Collageneous lectins are innate immune pattern recognition opsonins. They recognize microbial pathogens, NETs and dying cells. We aim to identify how collectins regulate infection and inflammation, and to improve the quality of specific collectins such as surfactant protein D (SP-D) for therapeutic use.

Antibodies of the Innate Immune System

Palaniyar - Adaptive + Innate Immunity + SPD

SP-D binds DNA

Palaniyar - SPD Structure + DNA

SP-D agglutinates and brings bacteria to NETs

Palaniyar + Douda - SPD agglutinates bacteria to NETs + Optical Density

A model for SP-D-mediated increase in NET function and clearance

Palaniyar - NETs + SPD in Airway with Bacteria