Recent Publications

Burton, CL., Lemire, M., Xiao, B., Corfield, E., …. Schachar, RJ., Crosbie, J., Arnold, PD. (2021). Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorders. Translational Psychiatry, 11(1): 91. View article

Bralten J, Widomska J, Witte W, … Arnold P, Lemire M, Burton CL, Franke B, Poelmans G. (2020). Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling. Translational Psychiatry. 10(1):121. View article.

Elgie, M., Cameron, DH., Rowa, K., Hall, GB., McCabe, R.E., MacKillop, J., Crosbie, J., Burton, CL., & Soreni, N. (2021). Investigating Executive Functions in Youth with OCD and Hoarding Symptoms. Bulletin of the Menninger Clinic (In Press)

Sinopoli VM, Erdman L, Burton CL, Park LS, Dupuis A, Shan J, Goodale T, Shaheen SM, Crosbie J, Schachar RJ, Arnold PD. (2020). Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study. Depression and Anxiety, 37(8): 760-770. View abstract

Sinopoli VM, Erdman L, Burton CL, Park LS, Dupuis A, Shan J, Goodale T, Shaheen SM, Crosbie J, Schachar RJ, Arnold PD. (2019). Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study. Journal of Child Psychology and Psychiatry, 60(12): 1289-1299. View abstract

Burton CL, Park LS, …Crosbie J, Schachar RJ, Arnold PD. (2018). Heritability of obsessive-compulsive trait dimensions in youth from the general population. Translational Psychiatry, 8(1): 191. View article

Park LS, Burton CL, Dupuis A, Shan J, Storch EA, Crosbie J, Schachar RJ, Arnold PD. (2016). The Toronto Obsessive-Compulsive Scale: psychometrics of a dimensional measure of obsessive-compulsive traits. Journal of the American Academy of Child and Adolescent Psychiatry, 55(4): 310-318. View abstract

Burton CL, Crosbie J, Dupuis A, Mathews CA, Soreni N, Schachar R, Arnold PD. (2016). Clinical correlate of hoarding with and without comorbid obsessive-compulsive symptoms in a community pediatric sample. Journal of the American Academy of Child and Adolescent Psychiatry, 55(2): 114-21. View abstract

Cost, K., Crosbie J., … Burton, CL, Schachar, RJ, Arnold PD, Korczak, D. (2021). Mostly worse, occasionally better: Impact of COVID-19 pandemic on the mental health of Canadian children and adolescents. European Journal of Child and Adolescent Psychiatry, Feb 26: 1-14. View article

Jacobs GR, Voineskos AN, Hawco C, … Schachar R, Crosbie J, Arnold PD, Goldenberg A, Erdman L, Ameis SH. (2021). Integration of brain and behavior measures for identification of data-driven groups cutting across children with ASD, ADHD, or OCD. Neuropsychopharmacology. 46(3):643-653. View abstract

Sanjeevan, T., Hammill, CF., Brian, J., Crosbie, J., Schachar, R., … Anagnostou, E. (2020). Exploring the Neural Structures Underlying the Procedural Memory Network as Predictors of Language Ability in Children and Adolescents with Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.  Frontiers of Human Neuroscience. Dec 10;14:587019. View article

Pearson DA, Santos CW, Aman MG, … Schachar RJ., Bukstein OG, & Cleveland LA. (2020).  Effects of extended release methylphenidate treatment on cognitive task performance in children with Autism Spectrum Disorder and ADHD.  Journal of Child and Adolescent Psychopharmacology, 30(7): 414-426. View abstract

Brierley, NJ., McDonnell, CG., Parks, KMA., …Crosbie, J, Schachar, R., Liu, X, Stevenson, RA. (2020). Factor Structure of Repetitive Behaviors Across Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. Journal of Autism and Developmental Disorders, Nov 24. View abstract

Choi EJ, Vandewouw MM, Taylor MJ, … Schachar RJ, Lerch JP, Anagnostou E. (2020). Beyond diagnosis: Cross-diagnostic features in canonical resting-state networks in children with neurodevelopmental disorders. Neuroimage. Clinical, 28:1022476. View article

