2024

Eroglu M, Zocher M, McAuley J, Webster R, Xiao MZX, Yu B, Mok C, Derry wB. Noncanonical inheritance of phenotypic information by protein amyloids. Nature Cell Biology. September 2, 2024.

Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat. TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing. Cell Reports. 2024 Jul 23;43(7):114417.

Webster R, Quintana M, Kafri R, Derry WB. CDK-4 regulates nucleolar size and anabolic metabolism as a fitness tradeoff in C. elegans. bioRXiv. 2024 doi.org/10.1101/2024.01.25.577258.
Popiel EM and Derry WB. MRCK-1 activates non-muscle myosin for outgrowth of a unicellular tube in Caenorhabditis elegans. bioRXiv. 2024 doi.org/10.1101/2024.01.25.577256

2023

FlemmingK, Smith E, Marchuk D, Derry WB, Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW and Amemiya A. Familial Cerebral Cavernous Malformations. GeneReviews. July 27, 2023. 
Derry WB. Role of developmental pathways in disease. FEBS J. 2023 Jul;290(13):3296-3299.
Urso SJ, Sathaseevan A, Brent Derry W, Lamitina T. Regulation of the hypertonic stress response by the 3′ mRNA cleavage and polyadenylation complex. Genetics. 2023 May 4;224(1):iyad051. 

2021

Subramanian A., Hall M., Hou H., Mufteev M., Yu B., Yuki KE., Nishimura H., Sathaseevan A., Lant B., Zhai B., Ellis J., Wilson MD., Daugaard M., Derry WB. Alternative polyadenylation is a determinant of oncogenic Ras function. Science Advances. 2021. Dec 17;7(51).
Tan C., Ginzberg MB., Webster R., Iyengar S., Liu S., Papadopoli D., Concannon J., Wang Y., Auld DS., Jenkins JL., Rost H., Topisirovic I., Hilfinger A., Derry WB., Patel N., Kafri R. Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK. Developmental cell. 2021 May 17;S1534-5807(21)00399-3.
Shahzad U, Taccone MS, Kumar SA, Okura H, Krumholtz S, Ishida J, Mine C, Gouveia K, Edgar J, Smith C, Hayes M, Huang X, Derry WB, Taylor M, Rutka JT., Modeling human brain tumours in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets. Neuro Oncology. 2021 May 5;23(5):718-731. 
Derry WB. CRISPR: development of a technology and its applications. FEBS Journal. 2021 Jan;288(2):358-359.

2020

Abdelilah-Seyfried S., Tournier-Lasserve E., and Brent Derry W. Blocking signalopathic events to treat Cerebral Cavernous Malformations. Trends in Molecular Medicine. 2020 Sep;26(9):874-887.

Popiel E, Derry WB. Affinity Purification and Preparation of Peptides for Mass Spectrometry from C. elegans. Methods in Molecular Biology. 2020;2152:479-485.

Popiel E, Derry WB. Generation and Analysis of CCM Phenotypes in C. elegans. Methods in Molecular Biology. 2020;2152:191-205.

Subramanian A, Hall M, Hou H, Mufteev M, Yu B, Yuki KE, Nishimura H, Sathaseevan A, Lant B, Zhai B, Ellis J, Wilson MD, Daugaard M, Derry WB. Alternative polyadenylation is a determinant of oncogenic Ras function. bioRxiv 2020.06.08.140145.

Tran, A.T, Chapman, E.M., Flamand, M.N., Yu, B., Krempel, S.J., Duchaine, T.F., Eroglu, M., & Derry, W.B. MiR-35 buffers apoptosis thresholds in the C. elegans germline by antagonizing both MAPK and core apoptosis pathways. (2019)  Cell Death & Differentiation,  published online.

Chapman, E.M., Lant, B., Ohashi, Y., Yu, B., Schertzberg, M., Go, C., Dogra, D., Koskimäki, J., Girard, R., Li, Y., Fraser, A.G., Awad, I.,A., Abdelilah-Seyfried, S., Gingras, A.C., & Derry, W.B. A Conserved CCM Complex Promotes Apoptosis Non-autonomously by Regulating Zinc Homeostasis. (2019) Nature Communications, 10 (1): 1791

Koskimäki J, Girard R, Li Y, Saadat L, Zeineddine HA, Lightle R, Moore T, Lyne S, Avner K, Shenkar R, Cao Y, Shi C, Polster SP, Zhang D, Carrión-Penagos J, Romanos S, Fonseca G, Lopez-Ramirez MA, Chapman EM, Popiel E, Tang AT, Akers A, Faber P, Andrade J, Ginsberg M, Derry WB, Kahn ML, Marchuk DA, Awad IA. Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes.  (2019) JCI Insight, published online.

