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Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis. Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., McGlade, C. J. (2022). Oncogene , 41 (14), 2079–2094.SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. Wybenga-Groot, L. E., Tench, A. J., Simpson, C. D., Germain, J. S., Raught, B., Moran, M. F., McGlade, C. J. (2021).Journal of molecular biology , 433 (8), 166880.Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex. Wybenga-Groot, L. E., & McGlade, C. J. (2021). Acta crystallographica. Section F, Structural biology communications , 77 (Pt 2), 37–46.SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response . Sharma, N., Ponce, M., Kaul, S., Pan, Z., Berry, D. M., Eiwegger, T., McGlade, C.J. (2019).Frontiers in immunology , 10 , 1020.Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho, S. E., Silva-Gagliardi, N., Morgese, F., Coyaud, E., Lamoureux, E., Berry, D. M., Raught, B., McGlade, C. J . (2019). Scientific reports , 9 (1), 12471.Screening of Chemical Libraries Using a Yeast Model of Retinal Disease. Scott, B. M., Wybenga-Groot, L. E., McGlade, C. J ., Heon, E., Peisajovich, S. G., Chang, B. (2019). SLAS discovery : advancing life sciences R & D , 24 (10), 969–977.
E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36. Lynn, B.D., Li, X., Hormuzdi, S.G., Griffiths, E.K. , McGlade, C.J. and J.I. Nagy. (2018) . European Journal of Neuroscience. Nov;48(9):3062-3081Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases. Sapir, T., Levy, T., Kozer, N., Shin, I., Zamor, V., Haffner-Krausz, R., McGlade, C.J ., Reiner, O. (2018). Cereb Cortex. Sep 1; 28(9):3115-3128Tie2 signalling through Erk1/2 regulates TLR4 driven inflammation . Smith T.L., Van Slyke, P., Jones, N., Dumont, D.J., and McGlade, C.J. (2018). Cell Signal. Aug 2:51:211-221. Doi 10.1016/j.cell sig.Mouse Crumbs2 promotes the gastrulation epithelial-to-mesenchymal transition . Ramkumar, N., Omelchenko, T., Silva-Gagliardi, N.F. , McGlade, C.J., Winjholds, J., and K.V. Anderson. (2016). Nature Cell Biology,Dec;18(12):1281-1291. Collaborator Integrated genomic and epi-genomic analysis identify subgroup specific therapeutic targets and CNS rhabdoid tumours . Torchia, J, D. Picard D, K. C. Ho, L.-L. Cousin, C. E. Hawkins, D. A. Khuong Quang, T. S. Y. Chan, L. Letourneau, P. Hu, B. J. Golbourn, D. M. A. Gendoo, M. Barszczyk, M Sin-Chan P, M. Dzamba, A. M. Mezlini, M. Warmuth-Metz, M. Bourgey, S. Morrissy, Y.-S. Ra, C. P. Dunham, S. Yip, H.-k. Ng, J.-Q. Lu, S. Albrecht, J. Pimentel, J. Chan, C. C. Faria, L. Roque, B. Baskin, D. Birks, N. Foreman, D. Strother, A. Klekner, G. Miklos, P. Hauser, T. Hortobágyi, B. Wilson, J. Hukin, A.-S. Caret, T. Van Meter, S.-H. Chiou, E. Hwang, H. Nakamura, H. Toledano, I. Fried, D. Fults, T. Wataya, C. Fryer, D. Eisenstat, K. Scheineman, D. Johnston, S. Zelcer, A. Fleming, N. Sirachainan, M. A. Barakzai, E. Kienha, A. Erdreich-Epstein, M. D. Krieger, J. Xu, G. D. Bader, C. J. McGlade , G. Bourque, A. Montpetit, D. Stephens, U. Schüller, T. Tihan, T. Nicolaides, J. Phillips, S. Rutkowski, T. Pietsch, S.-K. Kim, J. T. Rutka, M. D. Taylor, P. Dirks, A Judkins, M. Brudno, E. Bouffet, J. Majewski, N. Jabado and A.Huang. Cancer Cell. (2016) Dec 12;30(6):891-908.Oncogenic signaling through ERK regulates alternative splicing of Numb . Rajendran, D. Zhang-Y, Berry, D.M. and C J. McGlad. (2016). Oncogene, 29;35(39):5202-13. Myc associated transforming protein JPO2 cooperates with LEDGF/p75 to modulate AKT signaling . Chan T., Hawkins, C.E., Krieger, J.R. , McGlade , C.J. and A. Huang. (2016) .Cancer Research, 6(9):2802-2812.Protein O-glucosyltransferase 1 (Poglut1) is required for the activity of Crumbs2 during mouse gastrulation. Ramkumar, N., Lee, J.D., Harvey, B.M., Silva-Gagliardi, N.F ., McGlade, C.J., Haltiwanger, R.S., and K. V. Anderson. (2015). PLoS Genetics. 11(10):e1005551. Collaborator Tyrosine phosphorylation of the Lyn SH2 domain modulates its binding affinity and specificity . Jin, L., Wybenga-Groot, L.E., Tong, J., Taylor, P., McGlade, C.J ., Minden, M., Trudel, S., and M.F. Moran. (2015). 