Vandewouw MM, Choi E, Hammill C, Arnold P, Schachar R, Lerch JP, Anagnostou E, Taylor MJ. (2020). Emotional face processing across neurodevelopmental disorders: a dynamic faces study in children with autism spectrum disorder, attention deficit hyperactivity disorder and obsessive-compulsive disorder. Translational Psychiatry. 10(1):375. View article

Goodman SJ, Burton CL, … Arnold PD, Crosbie J, Schachar R, Weksberg R. (2020). Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation. Journal of Neurodevelopmental Disorders, 12(1):23. View article

Krakowski AD, Cost KT, Anagnostou E, Lai MC, Crosbie J, Schachar R, Georgiades S, Duku E, Szatmari P. (2020). Inattention and hyperactive/impulsive component scores do not differentiate between autism spectrum disorder and attention-deficit/hyperactivity disorder in a clinical sample. Molecular Autism, 11(1):28. View article

Zarrei M, Burton CL, Engchuan W, Young EJ,…Crosbie J, Schachar R, Stavropoulos DJ, Anagnostou E, Scherer SW. (2019). A large data resource of genomic copy number variation across neurodevelopmental disorders. NPJ Genomic Medicine, 4: 26. View Article

Cross-Disorder Group of the Psychiatric Genomics Consortium. (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7): 1469-1482. View abstract

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK,…. Murray, R. (2018). Analysis of shared heritability in common disorders of the brain. Science, 360(6395), pii: eaap8757. View article

Mogadam A, Keller AE, Arnold PD, Schachar R, Lerch JP, Anagnostou E, Pang EW. (2019). Magnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders. Journal of Neurodevelopmental Disorders,11(1): 19. View article

Baribeau DA, Dupuis A, Paton TA, Hammill C, Scherer SW, Schachar RJ,… Anagnostou E. (2019). Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network. Translational Psychiatry, 9(1): 72. View article

Kushki A, Anagnostou E, Hammill C, Duez P, Brian J, Iaboni A, Schachar R, Crosbie J, Arnold P, Lerch JP. (2019). Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach. Translational Psychiatry, 9(1): 318. View article

Mahendiran T, Dupuis A, Crosbie J, Georgiades S, Kelley E, Liu X, Nicolson R, Schachar R, Anagnostou E, Brian J. (2019). Sex Differences in Social Adaptive Function in Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder. Frontiers of Psychiatry [epub ahead of print]. View article

Baribeau DA, Dupuis A, Paton TA, Scherer SW, Schachar RJ,…Anagnostou E. (2017). Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders. Scientific Reports, 7(1): 11618. View article

van der Plas E, Dupuis A, Arnold P, Crosbie J, Schachar RJ. (2016). Association of Autism Spectrum Disorder with Obsessive-Compulsive and Attention-Deficit/Hyperactivity Traits and response inhibition in a community sample. Journal of Autism and Developmental Disorders, 46(9): 3115-25. View abstract

Ameis SH, Lerch JP, …Crosbie J, Brian J, Soreni N, Schachar R, Szatmari P, Arnold PD, Anagnostou E. (2016). A Diffusion Tensor Imaging Study in Children With ADHD, Autism Spectrum Disorder, OCD, and Matched Controls: Distinct and Non-Distinct White Matter Disruption and Dimensional Brain-Behavior Relationships. American Journal of Psychiatry, 173(12): 1213-1222. View abstract

Baribeau DA, Doyle-Thomas KA, … Schachar RJ, Soreni N, Szatmari P, Anagnostou E. (2015). Examining and comparing social perception abilities across childhood-onset neurodevelopmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 54(6): 479-486. View abstract

Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium. (2015). Psychiatric genome-wide association study analyses implicated neuronal, immune and histone pathways. Nature Neuroscience, 18(2): 199-209. View article

Lionel AC, Tammimies K, … Scherer SW.  (2014). Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes. Human Molecular Genetics, 23(10): 2752-2768. View article

Cross-Disorder Group of the Psychiatric Genomics Consortium, et al. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45(9): 984-94. View article

Lionel AC, Crosbie J, …Schachar R, Scherer SW.(2011). Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Science Translational Medicine, 3(95): 95ra75. View article

van der Plas E, Spencer Noakes TL, … Schachar RJ, Ito S, Nieman BJ. (2020). Quantitative MRI outcomes in child and adolescent leukemia survivors: Evidence for global alterations in gray and white matter. Neuroimage. Clinical, 28:102428. View article

van der Plas, E., Spencer-Oakes, L., … Schachar, R., Ito, S., Te, P., Galin-Corini, L., Wanstall, EA., Nieman, B. (2020). Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatric Research, Nov 17. View abstract

Roberts SD, McDonald KP, Danguecan A, Crosbie J, Westmacott R, Andrade B, Dlamini N, Williams TS. (2019). Longitudinal Academic Outcomes of Children with Secondary Attention Deficit/Hyperactivity Disorder following Pediatric Stroke. Developmental Neuropsychology, 44(4): 368-384. View abstract.

