2021 Publications

  1. Azzouz D, Khan M.A. & Palaniyar N. ROS induces NETosis by oxidizing DNA and initiating DNA repair. Cell Death Discov. 2021; 7:113.
  2. Banerjee S, Mohammed A, Wong HR, Palaniyar N, Kamaleswaran R. Machine Learning Identifies Complicated Sepsis Course and Subsequent Mortality Based on 20 Genes in Peripheral Blood Immune Cells at 24 H Post-ICU Admission. Front Immunol. 2021; 12:592303.

2020 Publications

  1. Oves M, Ravindran M, Rauf MA, Omaish Ansari M, Zahin M, Iyer AK, Ismail IMI, Khan MA, Palaniyar N. Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development. Pathogens. 2020; 9(12):985.
  2. Al-Hassan JM, Hinek A, Renno WM, Wang Y, Liu YF, Guan R, Wen XY, Litvack ML, Lindenmaier A, Afzal M, Paul B, Oommen S, Nair D, Kumar J, Khan MA, Palaniyar N, Pace-Asciak C. Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish: A Unique Furan Fatty Acid (F6) and Cholesta-3,5-Diene (S5) Recruit Neutrophils and Fibroblasts to Promote Wound Healing. Front Pharmacol. 2020; 11:899.

2019 Publications

  1. Arroyo R, Khan MA, Echaide M, Pérez-Gil J, Palaniyar N. SP-D attenuates LPS-induced formation of human neutrophil extracellular traps (NETs), protecting pulmonary surfactant inactivation by NETs. Commun Biol. 2019; 2:470.
  2. Sakuma M, Khan MAS, Yasuhara S, Martyn JA, Palaniyar N. Mechanism of pulmonary immunosuppression: extrapulmonary burn injury suppresses bacterial endotoxin-induced pulmonary neutrophil recruitment and neutrophil extracellular trap (NET) formation. FASEB J. 2019; 33(12):13602-13616.
  3. Khan MA, D’Ovidio A, Tran H, Palaniyar N. Anthracyclines Suppress Both NADPH Oxidase- Dependent and -Independent NETosis in Human Neutrophils. Cancers (Basel). 2019; 11(9):1328.
  4. Hamam HJ, Palaniyar N. Post-Translational Modifications in NETosis and NETs-Mediated Diseases. Biomolecules. 2019; 9(8):369.
  5. Ravindran M, Khan MA, Palaniyar N. Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology. Biomolecules. 2019; 9(8):365.
  6. Al-Hassan JM, Fang Liu Y, Khan MA, Yang P, Guan R, Wen XY, Afzal M, Oommen S, Paul BM, Nair D, Palaniyar N, Pace-Asciak C. Furanoic Lipid F-6, A Novel Anti-Cancer Compound that Kills Cancer Cells by Suppressing Proliferation and Inducing Apoptosis. Cancers (Basel). 2019; 11(7):960.
  7. Hamam HJ, Palaniyar N. Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis. Biomolecules. 2019; 9(5):184.
  8. Khan MA, Ali ZS, Sweezey N, Grasemann H, Palaniyar N. Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation. Genes (Basel). 2019; 10(3)183.
  9. Xiu F, Sabz Ali Z, Palaniyar N, Sweezey N. A dual neutrophil-T cell purification procedure and methodological considerations in studying the effects of estrogen on human Th17 cell differentiation. J Immunol Methods. 2019; 467:1-11.
  10. Hamam HJ, Khan MA, Palaniyar N. Histone Acetylation Promotes Neutrophil Extracellular Trap Formation. Biomolecules. 2019; 9(1):32.
  11. Caldarone L, Mariscal A, Sage A, Khan M, Juvet S, Martinu T, Zamel R, Cypel M, Liu M, Palaniyar N, Keshavjee S. Neutrophil extracellular traps in ex vivo lung perfusion perfusate predict the clinical outcome of lung transplant recipients. Eur Respir J. 2019 Apr 4;53(4)1801736.

2018 Publications

  1. Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, Nielsen CH, Vestbo J, Palaniyar N, Holmskov U, Sorensen GL. Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis. Front Immunol. 2018; 9:3013.
  2. Khan MA, Pace-Asciak C, Al-Hassan JM, Afzal M, Liu YF, Oommen S, Paul BM, Nair D, Palaniyar N. Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils. Biomolecules. 2018; 8(4):144.
  3. Azzouz D, Palaniyar N. ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis. Cell Death Dis. 2018; 9(8):839.
  4. Azzouz D, Khan MA, Sweezey N, Palaniyar N. Two-in-one: UV radiation simultaneously induces apoptosis and NETosis. Cell Death Discov. 2018; 4:51.
  5. Azzouz L, Cherry A, Riedl M, Khan M, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria. Mol Immunol. 2018; 97:71-81.
  6. Khan MA, Philip LM, Cheung G, Vadakepeedika S, Grasemann H, Sweezey N, Palaniyar N. Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis. Front Med (Lausanne). 2018; 5:19.
  7. Naffah de Souza C, Breda LCD, Khan MA, de Almeida SR, Câmara NOS, Sweezey N, Palaniyar N. Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone. Front Immunol. 2018; 8:1849.

