2021

Structure-function relationships of human milk oligosaccharides on the intestinal epithelial transcriptome in Caco-2 cells and a murine model of necrotizing enterocolitis. Wu RY, Li B, Horne RG, Ahmed A, Lee D, Robinson SC, Zhu H, Cadete M, Alganabi M, Filler R, Johnson-Henry KC, Delgado-Olguin P, Pierro A, Sherman. Mol Nutr and Food Res, December 2021, DOI: 10.1002/mnfr.202100893).

Amniotic fluid stem cell administration can prevent epithelial injury from necrotizing enterocolitis. Li B, Lee C, Cadete M, O’Connell JS, Alganabi M, Lee D, Ganji N, Miyake H, Botts SR, Johnson-Henry KC, Maattanen P, Sherman PM, Pierro A. Pediatr Res. 2021 Sep 24. doi: 10.1038/s41390-021-01657-6.

Antimicrobial susceptibilities and comparative whole genome analysis of two isolates of the probiotic bacterium Lactiplantibacillus plantarum, strain ATCC 202195. Pell, R. Horne, S. Huntley, H. Rahman, S. Kar, M. Islam, K. Evans, S. Saha, A. Campigotto, S. Morris, D. Roth, P. Sherman. Sci Rep. 2021 Aug 5;11(1):15893.

Probiotic stool secretory immunoglobulin A modulation in children with gastroenteritis: a r andomized clinical trial. Freedman, R. Horne, K. Johnson-Henry, J. Xie, S. Williamson-Urqhart, L. Chui, X-L Pang, B. Lee, S. Schuh, Y. Finkelstein, S. Grouin, K. Farion, N. Poonai, K. Hurley, D. Schnadower, P. Sherman.. Am J Clin Nutr. 2021 Apr 6;113(4):905-914.

High Fat-High Fructose Diet-Induced Changes in the Gut Microbiota Associated with Dyslipidemia in Syrian Hamsters.

Horne RG, Yu Y, Zhang R, Abdalqadir N, Rossi L, Surette M, Sherman PM, Adeli K. Nutrients. 2020 Nov 20;12(11):3557. doi: 10.3390/nu12113557.

 

Lactoferrin reduces necrotizing enterocolitis severity by upregulating intestinal epithelial proliferation.

Liu J, Zhu H, Li B, Robinson SC, Lee C, O’Connell JS, Bindi E, Zheng S, Sherman PM, Pierro A. Eur J Pediatr Surg. 2020 Feb;30(1):90-95. doi: 10.1055/s-0039-1693728.

 

A randomized trial evaluating virus-specific effects of a combination probiotic in children with acute gastroenteritis.

Freedman SB, Xie J, Nettel-Aguirre A, Pang XL, Chui L, Williamson-Urquhart S, Schnadower D, Schuh S, Sherman PM, Lee BE, Gouin S, Farion KJ, Poonai N, Hurley KF, Qiu Y, Ghandi B, Lloyd C, Finkelstein Y; Pediatric Emergency Research Canada Probiotic (PERC) Regimen for Outpatient Gastroenteritis Utility of Treatment (PROGUT) Trial Group. Nat Commun. 2020 May 21;11(1):2533. doi: 10.1038/s41467-020-16308-3. Clinical Trial.

 

Vitamin B12 deficiency alters the gut microbiota in a murine model of colitis.

Lurz E, Horne RG, Määttänen P, Wu RY, Botts SR, Li B, Rossi L, Johnson-Henry KC, Pierro A, Surette MG, Sherman PM. Front Nutr. 2020 Jun 5;7:83. doi: 10.3389/fnut.2020.00083. eCollection 2020.

 

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.

Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A. Nat Commun. 2020 Oct 2;11(1):4950. doi: 10.1038/s41467-020-18750-9.

 

Human milk oligosaccharides protect against necrotizing enterocolitis by activating intestinal cell differentiation.

Li B, Wu RY, Horne RG, Ahmed A, Lee D, Robinson SC, Zhu H, Lee C, Cadete M, Johnson-Henry KC, Landberg E, Alganabi M, Abrahamsson T, Delgado-Olguin P, Pierro A, Sherman PM. Mol Nutr Food Res. 2020 Sep 14:e2000519. doi: 10.1002/mnfr.202000519. Online ahead of print.

 

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis.

