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Septins
Primary Cilia
SNARE proteins
Scavenger Receptors
Septins in Yeast
Diffusion Barriers
Only recently have the filamentous septin family of GTPases been recognized to be the fourth component of the cytoskeleton, and their interactions with other cytoskeletal proteins, as well as a host of other molecules, allow them to function as signaling platforms for many critical cellular processes. Alterations in septin experssion patterns have been linked to cancer and mutations in septins have been associated with human diseases such as male infertility and hereditary neuralgic amyotrophy. Ongoing projects in the laboratory are aimed at understanding the mechanisms controlling septin filament assembly, their contributions to signal transduction, and their specific roles in cytokinesis and cell migration.
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