttenstock, E., Svergun, N., Pierro, A., Zani, A.. Journal of Neuroinflammation. 2019 May 10;16(1):97.

Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis. Li, B., Hock, A., Wu, R.Y., Minich, A., Botts, S.R., Lee, C., Antounians, L., Miyake, H., Koike, Y., Chen, Y., Zani, A., Sherman, P.M., Pierro, A. PLoS One. 2019 Jan 30;14(1):e0211431.
Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders. Li, B., Lee, C., Cadete, M., Miyake, H., Lee, D., Pierro, A. Pediatric Surgery International. 2019 Jan;35(1):3-7.
Live Imaging of Fetal Intra-abdominal Organs Using Two-Photon Laser-Scanning Microscopy. Koike, Y., Li, B., Chen, Y., Miyake, H., Lee, C., Chi, L., Wu, R., Inoue, M., Uchida, K., Kusunoki, M., Delgado-Olguin, P., Pierro, A. Methods in Molecular Biology. 2018;1752:63-69.
Liver damage, proliferation, and progenitor cell markers in experimental necrotizing enterocolitis. Miyake, H., Li, B., Lee, C., Koike, Y., Chen, Y., Seo, S., Pierro, A. Journal of Pediatric Surgery. 2018 May;53(5):909-913.
Influence of stress factors on intestinal epithelial injury and regeneration. Lee, C., Minich, A., Li, B., Miyake, H., Seo, S., Pierro, A. Pediatric Surgery International. 2018 Feb;34(2):155-160.

Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair. Li, B., Lee, C., Filler, T., Hock, A., Wu, R.Y., Li, Q., Chen, S., Koike, Y., Ip, W., Chi, L., Zani-Ruttenstock, E., Määttänen, P., Gonska, T., Delgado-Olguin, P., Zani, A., Sherman, P.M., Pierro, A. Scientific Reports. 2017 May;7:46616.

Gastric emptying is reduced in experimental NEC and correlates with the severity of intestinal damage. Koike, Y., Li, B., Lee, C., Cheng, S., Miyake, H., Welsh, C., Hock, A., Belik, J., Zani, A., Pierro, A.  Journal of Pediatric Surgery. 2017 Jan.

Breast milk-derived exosomes promote intestinal epithelial cell growth. Hock, A., Miyake, H., Li, B., Lee, C., Ermini, L., Koike, Y., Chen, Y., Maattanen, P., Zani, A., Pierro, A.  Journal of Pediatric Surgery. 2017 Jan.

Intestinal epithelial injury induced by maternal separation is protected by hydrogen sulfide. Li, B., Lee, C., Martin, Z., Li, X., Koike, Y., Hock, A., Zani-Ruttenstock, E., Zani, A., Pierro, A.  Journal of Pediatric Surgery. 2017 Jan;52(1):40-4.

Osmolality of enteral formula and severity of experimental necrotizing enterocolitis. Miyake, H., Chen, Y., Koike, Y., Hock, A., Li, B., Lee, C., Zani, A., Pierro, A. Pediatric Surgery International. 2016 Dec;32(12):1153-6.

Formula feeding and systemic hypoxia synergistically induce intestinal hypoxia in experimental necrotizing enterocolitis. Chen, Y., Koike, Y., Miyake, H., Li, B., Lee, C., Hock, A., Zani, A., Pierro, A. Pediatric Surgery International. 2016 Dec;32(12):1115-9.

Endoplasmic reticulum stress is involved in the colonic epithelium damage induced by maternal separation. Li, B., Zani, A., Lee, C., Zani-Ruttenstock, E., Zhang, Z., Li, X., Ip, W., Gonska, T., Pierro, A. Journal of Pediatric Surgery. 2016 Jun;51(6):1001-4.

Intestinal epithelial cell injury is rescued by hydrogen sulfide. Li, B., Zani, A., Martin, Z., Lee, C., Zani-Ruttenstock, E., Eaton, S., Pierro, A. Journal of Pediatric Surgery. 2016 May;51(5):775-8.

A spectrum of intestinal injury models in neonatal mice. Zani, A., Zani-Ruttenstock, E., Peyvandi, F., Lee, C., Li, B., Pierro, A. Pediatric Surgery International. 2016 January;32(1):65-70.

Early maternal separation induces alterations of colonic epithelial permeability and morphology. Li, B., Lee, C., Zani, A., Zani-Rutterstock, E., Ip, W., Chi, L., Delgado Olguin, P., Gonska, T., Pierro, A. Pediatric Surgery International. 2014 Dec;30(12):1217-22.

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Zani, A., Cananzi, M., Fascetti-Leon, F., Lauriti, G., Smith, V.V., Bollini, S., Ghionzoli, M., D’Arrigo, A., Pozzobon, M., Piccoli, M., Hicks, A., Wells, J., Siow, B., Sebire, N.J., Bishop, C., Leon, A., Atala, A., Lythgoe, M.F., Pierro, A., Eaton, S., De Coppi, P. Gut. 2014 Feb;63(2):300-9.

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