2017 Publications

  1. Djiadeu P, Farmakovski N, Azzouz D, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation. Mol Immunol. 2017; 92:190-198.
  2. Khan MA, Farahvash A, Douda DN, Licht JC, Grasemann H, Sweezey N, Palaniyar N. JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis. Sci Rep. 2017; 7(1):3409.
  3. Djiadeu P, Azzouz D, Khan MA, Kotra LP, Sweezey N, Palaniyar N. Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false-positive results for reactive oxygen species generation Pharmacol Res Perspect. 2017; 5(2):e00303.
  4. Khan MA, Palaniyar N. Transcriptional firing helps to drive NETosis. Sci Rep. 2017; 7:41749.
  5. Djiadeu P, Kotra LP, Sweezey N, Palaniyar N. Surfactant protein D delays Fas- and TRAIL-mediated extrinsic pathway of apoptosis in T cells. Apoptosis. 2017; 22(5):730-740.

2016 Publications

  1. Reidl M, Noone DG, Khan MA, Pluthero FG, Kahr WHA, Palaniyar N, Licht C. Complement Activation Induces Neutrophil Adhesion and Neutrophil-Platelet Aggregate Formation on Vascular Endothelial Cells. Kidney Int Rep. 2016; 2(1):66-75.
  2. Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C. Von Willebrand factor regulates complement on endothelial cells. Kidney Int. 21016; 90(1):123-34.
  3. Yuen J, Pluthero FG, Douda DN, Riedl M, Cherry A, Ulanova M, Kahr WH, Palaniyar N, Licht C. NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways. Front Immunol. 2016; 7:137.
  4. Gassas A, Krueger J, Zaidman I, Schechter T, Craig-Barnes H, Ali M, Palaniyar N. Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation. Pediatr Transplant. 2016; 20(2):303-6.

2015 Publications

  1. Douda DN, Khan MA, Grasemann H, Palaniyar N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. PNAS. 2015. 112(9):2817-22. SRA.
  2. Douda DN, Khan MA, Grasemann H, Pace-Asciak, C., Palaniyar N. A lipid mediator hepoxilin A3 is a natural inducer of neutrophil extracellular traps in human neutrophils. Mediators Inflamm. 2015; 2015:520871,7. SRA.
  3. Yildiz C, Palaniyar N, Otulakowski G, Khan MA, Post M, Kuebler WM, Tanswell K, Belcastro R, Masood A, Engelberts D, Kavanagh BP. Mechanical ventilation induces neutrophil extracellular trap formation. Anesthesiology. 2015. 2015 Apr;122(4):864-75. SRA.
  4. Palaniyar N, Mall MA, Taube C, Worgall S, Grasemann H. New Developments in Cystic Fibrosis Airway Inflammation. Mediators Inflamm. 2015; 2015:769425.
  5. Ghorbani P, Santhakumar P, Hu Q, Djiadeu P, Wolever TM, Palaniyar N, Grasemann H. Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth. Eur Respir J. 2015; 46(4):1033-45.
  6. Gassas A, Schechter T, Krueger J, Craig-Barnes H, Sung L, Ali M, Dell S, Egeler RM, Zaidman I, Palaniyar N. Serum Krebs Von Den Lungen-6 as a Biomarker for Early Detection of Bronchiolitis Obliterans Syndrome in Children Undergoing Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015; 21(8):1524-8.

2014 Publications

  1. Jin L, Batra S, Douda DN, Palaniyar N and Jeyaseelan S. CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions. J Immunol. 2014; 193(7):3549-58. C.

  2. Tolosa M, Palaniyar N. Severe respiratory insufficiency during pandemic H1N1 infection: prognostic value and therapeutic potential of pulmonary surfactant protein A. Crit Care. 2014; 18(4):479. SRA.

  3. Bade G, Khan MA, Srivastava AK, Khare P, Solaiappan KK, Guleria R, Palaniyar N and Talwar A. Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014; 9:759-73. CPA.

