BY TOPICS (SELECTED PUBLICATIONS)

Ion channel regulation of tumor cell-neuron interaction

• Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim TH, He Y, Wanggou S, Li X, Melnyk RA, Wang LY, Huang X (2023) A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. Nature Cancer 4, 1418–1436 (Cover Article) PMID: 37697045

Editorial highlights:

Editorial: The never-abating excitement for targeted therapies. Nature Cancer 4, 1397-1398

News & Views: Targeting network circuitry in glioma. Nature Cancer 4, 1406–1407

Behind the paper: Nature Cancer Community

Media coverage:

Video abstract

Discovery of protein-protein interaction lays foundation for future glioblastoma therapy

SickKids News, EurekAlert!, Bioengineer.org, Technology Networks, News Medical, The Daily Science, Press-News.org, Medical Xpress, Nouvelles Du Monde, Futur en Seine

Designer Peptide Targeting Protein-Protein Interaction Could Become Glioblastoma Treatment Inside Precision Medicine

Cracking the cancer-neuroscience connection Drug Discovery News

Researchers pave the way for new glioblastoma treatment Department of Molecular Genetics, University of Toronto

First-in-class多肽分子通过抑制肿瘤-神经元互作治疗脑胶质瘤 BioArt

SickKids科研突破：助力研发脑癌新疗法 SickKids病童医院基金会

Ion channel regulation of tumor cell-blood vessel interaction

• Chen X*, Momin A*, Wanggou S*, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan L, Zhang J, Ramaswamy V, Selvadurai H, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X^#, Huang X^#,§ (2023) Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron 111:30-48 (Cover Article) (* contributed equally, ^# corresponding author, ^§ lead contact) PMID: 36323321

Editorial highlights:

Preview: Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability. Neuron 111(1):3-5

Media coverage: 

New research rethinks the blood-tumour barrier and identifies novel path to brain cancer treatment

SickKids News, EurekAlert!, Medical Xpress, News-Medical, Technology Networks

Breaking through the blood-tumour barrier to better treat brain cancer OICR News

Study provides path for overcoming blood-tumor barrier in treating medulloblastoma The Science Advisory Board

Touch receptor plays a role in blood-tumor barrier BioWorld

机械敏感性肿瘤细胞构成的全新血-肿瘤屏障阻碍脑肿瘤化疗 BioArt

Ion channel regulation of tumor cell-extracellular matrix interaction

• Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, Huang X (2018) A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron 100(4):799-815.e7. PMID: 30344046

Editorial highlights:

Video abstract: how brain tumors stiffen and grow

Preview: Unlocking the dangers of a stiffening brain Neuron 100(4):763-765

F1000Prime Recommended

Best of Neuron 2018-2019

Media coverage: 

May the force not be with you SickKids News, Cancer Stem Cell News

Researchers find a new way to address the challenge of brain tumour “stiffness” OICR News

调节肿瘤组织机械特性或可成为肿瘤治疗新方式 BioArt

Ion channel regulation of tumor cell-intrinsic properties

• Fan JJ*, Wang X*, Erickson AW*, Skowron P*, Wang X, Chen X, Shan G, Bahrampour S, Xiong Y, Dong W, Abeysundara N, Francisco MA, Pusong RJ, Suarez RA, Farooq H, Holgado BL, Wu X, Daniels C, Dupuy AJ, Cadinanos J, Bradley A, Bagchi A, Moriarity BS, Largaespada DA, Morrissy AS, Ramaswamy V, Mack SC, Garzia L, Dirks PB, Wanggou S, Li X, Sun Y, Taylor MD^#, Huang X^#. In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma. bioRxiv (preprint) https://doi.org/10.1101/2022.07.23.501234 (* contributed equally, ^# corresponding author)

• Bahcheli AT*, Min HK*, Bayati M, Zhao H, Fortuna A, Dong W, Dzneladze I, Chan J, Chen X, Guevara-Hoyer K, Dirks PB, Huang X^#, Reimand J^# (2024) Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. The EMBO Journal 43: 196–224 (* contributed equally, ^#corresponding author) PMID:38177502

• Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X^#, Huang X^# (2020) Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. Journal of Experimental Medicine 217(5):e20190971. (^# corresponding author) PMID: 32097463

Media coverage:

Study shows common cell protein could be targeted to treat childhood brain cancers OICR News

氯离子通道CLIC1在髓母细胞瘤的致病作用机制 BioArt

• Huang X*, He Y*, Dubuc AM*, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens S, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN^#, Jan LY^# (2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nature Neuroscience 18(9): 1236-46. (* contributed equally, ^# corresponding author) PMID: 26258683

