Current Projects

Funder: Canadian Institutes of Health Research (CIHR)
Year Started: 2018
Role: Principal Investigator
Contact Person: Saunya Dover
Study Summary: Childhood arthritis is an important cause of pain for affected children and adolescents. Many youth with arthritis also have trouble sleeping. They often struggle to sleep through the night, wake up earlier, and are sleepier during the day compared to healthy children. Our research group, among others, has shown a strong link between sleep and pain. This is a randomized, crossover trial, whose purpose is to assess the impact of changing sleeping patterns on pain, and disease activity, in teenagers with arthritis.

Funder: Childhood Arthritis & Rheumatology Research Alliance (CARRA)
Year Started: 2018
Role: Principal Investigator
Contact Person: Ingrid Goh
Study Summary: This project seeks to look at ways that researchers can better engage patients and caregivers in participating in research.  From development of research projects, joining research as participants, to dissemination of research results; patients and caregivers provide a unique perspective that should be incorporated when developing and operationalizing research.

Funder: The Myositis Association (TMA)
Year Started:
2014
Role: Principal Investigator
Contact Person: Saunya Dover
Study Summary: The purpose of this research study is to find out if a natural health product called creatine, can improve muscle weakness or fatigue in children with dermatomyositis. We also want to know if patients like or dislike taking creatine and how often the medication is taken as instructed. This will help us determine how effective and feasible taking creatine is for improving the symptoms of the disease.

Funder: Cure JM Foundation
Year Started: 2018
Role: Principal Investigator
Contact Person: Saunya Dover
Study Summary: Children with juvenile dermatomyositis (JDM) are weak and get tired because their muscles aren’t able to work like healthy muscles. This can make it hard for them to do normal everyday things. This randomized, multiple baseline clinical trial is being done to see if having children with JDM take creatine and coenzyme Q10, two nutritional supplements that help muscles use energy and recover after exercise, can make them stronger and feel less tired.

Funder: Novo Nordisk Canada Inc.
Year Started:
2018
Role: Principal Investigator
Contact Person: Natasha Naraidoo
Study Summary: The aim of this study is to validate the MSK Assessment of Hemophilia: M.A.D.E online software program. MSK complications are a major issue for hemophilia patients. The M.A.D.E. study developed this software program to create a database on MSK information for hemophilia patients in Brazil. It enables users to share, combine and compare patient information obtained during regular assessments.

Funder: N/A
Year Started: 2018
Role: Principal Investigator
Contact Person: Hayyah Clairman
Study Summary: The goal of this study is to identify the trade-off between sample size and time on placebo in clinical trial design according to physicians, researchers, and patients/parents. This information will lead to the identification of the most preferred trial design based on the preferences for certain trial attributes.

Funder: N/A
Year Started: 2014
Role: Principal Investigator
Contact Person: Saunya Dover
Study Summary: The distribution of health-care funds has always been a questionable act due to subjective interpretations of society’s preferences. How are decisions made regarding the distribution of health-care funds – should more effective and more expensive treatments or less effective and significantly cheaper treatments receive funding? Should treatments targeting children or adults receive more funding? This study aims to determine what Canadians value in terms of health-care funding allocation using a discrete choice experiment approach.

Funder: The International Prophylaxis Study Group (IPSG)
Year Started: 2014
Role: Co-Principal Investigator
Contact Person: Audrey Abad
Study Summary: The HJHS is a musculoskeletal assessment tool developed to standardize joint evaluation in hemophilia. It has been validated in the paediatric population and is recognized as an optimal measurement of arthropathy in children and young adults. The primary aim of this study is to determine the convergent and discriminant construct validity of the HJHS 2.1 in adults with hemophilia, and to establish normative HJHS values in the adult population.

Funder: Ontario Sport & Recreation Communities Fund
Year Started: 2017
Role: Co-Investigator
Contact Person: Saunya Dover
Study Summary: Many children who come to hospitals find it difficult to be active with their friends. Some children tell us they are not good enough to play, some say they cannot keep up, and others are afraid they will get hurt. We are doing this study to find out if and how we can help those children who find it difficult to be active. If we can identify which children need extra support, we may be able to help them develop the skills and confidence required to play actively with their friends.

Funder: Childhood Arthritis & Rheumatology Research Alliance (CARRA)
Year Started: 2016
Role: Site-Principal Investigator
Contact Person: Ingrid Goh
Study Summary: The CARRA registry is an observational registry that collects clinical and patient reported information about patients with pediatric-onset rheumatic diseases. The goal of the CARRA Registry is to understand the long-term outcomes, as well as the long- and short-term safety and effectiveness of the medications used to treat pediatric rheumatic diseases. It provides opportunities for research through identification of subjects eligible for future studies and by serving as a data repository. More information can be found on the study website.

Funder: Patient-Centered Outcomes Research Trust Fund (PCORI)
Year Started: 2016
Role: Site-Principal Investigator
Contact Person: Ingrid Goh
Study Summary: STOP-JIA is a large-scale study comparing the effectiveness of initial versus delayed biologic therapy in children with polyarticular juvenile idiopathic arthritis (JIA) using CARRA’s consensus treatment plans. This study aims to help doctors and families understand whether starting a biologic medicine earlier or by itself would lessen bone or joint damage, or whether it would cause more side effects, or both. More information can be found on the study website.

Funder: Patient-Centered Outcomes Research Trust Fund (PCORI)
Year Started: 2017
Role: Site-Principal Investigator
Contact Person: Ingrid Goh
Study Summary: The FROST study aims to determine how newly diagnosed systemic juvenile idiopathic arthritis (JIA) patients do on the currently available treatments by assessing CARRA’s consensus treatment plans. More information can be found on the study website.

Funder: Canadian Institutes of Health Research (CIHR)
Year Started: 2010
Role: Site-Principal Investigator
Contact Person: Saunya Dover
Study Summary: The LEAP study is a Canada-wide study looking at the effect of juvenile idiopathic arthritis (JIA) on children’s physical activity, and the eventual impact on bones and muscles. More information can be found on the study website.