Lant, B., Pal, S., Chapman, E.M., Yu, B., Witvliet, D., Choi, S., Zhao, L., Albiges-Rizo, C., Faurobert, E. & Derry, W.B. Interrogating the ccm-3 gene network. (2018) Cell Reports, 24(11), 2857-2868

Otten, C., Knox, J., Boulday, G., Eymery, M., Haniszewski, M., Neuenschwander, M., Radetzki, S., Vogt, I., Hähn, K., De Luca, C., Cardoso, C., Hamad, S., Gil, C.I., Roy, P., Albiges-Rizo, C., Faurobert, E., von Kries, J., Campillos, M., Tournier-Lasserve, E., Derry, W.B., Seyfried, S. Systematic pharmacological suppression uncovers novel molecular pathways involved in cerebral cavernous malformations. (2018) EMBO Molecular Medicine, published online.

Verster, A.J., Styles, E.B., Mateo, A., Derry, W.B., Andrews, B.J., Fraser, A. Taxonomically restricted genes with essential functions frequently play roles in chromosome segregation in Caenorhabditis elegans and Saccharomyces cerevisiae. (2017) G3 (Bethesda). 7(10): 3337-3347.

Pal, S., Lant, B., Yu, B., Tian, R., Tong, J., Krieger, J.R., Moran, M.F., Gingras, A.C., & Derry, W. B. CCM-3 Promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. (2017) Current Biology. 27(6): 868-876.

Mateo, A.R. & Derry, W. B. CEP-1 is pro-choice for reproductive health in C. elegans. (2016) Invited editorial, Cell Cycle. 15(21): 2843-2844.

Derry, W.B. Chewing the fat about death with the neighbours. (2016) Invited editorial, Cell Death and Differentiation. 23(7): 1097-1098.

Eroglu, M. & Derry, W.B. (2016) Your neighbours matter – non-autonomous control of apoptosis in development and disease. Cell Death and Differentiation. 23(7): 1110-1118.

Mateo, A.R, Kessler, Z., Jolliffe, A.K., McGovern, O., Yu, B., Nicolucci, A., Yanowitz, J.L. & Derry, W.B. (2016) The p53-like protein CEP-1 is required for meiotic fidelity in C. elegans. Current Biology. 26(9): 1148-1158.

Phanse, S., Wan, C., Borgeson, B., Tu, F., Drew, K., Clark, G., Xiong, X., Kagan, O., Kwan, J., Berzginov, A., Chessman, K., Pal, S., Cromar, G., Papoulas, O., Ni, Z., Boutz, D.R., Stoilova, S., Havugimana, P.C., Guo, X., Malty, R.H., Sarov, M., Greenblatt, J., Babu, M., Derry, W.B., Tillier, E., Wallingford, J.B., Parkinson, J., Marcotte, E.M. & Emili. A. (2015) Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Data in Brief. 6: 715-721.

Wan C, Borgeson B, Phanse S, Tu F, Drew K, Clark G, Xiong X, Kagan O, Kwan J, Bezginov A, Chessman K, Pal S, Cromar G, Papoulas O, Ni Z, Boutz DR, Stoilova S, Havugimana PC, Guo X, Malty RH, Sarov M, Greenblatt J, Babu M, Derry WB, R Tillier E, Wallingford JB, Parkinson J, Marcotte EM, Emili A. (2015) Panorama of ancient metazoan macromolecular complexes. Nature. 525(7569): 339-344.

Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. (2015) CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nature Communications. 6: 6449.

Lant, B. & Derry, W.B. (2014). Immunostaining for markers of apoptosis in the Caenorhabditis elegans germline. Cold Spring Harbor Protocols. 2014(5) pii: pdb.prot080242.

Lant, B. & Derry, W.B. (2014). Analysis of apoptosis in Caenorhabditis elegans. Cold Spring Harbor Protocols. 2014(5): pii: pdb.top070458.

Lant, B. & Derry, W.B. (2014). High-throughput RNAi screening for germline apoptosis genes in Caenorhabditis elegans. Cold Spring Harbor Protocols. 2014(4): 428-434.

Lant, B. & Derry, W.B. (2014). Fluorescent visualization of germline apoptosis in living Caenorhabditis elegans. Cold Spring Harbor Protocols. 2014(4): 420-427.

Lant, B. & Derry, W.B. (2014). Visualizing apoptosis in embryos and the germline of Caenorhabditis elegans. Cold Spring Harbor Protocols. 2014(3): 278-283. Cover Article

Lant, B. & Derry, W.B. (2014). Induction of germline apoptosis in Caenorhabditis elegans. Cold Spring Harbor Protocols. 2014(3): 271-277.