Li B, Lee C, O’Connell JS, Antounians L, Ganji N, Alganabi M, Cadete M, Nascimben F, Koike Y, Hock A, Botts SR, Wu RY, Miyake H, Minich A, Maalouf MF, Zani-Ruttenstock E, Chen Y, Johnson-Henry KC, De Coppi P, Eaton S, Maattanen P, Delgado Olguin P, Zani A, Sherman PM, Pierro A. Cell Death Dis. 2020 Sep 14;11(9):750. doi: 10.1038/s41419-020-02964-2.

 

Plant- and fish-derived n-3 PUFAs suppress Citrobacter rodentium-induced colonic inflammation.

Määttänen P, Lurz E, Botts SR, Wu RY, Robinson SC, Yeung CW, Colas R, Li B, Johnson-Henry KC, Surette ME, Dalli J, Sherman PM. Mol Nutr Food Res. 2020 Mar;64(6):e1900873. doi: 10.1002/mnfr.201900873.

Lactobacillus for gastroenteritis in children. Reply.

Freedman SB, Sherman PM, Schuh S. N Engl J Med. 2019 May 9;380(19):e36.

Quantification and visualization of neutrophil extracellular traps (NETs) from murine bone marrow-derived neutrophils.

Vong L, Sherman PM, Glogauer M. Methods Mol Biol. 2019;1960:63-73.

Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis.

Li B, Lee C, Cadete M, Zhu H, Koike Y, Hock A, Wu RY, Botts SR, Minich A, Alganabi M, Chi L, Zani-Ruttenstock E, Miyake H, Chen Y, Mutanen A, Ngan B, Johnson-Henry KC, De Coppi P, Eaton S, Määttänen P, Delgado-Olguin P, Sherman PM, Zani A, Pierro A. Cell Death Dis. 2019 Oct 3;10(10):743. doi: 10.1038/s41419-019-1987-1.

Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis.

Li B, Hock A, Wu RY, Minich A, Botts SR, Lee C, Antounians L, Miyake H, Koike Y, Chen Y, Zani A, Sherman PM, Pierro A. PLoS One. 2019 Jan 30;14(1):e0211431.

Arguments against routine administration of probiotics for NEC prevention.

Pell LG, Loutet MG, Roth DE, Sherman PM. Curr Opin Pediatr. 2019 Apr;31(2):195-201.

Human milk oligosaccharides increase mucin expression in experimental necrotizing enterocolitis.

Wu RY, Li B, Koike Y, Määttänen P, Miyake H, Cadete M, Johnson-Henry KC, Botts SR, Lee C, Abrahamsson TR, Landberg E, Pierro A, Sherman PM. Mol Nutr Food Res. 2019 Feb;63(3):e1800658.

Comparative effectiveness of prophylactic therapies for necrotizing enterocolitis in preterm infants: Protocol for a network meta-analysis of randomized trials.

Sadeghirad B, Florez ID, Chang Y, Forutan F, Zeraatkar D, Morgan RL, Shahid S, Bala MM, Beyene J, Offringa M, Adams-Webber T, Sherman PM, El-Gouhary E, Guyatt GH, Johnston BC. Int J Prev Med. 2018 Sep 17;9:83.

Multicenter trial of a combination probiotic for children with gastroenteritis.

Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, Hurley K, Sherman PM, Finkelstein Y, Lee BE, Pang XL, Chui L, Schnadower D, Xie J, Gorelick M, Schuh S; PERC PROGUT Trial Group. N Engl J Med. 2018 Nov 22;379(21):2015-2026.

Human milk oligosaccharides increase mucin expression in experimental necrotizing enterocolitis.

Wu RY, Li B, Koike Y, Määttänen P, Miyake H, Cadete M, Johnson-Henry KC, Botts SR, Lee C, Abrahamsson TR, Landberg E, Pierro A, Sherman PM.

Mol Nutr Food Res. 2019 Feb;63(3):e1800658.

Määttänen P, Lurz E, Botts SR, Wu RY, Yeung CW, Li B, Abiff S, Johnson-Henry KC, Lepp D, Power KA, Pierro A, Surette ME, Sherman PM.

Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G788-G798.

Universal recommendations for the management of acute diarrhea in non-malnourished children.

Guarino A, Lo Vecchio A, Dias JA, Berkley JA, Boey C, Bruzzese D, Cohen MB, Cruchet S, Liguoro I, Salazar-Lindo E, Sandhu B, Sherman PM, Shimizu T.

J Pediatr Gastroenterol Nutr. 2018 Jun 12.

Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota.

Wu RY, Määttänen P, Napper S, Scruten E, Li B, Koike Y, Johnson-Henry KC, Pierro A, Rossi L, Botts SR, Surette MG, Sherman PM. Microbiome. 2017 Oct 10;5(1):135.

Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair.

Li B, Lee C, Filler T, Hock A, Wu RY, Li Q, Chen S, Koike Y, Ip W, Chi L, Zani-Ruttenstock E, Määttänen P, Gonska T, Delgado-Olguin P, Zani A, Sherman PM,

Pierro A. Sci Rep. 2017 May 11;7:46616.

Summary on Human Milk Oligosaccharides.

Sherman PM. Nestle Nutr Inst Workshop Ser. 2017;88:171-172.

Microbiota in Functional Gastrointestinal Disorders in Infancy: Implications for Management.

Abrahamsson TR, Wu RY, Sherman PM. Nestle Nutr Inst Workshop Ser. 2017;88:107-115.

Impact of prebiotics, probiotics, and gut derived metabolites on host immunity.

Richard Y. Wu, Michael P. Jeffrey, Kathene C. Johnson-Henry, Julia M. Green-Johnson, Philip M. Sherman. LymphoSign. 2017 vol 4 (doi: 10.14785/lymphosign-2016-0012).

Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function.

Wu RY, Abdullah M, Määttänen P, Pilar AV, Scruten E, Johnson-Henry KC, Napper S, O’Brien C, Jones NL, Sherman PM. Sci Rep. 2017 Jan 18;7:40820.

Probiotics, Prebiotics, and Synbiotics for the Prevention of Necrotizing Enterocolitis. Johnson-Henry KC, Abrahamsson TR, Wu RY, Sherman PM. Adv Nutr. 2016 Sep 15;7(5):928-37. Review.

Comparison of Recommendations in Clinical Practice Guidelines for Acute Gastroenteritis in Children. Lo Vecchio A, Dias JA, Berkley JA, Boey C, Cohen MB, Cruchet S, Liguoro I, Salazar Lindo E, Sandhu B, Sherman P, Shimizu T, Guarino A. J Pediatr Gastroenterol Nutr. 2016 Aug;63(2):226-35.

Novel antimicrobial peptide prevents C. rodentium infection in C57BL/6 mice by enhancing acid-induced pathogen killing.  Lackraj T, Johnson-Henry K, Sherman PM, Goodman SD, Segall AM, Barnett Foster D. Microbiology. 2016 Sep;162(9):1641-1650.

Mucosa-Associated Ileal Microbiota in New-Onset Pediatric Crohn’s Disease.  Assa A, Butcher J, Li J, Elkadri A, Sherman PM, Muise AM, Stintzi A, Mack D. Inflamm Bowel Dis. 2016 Jul;22(7):1533-9.

Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis.  Sima C, Cheng Q, Rautava J, Levesque C, Sherman P, Glogauer M.  J Periodontal Res. 2016 Apr;51(2):237-49.

Genome-based Definition of an Inflammatory Bowel Disease-associated Adherent-Invasive Escherichia coli Pathovar.  Desilets M, Deng X, Rao C, Ensminger AW, Krause DO, Sherman PM, Gray-Owen SD.  Inflamm Bowel Dis. 2016 Jan;22(1):1-12.

Adherent-invasive Escherichia coli Exacerbates Antibiotic-associated Intestinal Dysbiosis and Neutrophil Extracellular Trap Activation.  Vong L, Yeung CW, Pinnell LJ, Sherman PM.  Inflamm Bowel Dis. 2016 Jan;22(1):42-54.

Selective enrichment of commensal gut bacteria protects against Citrobacter rodentium-induced colitis. Vong L, Pinnell LJ, Määttänen P, Yeung CW, Lurz E, Sherman PM. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G181-92.

Phenotypic and genotypic characterisation of biallelic mismatch repair deficiency (BMMR-D) syndrome.  Durno CA, Sherman PM, Aronson M, Malkin D, Hawkins C, Bakry D, Bouffet E, Gallinger S, Pollett A, Campbell B, Tabori U; International BMMRD Consortium.  Eur J Cancer. 2015 May;51(8):977-83.

GLP-1R agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte GLP-1R.  Yusta B, Baggio LL, Koehler J, Holland D, Cao X, Pinnell LJ, Johnson-Henry KC, Yeung W, Surette MG, Bang KW, Sherman PM, Drucker DJ.  Diabetes. 2015 Jul;64(7):2537-49. doi: 10.2337/db14-1577. Epub 2015 Mar 3.

Emergency department treatment of children with diarrhea who attend day care: A randomized multidose trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic.  Freedman SB, Sherman PM, Willan A, Johnson D, Gouin S, Schuh S; Pediatric Emergency Research Canada (PERC).  Clin Pediatr (Phila). 2015 Oct;54(12):1158-66.

