Recent publications
Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells.
Zhang W, Ross PJ, Ellis J, Salter MW. Transl Psychiatry. 2022 Jun 9;12(1):243. doi: 10.1038/s41398-022-02010-z.
Glial-modulating agents for the treatment of pain: protocol for a systematic review.
Gilron I, Xiao MZX, Balanaser M, Carley M, Ghasemlou N, Salter MW, Hutchinson MR, Moulin DE, Moore RA, Ross-White A. BMJ Open. 2022 Apr 6;12(4):e055713. doi: 10.1136/bmjopen-2021-055713.
Microglia-independent peripheral neuropathic pain in male and female mice.
Tu Y, Muley MM, Beggs S, Salter MW. Pain. 2022 Apr 4. doi: 10.1097/j.pain.0000000000002643.
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain.
Halievski K, Sengar AS, Hicks J, Haight J, Salter MW, Steinberg BE. Mol Pain.. 2022 Jan-Dec;18:17448069221076634. doi: 10.1177/17448069221076634.
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Nat Commun.. 2022 Feb 11;13(1):843. doi: 10.1038/s41467-022-28473-8.
Past publications
Li H, Rajani V, Han L, Chung D, Cooke JE, Sengar AS, Salter MW. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2026411118. doi: 10.1073/pnas.2026411118.
Src and Fyn regulation of NMDA receptors in health and disease.
Rajani V, Sengar AS, Salter MW. Neuropharmacology. 2021 May 26;193:108615. doi: 10.1016/j.neuropharm.2021.108615.
The T-type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity.
Harding EK, Dedek A, Bonin RP, Salter MW, Snutch TP, Hildebrand ME. Br J Pharmacol. 2021 Apr 19. doi: 10.1111/bph.15498.
Purinergic signalling in spinal pain processing.
Tam TH, Salter MW. Purinergic Signal. 2021 Mar;17(1):49-54. doi: 10.1007/s11302-020-09748-5. Epub 2020 Nov 10.
Intracellular calcium responses encode action potential firing in spinal cord lamina I neurons.
Harding EK, Boivin B, Salter MW. J Neurosci. 2020 Apr 27. pii: JN-RM-0206-20. doi: 10.1523/JNEUROSCI.0206-20.2020
Sex-dependent mechanisms of chronic pain: A focus on microglia and P2X4R.
Halievski K, Ghazisaeidi S, Salter MW. J Pharmacol Exp Ther. 2020 Feb 29. pii: jpet.120.265017. doi: 10.1124/jpet.120.265017
Tripartite signalling by NMDA receptors.
Rajani V, Sengar AS, Salter MW. Mol Brain. 2020 Feb 18;13:23. doi: 10.1186/s13041-020-0563-z
Strangers in strange lands: mitochondrial proteins found at extra-mitochondrial locations.
Scanlon DP, Salter MW. Biochem J. 2019 Jan 7;476(1):25-37. doi: 10.1042/BCJ20180473.
Priming of adult incision response by early life injury: neonatal microglial inhibition has persistent but sexually dimorphic effects in adult rats.
Moriarty O, Tu Y, Sengar AS, Salter MW, Beggs S, Walker SM. J Neurosci. 2019 Feb 22. pii: 1786-18. doi: 10.1523/JNEUROSCI.1786-18.2019.
Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease.
Ward KR, Featherstone RE, Naschek MJ, Melnychenko O, Banerjee A, Yi J, Gifford RL, Borgmann-Winter KE, Salter MW, Hahn CG, Siegel SJ. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Feb 28. pii: S0278-5846(18)30865-0. doi: 10.1016/j.pnpbp.2019.02.017.
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons.
Zaslavsky K, Zhang WB, McCready FP, Rodrigues DC, Deneault E, Loo C, Zhao M, Ross PJ, El Hajjar J, Romm A, Thompson T, Piekna A, Wei W, Wang Z, Khattak S, Mufteev M, Pasceri P, Scherer SW, Salter MW, Ellis J. Nat Neurosci. 2019 Apr;22(4):556-564. doi: 10.1038/s41593-019-0365-8.
The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.
Tse K, Hammond D, Simpson D, Beynon RJ, Beamer E, Tymianski M, Salter MW, Sills GJ, Thippeswamy T. J Neurosci Res. 2019 May 15. doi: 10.1002/jnr.24441.
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Mapplebeck J.C.S., Lorenzo L.E., Lee K.Y., Gauthier C., Muley M.M., De Koninck Y., Prescott S.A., Salter M.W. Cell Rep. 2019 Jul 16. 28:590-596 e594. doi: 10.1016/j.celrep.2019.06.059.
Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS.
Ross P.J., Zhang W.B., Mok R.S.F., Zaslavsky K., Deneault E., D’Abate L., Rodrigues D.C., Yuen R.K.C., Faheem M., Mufteev M., Piekna A., Wei W., Pasceri P., Landa R.J., Nagy A., Varga B., Salter M.W., Scherer S.W., Ellis J. Biological psychiatry. 2019 Jul 29. doi: 10.1016/j.biopsych.2019.07.014.
Control of Long-Term Synaptic Potentiation and Learning by Alternative Splicing of the NMDA Receptor Subunit GluN1.
Sengar A.S., Li H., Zhang W., Leung C., Ramani A.K., Saw N.M., Wang Y., Tu Y., Ross P.J., Scherer S.W., Ellis J., Brudno M., Jia Z., Salter M.W. Cell Rep. 2019 Dec 24;29(13):4285-4294.e5. doi: 10.1016/j.celrep.2019.11.087.
Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats.
Mapplebeck JCS, Dalgarno R, Tu Y, Moriarty O, Beggs S, Kwok CHT, Halievski K, Assi S, Mogil JS, Trang T, Salter MW.
Pain. 2018 Apr 30. doi: 10.1097/j.pain.0000000000001265.
Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats.
Wang W, Duclot F, Groveman BR, Carrier N, Qiao H, Fang XQ, Wang H, Xin W, Jiang XH, Salter MW, Ding XS, Kabbaj M, Yu XM.
PLoS One. 2018 Apr 3. doi: 10.1371/journal.pone.0195095.
The role of the immune system in Alzheimer disease: Etiology and treatmentMicroglia emerge as central players in brain disease.
Jevtic S, Sengar AS, Salter MW, McLaurin J.
Ageing Res Rev. 2017 Sep 21. doi: 10.1016/j.arr.2017.08.005
Microglia emerge as central players in brain disease.
Salter MW, Stevens B.
Nat Med. 2017 Sep 8. doi: 10.1038/nm.4397.
Spatial gene expression analysis of neuroanatomical differences in mouse models.
Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Lerch JP.
Neuroimage. 2017 Sep 4. 10.1016/j.neuroimage.2017.08.065.
VIP cortical conductors set the tone for chronic pain.
Harding EK, Salter MW.
Nat Neurosci. 2017 July 26. doi: 10.1038/nn.4609.
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors.
Scanlon DP, Bah A, Krzeminski M, Zhang W, Leduc-Pessah HL, Dong YN, Forman-Kay JD, Salter MW.
Nat Commun. 2017 May 16. doi: 10.1038/ncomms15220.
Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance.
Chan KL, Tam TH, Boroumand P, Prescott D, Costford SR, Escalante NK, Fine N, Tu Y, Robertson SJ, Prabaharan D, Liu Z, Bilan PJ, Salter MW, Glogauer M, Girardin SE, Philpott DJ, Klip A.
Cell Rep. 2017 Mar 7;18(10):2415-2426. doi: 10.1016/j.celrep.2017.02.027.
Molecules in pain and sex: a developing story.
Mapplebeck JC, Beggs S, Salter MW.
Mol Brain. 2017 Mar 7;10(1):9. doi: 10.1186/s13041-017-0289-8.
Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.
Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW.
Cell Rep. 2016 Dec 6;17(10):2753. doi: 10.1016/j.celrep.2016.11.024.
Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.
Masuda T, Ozono Y, Mikuriya S, Kohro Y, Tozaki-Saitoh H, Iwatsuki K, Uneyama H, Ichikawa R, Salter MW, Tsuda M, Inoue K.
Nat Commun. 2016 Aug 12;7:12529. doi: 10.1038/ncomms12529.
Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel.
Joshi K, Shen L, Michaeli A, Salter M, Thibault-Messier G, Hashmi S, Eubanks JH, Cortez MA, Snead OC.
Ann Neurol. 2016 Jul 27. doi: 10.1002/ana.24749.
SnapShot: Microglia in Disease.
Beggs S, Salter MW.
Cell. 2016 May 19;165(5):1294-1294.e1. doi: 10.1016/j.cell.2016.05.036.
Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons.
Zhang WB, Ross PJ, Tu Y, Wang Y, Beggs S, Sengar AS, Ellis J, Salter MW.
Sci Rep. 2016 Apr; 6:23837.
Sex differences in pain: a tale of two immune cells.