Editorial highlights:

Channeling brain cancer. Science Signaling (2015): 8 (392), ec245

Therapy: Reinventing the wheel. Nature Reviews Cancer (2015): 15, 514

EAG2 potassium channel: A new regulator of malignancy and therapeutic target in medulloblastoma. Neuro-Oncology (2015): 17(12), 1547

Voltage spikes driving medulloblastoma. Cancer Research (2015): 75, 4439

Targeting ion channels in cancer. Lab Animal (2015): 44, 370

Media coverage: 

Common class of “channel blocking” drugs may find a role in cancer therapy ScienceDaily, EurekAlert!, Neuroscientist News, Newswise, HealthCanal, UCSF News Center

Potassium Channel Blockers Show Promise as Treatment for Brain Tumors OncoTherapy Network

Targeting an Ion Channel to Treat Common Pediatric Brain Tumor Northwestern University News Center

Ion Channels May Play a Role in a New Generation of Cancer Therapies Icagen

• Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes & Development 26(16): 1780-96. (Cover Article) PMID: 22855790

Editorial highlights:

Medulloblastoma: Pump up the volume. Nature Reviews Cancer, 12, 583

Targeting ion channels. Nature Structural & Molecular Biology, 19, 867

Ion Channel Activity Promotes Mitotic Entry and Tumor Cell Growth. Cancer Discovery, 2, 763

New tools for studying ionic signaling, measuring cell mechanics, and treating brain cancer

• Wang X, Gong Z, Wang T, Law J, Chen X, Wanggou S, Wang J, Ying B, Francisco MA, Dong W, Yi X, Fan JJ, Angers S, Dirks PB, Li X, Liu X, Huang X^#, Sun Y^# (2023) Mechanical nanosurgery of chemoresistant glioblastoma. Science Advances 9, eade5321 (^# corresponding author) PMID: 36989359

Editorial highlights:

Nanotubes disrupt brain tumours. Nature Reviews Neurology (2023) 19, 323

Mechanical nanosurgery for glioblastoma. Nature Reviews Materials (2023) 8, 307

Media coverage:

Video abstract: Mechanical Nanosurgery: Using Precision Magnetics To Destroy Tumor Cells From Within

Precision magnetics could be game-changer for therapy-resistant brain cancers

SickKids News, OICR News, EurekAlert!, Technology Networks, Newswise, HospiMedica, SciTechDaily, Head Topics, OncologyNews, Nanowerk

Robotic nano-surgery shown effective at treating aggressive brain cancer in mice University of Toronto News, University of Toronto Engineering News, BioMedWire

Nanotubes shred tumors in mice Drug Discovery News

Robotic nano-surgery shown to be effective at treating brain cancer in pre-clinical models Education News Canada

Nano-robotic scalpel swarm shreds brain cancer cells from the inside News Atlas

Robotic nano-surgery kills GBM cancer cells in mice’s brains Tech Informed

Mechanical nanosurgery attacks aggressive brain cancer Physics World

Tiny robots, giant steps: how nanotechnology could improve cancer and fertility treatment The Guardian

Talk science to me with Dan Riskin (begins at 4:40) iHeartRadio

磁石と鉄粉でグリオブラストーマを除去する All About Science Japan

利用磁控碳纳米管治疗耐药胶质母细胞瘤 bioon

• Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S^#, Huang X^#, Sun Y^# (2023) Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles. Proceedings of the National Academy of Sciences 120(36):e2307356120 (^# corresponding author) PMID:37639585

• Wang X*, Wang T*, Chen X, Law J, Shan G, Tang W, Gong Z, Pan P, Liu X, Yu J, Ru C^#, Huang X^#, Sun Y^# (2022) Microrobotic swarms for intracellular measurement with enhanced signal-to-noise ratio. ACS Nano16(7):10824–10839 (^# corresponding author) PMID:35786860

Reviews of ion channel functions in cancer

• Momin A*^,#, Bahrampour S*, Min HK*, Chen X*, Wang X, Sun Y, Huang X^# (2021) Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. Trends in Pharmacological Sciences 42(5):367-384. (Cover Article) (* contributed equally, ^# corresponding author) PMID:33752907

• Fan JJ^# and Huang X^# (2020) Ion channels in cancer: orchestrators of electrical signaling and cellular crosstalk. Reviews of Physiology, Biochemistry and Pharmacology (^# corresponding author) PMID: 32894333