Transforming growth factor-β1 protects against intestinal epithelial barrier dysfunction caused by hypoxia-reoxygenation.  Howe KL, Lorentz RJ, Assa A, Pinnell LJ, Johnson-Henry KC, Sherman PM.  Shock. 2015 May;43(5):483-9.

Vitamin D deficiency predisposes to adherent-invasive Escherichia coli-induced barrier dysfunction and experimental colonic injury.  Assa A, Vong L, Pinnell LJ, Rautava J, Avitzur N, Johnson-Henry KC, Sherman PM.  Inflamm Bowel Dis. 2015 Feb;21(2):297-306.

A recent situation.  Sherman PM.  J Oral Maxillofac Surg. 2015 Feb;73(2):202

Short-chain fructo-oligosaccharide and inulin modulate inflammatory responses and microbial communities in Caco2-bbe cells and in a mouse model of intestinal injury.  Johnson-Henry KC, Pinnell LJ, Waskow AM, Irrazabal T, Martin A, Hausner M, Sherman PM.  J Nutr. 2014 Nov;144(11):1725-33.

The time for a confirmative necrotizing enterocolitis probiotics prevention trial in the extremely low birth weight infant in North America is now! Abrahamsson TR, Rautava S, Moore AM, Neu J, Sherman PM.  J Pediatr. 2014 Aug;165(2):389-94.

Impact of emergency department probiotic treatment of pediatric gastroenteritis: study protocol for the PROGUT (Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment) randomized controlled trial.  Freedman SB, Williamson-Urquhart S, Schuh S, Sherman PM, Farion KJ, Gouin S, Willan AR, Goeree R, Johnson DW, Black K, Schnadower D, Gorelick MH; Pediatric Emergency Research Canada (PERC) Gastroenteritis Study Group.  Trials. 2014 May 14;15:170.

Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation.  Assa A, Vong L, Pinnell LJ, Avitzur N, Johnson-Henry KC, Sherman PM. J Infect Dis. 2014 Oct 15;210(8):1296-305.

Research agenda to support sodium reduction in Canada.  Sherman PM, Makarchuk MJ, Belanger P.  Appl Physiol Nutr Metab. 2014 Mar;39(3):396-8. doi: 10.1139/apnm-2013-0370.

Protein kinase C mediates enterohemorrhagic Escherichia coli O157:H7-induced attaching and effacing lesions.  Shen-Tu G, Kim H, Liu M, Johnson-Henry KC, Sherman PM.  Infect Immun. 2014 Apr;82(4):1648-56.

Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.  Vong L, Lorentz RJ, Assa A, Glogauer M, Sherman PM.  J Immunol. 2014 Feb 15;192(4):1870-7.

From diarrhea to obesity in prohormone convertase 1/3 deficiency: age-dependent clinical, pathologic, and enteroendocrine characteristics.  Bandsma RH, Sokollik C, Chami R, Cutz E, Brubaker PL, Hamilton JK, Perlman K, Zlotkin S, Sigalet DL, Sherman PM, Martin MG, Avitzur Y.  J Clin Gastroenterol. 2013 Nov-Dec;47(10):834-43.

Quantification and visualization of neutrophil extracellular traps (NETs) from murine bone marrow-derived neutrophils.  Vong L, Sherman PM, Glogauer M.  Methods Mol Biol. 2013;1031:41-50.

Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection.  Ho NK, Henry AC, Johnson-Henry K, Sherman PM.  Can J Gastroenterol. 2013;27(5):281-5. Review.

Setting research priorities to reduce mortality and morbidity of childhood diarrhoeal disease in the next 15 years.  Wazny K, Zipursky A, Black R, Curtis V, Duggan C, Guerrant R, Levine M, Petri WA Jr, Santosham M, Scharf R, Sherman PM, Simpson E, Young M, Bhutta ZA.  PLoS Med. 2013;10(5):e1001446.

An update on the use and investigation of probiotics in health and disease.  Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM, Mayer EA. Gut. 2013 May;62(5):787-96. Review.

Immune signalling responses in intestinal epithelial cells exposed to pathogenic Escherichia coli and lactic acid-producing probiotics.  Ho NK, Hawley SP, Ossa JC, Mathieu O, Tompkins TA, Johnson-Henry KC, Sherman PM.  Benef Microbes. 2013 Jun 1;4(2):195-209.

Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications.  Bäckhed F, Fraser CM, Ringel Y, Sanders ME, Sartor RB, Sherman PM, Versalovic J, Young V, Finlay BB.  Cell Host Microbe. 2012 Nov 15;12(5):611-22.

50 years ago in the Journal of Pediatrics: the intestinal flora of infants and children with diarrhea.  Sherman PM.  J Pediatr. 2012 Aug;161(2):196.

Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis.  Vong L, Ferraz JG, Dufton N, Panaccione R, Beck PL, Sherman PM, Perretti M, Wallace JL.  PLoS One. 2012;7(6):e39244.

Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis.  Rodrigues DM, Sousa AJ, Hawley SP, Vong L, Gareau MG, Kumar SA, Johnson-Henry KC,Sherman PM.  BMC Microbiol. 2012 Jun 13;12:105.

Workshop report: developing a pediatric inflammatory bowel diseases network and data platform in Canada.  Sherman PM, Brown S, Rose K, Murphy T, Makarchuk MJ, Paterson W, Belanger P.  J Pediatr Gastroenterol Nutr. 2012 Aug;55(2):125-30.

Enterohemorrhagic Escherichia coli O157:H7 Shiga toxins inhibit gamma interferon-mediated cellular activation.  Ho NK, Ossa JC, Silphaduang U, Johnson R, Johnson-Henry KC, Sherman PM.  Infect Immun. 2012 Jul;80(7):2307-15.

Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice.  Rodrigues DM, Sousa AJ, Johnson-Henry KC, Sherman PM, Gareau MG.  J Infect Dis. 2012 Jul 1;206(1):99-109.

Ingested magnets: catch or let go?  Sokollik C, Chan KJ, Sherman PM.  Gastroenterology. 2012 Apr;142(4):701, 1044-5.

Identifying mechanisms by which Escherichia coli O157:H7 subverts interferon-γ mediated signal transducer and activator of transcription-1 activation.  Ho NK, Crandall I, Sherman PM.  PLoS One. 2012;7(1):e30145.

Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes.  Sherman PM, Makarchuk MJ, Belanger P, Roberts EA.

Can J Gastroenterol. 2011 Oct;25(10):560-4.

Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha.  Gareau MG, Ho NK, Brenner D, Sousa AJ, Lebourhis L, Mak TW, Girardin SE, Philpott DJ, Sherman PM.  Microbiology. 2011 Oct;157(Pt 10):2963-73.

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.  Muise AM, Walters T, Xu W, Shen-Tu G, Guo CH, Fattouh R, Lam GY, Wolters VM, Bennitz J, van Limbergen J, Renbaum P, Kasirer Y, Ngan BY, Turner D, Denson LA, Sherman PM, Duerr RH, Cho J, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Glogauer M, Silverberg MS, Brumell JH.  Gastroenterology. 2011 Aug;141(2):633-41.

Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis.

Wallon C, Persborn M, Jönsson M, Wang A, Phan V, Lampinen M, Vicario M, Santos J, Sherman PM, Carlson M, Ericson AC, McKay DM, Söderholm JD.  Gastroenterology. 2011 May;140(5):1597-607.

Bacterial infection causes stress-induced memory dysfunction in mice.

Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, Macqueen G, Sherman PM.  Gut. 2011 Mar;60(3):307-17.

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.  Muise AM, Walters T, Xu W, Shen-Tu G, Guo CH, Fattouh R, Lam GY, Wolters VM, Bennitz J, van Limbergen J, Renbaum P, Kasirer Y, Ngan BY, Turner D, Denson LA, Sherman PM, Duerr RH, Cho J, Lees CW, Satsangi J, Wilson DC, Paterson AD, Griffiths AM, Glogauer M, Silverberg MS, Brumell JH.  Gastroenterology. 2011 Aug;141(2):633-41.

Adherent-invasive Escherichia coli target the epithelial barrier.  Wine E, Ossa JC, Gray-Owen SD, Sherman PM.  Gut Microbes. 2010 Mar;1(2):80-84.

[A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population].  Sherman PM, Hassall E, Fagundes-Neto U, Gold BD, Kato S, Koletzko S, Orenstein S, Rudolph C, Vakil N, Vandenplas Y.  Arch Pediatr. 2010 Nov;17(11):1586-93.

Probiotics and the gut microbiota in intestinal health and disease.  Gareau MG, Sherman PM, Walker WA.  Nat Rev Gastroenterol Hepatol. 2010 Sep;7(9):503-14. Review

Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling.  Donato KA, Gareau MG, Wang YJ, Sherman PM.  Microbiology. 2010 Nov;156(Pt 11):3288-97.

Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions.  Wine E, Shen-Tu G, Gareau MG, Goldberg HA, Licht C, Ngan BY, Sorensen ES, Greenaway J, Sodek J, Zohar R, Sherman PM.  Am J Pathol. 2010 Sep;177(3):1320-32.

The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations.  Durno CA, Holter S, Sherman PM, Gallinger S.  Am J Gastroenterol. 2010 Nov;105(11):2449-56.

Notice: the importance of adhering to The Journal’s Guide for Authors.  Sherman PM, Daniels SR, Long SS, Welch TR.  J Pediatr. 2010 May;156(5):860.

Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate.  Lewis K, Lutgendorff F, Phan V, Söderholm JD, Sherman PM, McKay DM.

Inflamm Bowel Dis. 2010 Jul;16(7):1138-48.

Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria.  Shen-Tu G, Schauer DB, Jones NL, Sherman PM.

Lab Invest. 2010 Feb;90(2):266-81.

Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice.  Gareau MG, Wine E, Reardon C, Sherman PM.  J Infect Dis. 2010 Jan 1;201(1):81-91.

Bacterial infections: new and emerging enteric pathogens.  Sherman PM, Ossa JC, Wine E.  Curr Opin Gastroenterol. 2010 Jan;26(1):1-4.

Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008.

Sherman PM, Cabana M, Gibson GR, Koletzko BV, Neu J, Veereman-Wauters G, Ziegler EE, Walker WA.  J Pediatr. 2009 Nov;155(5):S61-70.

Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells.  Wine E, Gareau MG, Johnson-Henry K, Sherman PM.  FEMS Microbiol Lett. 2009 Nov;300(1):146-52.

Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia.  Wine E, Ossa JC, Gray-Owen SD, Sherman PM.  BMC Microbiol. 2009 Aug 26;9:180.

A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population.  Sherman PM, Hassall E, Fagundes-Neto U, Gold BD, Kato S, Koletzko S, Orenstein S, Rudolph C, Vakil N, Vandenplas Y.  Am J Gastroenterol. 2009 May;104(5):1278-95; quiz 1296. Review.

Enterohemorrhagic Escherichia coli O157:H7 gene expression profiling in response to growth in the presence of host epithelia.  Jandu N, Ho NK, Donato KA, Karmali MA, Mascarenhas M, Duffy SP, Tailor C, Sherman PM.  PLoS One. 2009;4(3):e4889.

Unraveling mechanisms of action of probiotics.  Sherman PM, Ossa JC, Johnson-Henry K.  Nutr Clin Pract. 2009 Feb-Mar;24(1):10-4. Review.

Probiotics prevent enterohaemorrhagic Escherichia coli O157:H7-mediated inhibition of interferon-gamma-induced tyrosine phosphorylation of STAT-1.  Jandu N, Zeng ZJ, Johnson-Henry KC, Sherman PM.  Microbiology. 2009 Feb;155(Pt 2):531-40.

Escherichia albertii and Hafnia alvei are candidate enteric pathogens with divergent effects on intercellular tight junctions.  Donato KA, Zareie M, Jassem AN, Jandu N, Alingary N, Carusone SC, Johnson-Henry KC, Sherman PM.  Microb Pathog. 2008 Nov-Dec;45(5-6):377-85.

Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasion.  Wine E, Chan VL, Sherman PM.  Pediatr Res. 2008 Dec;64(6):599-604.

S100 calgranulin proteins S100A8, S100A9 and S100A12 are expressed in the inflamed gastric mucosa of Helicobacter pylori-infected children.  Leach ST, Mitchell HM, Geczy CL, Sherman PM, Day AS.  Can J Gastroenterol. 2008 May;22(5):461-4.

Scurvy diagnosed in a pediatric liver transplant patient awaiting combined kidney and liver retransplantation.  Samonte VA, Sherman PM, Taylor GP, Carricato MN, Fecteau A, Ling SC, Ng VL.  Pediatr Transplant. 2008 May;12(3):363-7.

Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function.  Johnson-Henry KC, Donato KA, Shen-Tu G, Gordanpour M, Sherman PM.  Infect Immun. 2008 Apr;76(4):1340-8.

Decreased epithelial barrier function evoked by exposure to metabolic stress and nonpathogenic E. coli is enhanced by TNF-alpha.  Lewis K, Caldwell J, Phan V, Prescott D, Nazli A, Wang A, Soderhölm JD, Perdue MH, Sherman PM, McKay DM.  Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G669-78.