14(3):695-706. Mol Cell Proteomics. Collaborator The SLAP adaptor proteins and regulation of receptor tyrosine kinase signaling . Wybenga-Groot, L.E. and C.J., McGlade. (2015). Cellular Signaling 27(2):267-274. Senior Responsible Author Comprehensive Phosphorylation Site Analysis of the Endocytic Adaptor Protein Numb . Krieger, J.R., Taylor, P., Moran, M.F. and C.J. McGlade. (2015). Proteomics. 15(2-3):434-446. Senior Responsible Author Structural basis of Rad53 kinase activation by dimerization and activation segment exchange . Wybenga-Groot, L.E., Ho, C.S., Sweeney, F.D., Ceccarelli, D.F., McGlade, C.J. , Durocher, D., and F. Sicheri. (2014). Cell Signal 26(9):1825-1836., Collaborator The E3 ubiquitin ligase RNF126 ubiquitinates GGA3 and regulates the endosomal sorting of the CI-MPR. Smith C. J. and C. J. McGlade. (2014). Exp Cell Res. 320(2):219-232. Senior Responsible Author Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through beta-sheet formation . Wybenga-Groot. L.E. and C. J. McGlade (2013). Cell Signal. Dec;25(12):2702-2708. Senior Responsible Author Gads (Grb2-related Adaptor Downstream of Shc) is Required for BCR-ABL mediated Lymphoid Leukemia. Gillis, L., Berry, D.M., Minden, M.D., McGlade, C.J. and D.L. Barber (2013)Leukemia. 27(8):1666-1676. [Epub 2013 Feb 12.] Co-Senior Responsible Author The ubiquitin ligases RNF126 and RabRING7 regulate endosomal sorting of the Epidermal Growth Factor Receptor . Smith, C.J., Berry, D.M ., and C.J. McGlade. (2013). J Cell Sci. 126:1366-1380. [Epub 2013 Feb 15.] Senior Responsible Author Identification and SRM Quantification of Endocytosis Factors Associated with Numb Isoforms . Krieger, J.R., Taylor, Gajadar, A.S., Guha, A., P. Moran, M.F. and C.J. McGlade .(2013). Mol. Cell. Proteomics. Feb;12(2):499-514. Senior Responsible Author Divergent lymphocyte signalling revealed by a powerful new tool for analysis of time lapse microscopy. Pham K., Shimoni, R.,. Ludford-Menting, M.J., Nowell C.J., Lobachevsky, L., Bomzon, Z., Gu, M, Speed, T.P., McGlade, C.J ., Russell, S.M. (2013) .Immunol Cell Biol. Jan;91(1):70-81. Collaborator Biochemical and Computational analysis of the LNX1 interaction network . Wolting, C.D., Griffiths, E.K., Sarao, R. Prevost, B., Wybenga-Groot, L., and C.J. McGlade . (2011). PLoS One 6(11):e26248. Senior Responsible Author Numb Regulates Notch1, but not Notch3, During Myogenesis . Beres BJ, George R, Lougher EJ, Barton M, Verrelli BC, McGlade CJ , Rawls JA, Wilson-Rawls J. (2011) Mech Dev. 2011 128(5-6):247-257. Collaborator A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. Agnihotri S, Wolf A, Munoz DM, Smith CJ , Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ , Stanford WL, Aldape K, Mischel PS, Hawkins C, Guha A. (2011). J Exp. Med. 2011 Apr 11;208(4):689-702. Collaborator Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation . Lau, K. , and C.J. McGlade. (2011). Exp. Cell Res. 2011 15;317(4):539-551. Senior Responsible Author Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer . Mesquitta-Ali, C.M., Cheng, E., Shai, O., Liu, N., McGlade, C.J ., Tsao, M.S., and B.J. Blencowe. (2011). Mol Cell Biol. 2011 Jan;31(1):138-150. Collaborator The SLAP adaptor proteins regulate GM-CSF Receptor signaling and dendritic cell maturation . Liontos LM , Dissanayake D, Ohashi PS, Weiss A, Dragone LL, and CJ. McGlade. (2011). J Immunol. 15;186(4):1923-1933. Senior Responsible Author Numb regulates post-endocytic trafficking and degradation of Notch1 . McGill, M.A . Dho, S.E., Weinmaster, G., and C.J. McGlade . (2009). J. Biol. Chem 284(39):26427-26438. Senior Responsible Author Yurt, Coracle, NeurexinIV and the Na(+), K(+)-ATPase form a novel group of epithelial polarity proteins . Laprise, P., Lau, K., Harris, K.P., Silva-Gagliardi, N., Paul, S.M., Beronja, S., Beitel, G.J., McGlade, C.J ., and U. Tepass. (2009) Y Nature. 