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Paediatric Neuroinflammatory Disorders Program
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OUR RESEARCH
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2025
A cross-sectional study investigating age of multiple sclerosis onset and its association with self-management knowledge and behaviors
Smouldering disease in paediatric-onset multiple sclerosis
Age of multiple sclerosis symptom onset affects mental and physical health-related quality of life in opposite directions
Physical activity demonstrates protective associations with structural visual metrics in children with multiple sclerosis through time
Vitamin D- should we all take it?
Emphasizing complementary in "Investigating the complementary value of OCT to MRI in cognitive impairment in relapsing-remitting multiple sclerosis"
Identifying axonal injury through the eye: can the cornea provide new clues to axonal injury in MS?
Evaluating Equity, Diversity, Indigeneity, Inclusion, and Accessibility Focused Scholarship in Faculty Promotions in Higher Education Institutions
When does multiple sclerosis start?
Access to therapy for children and adolescents with multiple sclerosis: global considerations in preventing disease progression
Validity of model for predicting risk of relapse in MOGAD
Exploring Treatment Approaches in Pediatric MOG Antibody-Associated Disease: A Survey of Neurologists
The P42 epitope in MOG associated disorders: Understanding regional variations and predictive value
Accelerated Aging in Children With Multiple Sclerosis: Can We Stop the Clock?
Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies
Associations between fronto-limbic white matter connections and internalizing symptoms in pediatric demyelinating disease
Infectious mononucleosis is a more realistic target for preventing multiple sclerosis
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Is there truly no progression in NMOSD and MOGAD?
Scoping review of the availability and uptake of disease modifying therapies in children and adolescents with multiple sclerosis
Embodiment of structural racism and multiple sclerosis risk and outcomes in the USA
2024
Neurological involvement in hospitalized children with SARS-CoV-2 infection: a multinational study
A Systematic Review of Methods Used by Pediatric Cost-Utility Analyses to Include Family Spillover Effects
Myelin oligodendrocyte glycoprotein antibody titers by fixed cell-based assay: positive predictive value and impact of sample collection timing
Brain Volumes in Opsoclonus-Myoclonus Ataxia Syndrome: A Longitudinal Study
Mediterranean diet and associations with the gut microbiota and pediatric-onset multiple sclerosis using trivariate analysis
A Systematic Review of Methods and Practice for Integrating Maternal, Fetal, and Child Health Outcomes, and Family Spillover Effects into Cost-Utility Analyses
Depression and anxiety in MS: symptoms or comorbidity?
Innovation and optimization in autoimmune encephalitis trials: the design and rationale for the Phase 3, randomized study of satralizumab in patients with NMDAR-IgG-antibody-positive or LGI1-IgG-antibody-positive autoimmune encephalitis (CIELO)
The risks and benefits of using AI for diagnosis: beware of unconscious bias
Social network characteristics and their relationships with physical activity in children with multiple sclerosis
Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis
Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation
Slowly Expanding Lesions Differentiate Pediatric Multiple Sclerosis from Myelin Oligodendrocyte Glycoprotein Antibody Disease
Smouldering-associated worsening or SAW: the next therapeutic challenge in managing multiple sclerosis
The fungal gut microbiota in pediatric-onset multiple sclerosis
Can placebo-controlled phase 2 disease-modifying therapy trials in MS still be justified?
Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis
Where does multiple sclerosis come from?
Real-life benefits of high-efficacy therapies for children with multiple sclerosis
OCT-Angiography in AQP4-positive NMOSD: finding subclinical disease using a new tool
Clinical features and outcomes in children with seronegative autoimmune encephalitis
Epstein-Barr Virus Strongly Associates With Pediatric Multiple Sclerosis, But Not Myelin Oligodendrocyte Glycoprotein-Antibody-Associated Disease
2023
Family health conditions and parental occupational status modify the relationship between pediatric-onset multiple sclerosis and parental health-related quality of life
Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset
A cross-sectional study of MRI features and the gut microbiome in pediatric-onset multiple sclerosis
Rapid and inexpensive bedside diagnosis of RAN binding protein 2-associated acute necrotizing encephalopathy
Interim guidelines for the assessment and treatment of pain in children with multiple sclerosis
A Systematic Review of Methods Used by Pediatric Cost-Utility Analyses to Include Family Spillover Effect
Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis
Challenges in the Clinical Recognition of Acute Flaccid Myelitis and its Implications
SARS-CoV-2 infection in technology-dependent children: a multicenter case series
Is it ethical to use teriflunomide as an active comparator in phase 3 trials?
Equity, diversity and inclusion in academic publishing: Can we move the needle?
Emboldened or not: The potential fall-out of a failed anti-EBV trial in multiple sclerosis
Inequality in accessing healthcare for people with MS
Is multiple sclerosis a glymphaticopathy?
