Sherman Laboratory 

Probiotics, Prebiotics and Dietary Micronutrients in Models of Inflammatory Bowel Disease


Our laboratory strives to better understand host-microbe interactions in the gut in the setting of disease.  With the use of complimentary in vitro tissue culture systems and in vivo murine models of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) (infectious-, stress-, and chemically-induced) we study the mechanisms by which pathogens (enterohemorrhagic Escherichia coli and adherent invasive E. coli from patients with Crohn disease), probiotics, prebiotics, and micronutrients (vitamins, polyunsaturated fatty acids) influence disease outcome.

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