Mapplebeck JC, Beggs S, Salter MW.
Pain. 2016 Feb;157 Suppl 1:S2-6.
Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome.
Khattak S, Brimble E, Zhang W, Zaslavsky K, Strong E, Ross PJ, Hendry J, Mital S, Salter MW, Osborne LR, Ellis J.
Mol Brain. 2015 Nov 24;8(1):77.
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
Fang XQ, Qiao H, Groveman BR, Feng S, Pflueger M, Xin WK, Ali MK, Lin SX, Xu J, Duclot F, Kabbaj M, Wang W, Ding XS, Santiago-Sim T, Jiang XH, Salter MW, Yu XM.
Mol Brain. 2015 Nov 19;8(1):75.
Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics.
Trang T, Al-Hasani R, Salvemini D, Salter MW, Gutstein H, Cahill CM.
J Neurosci. 2015 Oct 14;35(41):13879-88.
Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS.
Nat Neurosci. 2015 Aug;18(8):1081-3.
MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells.
Djuric U, Cheung AY, Zhang W, Mok RS, Lai W, Piekna A, Hendry JA, Ross PJ, Pasceri P, Kim DS, Salter MW, Ellis J.
Neurobiol Dis. 2015 Apr;76:37-45.
Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.
Kemp SW, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH.
Neuroscience. 2015 Jan 22;284:202-16.
Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse.
Cahill LS, Laliberté CL, Liu XJ, Bishop J, Nieman BJ, Mogil JS, Sorge RE, Jones CD, Salter MW, Henkelman RM.
Mol Pain. 2014 Sep 13;10:60.
Sublime microglia: expanding roles for the guardians of the CNS.
Salter MW, Beggs S.
Cell. 2014 Jul 3;158(1):15-24.
Deepening understanding of the neural substrates of chronic pain.
Salter MW.
Brain. 2014 Mar;137(Pt 3):651-3.
GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.
Hildebrand ME, Pitcher GM, Harding EK, Li H, Beggs S, Salter MW.
Sci Rep. 2014 Feb 13;4:4094.
Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses.
Wyeth MS, Pelkey KA, Petralia RS, Salter MW, McInnes RR, McBain CJ.
J Neurosci. 2014 Jan 8;34(2):622-8.
Calcium-permeable ion channels in pain signaling.
Bourinet E, Altier C, Hildebrand ME, Trang T, Salter MW, Zamponi GW.
Physiol Rev. 2014 Jan;94(1):81-140.
The known knowns of microglia-neuronal signalling in neuropathic pain.
Beggs S, Salter MW.
Neurosci Lett. 2013 Dec 17;557 Pt A:37-42.
Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors.
Han L, Campanucci VA, Cooke J, Salter MW.
Mol Brain. 2013 Aug 13;6:36.
TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.
Paltser G, Liu XJ, Yantha J, Winer S, Tsui H, Wu P, Maezawa Y, Cahill LS, Laliberté CL, Ramagopalan SV, DeLuca GC, Sadovnick AD, Astsaturov I, Ebers GC, Henkelman RM, Salter MW, Dosch HM.
Mol Med. 2013 Jul 24;19:149-59.
Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.
Sengar AS, Ellegood J, Yiu AP, Wang H, Wang W, Juneja SC, Lerch JP, Josselyn SA, Henkelman RM, Salter MW, Egan SE.
J Neurosci. 2013 Feb 27;33(9):4055-65.
Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons.
Ivakine EA, Acton BA, Mahadevan V, Ormond J, Tang M, Pressey JC, Huang MY, Ng D, Delpire E, Salter MW, Woodin MA, McInnes RR.
Proc Natl Acad Sci USA. 2013 Feb 26;110(9):3561-6.
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, DeKoninck Y.
Nat Neurosci. 2013 Feb;16(2):183-92.
Microglia and intractable chronic pain.
Tsuda M, Beggs S, Salter MW, Inoue K.
Glia. 2013 Jan;61(1):55-61.
Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.
Tang M, Ivakine E, Mahadevan V, Salter MW, McInnes RR.
PLoS One. 2012;7(12):e51433.
Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations.
Farra N, Zhang WB, Pasceri P, Eubanks JH, Salter MW, Ellis J.
Mol Psychiatry. 2012 Dec;17(12):1261-71.
The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.
Olausson P, Venkitaramani DV, Moran TD, Salter MW, Taylor JR, Lombroso PJ.
Neuroscience. 2012 Dec 6;225:1-8.
A role for NT-3 in the hyperinnervation of neonatally wounded skin.