Social network size and mental health outcomes in youth with neuroinflammatory disorders
Can we improve outcomes in MS around the world? Access and global considerations across income strata
Pediatric Multiple Sclerosis: Changing the Trajectory of Progression
Sleep, physical activity, and psychological outcomes in children and adolescents with pediatric onset multiple sclerosis
Beyond the B-cell as a treatment target in multiple sclerosis
Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination
Delayed oculomotor response associates with optic neuritis in youth with demyelinating disorders
Multiple types of relapses in MOG antibody disease
Are we ready for CD19-targeted CAR T-cell therapies in MS?
2022
Physical Activity and Sedentary Behavior Patterns Across Weekdays and Weekend Days in Youth With Multiple Sclerosis and Controls
Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study
Feasibility of a theory-informed mobile app for changing physical activity in youth with multiple sclerosis
Multiple sclerosis is one disease
The health-related quality of life of children with multiple sclerosis is mediated by the health-related quality of life of their parents
Cognitive function in pediatric-onset relapsing myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
Infection-Related Myelopathies
Outcomes in influenza and RANBP2 mutation-associated acute necrotizing encephalopathy of childhood
The metabolic potential of the paediatric-onset multiple sclerosis gut microbiome
Pandemic-associated mental health changes in youth with neuroinflammatory disorders
Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases
Is EBV the cause of multiple sclerosis?
Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study
Serum MOG-IgG in children meeting multiple sclerosis diagnostic criteria
Metagenomic Analysis of the Pediatric-Onset Multiple Sclerosis Gut Microbiome
Progressive retinal changes in pediatric multiple sclerosis
Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders
What are T-cells telling us about how EBV causes MS?
Linking X to MS: Immunity and demyelination on the X-chromosome in MS
High efficacy treatment is not enough in MS: Socioeconomic factors are key to improving outcomes
Implications of Low-Titer MOG Antibodies
Editorial: New Therapeutic Options for Rare Diseases
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective
Structural visual metrics associate with moderate to vigorous physical activity in youth with pediatric onset neuroinflammatory disorders
2021
Examining cognitive speed and accuracy dysfunction in youth and young adults with pediatric-onset multiple sclerosis using a computerized neurocognitive battery
Acute flaccid myelitis: long-term outcomes recorded in the CAPTURE study compared with paediatric transverse myelitis
Impact of COVID-19 public health measures on myelin oligodendrocyte glycoprotein IgG-associated disorders in children
APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes
Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease
It is time to move to alternative clinical trial designs: Reconsidering the holy grail of trial methodology
Real-world outcomes in pediatric MS: Psychiatric comorbidities and school performance
Comparison of Spinal Cord Magnetic Resonance Imaging Features Among Children With Acquired Demyelinating Syndromes
COVID-19 vaccines and multiple sclerosis disease-modifying therapies
Pro-inflammatory adiponectin in pediatric-onset multiple sclerosis
Acute flaccid myelitis: cause, diagnosis, and management
Infection-Related Myelopathies
It is time to move to alternative clinical trial designs: Reconsidering the holy grail of trial methodology
Lifestyle factors and outcomes in paediatric-onset multiple sclerosis
Longer-term Safety of B-Cell Therapy With Ocrelizumab in Multiple Sclerosis
Physical Activity in Youth with Multiple Sclerosis receiving the ATOMIC intervention: Social connectedness above all else
2020
Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study
Increased mental health care use by mothers of children with multiple sclerosis
Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis
Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations
Youth with multiple sclerosis have low levels of fitness
Could wider social networks prevent disability in MS and other neurologic disorders?
Tracking Therapies in MS: More Evidence in Favor of Neurofilament
Factors associated with health care utilization in pediatric multiple sclerosis.
Deep learning segmentation of orbital fat to calibrate conventional MRI for longitudinal studies.
Rituximab in children with myelin oligodendrocyte glycoprotein antibody and relapsing neuroinflammatory disease.
Serial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes.
Corrigendum: Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis
2019
Improving outcomes in pediatric onset MS
Therapeutic plasma exchange in children with acute demyelination: kids are not small adults!
Vaccination: Not a trigger for MS.
Demyelinating lesions and progressive MS: location, location, location
Evolution of regional brain atrophy in children with multiple sclerosis: Gray matters
Family functioning among adolescents with narcolepsy.
Forecasting outcomes in anti-NMDAR encephalitis
A surface‐in gradient of thalamic damage evolves in pediatric multiple sclerosis
Live-cell based assays are the gold standard for anti-MOG-Ab testing
Abnormal effector and regulatory T cell subsets in paediatric-onset multiple sclerosis
Enhanced Recruitment During Executive Control Processing in Cognitively Preserved Patients With Pediatric-Onset MS.
Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis.
Treatment of rituximab-associated chronic CNS enterovirus using IVIg and fluoxetine.
PANDAS/PANS in childhood: Controversies and evidence.
An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome.
Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.
Depressive symptoms, sleep patterns, and physical activity in adolescents with narcolepsy.
