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Hopyan Lab
Morphogenesis & Pattern Formation
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  • Home
  • Research
  • People
  • Papers
  • Location
  • Links
    • Developmental & Stem Cell Biology Program
    • Department of Molecular Genetics
    • Cette Semaine
    • Imaging Facility
    • The Centre for Phenogenomics
    • The Centre for Applied Genomics

Hopyan Lab

Morphogenesis & Pattern Formation

  • A fibronectin gradient remodels mixed-phase mesoderm.
    Zhu M, Gu B, Thomas EC, Huang Y, Kim YK, Tao H, Yung TM, Chen X, Zhang K, Woolaver EK, Nevin MR, Huang X, Winklbauer R, Rossant J, Sun Y, Hopyan S.
    Science Advances. (2024) doi: 10.1126/sciadv.adl6366.

  • Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion.
    Polsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP.
    Development. (2024) doi: 10.1242/dev.202596.

  • Shape driven confluent rigidity transition in curved biological tissues.
    Thomas E, Hopyan S.
    Biophysical Journal. (2023) doi: 10.1016/j.bpj.2023.10.001.

  • Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles.
    Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S, Huang X, Sun Y.
    Proc Natl Acad Sci U S A. (2023) doi: 10.1073/pnas.2307356120.

  • Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo.
    Fenelon KD, Thomas E, Samani M, Zhu M, Tao H, Sun Y, McNeill H, Hopyan S.
    Biology Open. (2022) doi: 10.1242/bio.059656.

  • Pitx2 patterns an accelerator-brake mechanical feedback through latent TGFβ to rotate the gut.
    Sanketi BD, Zuela-Sopilniak N, Bundschuh E, Gopal S, Hu S, Long J, Lammerding J, Hopyan S, Kurpios NA.
    Science. (2022) doi: 10.1126/science.abl3921.

  • Patterning the embryonic pulmonary mesenchyme.
    Goodwin K, Jaslove JM, Tao H, Zhu M, Hopyan S, Nelson CM.
    iScience. (2022) doi: 10.1016/j.isci.2022.103838.

  • Live imaging YAP signalling in mouse embryo development.
    Gu B, Bradshaw B, Zhu M, Sun Y, Hopyan S, Rossant J.
    Open Biology. (2022) Jan;12(1):210335.

  • Existing and potential applications of elastography for measuring the viscoelasticity of biological tissues in vivo.
    Zhang K, Zhu M, Thomas E, Hopyan S, Sun Y.
    Frontiers in Physics. (2021) doi:10.3389/fphy.2021.670571.

  • IRX3/5 regulate mitotic chromatid segregation and limb bud shape.
    Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S.
    Development. (    2020) Oct 5;147(19).

  • Magnetic micromanipulation for in vivo measurement of stiffness heterogeneity and anisotropy in the mouse mandibular arch.
    Zhu M, Zhang K, Tao H, Hopyan S, Sun Y.
    Research (Wash DC). (2020) Jun 22;2020:7914074.

  • Hedgehog-activated Fat4 and PCP pathways mediate mesenchymal cell clustering and villus formation in gut development.
    Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH.
    Developmental Cell. (2020) Mar 9;52(5):647-658.

  • Spatial mapping of tissue properties in vivo reveals a 3D stiffness gradient in the mouse limb bud.
    Zhu M, Tao H, Samani M, Luo M, Wang X, Hopyan S, Sun Y.
    Proceedings of the National Academy of Sciences of the Unitited States of America. (2020);     Mar 3;117(9):4781-4791.

  • Intracellular manipulation and measurement with multipole magnetic tweezers.
    Wang X, Ho C, Tsatskis Y, Law J, Zhang Z, Zhu M, Dai C, Wang F, Tan M, Hopyan S, McNeill H, Sun Y.
    Science Robotics. (2019) 4(28).

  • Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.
    Tao H, Zhu M, Lau K, Whitley OKW, Samani M, Xiao X, Chen XX, Hahn NA, Liu W, Valencia M, Wang X, Fenelon KS, Pasiliao CC, Hu D, Wu J, Spring S, Ferguson J, Karuna EP, Henkelman RM, Dunn A, Huang H, Ho HH, Atit R, Goyal S, Sun Y, Hopyan S.
    Nature Communications. 2019 Apr 12:10(1):1703. 

  • The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in human nephrogenesis and Wilms tumour development.
    Mengelbier LH, Lindell-Munther S, Jansson C, Esfandyari J, Karlsson J, Yasui H, Lau K, Bexell D, Hui CC, Hopyan S, Gisselsson D.
    Journal of Pathology. (2019) Jan; 247(1):86-98.

