Some of the recent publications are listed to the right. A more comprehensive list can be found on PubMed.

Publications

  1. Alam, F. B. Zanette, S. Munidasa, S. Braganza, D. Li, J. Woods, F. Ratjen, and G. Santyr. Intra- and Inter-visit Repeatability of 129 Xenon Multiple-Breath Washout MRI in Children With Stable Cystic Fibrosis Lung Disease. J. Magn. Reson. Imaging. 58(3):936-948. (2023)
  2. Genkin, D., B. Zanette, P. Grzela, T. Benkert, P. Subbarao, T. Moraes, S. Katz, F. Ratjen, G. Santyr, and M. Kirby. Semiautomated Segmentation and Analysis of Airway Lumen in Pediatric Patients Using Ultra Short Echo Time MRI. Acad. Radiol. S1076-6332(23)00358-6. (2023)
  3. Zanette, B., M. Greer, T. Moraes, F. Ratjen, and G. Santyr. The argument for utilising magnetic resonance imaging as a tool for monitoring lung structure and function in pediatric patients. Expert Rev. Respir. Med. 17(7):527-538. (2023)
  4. Munidasa, S., B. Zanette, M. Couch, R. Grimm, R. Seethamraju, M. Dumas, W. Wee, J. Au, S. Braganza, D. Li, J. Woods, F. Ratjen, and G. Santyr. Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease. Magn. Reson. Med. 89(5):2048-2061. (2023)
  5. Zanette, B. S. Munidasa, Y. Friedlander, F. Ratjen, and G. Santyr. A 3D stack-of-spirals approach for rapid hyperpolarized 129 Xe ventilation mapping in pediatric cystic fibrosis lung disease. Magn. Reson. Med. 89(3):1083-1091. (2023)
  6. Zanette, B., E. Schrauben, S. Munidasa, D. Goolaub, A. Singh, A. Coblentz, E. Stirrat, M. Couch, R. Grimm, A. Voskrebenzev, J. Vogel-Claussen, R. Seethamraju, C. Macgowan, M. Greer, E. Tam, and G. Santyr. Clinical Feasibility of Structural and Functional MRI in Free-Breathing Neonates and Infants. J Magn Reson. 55(6):1696-1707. (2022)
  7. Perron, S., A. Ouriadov, K. Wawryzn, S. Hickling, M. Fox, H. Serrai, and G. Santyr. Application of a 2D frequency encoding sectoral approach to hyperpolarized 129Xe MRI at low field. J Magn Reson. 336:107159. (2022)
  8. Friedlander, Y., B. Zanette, A. Lindenmaier, D. Li, S. Kadlecek, G. Santyr, and A. Kassner. Hyperpolarized 129 Xe MRI of the rat brain with chemical shift saturation recovery and spiral-IDEAL readout. Magn Reson Med. 87(4):1971-1979. (2022)

  9. Fliss, J.D., B. Zanette, Y. Friedlander, S. Sadanand, A. Lindenmaier, E. Stirrat, D. Li, M. Post, R. Jankov, and G. Santyr. Hyperpolarized 129Xe magnetic resonance spectroscopy in a rat model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 321(3):L507-L517. (2021)

  10. Safavi, S., S. Munidasa, B. Zanette, R. Dai, E. Stirrat, D. Li, T.J. Moraes, P. Subbarao, and G. Santyr. Evaluating post-bronchodilator response in well-controlled paediatric severe asthma using hyperpolarised 129Xe-MRI: A pilot study. Respiratory Medicine. 180. (2021)
  11. Munidasa, S., M. Couch, J.H. Rayment, A. Voskrevenzev, R. Seethamraju, J. Vogel-Claussen, F. Ratjen, and G. Santyr. Free-breathing MRI for monitoring ventilation changes following antibiotic treatment of pulmonary exacerbations in paediatric cystic fibrosis. Eur Respir J 57(4). (2021)
  12. Friedlander, Y., B. Zanette, A. Lindenmaier, J. Fliss, D. Li, K. Emami, R.P. Jankov, A. Kassner, and G. Santyr. Effect of inhaled oxygen concentration on 129Xe chemical shift of red blood cells in rat lung. Magn Reson Med. 86(3):1187-1193. (2021)
  13. Couch, M., S. Munidasa, J.H. Rayment, A. Voskrebenzev, R. Seethamraju, J. Vogel-Claussen, F. Ratjen, and G. Santyr. Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis. Academic Radiology. 28(8):e209-e2018. (2021)