• Huang X^# and Jan LY^# (2014) Targeting potassium channels in cancer. Journal of Cell Biology 206(2): 151-62. (^# corresponding author) PMID: 25049269

BY YEARS (ALL PUBLICATIONS)

The Hospital for Sick Children / University of Toronto

2024

• Bahcheli AT*, Min HK*, Bayati M, Zhao H, Fortuna A, Dong W, Dzneladze I, Chan J, Chen X, Guevara-Hoyer K, Dirks PB, Huang X^#, Reimand J^# (2024) Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. The EMBO Journal 43: 196–224 (* contributed equally, ^#corresponding author) PMID:38177502

2023

• Dong W, Fekete A, Chen X, Liu H, Beilhartz GL, Chen X, Bahrampour S, Xiong Y, Yang Q, Zhao H, Kong T, Morioka MS, Jung G, Kim JE, Schramek D, Dirks PB, Song Y, Kim TH, He Y, Wanggou S, Li X, Melnyk RA, Wang LY, Huang X (2023) A designer peptide against the EAG2-Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma. Nature Cancer 4, 1418-1436 PMID: 37697045

• Tang W, Chen X, Wang X, Zhu M, Shan G, Wang T, Dou W, Wang J, Law J, Gong Z, Hopyan S^#, Huang X^#, Sun Y^# (2023) Indentation induces instantaneous nuclear stiffening and unfolding of nuclear envelop wrinkles. Proceedings of the National Academy of Sciences 120(36):e2307356120 (^# corresponding author) PMID:37639585

• Dave BM, Chen X, McCready F, Charton CS, Morley RM, Tailor JK, Ellis J, Huang X, Dirks PB (2023) Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development 150 (13): dev201534. PMID:37381820

• Wang X, Gong Z, Wang T, Law J, Chen X, Wanggou S, Wang J, Ying B, Francisco MA, Dong W, Yi X, Fan JJ, Angers S, Dirks PB, Li X, Liu X, Huang X^#, Sun Y^# (2023) Mechanical nanosurgery of chemoresistant glioblastoma. Science Advances 9, eade5321 (^# corresponding author) PMID:36989358

• Dou W, Abdelkader D, Chen X, Wang T, Malhi M, Gong Z, Mirshafiei F, Zhu M, Shan G, Huang X, Maynes J, Sun Y (2023) Ultrathin and flexible bioelectronic arrays for functional measurement of iPSC-cardiomyocytes under cardiotropic drug administration and controlled microenvironments. Nano Letters 23, 6, 2321–2331 PMID:36893018

• Xu P, Wang S, Lin A, Min N, Zhou Z, Dou W, Sun Y, Huang X, Tran H^#, Liu X^# (2023) Conductive SWCNT/PDMS bottlebrush elastomers for ultrasoft electronics. Nature Communications 14(1):623 (^# corresponding author) PMID:36739447

• Chen X*, Momin A*, Wanggou S*, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan LK, Zhang J, Ramaswamy V, Selvadurai HJ, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X^#, Huang X^#,§ (2023) Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron 111(1):30-48 (* contributed equally, ^# corresponding author, ^§ lead contact) PMID:36323321

2022

• Hendrikse LD*, Haldipur P*, Saulnier O*, Millman J, Sjoboen AH, Erickson A, Ong W, Gordon V, L C-M, Mercier AL, Shokouhian M, Suárez RA, Ly M, Borlase S, Scott DS, Vladoiu MC, Farooq H, Sirbu O, Nakashima T, Nambu S, Funakoshi Y, Bahcheli A, Diaz-Mejia J, Golser J, Bach K, Phuong-Bao T, Skowron P, Wang E, Kumar S, Balin P, Visvanathan A, Lee JJY, Ayoub R, Chen X, Chen X, Mungall KL, Luu B, Bérubé P, Wang YC, Pfister SM, Delattre O, Kim S-K, Bourdeaut F, Doz FP, Masliah-Planchon J, Grajkowska WA, Loukides J, Dirks PB, Fèvre-Montange M, Jouvet A, French PJ, Kros JM, Zitterbart K, Bailey SD, Eberhart CG, Rao AAN, Giannini C, Olson JM, Garami M, Hauser P, Phillips JJ, Ra YS, de Torres C, Mora J, Li KKW, Ng H-K, Poon WS, Pollack IF, López-Aguilar E, Gillespie GY, Van Meter TE, Shofuda T, Vibhakar R, Thompson RC, Cooper MK, Rubin JB, Kumabe T, Jung S, Lach B, Ferrucci V, Antonellis PD, Zollo M, Robinson S, Stearns DS, Van Meir EG, Porrati P, Finocchiaro G, Massimino M, Carlotti CG, Faria CC, Roussel MF, Boop F, Chan JA, Aldinger KA, Razavi F, Silvestri E, McLendon RE, Thompson EM, Ansari M, Garre ML, de León FCP, Aguilar PE, Conti MPPD, Morrissy AS, Cavalli FMG, Wu X, Daniels C, Rich JN, Jones SJM, Moore RA, Marra MA, Huang X, Reimand J, Ellison DW, Sorensen PHB, Wechsler-Reya RJ, Weiss WA, Pugh TJ, Garzia L, Kleinman CL, Stein LD, Jabado N, Malkin D, Ayrault O, Doble B, Ramaswamy V, Werbowetski-Ogilvie TE^#, Suzuki H^#, Millen KJ^#, Taylor MD^# (2022) Failure of human rhombic lip differentiation constitutes medulloblastoma. Nature (* contributed equally, ^# corresponding author) 609(7929): 1021-2018 PMID: 36131014