Early neuroaxonal injury is seen in the acute phase of pediatric optic neuritis.
Therapeutic plasma exchange in children with acute demyelination: Kids are not small adults!
2018
Incidence and prevalence of MS in children: A population-based study in Ontario, Canada.
Physical activity and dentate gyrus volume in pediatric acquired demyelinating syndromes.
Natural history and extracutaneous involvement of congenital morphea: Multicenter retrospective cohort study and literature review.
Radiologically isolated syndrome in children: Current knowledge and future directions.
Neuroimmune disorders of the central nervous system in children in the molecular era.
Acute Flaccid Paralysis and Enteroviral Infections.
Adherence in Youth With Multiple Sclerosis: A Qualitative Assessment of Habit Formation, Barriers, and Facilitators.
Evaluation of an Ophthalmoscopy Simulator to Teach Funduscopy Skills to Pediatric Residents.
Detection and clinical correlation of leukocortical lesions in pediatric-onset multiple sclerosis on multi-contrast MRI.
Lyme disease presenting with multiple cranial neuropathies on MRI.
Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.
MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study.
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis.
Specific myelopathy diagnoses using advancing diagnostics
Involvement of the Amygdala in Memory and Psychosocial Functioning in Pediatric-Onset Multiple Sclerosis.
2017
Evaluation and treatment of Langerhans cell histiocytosis patients with central nervous system abnormalities: Current views and new vistas.
Radiologically isolated syndrome in children
A feasibility study of working memory training for individuals with paediatric-onset multiple sclerosis.
Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial
Monophasic demyelination reduces brain growth in children.
White matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders.
Interferon-Stimulated Gene Expression as a Preferred Biomarker for Disease Activity in Aicardi-Goutières Syndrome.
The computer-based Symbol Digit Modalities Test: establishing age-expected performance in healthy controls and evaluation of pediatric MS patients.
Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada.
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis
How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?
2016
The Changing Landscape of Childhood Inflammatory Central Nervous System Disorders
Physical Activity and Its Correlates in Youth with Multiple Sclerosis.
Cognitive and Behavioral Functioning in Childhood Acquired Demyelinating Syndromes.
Physical activity in pediatric onset multiple sclerosis: Validating a questionnaire for clinical practice and research.
Pediatric optic neuritis.
ROHHAD syndrome and evolution of sleep disordered breathing.
Canadian Paediatric Neurology Workforce Survey and Consensus Statement.
Contribution of the cerebellum to cognitive performance in children and adolescents with multiple sclerosis.
Long-Term Neurocognitive, Psychosocial, and Magnetic Resonance Imaging Outcomes in Pediatric-Onset Acute Disseminated Encephalomyelitis.
Fatigue in childhood multiple sclerosis
2015
The temporal evolution of structural and functional measures after acute optic neuritis.
Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis.
Physical activity and pediatric multiple sclerosis: Developing a research agenda.
Recovery From Central Nervous System Acute Demyelination in Children.
Outcomes after early administration of plasma exchange in pediatric central nervous system inflammatory demyelination.
Evaluation of fall Sun Exposure Score in predicting vitamin D status in young Canadian adults, and the influence of ancestry.
2014
Rituximab as a first-line preventive treatment in pediatric NMOSDs: Preliminary results in 5 children.
Functional-structural correlations in the afferent visual pathway in pediatric demyelination.
Antinuclear antibodies in pediatric acquired demyelinating diseases of the central nervous system.
White matter changes in childhood NMDA receptor encephalitis
Multicystic demyelinating myelopathy: widening spectrum of pediatric aquaporin-4 autoimmunity.
Tract-based spatial statistics analysis of diffusion-tensor imaging data in pediatric- and adult-onset multiple sclerosis.
2013
2010 McDonald criteria in a pediatric cohort: is positivity at onset associated with a more aggressive multiple sclerosis course?
Glatiramer acetate-induced acute hepatotoxicity in an adolescent with MS.
Fatigue and depression in children with demyelinating disorders.
Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis.
Synthesis and analysis of the all-(S) side chain of phosphomycoketides: a test of NMR predictions for saturated oligoisoprenoid stereoisomers.
Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis.
Bare-minimum fluorous mixture synthesis of a stereoisomer library of 4,8,12-trimethylnonadecanols and predictions of NMR spectra of saturated oligoisoprenoid stereoisomers.
Reversible diffusion weighted imaging changes in propionic acidemia.
2012
No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis.
The management of pediatric multiple sclerosis.
Management of children with multiple sclerosis.
Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis.
Neurologic complications of 2009 influenza-a H1N1 infection in children.
Multiple sclerosis: Which MRI findings predict MS development in children?
Acuted disseminated encephalomyelitis.
Regression-based norms improve the sensitivity of the National MS Society Consensus Neuropsychological Battery for Pediatric Multiple Sclerosis (NBPMS).
Consensus statement: evaluation of new and existing therapeutics for pediatric multiple sclerosis.
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