Multiplexed high-throughput electrokinetically-controlled immunoassay for the detection of specific bacterial antibodies in human serum.  Gao Y, Sherman PM, Sun Y, Li D.  Anal Chim Acta. 2008 Jan 7;606(1):98-107.

Probiotic and prebiotic influence beyond the intestinal tract.  Lenoir-Wijnkoop I, Sanders ME, Cabana MD, Caglar E, Corthier G, Rayes N, Sherman PM, Timmerman HM, Vaneechoutte M, Van Loo J, Wolvers DA.  Nutr Rev. 2007 Nov;65(11):469-89.  Review.

The natural history and significance of ultrasonographically defined polypoid lesions of the gallbladder in children.  Beck PL, Shaffer EA, Gall DG, Sherman PM.  J Pediatr Surg. 2007 Nov;42(11):1907-12.

Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.  Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W,Sherman PM, Silverberg MS, Rotin D.  Curr Biol. 2007 Jul 17;17(14):1212-8.

Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro.  Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Söderholm JD.  Gut. 2008 Jan;57(1):50-8.

Combined challenge of mice with Citrobacter rodentium and ionizing radiation promotes bacterial translocation.  Skinn AC, Vergnolle N, Cellars L, Sherman PM, MacNaughton WK.  Int J Radiat Biol. 2007 Jun;83(6):375-82.

Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.  Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.  Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.

Community-based case-control study of childhood chronic abdominal pain: role of selected laboratory investigations.  Soon GS, Saunders N, Ipp M, Sherman PM, Macarthur C.  J Pediatr Gastroenterol Nutr. 2007 Apr;44(4):524-6.

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation.  Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH.  Gut. 2007 Nov;56(11):1522-8. Epub 2007 Mar 5. Erratum in: Gut. 2008 Apr;57(4):560.

Meta-analysis: Helicobacter pylori eradication treatment efficacy in children.  Khurana R, Fischbach L, Chiba N, VAN Zanten SV, Sherman PM, George BA, Goodman KJ, Gold BD.  Aliment Pharmacol Ther. 2007 Mar 1;25(5):523-36.

Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1.  Jandu N, Shen S, Wickham ME, Prajapati R, Finlay BB, Karmali MA, Sherman PM.  Microb Pathog. 2007 Feb-Mar;42(2-3):62-71.

Gastrointestinal infections in children.  Bourke B, Sherman PM.  Curr Opin Gastroenterol. 1999 Jan;15(1):79-84.

Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells.  Johnson-Henry KC, Hagen KE, Gordonpour M, Tompkins TA, Sherman PM.  Cell Microbiol. 2007 Feb;9(2):356-67.

Hemolytic uremic syndrome after pediatric liver transplantation.  Turner D, Schreiber R, Grant D, Hebert D, Sherman PM.  J Pediatr Gastroenterol Nutr. 2006 Jul;43(1):109-12.

Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress.  Zareie M, Johnson-Henry K, Jury J, Yang PC, Ngan BY, McKay DM, Soderholm JD, Perdue MH,Sherman PM.  Gut. 2006 Nov;55(11):1553-60.

Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.  O’Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA.  Cell Microbiol. 2006 Apr;8(4):646-60.

Conditioned medium from enterohemorrhagic Escherichia coli-infected T84 cells inhibits signal transducer and activator of transcription 1 activation by gamma interferon.  Jandu N, Ceponis PJ, Kato S, Riff JD, McKay DM, Sherman PM.  Infect Immun. 2006 Mar;74(3):1809-18.

Anastomotic ulceration following small bowel transplantation.  Turner D, Martin S, Ngan BY, Grant D, Sherman PM.  Am J Transplant. 2006 Jan;6(1):236-40.

An electrokinetically-controlled immunoassay for simultaneous detection of multiple microbial antigens.  Gao Y, Hu G, Lin FY, Sherman PM, Li D. Biomed Microdevices. 2005 Dec;7(4):301-12.

Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.  Yang PC, Jury J, Söderholm JD, Sherman PM, McKay DM, Perdue MH.  Am J Pathol. 2006 Jan;168(1):104-14; quiz 363.

Enterocyte cytoskeleton changes are crucial for enhanced translocation of nonpathogenic Escherichia coli across metabolically stressed gut epithelia.  Nazli A, Wang A, Steen O, Prescott D, Lu J, Perdue MH, Söderholm JD, Sherman PM, McKay DM.  Infect Immun. 2006 Jan;74(1):192-201.

Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier function.  Zareie M, Riff J, Donato K, McKay DM, Perdue MH, Soderholm JD, Karmali M, Cohen MB, Hawkins J, Sherman PM.  Cell Microbiol. 2005 Dec;7(12):1782-97.