Beggs S, Alvares D, Moss A, Currie G, Middleton J, Salter MW, Fitzgerald M.
Pain. 2012 Oct;153(10):2133-9.
A brief educational intervention about pain and aging for older members of the community and health care workers.
Gagliese L, Katz L, Gibson M, Clark AJ, Lussier D, Gordon A, Salter MW.
J Pain. 2012 Sep;13(9):849-56.
P2X4 purinoceptor signaling in chronic pain.
Trang T, Salter MW.
Purinergic Signal. 2012 Sep;8(3):621-8.
P2X4R+ microglia drive neuropathic pain.
Beggs S, Trang T, Salter MW.
Nat Neurosci. 2012 Jul 26;15(8):1068-73.
ATP receptors gate microglia signaling in neuropathic pain.
Trang T, Beggs S, Salter MW.
Exp Neurol. 2012 Apr;234(2):354-61.
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.
Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS.
Nat Med. 2012 Mar 25;18(4):595-9.
Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.
Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF.
EMBO J. 2012 Feb 15;31(4):805-16.
Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity.
Beggs S, Currie G, Salter MW, Fitzgerald M, Walker SM.
Brain. 2012 Feb;135(Pt 2):404-17.
Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia.
Salter MW, Pitcher GM.
FEBS J. 2012 Jan;279(1):2-11.
Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice.
Sorge RE, LaCroix-Fralish ML, Tuttle AH, Sotocinal SG, Austin JS, Ritchie J, Chanda ML, Graham AC, Topham L, Beggs S, Salter MW, Mogil JS.
J Neurosci. 2011 Oct 26;31(43):15450-4.
Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses.
Li HB, Jackson MF, Yang K, Trepanier C, Salter MW, Orser BA, Macdonald JF.
Hippocampus. 2011 Oct;21(10):1053-61.
DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.
Asrar S, Kaneko K, Takao K, Negandhi J, Matsui M, Shibasaki K, Miyakawa T, Harrison RV, Jia Z, Salter MW, Tominaga M, Fukumi-Tominaga T.
Mol Brain. 2011 Oct 21;4:39.
Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.
Hildebrand ME, Mezeyova J, Smith PL, Salter MW, Tringham E, Snutch TP.
Mol Pain. 2011 Sep 12;7:67.
Neto1 is an auxiliary subunit of native synaptic kainate receptors.
Tang M, Pelkey KA, Ng D, Ivakine E, McBain CJ, Salter MW, McInnes RR.
J Neurosci. 2011 Jul 6;31(27):10009-18.
Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.
Pitcher GM, Kalia LV, Ng D, Goodfellow NM, Yee KT, Lambe EK, Salter MW.
Nat Med. 2011 Apr;17(4):470-8.
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K.
Brain. 2011 Apr;134(Pt 4):1127-39.
Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain.
Trang T, Beggs S, Salter MW.
Neuron Glia Biol. 2011 Feb;7(1):99-108.
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Kimura T, Kawabe H, Jiang C, Zhang W, Xiang YY, Lu C, Salter MW, Brose N, Lu WY, Rotin D.
Proc Natl Acad Sci USA. 2011 Feb 22;108(8):3216-21.
A straightjacket for pain?
Beggs S, Salter MW. Cell. 2010 Nov 12;143(4):505-7.
Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier.
Beggs S, Liu XJ, Kwan C, Salter MW. Mol Pain. 2010 Nov 2;6:74.
Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0.
Beggs S, Salter MW. Curr Opin Neurobiol. 2010 Aug;20(4):474-80.
Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn.
Liu XJ, Salter MW. Eur J Neurosci. 2010 Jul;32(2):278-89.
alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.
Vargas-Caballero M, Martin LJ, Salter MW, Orser BA, Paulsen O. Neuropharmacology. 2010 Mar;58(3):668-75.
Regulation of NMDA Receptors by Kinases and Phosphatases.
Salter MW, Dong Y, Kalia LV, Liu XJ, Pitcher G. In: Van Dongen AM, editor. Biology of the NMDA Receptor. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 7.
Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms.
Okada-Ogawa A, Suzuki I, Sessle BJ, Chiang CY, Salter MW, Dostrovsky JO, Tsuboi Y, Kondo M, Kitagawa J, Kobayashi A, Noma N, Imamura Y, Iwata K. J Neurosci. 2009 Sep 9;29(36):11161-71.
P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation.
Trang T, Beggs S, Wan X, Salter MW. J Neurosci. 2009 Mar 18;29(11):3518-28.