  14. Friedlander, Y., B. Zanette, A. Lindenmaier, S. Sadanand, D. Li, E. Stirrat, M. Couch, A. Kassner, R.P. Jankov, and G. Santyr. Chemical shift of 129Xe dissolved in red blood cells: Application to a rat model of bronchopulmonary dysplasia. Magn Reson Med. 84(1):52-60. (2019)
  15. Couch, M., F. Morgado, N. Kanhere, K. Kowalik. J.H. Rayment, F. Ratjen, and G. Santyr. Assessing the feasibility of hyperpolarized 129Xe multiple-breath washout MRI in pediatric cystic fibrosis. Magn Reson Med. 84(1):304-311. (2019)
  16. Riberdy, V., M. Litvak, E. Stirrat, M. Couch, M. Post, and G. Santyr. Hyperpolarized 129 Xe imaging of embryonic stem cell-derived alveolar-like macrophages in rat lungs: proof-of-concept study using superparamagnetic iron oxide nanoparticles. Magn Reson Med. (2019)
  17. Zanette, B., and G. Santyr. Accelerated interleaved spiral-IDEAL imaging of hyperpolarized 129 Xe for parametric gas exchange mapping in humans. Magn Reson Med. 82(3):1113-1119. (2019).
  18. Couch, M.J., R. Thomen, N. Kanhere, R. Hu, F. Ratjen, J. Woods, and G. Santyr. A two-center analysis of hyperpolarized 129Xe lung MRI in stable pediatric cystic fibrosis: Potential as a biomarker for multi-site trials. J Cyst Fibros. 18(5):728-733 (2019).
  19. Rayment, J.H., M. Couch, N. McDonald, N. Kanhere, D. Manson, G. Santyr, and F. Ratjen. Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis. Eur Respir J. 2;53(5) (2019).
  20. Santyr, G., N. Kanhere, F. Morgado, J. Rayment, F. Ratjen, and M. Couch. Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease. Acad Radiol. 26(3):344-354 (2019).
  21. Morgado, F., M. Couch, E. Stirrat, and G. Santyr. Effect of T1 relaxation on ventilation mapping using hyperpolarized 129 Xe multiple breath wash-out imaging. Magn Reson Med. 80(6):2670-2680 (2018).
  22. Zanette B., E. Stirrat, S. Jelvej, A. Hope and G. Santyr. Physiological gas exchange mapping of hyperpolarized 129 Xe using spiral-IDEAL and MOXE in a model of regional radiation-induced lung injury. Med. Phys 45(2):803-816. (2018).
  23. Zanette B., E. Stirrat, S. Jelveh, A. Hope and G. Santyr, Detection of Regional Radiation-Induced Lung Injury using Hyperpolarized 129Xe Chemical Shift Imaging in a Rat Model involving Partial Lung Irradiation: Proof-of-Concept Demonstration, Adv. in Radiat. Oncology 2(3): 475-484 (2017). 
  24. Kanhere N., M. Couch, K. Kowalik, B. Zanette, J. Rayment, D. Manson, P. Subbarao, F. Ratjen and G. Santyr, Correlation of LCI with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric CF Subjects, AJRCCM (2017). doi: 10.1164/rccm.201611-2228LE.
  25. Ouriadov A. and G. Santyr, High Spatial Resolution Hyperpolarized 3He MRI of the Rodent Lung using a Single Breath x-Centric Gradient-Recalled Echo Approach, Magn. Reson.in Med. (2017). doi: 10.1002/mrm.26602.
  26. Rayment J, N. Kanhere, K. Kowalik, M. Couch, B. Kavanagh, F. Ratjen and G. Santyr, Correlation of Lung Clearance Index With Hyperpolarized 129Xe Pulmonary MRI in Pediatric Cystic Fibrosis,Pediatr Pulmonol (2016);51(S45):286.
  27. Doganay O., E. Stirrat, C.A. McKenzie, R.F. Schulte and G.E. Santyr Quantification of Regional Early Stage Gas Exchange Changes using Hyperpolarized 129Xe MRI in a Rat Model of Radiation-induced Lung Injury, Med. Phys 43(5): 2410 (2016).
  28. Doganay O., T. Wade, E. Hegarty, C.A. McKenzie, R.F. Schulte and G.E. Santyr. Hyperpolarized 129Xe MRI of the Lung using Spiral IDEAL, Magn. Reson. Med. 76(2): 566-576 (2016).