Funder: Bas-Stichting
Year Started: 2017
Role: Site-Principal Investigator
Contact Person: Hayyah Clairman
Study Summary: This study will follow JDM patients at SickKids and in the Netherlands with the aim of identifying markers/molecules in the blood (biomarkers) that can improve molecule diagnostics (testing) and guide treatment of juvenile dermatomyositis (JDM). This is being be done by measuring the amount and the activity of molecules in the blood, combined with doctor and patient assessments of disease activity and well-being.

Selected Publications

Methodological Studies

  • Abrahamyan L, Beyene J, Feng J, Chon Y, Willan AR, Schmeling H, Horneff G, Keystone EC, Feldman BM. Response times follow lognormal or gamma distribution in arthritis patients. J Clin Epidemiol. 2010 Dec; 63(12):1363-9. PMID: 20430577. View in: PubMed
  • Abrahamyan L, Li CS, Beyene J, Willan AR, Feldman BM. Survival distributions impact the power of randomized placebo-phase design and parallel groups randomized clinical trials. J Clin Epidemiol. 2011 Mar; 64(3):286-92. PMID: 20926258. View in: PubMed
  • Feldman B, Wang E, Willan A, Szalai JP. The randomized placebo-phase design for clinical trials. J Clin Epidemiol. 2001 Jun; 54(6):550-7. PMID: 11377114. View in: PubMed
  • Feldman BM. Innovative strategies for trial design. J Rheumatol Suppl. 2000 Apr; 58:4-7. PMID: 10782848. View in: PubMed
  • Huber AM, Tomlinson GA, Koren G, Feldman BM. Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials. J Rheumatol. 2007 May; 34(5):1125-32. PMID: 17444584. View in: PubMed
  • Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P, Ota S, Feldman BM. Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer. 2007 May; 43(8):1269-75. PMID: 17383174. View in: PubMed
  • Sung L, Feldman BM. N-of-1 trials: innovative methods to evaluate complementary and alternative medicines in pediatric cancer. J Pediatr Hematol Oncol. 2006 Apr; 28(4):263-6. PMID: 16679928. View in: PubMed
  • Nathan PC, Tomlinson G, Dupuis LL, Greenberg ML, Ota S, Bartels U, Feldman BM. A pilot study of ondansetron plus metopimazine vs. ondansetron monotherapy in children receiving highly emetogenic chemotherapy: a Bayesian randomized serial N-of-1 trials design. Support Care Cancer. 2006 Mar; 14(3):268-76. PMID: 16052316. View in: PubMed
  • Johnson SR, Tomlinson GA, Hawker GA, Granton JT, Feldman BM. Propensity Score Methods for Bias Reduction in Observational Studies of Treatment Effect. Rheum Dis Clin North Am. 2018 05; 44(2):203-213. PMID: 29622292. View in: PubMed
  • Tian SY, Silverman ED, Pullenayegum E, Brown PE, Beyene J, Feldman BM. Comparative Effectiveness of Mycophenolate Mofetil for the Treatment of Juvenile-Onset Proliferative Lupus Nephritis. Arthritis Care Res (Hoboken). 2017 12; 69(12):1887-1894. PMID: 28182833. View in: PubMed
  • Lim LS, Pullenayegum E, Moineddin R, Gladman DD, Silverman ED, Feldman BM. Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: a review & worked example using a clinic-based cohort of juvenile dermatomyositis patients. Pediatr Rheumatol Online J. 2017 Mar 29; 15(1):18. PMID: 28356102. View in: PubMed
  • Abrahamyan L, Willan AR, Beyene J, Mclimont M, Blanchette V, Feldman BM. Using value-of-information methods when the disease is rare and the treatment is expensive–the example of hemophilia A. J Gen Intern Med. 2014 Aug; 29 Suppl 3:S767-73. PMID: 25029970; PMCID: PMC4124117. View in: PubMedPubMed Central
  • Lim LS, Feldman BM. The risky business of studying prognosis. J Rheumatol. 2013 Jan; 40(1):9-15. PMID: 23204219. View in: PubMed
  • Pullenayegum EM, Feldman BM. Doubly robust estimation, optimally truncated inverse-intensity weighting and increment-based methods for the analysis of irregularly observed longitudinal data. Stat Med. 2013 Mar 15; 32(6):1054-72. PMID: 23047604. View in: PubMed
  • Johnson SR, Granton JT, Tomlinson GA, Grosbein HA, Le T, Lee P, Seary ME, Hawker GA, Feldman BM. Warfarin in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. A Bayesian approach to evaluating treatment for uncommon disease. J Rheumatol. 2012 Feb; 39(2):276-85. PMID: 22247353. View in: PubMed
  • Johnson SR, Granton JT, Tomlinson GA, Grosbein HA, Hawker GA, Feldman BM. Effect of warfarin on survival in scleroderma-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH. Belief elicitation for Bayesian priors. J Rheumatol. 2011 Mar; 38(3):462-9. PMID: 21159827. View in: PubMed
  • Johnson SR, Tomlinson GA, Hawker GA, Granton JT, Grosbein HA, Feldman BM. A valid and reliable belief elicitation method for Bayesian priors. J Clin Epidemiol. 2010 Apr; 63(4):370-83. PMID: 19926253. View in: PubMed