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR. PLoS Biol. 2009 Feb 24;7(2):e41.
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.
Liu XJ, Gingrich JR, Vargas-Caballero M, Dong YN, Sengar A, Beggs S, Wang SH, Ding HK, Frankland PW, Salter MW. Nat Med. 2008 Dec;14(12):1325-32.
NMDA receptors in clinical neurology: excitatory times ahead.
Kalia LV, Kalia SK, Salter MW. Lancet Neurol. 2008 Aug;7(8):742-55.
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, Ryan CL, Bernard PB, Lau A, Forder JP, Salter MW, Wang YT, Tasker RA, Tymianski M. Stroke. 2008 Sep;39(9):2544-53.
Taking two cuts at pain.
Beggs S, Salter MW. Nat Med. 2008 Mar;14(3):243-4.
ErbB4 is a suppressor of long-term potentiation in the adult hippocampus.
Pitcher GM, Beggs S, Woo RS, Mei L, Salter MW. Neuroreport. 2008 Jan 22;19(2):139-43.
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain.
Keller AF, Beggs S, Salter MW, DeKoninck Y. Mol Pain. 2007 Sep 27;3:27.
PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors.
Cui H, Hayashi A, Sun HS, Belmares MP, Cobey C, Phan T, Schweizer J, Salter MW, Wang YT, Tasker RA, Garman D, Rabinowitz J, Lu PS, Tymianski M. J Neurosci. 2007 Sep 12;27(37):9901-15.
Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury.
Beggs S, Salter MW. Brain Behav Immun. 2007 Jul;21(5):624-33.
The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala.
Paul S, Olausson P, Venkitaramani DV, Ruchkina I, Moran TD, Tronson N, Mills E, Hakim S, Salter MW, Taylor JR, Lombroso PJ. Biol Psychiatry. 2007 May 1;61(9):1049-61.
Spinal microglia and neuropathic pain in young rats.
Moss A, Beggs S, Vega-Avelaira D, Costigan M, Hathway GJ, Salter MW, Fitzgerald M.
Pain. 2007 Apr;128(3):215-24.
Recent advances in basic neurosciences and brain disease: from synapses to behavior.
Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, Jia Z, Kaang BK, Kawamata M, Kida S, Klann E, Kohno T, Li M, Li XJ, MacDonald JF, Nader K, Nguyen PV, Oh U, Ren K, Roder JC, Salter MW, Song W, Sugita S, Tang SJ, Tao Y, Wang YT, Woo N, Woodin MA, Yan Z, Yoshimura M, Xu M, Xu ZC, Zhang X, Zhen M, Zhuo M.
Mol Pain. 2006 Dec 30;2:38.
Purinoceptors in microglia and neuropathic pain.
Trang T, Beggs S, Salter MW.
Pflugers Arch. 2006 Aug;452(5):645-52.
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM.
Cell. 2006 Dec 15;127(6):1123-35.
Neuroscience: controlled capillaries.
MacVicar BA, Salter MW.
Nature. 2006 Oct 12;443(7112):642-3.
PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex.
Kalia LV, Pitcher GM, Pelkey KA, Salter MW.
EMBO J. 2006 Oct 18;25(20):4971-82.
Purinoceptors in microglia and neuropathic pain.
Trang T, Beggs S, Salter MW.
Pflugers Arch. 2006 Aug;452(5):645-52.
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.
Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y.
Nature. 2005 Dec 15;438(7070):1017-21.
Regulation of NMDA receptor trafficking by amyloid-beta.
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P.
Nat Neurosci. 2005 Aug;8(8):1051-8.
Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development.
Salter MW.
Curr Top Med Chem. 2005;5(6):557-67.
Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn).
Chiang CY, Zhang S, Xie YF, Hu JW, Dostrovsky JO, Salter MW, Sessle BJ.
J Neurophysiol. 2005 Sep;94(3):1751-60.
Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation.
Taverna FA, Georgiou J, McDonald RJ, Hong NS, Kraev A, Salter MW, Takeshima H, Muller RU, Roder JC.
J Physiol. 2005 Jun 1;565(Pt 2):579-91.
Purines and pain mechanisms: recent developments.
Liu XJ, Salter MW.
Curr Opin Investig Drugs. 2005 Jan;6(1):65-75. Review
Neuropathic pain and spinal microglia: a big problem from molecules in “small” glia.
Tsuda M, Inoue K, Salter MW.
Trends Neurosci. 2005 Feb;28(2):101-7. Review
Cellular neuroplasticity mechanisms mediating pain persistence.