• Law J*, Wang X*, Luo M, Xin L, Du X, Dou W, Wang T, Shan G, Wang Y, Song P^#, Huang X, Yu J^#, Sun Y^# (2022) Microrobotic swarms for selective embolization. Science Advances 22;8(29):eabm5752 (^# corresponding author) PMID: 35857830

• Wang X*, Wang T*, Chen X, Law J, Shan G, Tang W, Gong Z, Pan P, Liu X, Yu J, Ru C^#, Huang X^#, Sun Y^# (2022) Microrobotic swarms for intracellular measurement with enhanced signal-to-noise ratio. ACS Nano 16(7):10824-10839 (* contributed equally, ^# corresponding author) PMID:35786860

• Yang Q, Jiang N, Zou H, Fan X, Liu T, Huang X, Wanggou S, Li X (2022) Alterations in 3D chromatin organization contribute to tumorigenesis of EGFR-amplified glioblastoma. Computational and Structural Biotechnology Journal 20:1967-1978 PMID: 35521558

2021

• Son JE^#, Dou Z, Wanggou S, Chan J, Mo R, Li X, Huang X, Kim K, Michaud JL, Hui CC^# (2021) Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency. Science Advances 7(44):eabh4503 (^# corresponding author) PMID: 34705510

• Zhang Z, Dai C, Shan G, Chen X, Liu H, Abdalla K, Kuznyetsova I, Moskovstev S, Huang X, Librach C, Jarvi K, Sun Y (2021) Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection. Fertility and Sterility 116(5):1308-1318. PMID: 34266663

• Son JE*, Dou Z*, Kim K, Wanggou S, Cha VSB, Mo R, Zhang X, Ketela T, Chen X, Li X, Huang X, Hui CC (2021) Expression of Irx3 and Irx5 in Ins2-Cre+ cells regulates hypothalamic postnatal neurogenesis and leptin response. Nature Metabolism 3(5):701-713 (* contributed equally) PMID: 33859429

• Pryszlak M*, Wiggans M*, Chen X, Jaramillo JE, Burns SE, Richards LM, Pugh TJ, Kaplan DR, Huang X, Dirks PD, Pearson BJ (2021) The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports 34(13):108903 (* contributed equally)  PMID: 33789112

• Momin A*^,#, Bahrampour S*, Min HK*, Chen X*, Wang X, Sun Y, Huang X^# (2021) Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. Trends in Pharmacological Sciences 42(5):367-384 (* contributed equally, ^# corresponding author) PMID: 33752907

• Shahzad U, Taccone M, Kumar S, Okura H, Krumholtz S, Ishida J, Mine C, Gouveia K, Edgar J, Smith C, Hayes M, Huang X, Derry BW, Taylor MD, and Rutka JT (2021) Modeling human brain tumours in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets. Neuro-Oncology 23(5):718-731. PMID: 33378446

2020

• Fan JJ^# and Huang X^#,§ (2020) Ion channels in cancer: orchestrators of electrical signaling and cellular crosstalk. Reviews of Physiology, Biochemistry and Pharmacology (^# corresponding author) PMID: 32894333

• Francisco MA, Wanggou S, Fan JJ, Dong W, Chen X, Momin A, Abeysundara N, Min HK, Chan J, McAdam R, Sia M, Pusong RJ, Liu S, Patel N, Ramaswamy V, Kijima N, Wang LY, Song Y, Kafri R, Taylor MD, Li X^#, Huang X^#,§ (2020) Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth. Journal of Experimental Medicine 217.5: e20190971 (^# corresponding author) PMID:32097463