  29. Ouriadov A., M. Fox, E. Hegarty, G. Parraga, E. Wong and G. Santyr. Early Stage Radiation-Induced Lung Injury Detected with Hyperpolarized 129Xe Morphometry: Proof-of-concept Demonstration in a Rat Model, Magn. Reson. Med. 75(6): 2421-2431 (2016).
  30. Doganay O., K. Thind, T. Wade, A. Ouriadov and G. Santyr. Transmit-Only/Receive-Only Radiofrequency Coil Configuration for Hyperpolarized 129Xe Imaging of Rodent Lung, Concepts in MR Part B 45(3): 115-124 (2015).
  31. Ouriadov A., A. Farag, M. Kirby, D.G. McCormack, G. Parraga and G.E. Santyr. Pulmonary Hyperpolarized 129Xe Morphometry for Mapping Xenon Gas Concentrations and Alveolar Oxygen Partial Pressure:  Proof-of-concept Demonstration in Healthy and COPD Subjects, Magn. Reson. Med. 74(6): 1726-1732 (2015).
  32. Santyr G., M. Fox, K. Thind, E. Hegarty, A. Ouriadov, M. Jensen, T. Scholl, J. VanDyk and E. Wong. Anatomical, Functional and Metabolic MRI of Lung Injury using Hyperpolarized Nuclei, NMR Biomed. 27(12): 1515-1524 (2014).
  33. Kirby M, A. Ouriadov, S. Svenningsen, A. Owrangi, A. Wheatley, R. Etemad-Rezai, G.E. Santyr, D.G. McCormack, G. Parraga, Hyperpolarized 3He and 129Xe MRI Apparent Diffusion Coefficients: Physiological Relevance in Older Never- and Ex-smokers, Physiol Rep. 2(7): 1-15 (2014).
  34. Fox M., A. Ouriadov, K. Thind, Hegarty E, E. Wong, A. Hope and G.E. Santyr. Detection of Radiation-Induced Lung Injury in Rats Using Dynamic Hyperpolarized 129Xe Magnetic Resonance Spectroscopy, Med Phys. 41(7): 072302 (2014).
  35. Thind K., M.D. Jensen, E. Hegarty, A.P. Chen, H. Lim, P. Martinez, J. VanDyk, E. Wong, T. Scholl and G.E. Santyr. Mapping Metabolic Changes Associated with Early Radiation Induced Lung Injury post Conformal Radiotherapy using Hyperpolarized 13C-pyruvate Magnetic Resonance Spectroscopic Imaging, Radiother Oncol 110(2): 317-322 (2014).
  36. Fox. M., A. Ouriadov and G.E. Santyr. Comparison of Hyperpolarized 3He and 129Xe MR Imaging for Measurement of Absolute Ventilated Lung Volume in Rats, Magn. Reson. Med. 71:1130-1136 (2013).
  37. Ouriadov A., A. Farag, M. Kirby, D.G. McCormack, G. Parraga and G.E. Santyr. Lung Morphometry using Hyperpolarized 129Xe Apparent Diffusion Coefficient Anisotropy in Chronic Obstructive Pulmonary Disease, Magn. Reson. Med. 70:1699-1706 (2013).
  38. Thind K., L. Friesen-Waldner, A. Chen, A. Ouriadov, T. Scholl, M. Fox, E. Wong, J. VanDyk, R. Hill, A. Hope and G.E. Santyr. Detection of Radiation-Induced Lung Injury Using Hyperpolarized 13C Magnetic Resonance Spectroscopy and Imaging, Magn. Reson. Med. 70:601-609 (2013).
  39. Kirby M., S. Svenningsen, N. Kanhere, A. Owrangi, A. Wheatley, H.O. Coxon, G.E. Santyr, N.A.M. Paterson, D.G. McCormack and G. Parraga
    Pulmonary Ventilation Visualized using Hyperpolarized Helium-3 and Xenon-129 Magnetic Resonance Imaging: Differences in COPD and Relationship to Emphysema, J. Appl. Physiol. 114:707-715 (2013).
  40. Boudreau M., X. Xu and G. E. Santyr. Measurement of 129Xe Apparent Diffusion Coefficient Anisotropy in an Elastase-instilled Rat Model of Emphysema, Magn. Reson. Med. 69: 211-220 (2013).