  4. Dhanju R, Min W, Ackerley C, Cimpean L, Palaniyar N, Roifman CM and Grunebaum E. Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice. J Allergy Clin Immunol. 2014; 133(5):1467-71. C.

  5. Cote O, Clark ME, Viel L, Labbe G, Seah SY, Khan MA, Douda DN, Palaniyar N and Bienzle D. Secretoglobin 1A1 and 1A1A differentially regulate neutrophil reactive oxygen species production, phagocytosis and extracellular trap formation. PLoS One. 2014; 9(4):e96217. C.

  6. Mehl, A., Ghorbani, P., Douda DN, Huang, H., Palaniyar N, Ratjen, F., Grasemann H. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia. PLoS One. 2014; 9(3): e90232. C.

  7. Douda DN, Yip L, Khan MA, Grasemann H and Palaniyar N. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. Blood. 2014; 123(4): 597-600. SRA.

  8. Peter MR, Jerkic M, Sotov V, Douda DN, Ardelean DS, Ghamami N, Lakschevitz F, Khan MA, Robertson SJ, Glogauer M, Philpott DJ, Palaniyar N and Letarte M. Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis. Mediators Inflamm. 2014; 2014: 767185. C.

2013 Publications

  1. Madsen J, Gaiha GD, Palaniyar N, Dong T, Mitchell DA, Clark HW. Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells. PLoS One. 2013; 8(3): e59047. C.

  2. Gassas A, Craig-Barnes H, Dell SD, Cox P, Schechter T, Doyle J, Sung L, Egeler M and Palaniyar N. Severe lung injury and lung biopsy in children post-hematopoietic stem cell transplantation: The differences between allogeneic and autologous transplantation. Pediatr Transplant. 2013; 17(3): 278-84. SRA.

  3. Cheng OZ, Palaniyar N. NET balancing: a problem in inflammatory lung diseases. Front Immunol. 2013; 4: 1. SRA.

  4. Gassas A, Craig-Barnes H, Dell S, Doyle J, Schechter T, Sung L, Egeler M, Palaniyar N. Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT. Bone Marrow Transplant. 2012; 2013; 17(3): 814-8. SRA.

2012 Publications

  1. Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS One. 2012; 7(4): e35812. C.

  2. Jeyaseelan S, Palaniyar N. Comment and Response on “Innate immue collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping”. Journal of Immunology. 2012; 188(1). SRA.

2010 Publications

  1. Hansen S, Selman L, Palaniyar N, Ziegler K, Brandt J, Kliem A, Jonasson M, Nielsen O, Hartshorn K, Jørgensen TJD, Skjødt K, Holmskov U. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity. J.Immunol. 2010; 185(10):6096-104. CPA.

  2. Litvack ML, Djiadeu P, Sy S, SriRenganathan S, Post M, Palaniyar N. Natural IgM and innate immune collectin SP-D bind to late apoptotic cells and enhance their clearance by alveolar macrophages in vivo. Mol Immunol. 2010; 8(1-3):37-47. SRA.

  3. Krogh-Meibom T, Ingvartsen TL, Tørnoe I, Palaniyar N, Willis AC, Holmskov U. A simple two-step purification procedure for the iC3b binding collectin conglutinin. J. Immunol. Method. 2010; 362(1-2):204-8. CPA.

  4. Palaniyar N. Antibody equivalent molecules of the innate immune system: parallels between innate and adaptive immune proteins. Innate Immunity. 2010; 16(3) 131-7. SRA.

  5. Litvack ML, Palaniyar N. Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation. Innate Immunity. 2010; 16(3): 191-200. SRA.

  6. Craig-Barnes H, Doumouras BS, Palaniyar N. Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential. J Biol Chem. 2010;285(18): 13461-70. SRA

  7. Breuiller-Fouché M, Dubois O, Sediki M, Garcia-Verdugo I, Palaniyar N, Tanfin Z, Chissey A, Cabrol D, Charpigny G, Mehats C. Secreted surfactant protein A from fetal membranes induces stress fibers in cultured human myometrial cells. Am J Physiol Endocrinol & Metab. 2010;298(6):E1188-97. C.

  8. Thomsen T, Moeller JB, Schlosser A, Sorensen GL, Moestrup SK, Palaniyar N, Wallis R, Mollenhauer J, Holmskov U. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. J Biol Chem. 2010; 285(2):1229-38. C.

  9. Lee BH, Kushwah R, Wu, J, Ng P, Palaniyar N, Grinstein S, Philpott DJ, Hu J. Adenoviral vectors stimulate innate immune responses in macrophages through cross-talk with epithelial cells. Immunol Lett. 2010; 134(1):93-102. C.

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