2019

• Pigott BJ, Peters CJ, He Y, Huang X, Younger S, Jan LY, Jan YN (2019) Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors. Genes & Development 1;33(23-24):1739-1750. PMID:31753914

• Suzuki H*, Kumar SA*, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD (2019) Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature 574(7780):707-711 (* contributed equally) PMID:31664194

2018

• Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, Guo C, Xiang B, Zhou M, Ma J, Huang X, Wu X, Li Y, Li GY, Zeng ZY, Xiong W (2018) Effects of tumor metabolic microenvironment on regulatory T cells. Molecular Cancer 17(1):168. PMID:30477520

• Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, Yin WC, Min HK, Hu M, Draghici D, Dou W, Li F, Coutinho FJ, Whetstone H, Kushida MM, Dirks PB, Song Y, Hui CC, Sun Y, Wang LY, Li X, and Huang X (2018) A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron 100(4):799-815.e7. PMID:30344046

• Frattini V, Pagnotta SM, Tala, Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, Iavarone A (2018) A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature 553, 222–227. PMID:29323298

2017

• Park NI, Guilhamon P, Desai K, McAdam RF, Langille E, O’Connor M, Lan X, Whetstone H, Coutinho FC, Vanner RJ, Ling E, Prinos P, Lee L, Selvadurai, H, Atwal G, Kushida M, Clarke ID, Voisin V, Cusimano MD, Bernstein M, Das S, Bader G, Arrowsmith CH, Angers S, Huang X, Lupien M, Dirks PB (2017) ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity. Cell Stem Cell 21(2):209-224.e7. PMID: 28712938

2016

• Agnihotri S, Golbourn B, Huang X, Remke M, Younger S, Cairns RA, Chalil A, Smith CA, Krumholtz SL, MacKenzie D, Rakopoulos P, Ramaswamy V, Taccone MS, Mischel PS, Fuller GN, Hawkins C, Stanford WL, Taylor MD, Zadeh G, Rutka JT (2016) PINK1 is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma. Cancer Research 76(16):4708-19. PMID: 2732564

• Morrissy AS*, Garzia L*, Shih DJH, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay P, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Yusanne M, Tse K, Zeng T, Shumansky K, Roth AJL, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJY, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michaelraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfied YSN, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff J, Garvin JH, Stearns DS, Massimi L, Schuller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DPC, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischack G, Tippelt S, Ra YS, Bailey S, Lindsay JC, Clifford SC, Eberhart CG, Cooper MK, Packer R, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins C, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DTW, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones JM, Malkin D, Marra MA^#. Taylor MD^# (2016) Divergent Clonal Selection Drives Medulloblastoma at Recurrence. Nature 529, 351–357 (* contributed equally, ^# corresponding author). PMID: 26760213

2004 – 2010 (Vanderbilt University)

• Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, Litingtung Y, Chiang C (2010) Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proceedings of the National Academy of Sciences 107(18): 8422-7. PMID: 20400693

• Huang X, Sarangi A, Ketova T, Litingtung Y, Cooper MK, Chiang C (2010) Intracranial orthotopic allografting of medulloblastoma cells in immunocompromised mice. Journal of Visualized Experiments (44). pii: 2153. PMID: 20972404

• Huang X, Ketova T, Litingtung Y, Chiang C (2010) Isolation, enrichment and maintenance of medulloblastoma stem cells. Journal of Visualized Experiments (43). pii: 2086. PMID: 20834221

• Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C (2009) Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 136(15): 2535-43. PMID: 19570847

Editorial highlight:

Shh, choroid plexus growth in progress. Development. (2009) 136: e1502

• Oh S*, Huang X*, Liu J, Litingtung Y, Chiang C (2009) Shh and Gli3 activities are required for timely generation of motor neuron progenitors. Developmental Biology 331(2): 261-9. (* contributed equally) PMID: 19433083

• Huang X*, Goudy SL*, Ketova T, Litingtung Y, Chiang C (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Developmental Dynamics 237(10): 3079-87 (* contributed equally) PMID: 18816854

• Fogel JL, Chiang C, Huang X, Agarwala S (2008) Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Developmental Dynamics 237(5): 1359-72. PMID: 18429041

• Huang X, Litingtung Y, Chiang C (2007) Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development 134(11): 2095-10 PMID: 17507410

• Huang X, Litingtung Y, Chiang C (2007) Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Human Molecular Genetics 16(12): 1454-68. PMID: 17468181

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