Salter MW.
J Orofac Pain. 2004 Fall;18(4):318-24.
Src in synaptic transmission and plasticity.
Kalia LV, Gingrich JR, Salter MW.
Oncogene. 2004 Oct 18;23(48):8007-16. Review
NMDA receptors are movin’ in.
Nong Y, Huang YQ, Salter MW.
Curr Opin Neurobiol. 2004 Jun;14(3):353-61. Review.
Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2.
Gingrich JR, Pelkey KA, Fam SR, Huang Y, Petralia RS, Wenthold RJ, Salter MW.
Proc Natl Acad Sci USA. 2004 Apr 20;101(16):6237-42.
Erratum in: Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9744.
Src kinases: a hub for NMDA receptor regulation.
Salter MW, Kalia LV.
Nat Rev Neurosci. 2004 Apr;5(4):317-28. Review.
Interactions between Src family protein tyrosine kinases and PSD-95.
Kalia LV, Salter MW.
Neuropharmacology. 2003 Nov;45(6):720-8.
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K.
Nature. 2003 Aug 14;424(6950):778-83.
Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors.
Gallagher CJ, Salter MW.
J Neurosci. 2003 Jul 30;23(17):6728-39.
Differential frequency dependence of P2Y1- and P2Y2- mediated Ca 2+ signaling in astrocytes.
Fam SR, Gallagher CJ, Kalia LV, Salter MW.
J Neurosci. 2003 Jun 1;23(11):4437-44.
D1 and NMDA receptors hook up: expanding on an emerging theme.
Salter MW.
Trends Neurosci. 2003 May;26(5):235-7. Review.
Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
Ma L, Huang YZ, Pitcher GM, Valtschanoff JG, Ma YH, Feng LY, Lu B, Xiong WC, Salter MW, Weinberg RJ, Mei L.
J Neurosci. 2003 Apr 15;23(8):3164-75.
Glycine binding primes NMDA receptor internalization.
Nong Y, Huang YQ, Ju W, Kalia LV, Ahmadian G, Wang YT, Salter MW.
Nature. 2003 Mar 20;422(6929):302-7.
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.
Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, Wang YT, Salter MW, Tymianski M.
Science. 2002 Oct 25;298(5594):846-50.
Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation.
Pelkey KA, Askalan R, Paul S, Kalia LV, Nguyen TH, Pitcher GM, Salter MW, Lombroso PJ.
Neuron. 2002 Mar 28;34(1):127-38.
DREAM is a critical transcriptional repressor for pain modulation.
Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, Salter MW, Penninger JM.
Cell. 2002 Jan 11;108(1):31-43.
LTP gets culture.
Salter MW.
Trends Neurosci. 2001 Oct;24(10):560-1. Review.
NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity.
Ali DW, Salter MW.
Curr Opin Neurobiol. 2001 Jun;11(3):336-42. Review.
CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus.
Huang Y, Lu W, Ali DW, Pelkey KA, Pitcher GM, Lu YM, Aoto H, Roder JC, Sasaki T, Salter MW, MacDonald JF.
Neuron. 2001 Feb;29(2):485-96.
Fam SR, Gallagher CJ, Salter MW.
J Neurosci. 2000 Apr 15;20(8):2800-8.
Neuronal plasticity: increasing the gain in pain.
Woolf CJ, Salter MW.
Science. 2000 Jun 9;288(5472):1765-9. Review.
Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.
Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L.
Neuron. 2000 May;26(2):443-55.
Sodium channels develop a tyrosine phosphatase complex.
Salter MW, Wang YT.
Nat Neurosci. 2000 May;3(5):417-9.
The Lurcher mutation of an alpha-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid receptor subunit enhances potency of glutamate and converts an antagonist to an agonist.
Taverna F, Xiong ZG, Brandes L, Roder JC, Salter MW, MacDonald JF.
J Biol Chem. 2000 Mar 24;275(12):8475-9.
Nucleotide receptor signalling in spinal cord astrocytes: findings and functional implications.
Gallagher CJ, Salter MW.
Prog Brain Res. 1999;120:311-22. Review.
Src potentiation of NMDA receptors in hippocampal and spinal neurons is not mediated by reducing zinc inhibition.
Xiong ZG, Pelkey KA, Lu WY, Lu YM, Roder JC, MacDonald JF, Salter MW.
J Neurosci. 1999 Nov 1;19(21):RC37.
A pinch of salt for NMDA receptors.
Salter MW.
