Trimble Lab | Cell Biology
Using multidisciplinary approaches involving biochemistry, molecular and cell biology, the Trimble Lab’s overarching aim is to investigate the mechanisms by which membranes and the cytoskeleton interact to control complex cellular processes.
One area of focus involves the study of the septin family of cytoskeletal proteins and their roles as signaling platforms to control cellular activities such as cell division, cell migration and the development of cancer.
A second area involves the study of membrane and cytoskeletal proteins implicated in the formation of the primary cilium, and their possible roles in cell and tissue polarity.
Thirdly, we investigate how specific membrane proteins, such as the scavenger receptors CD36 and SR-B1, transport lipid into cells.
Finally, we study the SNARE proteins that mediate membrane fusion and their regulators such as the AAA ATPase NSF, particularly in the context of neurotransmitter release.
Contact us:
Rashna Irani
Administrative Coordinator
SickKids Research Institute
Peter Gilgan Centre for Research and Learning
686 Bay Street, Room 19.9800
Toronto, ON M5G 0A4
Phone: 416-813-5727
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