Protein-tyrosine phosphatase sigma is associated with ulcerative colitis.  Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W,Sherman PM, Silverberg MS, Rotin D.  Curr Biol. 2007 Jul 17;17(14):1212-8.

Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro.  Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Söderholm JD.  Gut. 2008 Jan;57(1):50-8.

Combined challenge of mice with Citrobacter rodentium and ionizing radiation promotes bacterial translocation.  Skinn AC, Vergnolle N, Cellars L, Sherman PM, MacNaughton WK.  Int J Radiat Biol. 2007 Jun;83(6):375-82.

Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.  Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.  Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.

Community-based case-control study of childhood chronic abdominal pain: role of selected laboratory investigations.  Soon GS, Saunders N, Ipp M, Sherman PM, Macarthur C.  J Pediatr Gastroenterol Nutr. 2007 Apr;44(4):524-6.

Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation.  Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH.  Gut. 2007 Nov;56(11):1522-8. Erratum in: Gut. 2008 Apr;57(4):560.

Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability.  Fedwick JP, Lapointe TK, Meddings JB, Sherman PM, Buret AG.  Infect Immun. 2005 Dec;73(12):7844-52.

Cholesterol-enriched membrane microdomains are required for inducing host cell cytoskeleton rearrangements in response to attaching-effacing Escherichia coli.  Riff JD, Callahan JW, Sherman PM.  Infect Immun. 2005 Nov;73(11):7113-25.

Probiotics reduce enterohemorrhagic Escherichia coli O157:H7- and enteropathogenic E. coli O127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements.  Sherman PM, Johnson-Henry KC, Yeung HP, Ngo PS, Goulet J, Tompkins TA.  Infect Immun. 2005 Aug;73(8):5183-8.

Extradigestive manifestation of Helicobacter pylori infection in children and adolescents.  Sherman PM, Lin FY.  Can J Gastroenterol. 2005 Jul;19(7):421-4. Review.

Epithelial cell signaling responses to enterohemorrhagic Escherichia coli infection.  Ceponis PJ, Riff JD, Sherman PM.  Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:199-203. Epub 2005 Jun 14. Review.

A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.  Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Pan Z, Baruch A, Wallace JL, Hollenberg MD, Vergnolle N.  Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8363-8.

Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics.  Johnson-Henry KC, Nadjafi M, Avitzur Y, Mitchell DJ, Ngan BY, Galindo-Mata E, Jones NL,Sherman PM.  J Infect Dis. 2005 Jun 15;191(12):2106-17.

What is new related to Helicobacter pylori infection in children and teenagers?  Kato S, Sherman PM.  Arch Pediatr Adolesc Med. 2005 May;159(5):415-21. Review.

Development of a nanoparticle-labeled microfluidic immunoassay for detection of pathogenic microorganisms.  Lin FY, Sabri M, Alirezaie J, Li D, Sherman PM.  Clin Diagn Lab Immunol. 2005 Mar;12(3):418-25.

Confirmation of an old adage: you find what you seek.  Sherman PM, Tarr PI.  J Pediatr. 2005 Jan;146(1):11-3.

Helicobacter pylori infection induces interleukin-18 production in gastric epithelial (AGS) cells.  Day AS, Su B, Ceponis PJ, Jones NL, Yau E, Sieveking D, Sherman PM.  Dig Dis Sci. 2004 Nov-Dec;49(11-12):1830-5.

Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor alpha.  Söderholm JD, Streutker C, Yang PC, Paterson C, Singh PK, McKay DM, Sherman PM, Croitoru K, Perdue MH. Gut. 2004 Dec;53(12):1817-24.

Appropriate strategies for testing and treating Helicobacter pylori in children: when and how?  Sherman PM.  Am J Med. 2004 Sep 6;117 Suppl 5A:30S-35S. Review.

Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice.  Johnson-Henry KC, Mitchell DJ, Avitzur Y, Galindo-Mata E, Jones NL, Sherman PM.  Dig Dis Sci. 2004 Aug;49(7-8):1095-102.

Development of a novel microfluidic immunoassay for the detection of Helicobacter pylori infection.  Lin FY, Sabri M, Erickson D, Alirezaie J, Li D, Sherman PM.  Analyst. 2004 Sep;129(9):823-8.

Development of a novel hand-held immunoassay for the detection of enterohemorrhagic Escherichia coli O157:H7.  Lin FY, Sherman PM, Li D.  Biomed Microdevices. 2004 Jun;6(2):125-30.