  • Characterizing inner pressure and stiffness of trophoblast and inner cell mass of blastocysts.
    Wang X, Zhang Z, Tao H, Liu J, Hopyan S, Sun Y.
    Biophysical Journal. 2018 Dec 18;115(12):2443-2450. 

  • Mechanical stability of the cell nucleus – roles played by the cytoskeleton in nuclear deformation and strain recovery.
    Wang X, Liu H, Zhu M, Cao C, Xu Z, Tsatskis Y, Lau K, Kuok C, Filleter T, McNeill H, Simmons CA, Hopyan S, Sun Y.
    Journal of Cell Science. 2018 Jul 4;131(13).

  • Genetic interaction between Gli3 and Ezh2 during limb pattern formation.
    Deimling SJ, Lau K, Hui CC, Hopyan S.
    Mechanisms of Development. 2018 Jun;151:30-36. 

  • Cell ingression: Relevance to limb development and for adaptive evolution.
    Pasiliao C.C., Hopyan S.
    Genesis 2018 Jan;56 (1). 

  • Biophysical regulation of early limb bud morphogenesis.
    Hopyan S.
    Developmental Biology. 2017 Sep 15;429(2):429-433.

  • Structural components of nuclear integrity with gene regulatory potential.
    Fenelon KD, Hopyan S.
    Current Opinion in Cell Biology. 2017 Jun 19;48:63-71. 

  • Cell and tissue scale forces coregulate Fgfr2-dependent tetrads and rosettes in the mouse embryo.
    Wen J, Tao H, Lau K, Simmons CA, Sun Y, Hopyan S.

    Biophysical Journal. 2017 May 23;112 (10) 2209-2218.

  • The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies.
    Tao H, Kawakami Y, Hui CC, Hopyan S.
    Wiley Interdisciplinary Reviews: Developmental Biology.  2017 Jul;6(4)

  • Visualization and force measurement during mouse development.
    Tao H, Hopyan S.
    Seitai no kagaku/Science of the living body. (2017) 68(5):454-455.

  • Tibial hemimilia associated with GLI3 truncation.
    Deimling S, Sotiropoulos C, Lau K, Chaudhry S, Sturgeon K, Kelley S, Narayanan U, Howard A, Hui CC, Hopyan S.
    Journal of Human Genetics. 2016 May;61(5):443-6. 

  • Anisotropic stress orients remodelling of mammalian limb bud ectoderm.
    Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S.
    Nature Cell Biology. 2015 May;17(5):569-79.

  • A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers.
    Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC.
    Developmental Cell. 2014 Apr 28;29(2):241-9.

  • Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.
    Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC.
    Developmental Cell. 2014 Apr 28;29(2):233-40.

  • In situ mechanical characterization of the cell nucleus by atomic force microscopy.
    Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y.
    ACS Nano. 2014 Apr 22;8(4):3821-8.

  • Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
    Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S.
    Development. 2011 Sep;138(17):3759-67.

  • Budding behaviors: Growth of the limb as a model of morphogenesis.
    Hopyan S, Sharpe J, Yang Y.
    Developmental Dynamics. 2011 May;240(5):1054-62.

  • Oriented cell motility and division underlie early limb bud morphogenesis.
    Wyngaarden LA, Vogeli KM, Ciruna BG, Wells M, Hadjantonakis AK, Hopyan S.
    Development. 2010 Aug 1;137(15):2551-8.

  • Plasticity of proximal-distal cell fate in the mammalian limb bud.
    Wyngaarden LA, Hopyan S.
    Developmental Biology. 2008 Jan 1;313(1):225-33.

  • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.
    Mau E, Whetstone H, Yu C, Hopyan S, Wunder JS, Alman BA.
    Developmental Biology. 2007 May 1;305(1):28-39.

  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.
    Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS.
    American Journal of Pathology. 2006 Jan;168(1):321-30.

  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.
    Hopyan S, Nadesan P, Yu C, Wunder J, Alman BA.
    Journal of Pathology. 2005 Jun;206(2):143-50.

  • A mutant PTH/PTHrP type I receptor in enchondromatosis.
    Hopyan S, Gokgoz N, Poon R, Gensure RC, Yu C, Cole WG, Bell RS, Jüppner H, Andrulis IL, Wunder JS, Alman BA.
    Nature Genetics. 2002 Mar;30(3):306-10.

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