Our Research Themes

Genomics and precision medicine are being increasingly integrated into clinical practice. These technologies may lead to better diagnostic accuracy, earlier referral to appropriate treatment interventions and a better treatment response based on targeted use of drugs and other interventions. However, new generations of sequencing technologies are costly and can produce additional findings that result in further downstream healthcare costs. It is not yet clear whether such technologies are cost-effective or where they should be positioned in a diagnostic pathway to maximize value for money. TASK force members are working to generate evidence regarding economic value, including social and ethical considerations to inform implementation.

Table of contents

  1. Cost and cost-effectiveness of whole genome sequencing in paediatric cardiac conditions
  2. Cost and cost-effectiveness of alternative genome-based diagnostic strategies
  3. The clinical and personal utility of genomic testing
  4. Cascade genetic testing
  5. Genome sequencing policy research
  6. A cost-effectiveness analysis of maternal genotyping to guide treatment for postpartum pain and avert infant adverse events
  7. Cost-effectiveness analysis of thiopurine methyltransferase genotype testing
  8. Genetic counselling
  9. Other

Cost and cost-effectiveness of whole genome sequencing in paediatric cardiac conditions

Prospective study led by Drs. Wendy Ungar and Robin Hayeems on clinical utility and cost-effectiveness of whole genome sequencing for children with cardiomyopathy. In progress.

Cost and cost-effectiveness of alternative genome-based diagnostic strategies in pediatric neurodevelopment disorders and rare diseases

The clinical and personal utility of genomic testing

Prospective study led by Drs. Robin Hayeems and Wendy Ungar to develop and validate psychometric tools to quantify the clinical and personal utility of genetic tests. In Progress.

Cascade genetic testing

Genome sequencing policy research

A cost-effectiveness analysis of maternal genotyping to guide treatment for postpartum pain and avert infant adverse events

Cost-effectiveness analysis of thiopurine methyltransferase genotype testing

Genetic counselling

Other

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Children with neurodevelopment disorders (NDDs) and their families face life-long challenges and require extensive ongoing educational, health and social service support. The severity and high prevalence of NDDs place a high economic burden on parents and public service systems. It is crucial to understand which programs, treatments and services provide the best value for money. The TASK team is involved in a number of projects in the area of paediatric NDDs, collecting cost data and evaluating cost-effectiveness of existing and novel interventions.

Table of contents

  1. Health economics evaluation platform within CHILD BRIGHT
  2. PACE (Parent And Child Early)coaching project
  3. Cost-effectiveness and value of alternative clinical screening and assessment approaches in autism spectrum disorder
  4. The pathways in autism spectrum disorder (ASD) cohort study
  5. The pre-school autism treatment impact (PATI) study: A population-based comparative effectiveness, cost and policy study of intervention models for preschoolers with autism spectrum disorders
  6. Other projects

Health economics evaluation platform within CHILD BRIGHT

Dr. Ungar is leading economic evaluations of interventions being studied by researchers within the CHILD-BRIGHT Network, a pan-Canadian research network examining interventions to optimize the health of Canadian children born with brain-based disorders. In progress.

PACE (Parent And Child Early) coaching project

As part of a collaborative multi-disciplinary PACE Coaching Project, TASK leads a cost-effectiveness analysis comparing parent coaching to services ordinarily available to toddlers at risk for autism spectrum disorder in British Columbia.

Cost-effectiveness and value of alternative clinical screening and assessment approaches in autism spectrum disorder

The pathways in autism spectrum disorder (ASD) cohort study

Using data collected by the Pathways in ASD cohort study, TASK is examining how child and youth health, education and community services are integrated to support optimal trajectories of developmental health.

 

The pre-school autism treatment impact (PATI) study: A population-based comparative effectiveness, cost and policy study of intervention models for preschoolers with autism spectrum disorders

A multi-disciplinary and multi-site prospective study, where TASK is leading a cost analysis of the New Brunswick and Nova Scotia early intensive behavioural programs for preschoolers with autism spectrum disorder.

Other projects

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Health technology assessment (HTA) provides evidence for informed decision making in health policy. As part of its HTA activities, TASK informs policies in child health. TASK also conducts research specifically in the area of public health and pharmaceutical policy. For example, the TASK team has examined gaps in prescription drug coverage for paediatric drugs and is examining the value of pharmacogenomics testing.

Table of contents

  1. Public health and policy decision-making
  2. Prescription medicines

Public health and policy decision-making

Prescription medicines

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TASK’s projects in health economic methods include patient preferences research; development and assessment of instruments to measure resource use, costs or quality of life; reviews of economic evaluation methods; and the use and applicability of the PEDE database and other economic evaluation databases for decision-making.

Table of contents

  1. Caregiver and spillover effects
  2. Health economic methods
  3. Instrument and tool development
  4. Quality of life and utility research
  5. Preferences and preference elicitation techniques
  6. Systematic reviews
  7. Trends in evidence

Caregiver and spillover effects

Health economic methods

Instrument and tool development

Quality of life and utility research

Preferences and preference elicitation techniques

Systematic reviews

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TASK performs systematic reviews, cost-effectiveness analyses and methods research in the area of respiratory conditions, including asthma and bronchiolitis.

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Juvenile idiopathic arthritis research conducted at TASK includes assessing patient preferences for drug treatment and cost effectiveness of biologic response modifiers.

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TASK conducts cost-effectiveness analysis of paediatric health interventions and devices in the fields of infectious disease, appendicitis, fetal alcohol spectrum disorder, oncology and surgical interventions.

Table of contents

  1. Infectious diseases
  2. Appendicitis
  3. Fetal disorders
  4. Oncology
  5. Gastrointestinal disease
  6. Surgical interventions
  7. Haemophilia
  8. Ophthalmology

Infectious diseases

Appendicitis

Fetal disorders

Oncology

Gastrointestinal disease

TASK conducts research on cost-effectiveness and quality of life in pediatric inflammatory bowel disease including Crohn’s disease, and gastroenterology.

Surgical interventions

Haemophilia

Ophthalmology

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