Publications and Media

A complete list of Dr. Howell’s publications can be found via PubMed or Google Scholar.

20 most recent publications:

The Metabolic Usage and Glycan Destinations of GlcNAz in E. coli. Eddenden A, Dooda MK, Morrison ZA, Subramanian AS, Howell PL, Troutman JM, Nitz M.  bioRxiv [Preprint]. 2023 Aug 17:2023.08.17.553294.

Distinct types of multicellular aggregates in Pseudomonas aeruginosa liquid cultures. Melaugh G, Martinez VA, Baker P, Hill PJ, Howell PL, Wozniak DJ, Allen RJ.  NPJ Biofilms Microbiomes. 2023 Jul 28;9(1):52.

Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation. Razvi E, DiFrancesco BR, Wasney GA, Morrison ZA, Tam J, Auger A, Baker P, Alnabelseya N, Rich JD, Sivarajah P, Whitfield GB, Harrison JJ, Melnyk RA, Nitz M, Howell PL.  Microbiol Spectr. 2023 Jun 15;11(3):e0029623.

Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. Razvi E, Whitfield GB, Reichhardt C, Dreifus JE, Willis AR, Gluscencova OB, Gloag ES, Awad TS, Rich JD, da Silva DP, Bond W, Le Mauff F, Sheppard DC, Hatton BD, Stoodley P, Reinke AW, Boulianne GL, Wozniak DJ, Harrison JJ, Parsek MR, Howell PL.  NPJ Biofilms Microbiomes. 2023 Feb 2;9(1):7.

Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis. AJ, Yau YCW, Park S, Eisha S, McDonald N, Parsek MR, Howell PL, Hoffman LR, Nguyen D, DiGiandomenico A, Rooney AM, Coburn B, Grana-Miraglia L, Wang P, Guttman DS, Wozniak DJ, Waters VJ.  Sci Rep. 2022 Dec 12;12(1):21444.

Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa. AA, Li YE, Kitova EN, Bui DT, Pfoh R, Low KE, Whitfield GB, Walvoort MTC, Zhang Q, Codée JDC, Klassen JS, Howell PL.  Nat Commun. 2022 Dec 9;13(1):7631.

The Sia System and c-di-GMP Play a Crucial Role in Controlling Cell-Association of Psl in Planktonic P. aeruginosa. JE, O’Neal L, Jacobs HM, Subramanian AS, Howell PL, Wozniak DJ, Parsek MR.  J Bacteriol. 2022 Dec 20;204(12):e0033522.

Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen. AR, Gutierrez-Ferman JL, Yount KS, Love CF, Choi HG, Vargas MA, Raju D, Corps KN, Howell PL, Dubey P, Deora R.  PLoS Pathog. 2022 Aug 15;18(8):e1010764.

The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing. R, Subramanian AS, Huang J, Little DJ, Forman A, DiFrancesco BR, Balouchestani-Asli N, Kitova EN, Klassen JS, Pomès R, Nitz M, Howell PL.  PLoS Pathog. 2022 Aug 5;18(8):e1010750.

Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection. H, Raju D, Corsini R, Lehoux M, Lacdao I, Gilbert S, Sivarajah P, Bamford NC, Baker P, Gravelat FN, Howell PL, Sheppard DC.  Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0005222.

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine. Le Mauff F, Razvi E, Reichhardt C, Sivarajah P, Parsek MR, Howell PL, Sheppard DC.  Commun Biol. 2022 May 26;5(1):502. doi: 10.1038/s42003-022-03453-2. Erratum in: Commun Biol. 2022 Jun 24;5(1):624.

Co-Operative Biofilm Interactions between Aspergillus fumigatus and Pseudomonas aeruginosa through Secreted Galactosaminogalactan Exopolysaccharide. H, Le Mauff F, Gravelat FN, Snarr BD, Bamford NC, Van Loon JC, McKay G, Nguyen D, Howell PL, Sheppard DC.  J Fungi (Basel). 2022 Mar 24;8(4):336.

Termination of Poly-N-acetylglucosamine (PNAG) Polymerization with N-Acetylglucosamine Analogues. ZA, Eddenden A, Subramanian AS, Howell PL, Nitz M. ACS Chem Biol. 2022 Nov 18;17(11):3036-3046.

The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesis. Gheorghita AA, Wolfram F, Whitfield GB, Jacobs HM, Pfoh R, Wong SS, Guitor AK, Goodyear MC, Berezuk AM, Khursigara CM, Parsek MR, Howell PL.  Journal of Biological Chemistry. 2022 Jan 3:101560.

Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis. Ostapska H, Raju D, Lehoux M, Lacdao I, Gilbert S, Sivarajah P, Bamford NC, Baker P, Nguyen TTM, Zacharias CA, Gravelat FN, Howell PL, Sheppard DC.  mBio. 2021 Oct 26;12(5):e0244621. doi: 10.1128/mBio.02446-21.

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis. Morris AJ, Jackson L, Cw Yau Y, Reichhardt C, Beaudoin T, Uwumarenogie S, Guttman KM, Howell PL, Parsek MR, Hoffman LR, Nguyen D, DiGiandomenico A, Guttman DS, Wozniak DJ, Waters VJ.  NPJ Biofilms Microbiomes. 2021 Aug 4;7(1):63. doi: 10.1038/s41522-021-00234-3.

Protective Liquid Crystal Nanoparticles for Targeted Delivery of PslG: A Biofilm Dispersing Enzyme. Thorn CR, Raju D, Lacdao I, Gilbert S, Sivarajah P, Howell PL, Prestidge CA, Thomas N. ACS Infect Dis. 2021 Apr 28. doi: 10.1021/acsinfecdis.1c00014. Epub ahead of print.

The Matrix Revisited: Opening Night for the Pel Polysaccharide Across Eubacterial Kingdoms. Microbiol Insights. Whitfield GB, Howell PL. 2021 Feb 15;14:1178636120988588. doi: 10.1177/1178636120988588.

Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance. Katharios-Lanwermeyer S, Whitfield GB, Howell PL, O’Toole GA. mBio. 2021 Feb 2;12(1):e03384-20. doi: 10.1128/mBio.03384-20.

A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL. Mol Cell. 2021 Feb 4;81(3):571-583.e6. doi: 10.1016/j.molcel.2020.12.011. Epub 2021 Jan 6.