  • Pullenayegum EM, Lam C, Manlhiot C, Feldman BM. Fitting marginal structural models: estimating covariate-treatment associations in the reweighted data set can guide model fitting. J Clin Epidemiol. 2008 Sep; 61(9):875-81. PMID: 18486447. View in: PubMed
  • Stephens S, Beyene J, Tremblay MS, Faulkner G, Pullnayegum E, Feldman BM. Strategies for Dealing with Missing Accelerometer Rheum Dis Clin North Am. 2018 May; 44(2):317-326. PMID: 29622298. View in: PubMed
  • Feldman BM. The outcomes of haemophilia and its treatment: why we need a core set. Haemophilia. 2017 07; 23(4):485-487. PMID: 28722832. View in: PubMed
  • Church PC, Greer MC, Cytter-Kuint R, Doria AS, Griffiths AM, Turner D, Walters TD, Feldman BM. Magnetic resonance enterography has good inter-rater agreement and diagnostic accuracy for detecting inflammation in pediatric Crohn disease. Pediatr Radiol. 2017 May; 47(5):565-575. PMID: 28283726. View in: PubMed
  • Avila ML, Brandão LR, Williams S, Montoya MI, Stinson J, Kiss A, Feldman BM. Development of CAPTSureTM – a new index for the assessment of pediatric postthrombotic syndrome. J Thromb Haemost. 2016 12; 14(12):2376-2385. PMID: 27709837. View in: PubMed
  • Peters S, Ota S, Bolous E, Reich E, Chait S, Feldman BM. The Responsiveness of the Modified Childhood Health Assessment Questionnaire. J Rheumatol. 2016 10; 43(10):1904-1908. PMID: 27481906. View in: PubMed
  • Stephens SL, Tremblay MS, Faulkner G, Beyene J, Nguyen TH, Koohsari S, Limenis E, Feldman BM. Validity of the Stage of Exercise Scale in Children with Rheumatologic Conditions. J Rheumatol. 2016 12; 43(12):2189-2198. PMID: 27803137. View in: PubMed
  • Avila ML, Brandão LR, Williams S, Ward LC, Montoya MI, Stinson J, Kiss A, Lara-Corrales I, Feldman BM. Pediatric post-thrombotic syndrome in children: Toward the development of a new diagnostic and evaluative measurement tool. Thromb Res. 2016 Aug; 144:184-91. PMID: 27393923. View in: PubMed
  • Stephens S, Takken T, Esliger DW, Pullenayegum E, Beyene J, Tremblay M, Schneiderman J, Biggar D, Longmuir P, McCrindle B, Abad A, Ignas D, Van Der Net J, Feldman B. Validation of Accelerometer Prediction Equations in Children with Chronic Disease. Pediatr Exerc Sci. 2016 Feb; 28(1):117-32. PMID: 26182189. View in: PubMed
  • David JA, Feldman BM. Assessing activities, participation, and quality of life in hemophilia: relevance, current limitations, and possible options. Semin Thromb Hemost. 2015 Nov; 41(8):894-900. PMID: 26485720. View in: PubMed
  • Avila ML, Stinson J, Kiss A, Brandão LR, Uleryk E, Feldman BM. A critical review of scoring options for clinical measurement tools. BMC Res Notes. 2015 Oct 28; 8:612. PMID: 26510822. View in: PubMed
  • Adunuri NR, Feldman BM. Critical appraisal of studies measuring quality of life in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2015 May; 67(6):880-4. PMID: 25384887. View in: PubMed
  • Feldman BM, Pullaneyagum E. Response to ‘Limits of agreement between raters are required for use of HJHS 2.1 in clinical studies’. Haemophilia. 2015 Jan; 21(1):e71. PMID: 25412703. View in: PubMed
  • Luca NJ, Feldman BM. Health outcomes of pediatric rheumatic diseases. Best Pract Res Clin Rheumatol. 2014 Apr; 28(2):331-50. PMID: 24974066. View in: PubMed
  • Limenis E, Grosbein HA, Feldman BM. The relationship between physical activity levels and pain in children with juvenile idiopathic arthritis. J Rheumatol. 2014 Feb; 41(2):345-51. PMID: 24334648. View in: PubMed
  • Luca NJ, Feldman BM. Disease activity measures in paediatric rheumatic diseases. Int J Rheumatol. 2013; 2013:715352. PMID: 24089617; PMCID: PMC3781994. View in: PubMedPubMed Central
  • Doria AS, Crawley A, Babyn P, Rayner T, McLimont M, Moineddin R, Laxer R, Feldman B. BOLD MRI at 1.5 Tesla in juvenile idiopathic arthritis: preliminary experience. Clinics (Sao Paulo). 2013 May; 68(5):721-4. PMID: 23778406; PMCID: PMC3654309. View in: PubMedPubMed Central
  • Feldman BM. Issues in the measurement of quality of life in hemophilia. Rev Bras Hematol Hemoter. 2013; 35(5):299-301. PMID: 24255605; PMCID: PMC3832302. View in: PubMedPubMed Central
  • Luca NJ, Feldman BM. Paediatric rheumatic disease: Defining clinically inactive disease in juvenile dermatomyositis. Nat Rev Rheumatol. 2012 Nov; 8(11):638-9. PMID: 23027027. View in: PubMed
  • Feldman BM. Implementing musculoskeletal outcome assessments in clinical practice. Haemophilia. 2012 Jul; 18 Suppl 4:120-4. PMID: 22726094. View in: PubMed
  • Poonnoose P, Keshava S, Gibikote S, Feldman BM. Outcome assessment and limitations. Haemophilia. 2012 Jul; 18 Suppl 4:125-30. PMID: 22726095. View in: PubMed