  41. Fox M., I. Welch, D. Hobson and G. E. Santyr. A Novel Intubation Technique for Non-Invasive Longitudinal Studies of Rat Lungs using hyperpolarized 3He MRI, Laboratory Animal 46, 311-317 (2012).
  42. Kirby M., A. Owrangi, S. Svenningsen, A. Wheatley, A. Farag, A. Ouriadov, G.E. Santyr, D.G. McCormack and G. Parraga
    Hyperpolarized 3He and 129Xe MRI in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease, Radiology 265, 600-610 (2012).
  43. Shukla Y., D.M. McCormack, N. Patterson, A. Wheatley, A. Farag, G.E. Santyr and G. Parraga. Hyperpolarized 129Xe MRI: Tolerability in Healthy Volunteers and Subjects with Pulmonary Disease, Academic Radiology 19, 941-951 (2012).
  44. Couch M., A.V. Ouriadov and G. E. Santyr. Regional Ventilation Mapping of the Rat Lung using Hyperpolarized 129Xe Magnetic Resonance Imaging, Magn. Reson. Med. 68: 1623-1631 (2012).
  45. Xu X., M. Boudreau, A. Ouriadov and G.E. Santyr
    Mapping of 3He Apparent Diffusion Coefficient Anisotropy at Sub-millisecond Diffusion Times in an Elastase-instilled Rat Model of Emphysema, Magn. Reson. Med. 67: 1146-1153 (2012).
  46. Mathew L., M. Kirby, D. Farquahar, C. Licskai, G. Santyr, R. Etemad-Rezai, G. Parraga and D.G. McCormack. Hyperpolarized 3He Magnetic Resonance Imaging of Bronchoscopic Airway Bypass in Chronic Obstructive Pulmonary Disease Can Resp J 19: 41-43 (2012).
  47. Carias M., W. Dominguez-Viqueira and G.E. Santyr. Improving SNR of Hyperpolarized Noble Gas MRI at 73.5 mT using Multi-turn Litz Wire Radiofrequency Receive Coils, Concepts in MR Part B MR Engineering 39B: 37-42 (2011).
  48. W. Dominguez-Viqueira, A. Ouriadov, R. O’Halloran, S. Fain and G.E. Santyr. Signal-to-Noise Ratio for Hyperpolarized 3He MR Imaging of Human Lungs: A 1.5 T and 3 T Comparison, Magn. Reson. Med. 66: 1400-1404 (2011).
  49. Olding T., O. Holmes, P. DeJean, K. McAuley, K. Nkongchu, G.E. Santyr and L. J. Schreiner. Small Field Dose Delivery Evaluations Using Cone Beam Optical Computed Tomography-Based Polymer Gel Dosimetry, J. of Medical Physics 36: 3-14 (2011).
  50. Santyr G.E., M.J. Couch, W.W. Lam, A. Ouriadov, M. Drangova, D.G. McCormack and D.W. Holdsworth. Comparison of Hyperpolarized 3He MR with Xe-enhanced CT Imaging for Ventilation Mapping of the Rat Lung, NMR in Biomedicine. 24, 1073-1080 (2011).
  51. Kraayvanger R., C. Bidinosti, W. Dominguez-Viqueira, J. Parra-Robles, M. Fox, W.W. Lam and G.E. Santyr. Measurement of Alveolar Oxygen Partial Pressure in the Rat Lung Using Spin-Spin Relaxation Times of Hyperpolarized 3He and 129Xe at 74 mT, Magn. Reson. Med. 64: 1484-1490 (2010).
  52. Kirby M., L. Mathew, A. Wheatley, G.E. Santyr, D.G. McCormack and G. Parraga. Chronic Obstructive Pulmonary Disease: Longitudinal Hyperpolarized 3He Magnetic Resonance Imaging, Radiology 256: 280-289 (2010).
  53. Dominguez-Viqueira W., W. Berger, J. Parra-Robles, G.E. Santyr. Litz Wire Radiofrequency Receive Coils for Hyperpolarized Noble Gas MR Imaging of Rodent Lungs at 74 mT, Concepts in MR Part B MR Engineering 37B: 75-85 (2010).
  54. Akhavan Sharif M.R., W.W. Lam, A.V. Ouriadov, D.W. Holdsworth and G.E. Santyr. Comparison of Hyperpolarized 3He MRI Rat Lung Volume Measurement with Micro-Computed Tomography, NMR in Biomedicine 23: 359-367 (2010).