BmpRE adult heart

Dr. Ian Scott

Senior Scientist – Developmental & Stem Cell Biology, The Hospital for Sick Children (SickKids)
Professor – Department of Molecular Genetics, University of Toronto

Born and raised in Ottawa, my interest in biology wasn’t really piqued until I carried out my undergraduate studies at Queen’s University. Convinced I wanted to become a biochemist by several summers of liquid chromatography, I started my PhD studies at the University of Toronto where I was first exposed to developmental biology and the endlessly fascinating questions of how a single cell becomes an organism.

Following my PhD studies in Toronto on mouse placental development, I was fortunate to be able to carry out my postdoctoral studies with Dr. Didier Stainier at University of California San Francisco (UCSF). This turned out to be a great move! Aside from being exposed to the zebrafish model and excellent mentorship, I had the chance to participate in a full genetic screen. Countless hours of observing cardiac mutants fully tempered my scientific interests, with identification and (eventual…) cloning of the grinch mutant setting my interest in early development and cardiogenesis. On top of that, I got to live in San Francisco, AND meet my future wife. As a Principal Investigator, I truly enjoy my role as a facilitator for the development of trainees as independent scientists. My best days are those where people bring me their new ideas (and of course data) as they become masters of their own projects. Outside the lab, I enjoy family time, sports/CrossFit, reading, and playing Dungeons and Dragons with my boys and others. 

See Dr. Scott’s full profile

CURRENT MEMBERS

Laura McDonald

Laboratory Manager

Laura McDonald - Lab Manager Ian Scott labLaura joined the Scott lab in 2013. In addition to the support role that she performs for the lab, her research is focused on building a brain tumour model in zebrafish. She is interested in using CRISPR/Cas tools to study cardiac genes. Prior to joining the Scott lab, Laura worked as a protein crystallographer in Montreal. Outside of the lab, she enjoys attending arts and cultural events.

Tvisha Misra

Postdoctoral Fellow

Tvisha Misra - Postdoctoral fellow in Ian Scott's labTvisha joined the lab as a postdoctoral fellow in 2016. She’s interested in studying cerebral cavernous malformations (CCM) in zebrafish with a focus on the role of Ccm3 and its interaction partners in early vascular development specifically in cranial vasculature using various live imaging techniques in embryos.

Chris Onderisin

PhD Candidate

Chris Onderisin - PhD Candidate Ian Scott labChris is interested in understanding the remarkable regenerative capacity of zebrafish following cardiac injury. In particular, he is exploring the roles that deeply conserved cis-regulatory elements play in coordinating the regenerative response. When Chris isn’t busy with lab work, he enjoys cooking, cycling the streets of Toronto, and subjecting himself to the roller coaster ride that is being a fan of the Toronto Maple Leafs. 

Shimon Rosenthal

PhD Candidate

Shimon Rosenthal - PhD candidate in Scott labShimon is a PhD candidate in the Scott lab. He is co-supervised by Anne-Claude Gingras at the Lunenfeld-Tanenbaum Research Institute. Shimon in interested in developing methods for performing interaction proteomics in vivo in zebrafish. He is utilizing the developed methods to interrogate the in vivo interactome of the Cerebral Cavernous Malformation causing protein CCM3 to better understand the molecular mechanisms of this disease. Outside the lab Shimon enjoys participating in team sports, and spending time with his family and friends. 

Nathan Stutt

PhD Candidate

Nathan Stutt - PhD student in Ian Scott's labNathan began his PhD in 2016 after discovering an interest in developmental biology during his undergraduate at the University of Guelph. His project focuses on the function of the Apelin Receptor in cardiac lineage development. He is particularly interested in how this GPCR interacts with other cell signalling pathways to regulate cellular specification and migration. In his free time Nathan likes to escape Toronto and go camping in Ontario’s beautiful wilderness.

Casey Carlisle

PhD Candidate

Casey Carlisle PhD Candidate Ian Scott lbCasey started her PhD in September 2019, after completing a MSc degree at the University of Alberta. Using bioinformatic and molecular genetic techniques, she studies conserved non-coding regions and the genes they regulate, in both healthy and abnormal heart development. When not in the lab, Casey enjoys bouldering, Dungeons & Dragons, Raptors basketball, and craft beer. 

Mengyi (Candy) Song

PhD Candidate

Mengyi (Candy) Song PhD Candidate Ian Scott labMengyi is a graduate student in Molecular Genetics at The University of Toronto and is co-supervised by Drs. Ian Scott and Michael Wilson. She did her undergraduate at Peking University in China. She is interested in understanding how the transcription factors gata5/6 mediate the early segregation of the cardiac lineage using single-cell genomics. 

Palak Desai

M.Sc. Candidate

Palak Desai - graduate student in Ian Scott's labPalak joined the Scott lab Winter 2020 after graduating with a B.Sc. in Biochemistry from North Carolina State University. She is interested in using transcriptomics to characterize cardiac progenitor cell fate decisions during early development. Outside of lab, her hobbies include painting and photography. 

Harsha Murthy

Research Technologist

Harsha Murthy - technologist in Ian Scott's labHarsha joined the Scott lab in 2017. He was first introduced to the zebrafish as Master’s student and was immediately drawn to its similarity to human physiology and power as a model organism. In the Scott lab, he works to create models of heart failure to study the in vivo function of novel genes and their contribution to heart failure. 

Meaghan Leslie

Research Technologist

Meaghan Leslie technologist in Ian Scott's labMeaghan is a recent M.Sc. graduate of the Scott Lab. She is interested in the early heterogeneity and spatial patterning of the cardiac mesoderm. Meaghan is exploring the molecular signature of atrial, ventricular, and second heart field progenitor cells in the zebrafish embryo. In her free time, Meaghan enjoys playing sports, and is a proud member of the MoGen intramural basketball team. Meaghan will be pursuing an M.Sc. in Genetic Counselling at the University of Toronto in Fall 2020.