Mol Psychiatry. 1999 May;4(3):209-11.
Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors.
Yu XM, Salter MW.
Proc Natl Acad Sci USA. 1999 Jul 6;96(14):7697-704. Review.
An ambiguous fast synapse: a new twist in the tale of two transmitters.
Salter MW, De Koninck Y.
Nat Neurosci. 1999 Mar;2(3):199-200.
Gain control of NMDA-receptor currents by intracellular sodium.
Yu XM, Salter MW.
Nature. 1998 Dec 3;396(6710):469-74.
Src, N-methyl-D-aspartate (NMDA) receptors, and synaptic plasticity.
Salter MW.
Biochem Pharmacol. 1998 Oct 1;56(7):789-98. Review.
P2Y and P2U receptors differentially release intracellular Ca2+ via the phospholipase c/inositol 1,4,5-triphosphate pathway in astrocytes from the dorsal spinal cord.
Idestrup CP, Salter MW.
Neuroscience. 1998 Oct;86(3):913-23.
Src activation in the induction of long-term potentiation in CA1 hippocampal neurons.
Lu YM, Roder JC, Davidow J, Salter MW.
Science. 1998 Feb 27;279(5355):1363-7.
Reduction of tyrosine kinase activity and protein tyrosine dephosphorylation by anoxic stimulation in vitro.
Braunton JL, Wong V, Wang W, Salter MW, Roder J, Liu M, Wang YT.
Neuroscience. 1998 Jan;82(1):161-70.
Modulation of GABAA receptor function by tyrosine phosphorylation of beta subunits.
Wan Q, Man HY, Braunton J, Wang W, Salter MW, Becker L, Wang YT.
J Neurosci. 1997 Jul 1;17(13):5062-9.
NMDA channel regulation by channel-associated protein tyrosine kinase Src.
Yu XM, Askalan R, Keil GJ 2nd, Salter MW.
Science. 1997 Jan 31;275(5300):674-8.
Extracellular chloride regulates mesangial cell calcium response to vasopressor peptides.
Stevanovic ZS, Salter MW, Whiteside CI.
Am J Physiol. 1996 Jul;271(1 Pt 2):F21-9.
Ca(2+)-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase.
Wang YT, Yu XM, Salter MW.
Proc Natl Acad Sci USA. 1996 Feb 20;93(4):1721-5.
Palmitoylation of the GluR6 kainate receptor.
Pickering DS, Taverna FA, Salter MW, Hampson DR.
Proc Natl Acad Sci USA. 1995 Dec 19;92(26):12090-4.
A novel P2-purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat.
Ho C, Hicks J, Salter MW.
Br J Pharmacol. 1995 Dec;116(7):2909-18.
ATP causes release of intracellular Ca2+ via the phospholipase C beta/IP3 pathway in astrocytes from the dorsal spinal cord.
Salter MW, Hicks JL.
J Neurosci. 1995 Apr;15(4):2961-71.
Regulation of intracellular calcium and preprotachykinin neurotransmitter precursor gene expression by patterned electrical stimulation in rat sympathetic neurons.
Hodaie M, Jeevaratnam P, Salter MW, Roach A.
Neurosci Lett. 1995 Feb 13;185(3):195-8.
Substance P released endogenously by high-intensity sensory stimulation potentiates purinergic inhibition of nociceptive dorsal horn neurons induced by peripheral vibration.
De Koninck Y, Salter MW, Henry JL.
Neurosci Lett. 1994 Jul 18;176(1):128-32.
Regulation of NMDA receptors by tyrosine kinases and phosphatases.
Wang YT, Salter MW.
Nature. 1994 May 19;369(6477):233-5.
ATP-evoked increases in intracellular calcium in neurons and glia from the dorsal spinal cord.
Salter MW, Hicks JL.
J Neurosci. 1994 Mar;14(3 Pt 2):1563-75.
Physiological roles for adenosine and ATP in synaptic transmission in the spinal dorsal horn.
Salter MW, De Koninck Y, Henry JL.
Prog Neurobiol. 1993 Aug;41(2):125-56. Review.
Rundown of NMDA-receptor mediated currents is resistant to lowering intracellular [Ca2+] and is prevented by ATP in rat spinal dorsal horn neurons.
Wang YT, Pak YS, Salter MW.
Neurosci Lett. 1993 Jul 23;157(2):183-6.
A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover.
Pickering DS, Thomsen C, Suzdak PD, Fletcher EJ, Robitaille R, Salter MW, MacDonald JF, Huang XP, Hampson DR.