Baruah, A., Chang, H., Hall, M., Yuan, J., Gordon, S., Johnson, E., Shtessel, L.L., Yee, C., Hekimi, S., Derry, W.B., & Lee, S.S. (2014). CEP1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants. PLoS Genetics. 10(2): e1004097.

Lant, B. & Derry, W.B. (2013). Methods for detection and analysis of apoptosis signalling in the C. elegans germline. Methods. 61(2): 174-182.

Leprivier, G., Remke, M., Dubuc, A., Rotblat, B., Kool, M., Agnihotr, S., El-Naggar, A., Yu, B., Mateo, A.R.F., Somasekharan, S., Tognon, C.E., Mathers, J., Thomas, R., Barokas, A., Bowden, M., Smith, S., Wu, X., Korshunov, A., Hielscher, T., Northcott, P.A., McCabe, M.G., Delattre, O., Gleave, M.E., Jan, E., Proud, C.G., Pfister, SM., Derry, W.B., Taylor, M.D., and Sorensen, P.H.B. (2013). The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell. 153(5): 1064-1079.

Perrin, A.J., Gunda, M., Yu, B., Yen, K., Ito, S., Forster, S., Young, J., Tissenbaum, H.A. & Derry, W.B. (2013). Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death and Differentiation. 20(1): 97-107.

Jolliffe, A.K. & Derry, W.B. (2013). The p53 signaling network in mammals and worms. Briefings in Functional Genomics. 12(2): 129-141.

Ceccarelli, D.F., Laister, R.C., Mulligan, V.K., Kean, M.J., Goudreault, M., Scott, I.C., Derry, W.B., Chakrabartty, A., Gingras, A.C. & Sicheri, F. (2011). CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. Journal of Biological Chemistry. 286(28): 25056-25064.

Kean,M.J., Ceccarelli, D., Goudreault, M., Sanches, M., Tate, S., Larsen, B., Gibson, L.C., Derry, W.B., Scott, I.C., Pelletier, L., Baillie, G., Sicheri, F. & Gingras, A.C. (2011). Structure-function analysis of core STRIPAK: a signalling complex implicated in golgi polarization. Journal of Biological Chemistry. 286(28): 25065-25075.

Ross, A.J., Li, M., Yu, B., Gao, M.X. & Derry, W.B. (2011). The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Cell Death and Differentiation. 18(7): 1140-1149.

Ito, S., Greiss, S., Gartner, A. & Derry, W.B. (2010). Cell-nonautonomous regulation of C. elegans germ cell death by kri-1. Current Biology. 20(4): 333-338.

Gao, X. Liao, E., Yu, B., Wang, Y., Zhen, M. & Derry, W.B. (2008). The SCFFSN-1 ubiquitin ligase controls CEP-1/p53-dependent apoptosis in Caenorhabditis elegans. Cell Death and Differentiation. 15(6): 1054-1062.

Taylor, R.C., Brumatti, G., Ito, S., Hengartner, M.O., Derry, W.B. & Martin SJ. (2007). Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. Journal of Biological Chemistry. 282(20): 15011-15021.

Derry, W.B., Bierings, R., van Iersel, M. , Satkunendran, T., Reinke, V. & Rothman, J.H. (2007). Regulation of developmental timing and germ cell proliferation in C. elegans by the p53 gene network. Cell Death and Differentiation. 14(4): 662-670.

Quevedo, C., Kaplan, D.R. & Derry, W.B. (2007). AKT-1 regulates DNA-damage induced germline apoptosis in C. elegans. Current Biology. 17(3): 286-292.

Huyen, Y., Stavridi, E.S., Derry, W.B., Jeffrey, P., Rothman, J.H., Pavletich, N.P. & Halazonetis, T.D. (2004). Structural differences in the DNA binding domains of human p53 and its evolutionary ancestor C. elegans CEP-1. Structure. 12(7): 1237-1243.

Dumontet, C., Jaffrezou, J.P., Tsuchiya, E., Duran, G.E., Chen, G., Derry, W.B., Wilson, L., Jordan, M.A., Sikic, B.I. (2004). Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization. Bulletin du Cancer. 91(5): E81-E112.

 

Fukuyama, M, Gendreau, S.B., Derry, W.B. & Rothman, J.H. (2003). Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C. elegans. Developmental Biology. 260(1): 273-286.

Derry, W.B., Putzke, A.P. & Rothman, J.H. (2001). Caenorhabditis elegans p53: Role in apoptosis, meiosis, and stress resistance. Science. 294(5542): 591-594.

Sugimoto, A, Kusano, A., Hozak, R.R., Derry, W.B., Zhu, J. & Rothman, J.H. (2001). Many genomic regions are required for normal embryonic programmed cell death in Caenorhabditis elegans. Genetics. 158(1): 237-252.

Precambrian Era