Spencer Noakes TL,…Schachar RJ, Hitzler J, Ito S, van der Plas E, Nieman BJ. (2018). Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment. Clinical Cancer Research, 24(23): 6040-6052. View article

Williams TS, Roberts SD, Coppens AM, Crosbie J, Dlamini N, Westmacott R.(2018). Secondary attention-deficit/hyperactivity disorder following perinatal and childhood stroke: impact on cognitive and academic outcomes. Child Neuropsychology, 24(6): 763-783. View abstract

Van Der Plas E, … Schachar RJ, Ito S, Spiegler BJ. (2018). Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. Child Neuropsychology, 24(8): 999-1014. View article

Wilkinson AA, Dennis M, …Schachar R; Canadian Critical Care Trials Group (CCCTG). (2017). Performance Monitoring in Children Following Traumatic Brain Injury Compared to Typically Developing Children. Child Neurology Open, 4: 2329048X17732713. View article

van der Plas E, Schachar RJ, Hitzler J, Crosbie J, Guger SL, Spiegler BJ., Ito, S., Nieman, BJ. (2016). Brain structure, working memory and response inhibition in childhood leukemia survivors. Brain and Behavior, 7(2): e00621. View article

Schachar R, Park LS, Dennis M. (2015). Mental health implications of traumatic brain injury in children and youth. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 24(2): 100-108. View abstract

van der Plas E, Nieman BJ, Butcher DT, Hitzler JK, Weksberg R, Ito S, Schachar R. (2015). Neurocognitive Late Effects of Chemotherapy in Survivors of Acute Lymphoblastic Leukemia: Focus on Methotrexate. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 24(1): 25-32. View article

Soltanifar, M., Knight, K., Dupuis, A., Schachar, RJ., Escobarand, M., Escobar, M. (2020). Time Series-Based Point Estimation of Stop Signal Reaction Times: More Evidence on the Role of Reactive Inhibition-Proactive Inhibition Interplay on the SSRT Estimations. Brain Sciences, 10(9): 598. View article

Blanchette CA, Kurdi V, Fouquet C, Schachar R, Boivin M, Hastings P, Robaey P, West GL, Bohbot VD. (2020). Opposing effects of cortisol on learning and memory in children using spatial versus response-dependent navigation strategies. Neurobiology Learning & Memory. Mar;169:107172. View abstract

Verbruggen F, Aron AR, Band GP,….Schachar RJ, Schall JD, Stock AK, Swann NC, Thakkar KN, van der Molen MW, Vermeylen L, Vink M, Wessel JR, Whelan R, Zandbelt BB, Boehler CN. (2019). A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task. Elife, 8. View article

Soltanifar, M., K. Knight, A. Dupuis, R. Schachar, and M. Escobar. (2019). A Time Series-based Point Estimation of Stop Signal Reaction Times. In JSM Proceedings, SSC Section. Alexandria, VA: American Statistical Association. 1515 – 1528. View abstract

Dupuis A, Indralingam M, Chevrier A, Crosbie J, Arnold P, Burton CL, Schachar R. (2019). Response Time Adjustment in the Stop Signal Task: Development in Children and Adolescents. Child Development, 90(2): e263-e272. View abstract

Chevrier A, Cheyne D, Graham S, Schachar R. (2015). Dissociating two stages of preparation in the stop signal task Using fMRI. PLoS One, 10(6): e0130992. View abstract

Wright L, Lipszyc J, Dupuis A, Thayapararajah SW, Schachar R. (2014). Response inhibition and psychopathology: a meta-analysis of go/no-go task performance. Journal of Abnormal Psychology, 123(2): 429-439. View abstract

Russell Schachar

Jennifer Crosbie