J Neurochem. 1993 Jul;61(1):85-92.
ATP-sensitive K+ channels mediate an IPSP in dorsal horn neurones elicited by sensory stimulation.
Salter MW, De Koninck Y, Henry JL.
Synapse. 1992 Jul;11(3):214-20.
Recruitment of NMDA receptors into synaptic transmission after kindling-induced epilepsy and its possible mechanism.
Mody I, Heinemann U, MacDonald JF, Salter MW.
Epilepsy Res Suppl. 1992;8:307-10; discussion 310-1.
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases.
Wang LY, Salter MW, MacDonald JF.
Science. 1991 Sep 6;253(5024):1132-5.
Analysis of the glycoprotein gene of Tacaribe virus and neutralization-resistant variants.
Allison LM, Salter MW, Kiguwa S, Howard CR.
J Gen Virol. 1991 Aug;72 ( Pt 8):2025-9.
Mammalian neurons in dissociated cultures form clusters in the presence of retinal pigment epithelium.
MacDonald JF, Brandes L, Deverill M, Mody I, Salter MW, Theriault E.
Exp Brain Res. 1991;83(3):643-55.
Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones.
MacDonald JF, Bartlett MC, Mody I, Pahapill P, Reynolds JN, Salter MW, Schneiderman JH, Pennefather PS.
J Physiol. 1991 Jan;432:483-508.
Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin.
Salter MW, Henry JL.
Neuroscience. 1991;43(2-3):601-10.
Mody I, Reynolds JN, Salter MW, Carlen PL, MacDonald JF.
Brain Res. 1990 Oct 29;531(1-2):88-94.
Differential responses of nociceptive vs. non-nociceptive spinal dorsal horn neurones to cutaneously applied vibration in the cat.
Salter MW, Henry JL.
Pain. 1990 Mar;40(3):311-22.
Physiological characteristics of responses of wide dynamic range spinal neurones to cutaneously applied vibration in the cat.
Salter MW, Henry JL.
Brain Res. 1990 Jan 15;507(1):69-84.
The PCP site of the NMDA receptor complex.
MacDonald JF, Bartlett MC, Mody I, Reynolds JN, Salter MW.
Adv Exp Med Biol. 1990;268:27-34. Review.
A method for isolating and patch-clamping single mammalian taste receptor cells.
Spielman AI, Mody I, Brand JG, Whitney G, MacDonald JF, Salter MW.
Brain Res. 1989 Dec 4;503(2):326-9.
Regulation of N-methyl-D-aspartate receptors revealed by intracellular dialysis of murine neurones in culture.
MacDonald JF, Mody I, Salter MW.
J Physiol. 1989 Jul;414:17-34.
Whole-cell voltage-clamp recordings in granule cells acutely isolated from hippocampal slices of adult or aged rats.
Mody I, Salter MW, MacDonald JF.
Neurosci Lett. 1989 Jan 2;96(1):70-5.
The regulation of NMDA receptors in the central nervous system.
MacDonald JF, Mody I, Salter MW, Pennefather P, Schneiderman JH.
Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(3-4):481-8. Review.
Requirement of NMDA receptor/channels for intracellular high-energy phosphates and the extent of intraneuronal calcium buffering in cultured mouse hippocampal neurons.
Mody I, Salter MW, MacDonald JF.
Neurosci Lett. 1988 Oct 31;93(1):73-8.
Tachykinins enhance the depression of spinal nociceptive neurons caused by cutaneously applied vibration in the cat.
Salter MW, Henry JL.
Neuroscience. 1988 Oct;27(1):243-9.
Purine-induced depression of dorsal horn neurons in the cat spinal cord: enhancement by tachykinins.
Salter MW, Henry JL.
Neuroscience. 1987 Dec;23(3):903-15.
Evidence that adenosine mediates the depression of spinal dorsal horn neurons induced by peripheral vibration in the cat.
Salter MW, Henry JL.
Neuroscience. 1987 Aug;22(2):631-50.
Temporomandibular pain and dysfunction syndrome: the relationship of clinical and psychological data to outcome.
Salter MW, Brooke RI, Merskey H.
J Behav Med. 1986 Feb;9(1):97-109.
Effects of adenosine 5′-monophosphate and adenosine 5′-triphosphate on functionally identified units in the cat spinal dorsal horn. Evidence for a differential effect of adenosine 5′-triphosphate on nociceptive vs non-nociceptive units.
Salter MW, Henry JL.
Neuroscience. 1985 Jul;15(3):815-25.