  • Webb BD, Barrera M, Beyene J, Carcao M, Daneman D, Elliott I, Gong GW, Halperin IJ, Lord S, Melville H, Narayanan UG, Ota S, Solomon M, Sung L, Young NL, Zachos M, Feldman BM. Determinants of quality of life in children with chronic somatic disease: pilot data from the GapS Questionnaire. Qual Life Res. 2013 Mar; 22(2):339-49. PMID: 22461136. View in: PubMed
  • Luca N, Feldman BM. Pediatric rheumatology: Improving the assessment of children with JIA. Nat Rev Rheumatol. 2011 Jul 05; 7(8):442-4. PMID: 21727934. View in: PubMed
  • Takken T, Stephens S, Balemans A, Tremblay MS, Esliger DW, Schneiderman J, Biggar D, Longmuir P, Wright V, McCrindle B, Hendricks M, Abad A, van der Net J, Beyene J, Feldman BM. Validation of the Actiheart activity monitor for measurement of activity energy expenditure in children and adolescents with chronic disease. Eur J Clin Nutr. 2010 Dec; 64(12):1494-500. PMID: 20877392. View in: PubMed
  • Miller ML, LeBovidge J, Feldman B. Health-related quality of life in children with arthritis. Rheum Dis Clin North Am. 2002 Aug; 28(3):493-501, vi. PMID: 12380367. View in: PubMed
  • Feldman BM, Funk SM, Bergstrom BM, Zourikian N, Hilliard P, van der Net J, Engelbert R, Petrini P, van den Berg HM, Manco-Johnson MJ, Rivard GE, Abad A, Blanchette VS. Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: validity of the hemophilia joint health score. Arthritis Care Res (Hoboken). 2011 Feb; 63(2):223-30. PMID: 20862683. View in: PubMed
  • Feldman BM, Funk S, Lundin B, Doria AS, Ljung R, Blanchette V. Musculoskeletal measurement tools from the International Prophylaxis Study Group (IPSG). Haemophilia. 2008 Jul; 14 Suppl 3:162-9. PMID: 18510537. View in: PubMed
  • Stephens S, Singh-Grewal D, Bar-Or O, Beyene J, Cameron B, Leblanc CM, Schneider R, Schneiderman-Walker J, Selvadurai H, Silverman E, Spiegel L, Tse SM, Wright V, Feldman BM. Reliability of exercise testing and functional activity questionnaires in children with juvenile arthritis. Arthritis Rheum. 2007 Dec 15; 57(8):1446-52. PMID: 18050186. View in: PubMed
  • Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P, Ota S, Feldman BM. Validation of the oral mucositis assessment scale in pediatric cancer. Pediatr Blood Cancer. 2007 Aug; 49(2):149-53. PMID: 16628556. View in: PubMed
  • Gong GW, Barrera M, Beyene J, Bhat S, Carcao M, Lord S, Narayanan UG, Sung L, Young NL, Feldman BM. The Gap Study (GapS) interview–developing a process to determine the meaning and determinants of quality of life in children with arthritis and rheumatic disease. Clin Exp Rheumatol. 2007 May-Jun; 25(3):486-93. PMID: 17631751. View in: PubMed
  • Gong GW, Young NL, Dempster H, Porepa M, Feldman BM. The Quality of My Life questionnaire: the minimal clinically important difference for pediatric rheumatology patients. J Rheumatol. 2007 Mar; 34(3):581-7. PMID: 17183614. View in: PubMed
  • Hilliard P, Funk S, Zourikian N, Bergstrom BM, Bradley CS, McLimont M, Manco-Johnson M, Petrini P, van den Berg M, Feldman BM. Hemophilia joint health score reliability study. Haemophilia. 2006 Sep; 12(5):518-25. PMID: 16919083. View in: PubMed
  • Doria AS, Babyn PS, Feldman B. A critical appraisal of radiographic scoring systems for assessment of juvenile idiopathic arthritis. Pediatr Radiol. 2006 Aug; 36(8):759-72. PMID: 16552589. View in: PubMed
  • Brown GT, Wright FV, Lang BA, Birdi N, Oen K, Stephens D, McComas J, Feldman BM. Clinical responsiveness of self-report functional assessment measures for children with juvenile idiopathic arthritis undergoing intraarticular corticosteroid injections. Arthritis Rheum. 2005 Dec 15; 53(6):897-904. PMID: 16342103. View in: PubMed
  • Ramanan AV, Schneider R, Batthish M, Achonu C, Ota S, McLimont M, Young NL, Feldman BM. Developing a disease activity tool for systemic-onset juvenile idiopathic arthritis by international consensus using the Delphi approach. Rheumatology (Oxford). 2005 Dec; 44(12):1574-8. PMID: 16159950. View in: PubMed
  • Sung L, Hayden J, Greenberg ML, Koren G, Feldman BM, Tomlinson GA. Seven items were identified for inclusion when reporting a Bayesian analysis of a clinical study. J Clin Epidemiol. 2005 Mar; 58(3):261-8. PMID: 15718115. View in: PubMed
  • Batthish M, Schneider R, Ramanan AV, Achonu C, Young NL, Feldman BM. What does “active disease” mean? patient and parent perceptions of disease activity in the systemic arthritis form of juvenile idiopathic arthritis (SO-JIA). Rheumatology (Oxford). 2005 Jun; 44(6):796-9. PMID: 15784631. View in: PubMed
  • Lam C, Young N, Marwaha J, McLimont M, Feldman BM. Revised versions of the Childhood Health Assessment Questionnaire (CHAQ) are more sensitive and suffer less from a ceiling effect. Arthritis Rheum. 2004 Dec 15; 51(6):881-9. PMID: 15593357. View in: PubMed
  • Sung L, Young NL, Greenberg ML, McLimont M, Samanta T, Wong J, Rubenstein J, Ingber S, Doyle JJ, Feldman BM. Health-related quality of life (HRQL) scores reported from parents and their children with chronic illness differed depending on utility elicitation method. J Clin Epidemiol. 2004 Nov; 57(11):1161-6. PMID: 15567632. View in: PubMed
  • Sung L, Greenberg ML, Young NL, McLimont M, Ingber S, Rubenstein J, Wong J, Samanta T, Doyle JJ, Stain AM, Feldman BM. Validity of a modified standard gamble elicited from parents of a hospital-based cohort of children. J Clin Epidemiol. 2003 Sep; 56(9):848-55. PMID: 14505769. View in: PubMed
  • Brunner HI, Maker D, Grundland B, Young NL, Blanchette V, Stain AM, Feldman BM. Preference-based measurement of health-related quality of life (HRQL) in children with chronic musculoskeletal disorders (MSKDs). Med Decis Making. 2003 Jul-Aug; 23(4):314-22. PMID: 12926581. View in: PubMed
  • Brunner HI, Silverman ED, Bombardier C, Feldman BM. European Consensus Lupus Activity Measurement is sensitive to change in disease activity in childhood-onset systemic lupus erythematosus. Arthritis Rheum. 2003 Jun 15; 49(3):335-41. PMID: 12794788. View in: PubMed
  • Sung L, Greenberg ML, Doyle JJ, Young NL, Ingber S, Rubenstein J, Wong J, Samanta T, McLimont M, Feldman BM. Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy. Br J Cancer. 2003 Apr 22; 88(8):1185-90. PMID: 12698182; PMCID: PMC2747569. View in: PubMedPubMed Central
  • Dhanani S, Quenneville J, Perron M, Abdolell M, Feldman BM. Minimal difference in pain associated with change in quality of life in children with rheumatic disease. Arthritis Rheum. 2002 Oct 15; 47(5):501-5. PMID: 12382298. View in: PubMed
  • Naraine VS, Risebrough NA, Oh P, Blanchette VS, Lee S, Stain AM, Hedden D, Teitel JM, Feldman BM. Health-related quality-of-life treatments for severe haemophilia: utility measurements using the Standard Gamble technique. Haemophilia. 2002 Mar; 8(2):112-20. PMID: 11952846. View in: PubMed
  • Dempster H, Porepa M, Young N, Feldman BM. The clinical meaning of functional outcome scores in children with juvenile arthritis. Arthritis Rheum. 2001 Aug; 44(8):1768-74. PMID: 11508427. View in: PubMed
  • Huber AM, Hicks JE, Lachenbruch PA, Perez MD, Zemel LS, Rennebohm RM, Wallace CA, Lindsley CB, Passo MH, Ballinger SH, Bowyer SL, Reed AM, White PH, Katona IM, Miller FW, Rider LG, Feldman BM. Validation of the Childhood Health Assessment Questionnaire in the juvenile idiopathic myopathies. Juvenile Dermatomyositis Disease Activity Collaborative Study Group. J Rheumatol. 2001 May; 28(5):1106-11. PMID: 11361197. View in: PubMed
  • Feldman BM, Grundland B, McCullough L, Wright V. Distinction of quality of life, health related quality of life, and health status in children referred for rheumatologic care. J Rheumatol. 2000 Jan; 27(1):226-33. PMID: 10648043. View in: PubMed
  • Feldman BM, Ayling-Campos A, Luy L, Stevens D, Silverman ED, Laxer RM. Measuring disability in juvenile dermatomyositis: validity of the childhood health assessment questionnaire. J Rheumatol. 1995 Feb; 22(2):326-31. PMID: 7738957. View in: PubMed
  • Aggarwal R, Ringold S, Khanna D, Neogi T, Johnson SR, Miller A, Brunner HI, Ogawa R, Felson D, Ogdie A, Aletaha D, Feldman BM. Distinctions between diagnostic and classification criteria? Arthritis Care Res (Hoboken). 2015 Jul; 67(7):891-7. PMID: 25776731. View in: PubMed
  • Abrahamyan L, Diamond IR, Johnson SR, Feldman BM. A new toolkit for conducting clinical trials in rare disorders. J Popul Ther Clin Pharmacol. 2014; 21(1):e66-78. PMID: 24671886. View in: PubMed
  • Johnson SR, Tomlinson GA, Hawker GA, Granton JT, Feldman BM. Methods to elicit beliefs for Bayesian priors: a systematic review. J Clin Epidemiol. 2010 Apr; 63(4):355-69. PMID: 19716263. View in: PubMed
  • Ota S, Cron RQ, Schanberg LE, O’Neil K, Mellins ED, Fuhlbrigge RC, Feldman BM. Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus. Pediatr Rheumatol Online J. 2008 Apr 01; 6:5. PMID: 18380905; PMCID: PMC2330140. View in: PubMedPubMed Central
  • Abrahamyan L, Johnson SR, Beyene J, Shah PS, Feldman BM. Quality of randomized clinical trials in juvenile idiopathic arthritis. Rheumatology (Oxford). 2008 May; 47(5):640-5. PMID: 18245800. View in: PubMed
  • Feldman BM. Treating children with arthritis: towards an evidence-based culture. J Rheumatol Suppl. 2005 Jan; 72:33-5. PMID: 15660463. View in: PubMed
  • Feldman BM, Giannini EH. Where’s the evidence? Putting clinical science into pediatric rheumatology. J Rheumatol. 1996 Sep; 23(9):1502-4. PMID: 8877915. View in: PubMed

Applied Studies

  • Cantez S, Gross GJ, MacLusky I, Feldman BM. Cardiac findings in children with juvenile Dermatomyositis at disease presentation. Pediatr Rheumatol Online J. 2017 Jul 11; 15(1):54. PMID: 28693511. View in: PubMed
  • Huber A, Feldman BM. An update on inflammatory myositis in children. Curr Opin Rheumatol. 2013 Sep; 25(5):630-5. PMID: 23912317. View in: PubMed
  • Luca NJ, Atkinson A, Hawkins C, Feldman BM. Anti-signal recognition particle-positive juvenile polymyositis successfully treated with rituximab. J Rheumatol. 2012 Jul; 39(7):1483-5. PMID: 22753802. View in: PubMed
  • Lam CG, Manlhiot C, Pullenayegum EM, Feldman BM. Efficacy of intravenous Ig therapy in juvenile dermatomyositis. Ann Rheum Dis. 2011 Dec; 70(12):2089-94. PMID: 21978999. View in: PubMed
  • Butbul Aviel Y, Stremler R, Benseler SM, Cameron B, Laxer RM, Ota S, Schneider R, Spiegel L, Stinson JN, Tse SM, Feldman BM. Sleep and fatigue and the relationship to pain, disease activity and quality of life in juvenile idiopathic arthritis and juvenile dermatomyositis. Rheumatology (Oxford). 2011 Nov; 50(11):2051-60. PMID: 21873265. View in: PubMed
  • Batthish M, Feldman BM. Juvenile dermatomyositis. Curr Rheumatol Rep. 2011 Jun; 13(3):216-24. PMID: 21312074. View in: PubMed
  • Schmeling H, Stephens S, Goia C, Manlhiot C, Schneider R, Luthra S, Stringer E, Feldman BM. Nailfold capillary density is importantly associated over time with muscle and skin disease activity in juvenile dermatomyositis. Rheumatology (Oxford). 2011 May; 50(5):885-93. PMID: 21156669. View in: PubMed
  • Stringer E, Bohnsack J, Bowyer SL, Griffin TA, Huber AM, Lang B, Lindsley CB, Ota S, Pilkington C, Reed AM, Scuccimarri R, Feldman BM. Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey. J Rheumatol. 2010 Sep; 37(9):1953-61. PMID: 20595275. View in: PubMed
  • Huber AM, Giannini EH, Bowyer SL, Kim S, Lang B, Lindsley CB, Pachman LM, Pilkington C, Reed AM, Rennebohm RM, Rider LG, Wallace CA, Feldman BM. Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children’s Arthritis and Rheumatology Research Alliance Consensus Conference. Arthritis Care Res (Hoboken). 2010 Feb; 62(2):219-25. PMID: 20191521. View in: PubMed
  • Stringer E, Singh-Grewal D, Feldman BM. Predicting the course of juvenile dermatomyositis: significance of early clinical and laboratory features. Arthritis Rheum. 2008 Nov; 58(11):3585-92. PMID: 18975314. View in: PubMed
  • Feldman BM, Rider LG, Reed AM, Pachman LM. Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood. Lancet. 2008 Jun 28; 371(9631):2201-12. PMID: 18586175. View in: PubMed
  • Manlhiot C, Liang L, Tran D, Bitnun A, Tyrrell PN, Feldman BM. Assessment of an infectious disease history preceding juvenile dermatomyositis symptom onset. Rheumatology (Oxford). 2008 Apr; 47(4):526-9. PMID: 18304939. View in: PubMed
  • Manlhiot C, Tyrrell PN, Liang L, Atkinson AR, Lau W, Feldman BM. Safety of intravenous immunoglobulin in the treatment of juvenile dermatomyositis: adverse reactions are associated with immunoglobulin A content. Pediatrics. 2008 Mar; 121(3):e626-30. PMID: 18299304. View in: PubMed
  • Compeyrot-Lacassagne S, Feldman BM. Inflammatory myopathies in children. Rheum Dis Clin North Am. 2007 Aug; 33(3):525-53, vii. PMID: 17936176. View in: PubMed
  • Stringer E, Feldman BM. Advances in the treatment of juvenile dermatomyositis. Curr Opin Rheumatol. 2006 Sep; 18(5):503-6. PMID: 16896290. View in: PubMed
  • Pope E, Janson A, Khambalia A, Feldman B. Childhood acquired lipodystrophy: a retrospective study. J Am Acad Dermatol. 2006 Dec; 55(6):947-50. PMID: 17097389. View in: PubMed
  • Huber A, Feldman BM. Long-term outcomes in juvenile dermatomyositis: how did we get here and where are we going? Curr Rheumatol Rep. 2005 Dec; 7(6):441-6. PMID: 16303103. View in: PubMed
  • Ramanan AV, Campbell-Webster N, Ota S, Parker S, Tran D, Tyrrell PN, Cameron B, Spiegel L, Schneider R, Laxer RM, Silverman ED, Feldman BM. The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids. Arthritis Rheum. 2005 Nov; 52(11):3570-8. PMID: 16255046. View in: PubMed
  • Akikusa JD, Tennankore DK, Levin AV, Feldman BM. Eye findings in patients with juvenile dermatomyositis. J Rheumatol. 2005 Oct; 32(10):1986-91. PMID: 16206356 .View in: PubMed
  • Compeyrot-Lacassagne S, Feldman BM. Inflammatory myopathies in children. Pediatr Clin North Am. 2005 Apr; 52(2):493-520, vi-vii. PMID: 15820377. View in: PubMed
  • Ramanan AV, Feldman BM. Clinical features and outcomes of juvenile dermatomyositis and other childhood onset myositis syndromes. Rheum Dis Clin North Am. 2002 Nov; 28(4):833-57. PMID: 12506775. View in: PubMed
  • Ramanan AV, Feldman BM. Clinical outcomes in juvenile dermatomyositis. Curr Opin Rheumatol. 2002 Nov; 14(6):658-62. PMID: 12410087. View in: PubMed
  • Tse S, Lubelsky S, Gordon M, Al Mayouf SM, Babyn PS, Laxer RM, Silverman ED, Schneider R, Feldman BM. The arthritis of inflammatory childhood myositis syndromes. J Rheumatol. 2001 Jan; 28(1):192-7. PMID: 11196524. View in: PubMed
  • Al-Mayouf SM, Laxer RM, Schneider R, Silverman ED, Feldman BM. Intravenous immunoglobulin therapy for juvenile dermatomyositis: efficacy and safety. J Rheumatol. 2000 Oct; 27(10):2498-503. PMID: 11036850. View in: PubMed
  • Huber AM, Lang B, LeBlanc CM, Birdi N, Bolaria RK, Malleson P, MacNeil I, Momy JA, Avery G, Feldman BM. Medium- and long-term functional outcomes in a multicenter cohort of children with juvenile dermatomyositis. Arthritis Rheum. 2000 Mar; 43(3):541-9. PMID: 10728746. View in: PubMed
  • Laxer RM, Feldman BM. General and local scleroderma in children and dermatomyositis and associated syndromes. Curr Opin Rheumatol. 1997 Sep; 9(5):458-64. PMID: 9309202. View in: PubMed
  • Feldman BM, Reichlin M, Laxer RM, Targoff IN, Stein LD, Silverman ED. Clinical significance of specific autoantibodies in juvenile dermatomyositis. J Rheumatol. 1996 Oct; 23(10):1794-7. PMID: 8895161. View in: PubMed
  • Feldman BM, Rivard GE, Babyn P, Wu JKM, Steele M, Poon MC, Card RT, Israels SJ, Laferriere N, Gill K, Chan AK, Carcao M, Klaassen RJ, Cloutier S, Price VE, Dover S, Blanchette VS. Tailored frequency-escalated primary prophylaxis for severe haemophilia A: results of the 16-year Canadian Hemophilia Prophylaxis Study longitudinal cohort. Lancet Haematol. 2018 Jun; 5(6):e252-e260. PMID: 29731369. View in: PubMed
  • Carneiro JDA, Blanchette V, Ozelo MC, Antunes SV, Villaca PR, Young NL, Castro D, Brandão LR, Carcao M, Abad A, Feldman BM. Comparing the burden of illness of haemophilia between resource-constrained and unconstrained countries: the São Paulo-Toronto Hemophilia Study. Haemophilia. 2017 Sep; 23(5):682-688. PMID: 28440005. View in: PubMed
  • Crivianu-Gaita V, Rivard GE, Carcao M, Teitel J, St-Louis J, Blanchette V, Pullenayegum E, Abad A, Feldman BM. Pilot study of once-a-day prophylaxis for youth and young adults with severe haemophilia A. Haemophilia. 2016 Sep; 22(5):e401-5. PMID: 27481574. View in: PubMed
  • Hilliard P, Zourikian N, Blanchette V, Chan A, Elliott B, Israels SJ, Nilson J, Poon MC, Laferriere N, Van Neste C, Jarock C, Wu J, McLimont M, Feldman B. Musculoskeletal health of subjects with hemophilia A treated with tailored prophylaxis: Canadian Hemophilia Primary Prophylaxis (CHPS) Study. J Thromb Haemost. 2013 Mar; 11(3):460-6. PMID: 23301594. View in: PubMed
  • Feldman BM, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Willan AR, Schramm W. Haemophilia prophylaxis: how can we justify the costs? Haemophilia. 2012 Sep; 18(5):680-4. PMID: 22507524. View in: PubMed
  • Hang MX, Blanchette VS, Pullenayegum E, McLimont M, Feldman BM. Age at first joint bleed and bleeding severity in boys with severe hemophilia A: Canadian Hemophilia Primary Prophylaxis Study. J Thromb Haemost. 2011 May; 9(5):1067-9. PMID: 21320278. View in: PubMed
  • Risebrough N, Oh P, Blanchette V, Curtin J, Hitzler J, Feldman BM. Cost-utility analysis of Canadian tailored prophylaxis, primary prophylaxis and on-demand therapy in young children with severe haemophilia A. Haemophilia. 2008 Jul; 14(4):743-52. PMID: 18422610. View in: PubMed
  • Nicholson A, Berger K, Bohn R, Carcao M, Fischer K, Gringeri A, Hoots K, Mantovani L, Schramm W, van Hout BA, Willan AR, Feldman BM. Recommendations for reporting economic evaluations of haemophilia prophylaxis: a nominal groups consensus statement on behalf of the Economics Expert Working Group of The International Prophylaxis Study Group. Haemophilia. 2008 Jan; 14(1):127-32. PMID: 18005148. View in: PubMed
  • Feldman BM, Aledort L, Bullinger M, Delaney FM, Doria AS, Funk S, Giangrande P, Lundin B, Manco-Johnson M, Miners A, Scriba PC, Srivastava A, Schramm W, Blanchette VS. The economics of haemophilia prophylaxis: governmental and insurer perspectives. Proceedings of the Second International Prophylaxis Study Group (IPSG) symposium. Haemophilia. 2007 Nov; 13(6):745-9. PMID: 17850325. View in: PubMed
  • Ota S, Mclimont M, Carcao MD, Blanchette VS, Graham N, Paradis E, Feldman BM. Definitions for haemophilia prophylaxis and its outcomes: the Canadian consensus study. Haemophilia. 2007 Jan; 13(1):12-20. PMID: 17212719. View in: PubMed
  • Feldman BM, Pai M, Rivard GE, Israels S, Poon MC, Demers C, Robinson S, Luke KH, Wu JK, Gill K, Lillicrap D, Babyn P, McLimont M, Blanchette VS. Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study. J Thromb Haemost. 2006 Jun; 4(6):1228-36. PMID: 16706965.V iew in: PubMed
  • Feldman BM, Babyn P, Doria AS, Heijnen L, Jacobson J, Kilcoyne R, Lundin B, Manco-Johnson M, McLimont M, Petrini P, Pettersson H, Blanchette VS. Proceedings of the International Haemophilia Prophylaxis Study Group Meeting, November 2003, Montreal, PQ, Canada. Haemophilia. 2005 Jan; 11(1):58-63. PMID: 15660990. View in: PubMed
  • Kern M, Blanchette V, Stain AM, Einarson TR, Feldman BM. Clinical and cost implications of target joints in Canadian boys with severe hemophilia A. J Pediatr. 2004 Nov; 145(5):628-34. PMID: 15520762. View in: PubMed
  • Revel-Vilk S, Golomb MR, Achonu C, Stain AM, Armstrong D, Barnes MA, Anderson P, Logan WJ, Sung L, McNeely M, Blanchette V, Feldman BM. Effect of intracranial bleeds on the health and quality of life of boys with hemophilia. J Pediatr. 2004 Apr; 144(4):490-5. PMID: 15069398. View in: PubMed
  • Carcao M, Ungar WJ, Feldman BM. Cost-utility analysis in evaluating prophylaxis in haemophilia. Haemophilia. 2004 Mar; 10 Suppl 1:50-7. PMID: 14987249. View in: PubMed
  • Feldman BM. Preventing joint damage from hemophilia. J Rheumatol. 2000 Jul; 27(7):1579-81. PMID: 10914833. View in: PubMed
  • Heale LD, Dover S, Goh YI, Maksymiuk VA, Wells GD, Feldman BM. A wearable activity tracker intervention for promoting physical activity in adolescents with juvenile idiopathic arthritis: a pilot study. Pediatr Rheumatol Online J. 2018 Oct 22; 16(1):66. PMID: 30348203. View in: PubMed
  • Feldman BM. Exercise as Medicine for Children with Arthritis. J Rheumatol. 2017 08; 44(8):1103-1105. PMID: 28765342. View in: PubMed
  • Hutzal CE, Wright FV, Stephens S, Schneiderman-Walker J, Feldman BM. A qualitative study of fitness instructors’ experiences leading an exercise program for children with juvenile idiopathic arthritis. Phys Occup Ther Pediatr. 2009; 29(4):409-25. PMID: 19916825.View in: PubMed
  • Stephens S, Feldman BM, Bradley N, Schneiderman J, Wright V, Singh-Grewal D, Lefebvre A, Benseler SM, Cameron B, Laxer R, O’Brien C, Schneider R, Silverman E, Spiegel L, Stinson J, Tyrrell PN, Whitney K, Tse SM. Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: results of a randomized controlled pilot trial. Arthritis Rheum. 2008 Oct 15; 59(10):1399-406. PMID: 18821656.View in: PubMed
  • Singh-Grewal D, Schneiderman-Walker J, Wright V, Bar-Or O, Beyene J, Selvadurai H, Cameron B, Laxer RM, Schneider R, Silverman ED, Spiegel L, Tse S, Leblanc C, Wong J, Stephens S, Feldman BM. The effects of vigorous exercise training on physical function in children with arthritis: a randomized, controlled, single-blinded trial. Arthritis Rheum. 2007 Oct 15; 57(7):1202-10. PMID: 17907238.View in: PubMed
  • Singh-Grewal D, Wright V, Bar-Or O, Feldman BM. Pilot study of fitness training and exercise testing in polyarticular childhood arthritis. Arthritis Rheum. 2006 Jun 15; 55(3):364-72. PMID: 16739204.View in: PubMed
  • Stinson JN, Toomey PC, Stevens BJ, Kagan S, Duffy CM, Huber A, Malleson P, McGrath PJ, Yeung RS, Feldman BM. Asking the experts: exploring the self-management needs of adolescents with arthritis. Arthritis Rheum. 2008 Jan 15; 59(1):65-72. PMID: 18163408. View in: PubMed
  • Singh-Grewal D, Schneider R, Bayer N, Feldman BM. Predictors of disease course and remission in systemic juvenile idiopathic arthritis: significance of early clinical and laboratory features. Arthritis Rheum. 2006 May; 54(5):1595-601. PMID: 16645998. View in: PubMed
  • Spiegel LR, Schneider R, Lang BA, Birdi N, Silverman ED, Laxer RM, Stephens D, Feldman BM. Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study. Arthritis Rheum. 2000 Nov; 43(11):2402-9. PMID: 11083261. View in: PubMed
  • Feldman BM, Birdi N, Boone JE, Dent PB, Duffy CM, Ellsworth JE, Lang BA, Laxer RM, Lewkonia RM, Malleson PN, Oen KG, Paquin JD, Rosenberg AM, Schneider R, Silverman ED. Seasonal onset of systemic-onset juvenile rheumatoid arthritis. J Pediatr. 1996 Oct; 129(4):513-8. PMID: 8859257. View in: PubMed
  • Feldman BM, Silverman ED. Methotrexate therapy for juvenile rheumatoid arthritis. J Pediatr. 1991 Jun; 118(6):992-3. PMID: 2040940. View in: PubMed
  • Nulman I, Koren G, Rovet J, Barrera M, Streiner DL, Feldman BM. Neurodevelopment of children prenatally exposed to selective reuptake inhibitor antidepressants: Toronto sibling study. J Clin Psychiatry. 2015 Jul; 76(7):e842-7. PMID: 26231010. View in: PubMed
  • Nulman I, Koren G, Rovet J, Barrera M, Pulver A, Streiner D, Feldman B. Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression. Am J Psychiatry. 2012 Nov; 169(11):1165-74. PMID: 23128923. View in: PubMed
  • Lang BA, Yeung RS, Oen KG, Malleson PN, Huber AM, Riley M, Ebbeson R, Ramsey SE, Laxer RM, Silverman ED, McCrindle BW, Ratnapalan S, Feldman BM. Corticosteroid treatment of refractory Kawasaki disease. J Rheumatol. 2006 Apr; 33(4):803-9. PMID: 16583481. View in: PubMed
  • Scolnik D, Matthews P, Caulfeild J, Williams C, Feldman BM. Pagers in a busy paediatric emergency waiting room: A randomized controlled trial. Paediatr Child Health. 2003 Sep; 8(7):422-6. PMID: 20019948; PMCID: PMC2791651. View in: PubMedPubMed Central
  • Hagen LE, Schneider R, Stephens D, Modrusan D, Feldman BM. Use of complementary and alternative medicine by pediatric rheumatology patients. Arthritis Rheum. 2003 Feb 15; 49(1):3-6. PMID: 12579587. View in: PubMed
  • Sung L, Greenberg ML, Koren G, Tomlinson GA, Tong A, Malkin D, Feldman BM. Vitamin E: the evidence for multiple roles in cancer. Nutr Cancer. 2003; 46(1):1-14. PMID: 12925298.View in: PubMed
  • Brunner HI, Chan WS, Ginsberg JS, Feldman BM. Longterm anticoagulation is preferable for patients with antiphospholipid antibody syndrome. result of a decision analysis. J Rheumatol. 2002 Mar; 29(3):490-501. PMID: 11908562. View in: PubMed
  • Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM. Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damage. Arthritis Rheum. 2002 Feb; 46(2):436-44. PMID: 11840446. View in: PubMed
  • Uziel Y, Laxer RM, Krafchik BR, Yeung RS, Feldman BM. Children with morphea have normal self-perception. J Pediatr. 2000 Nov; 137(5):727-30. PMID: 11060543. View in: PubMed
  • Feldman BM, Stephens D, Wang EE. How should excess admission laboratory test utilization be curtailed? –paediatricians’ preferences. Clin Invest Med. 1995 Dec; 18(6):502-9. PMID: 8714793. View in: PubMed
  • Feldman BM, Zabriskie JB, Silverman ED, Laxer RM. Diagnostic use of B-cell alloantigen D8/17 in rheumatic chorea. J Pediatr. 1993 Jul; 123(1):84-6. PMID: 8320631. View in: PubMed

Find the complete list of published work on Dr. Feldman’s REACH profile.

Funding Sources

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