459(7250):1141-1145. Collaborator Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 . Hughes CE, Auger JM, McGlade J , Eble JA, Pearce AC, Watson SP. (2008) . J Thromb Haemost. 2008 Dec;6(12):2152-2159 Collaborator Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenillin complex in culture cells. Pardossi-Piquard, R., Chen, F., Silva-Gagliardi, N.F., Szego, M., McInnes, R., McGlade, C.J ., St George-Hyslop, P., and P.E. Fraser. (2007) . Biochemistry 48:13704-13710. Collaborator SLAP-2 mediates c-Cbl dependent down regulation of Colony Stimulating Factor-1 Receptor signaling . Pakuts, B. Debonneville, C., Liontos, L.M., Loreto, M.P ., and C.J. McGlade (2007) . J. Biol. Chem . 282:17953-17963. Senior Responsible Author The FERM protein Epb4.1l5 is required for organization of the neural plate and the epithelial-mesenchymal transition at the primitive streak of the mouse . Lee, J.D., Silva-Gagliardi, N.F ., Tepass, U., McGlade, C..J ., and K.V. Anderson. (2007) . Development. 134(11):2007-2016. Collaborator TCR signaling requires a high affinity interaction between Gads C-SH3 domain and the SLAP-76 RXXK motif . Seet, B.T., Berry, D.M ., Maltzman, J., Shabason, J., Raina, M., Koretzky, G.A., McGlade, C.J ., and T. Pawson. (2007). EMBO J 26:678-689. Collaborato raPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb . Smith, CA., Lau, K., Rahmani, Z., Dho, SE, Brothers, G., She, Y., Bonneil, E., Thibault, P., Berry, DM , Le Borgne. R., Shweisguth, F., and C.J. McGlade. (2007). EMBO J. Jan 24;26(2):468-80. Senior Responsible Author PTP1B and TC-PTP: Novel roles in immune cell signaling . Simoncic, PD . McGlade, CJ ., and ML. Tremblay (2006) PTP1B and TC-PTP: Can J Physiol. Pharm. 2006 Jul;84(7):667-75 Collaborator Cluster analysis of protein array results via similarity of gene ontology annotation . Wolting , C., McGlade, CJ ., and D. Tritchler. (2006) BMC Bioinformatics, 7:338 Co-author (CW supervisor) Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane . Dho, S.E., Siderovski, D.P., Trejo, J., and C. J. McGlade (2006) Mol Biol. Cell Sep;17(9):4142-55 Senior Responsible Author The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Laprise, P. Beronja, S., Silva-Gagliardi, N., Pellikka, M., Jensen, A., McGlade, C.J . and U. Tepass. (2006). Dev. Cell, 11(3):363-374. Collaborator T-cell Protein Tyrosine Phosphatase (Tcptp) is a negative regulator of CSF-1 signaling and mononuclear phagocyte development . Simoncic, D.P ., Bourdeau, A., Lee-Loy, A., Rohrschneider, L.R., Tremblay, M.L., Stanley, E.R. and C.J. McGlade . (2006) Mol. Cell Biol. 26:4149-4160. Senior Responsible Author LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2 . Young, P., Nie, J ., Wang, X., McGlade, CJ ., Rich, MM., G. Feng. (2005) Mol. Cell. Neuroscience, 30(2):238-248. Collaborator The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades . Zhu, Y.X., Benn, S. , Li, Z.H., Wei, E., Masih-Khan, E., Trieu, Y., Bali, M., McGlade, C.J ., Claudio, J.O., and A.K. Stewart. (2004) J. Exp. Med. 200(6):737-747. Collaborator The cell fate determinant Numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling . Smith, C.A., Dho, S.E ., and C.J. McGlade . (2004). Mol. Biol. Cell.15: 3698-3708. Senior Responsible Author A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb . J. Nie, S.C. Li and C. J. McGlade . (2004). J. Biol. Chem. 279:20807-20815. Senior Responsible Author Mammalian Numb proteins inhibit Notch nuclear activity and promote Notch ubiquitination . McGill, M.A. and McGlade C.J . (2003). J. Biol. Chem. 278:23196-203. Senior Responsible Author Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity . Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P-Y.B., Berry, DM ., Tamblyn, L., Shehabeldin, A., Migon, E., Wakeham, A., Bouchard, D., Yeh, W-C., McGlade, C.J ., Ohashi, P.S., and R. Hakem (2003). Genes Dev. 17(7):883-95. Collaborator Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells . Yamasaki, S., Sakuma, Ritsuko, M., Shina-Suzuki, R., Berry, D. Nishida, K., Hirano, T., McGlade, CJ and Saito, T. (2003) . Mol. Cell. Biol. 23:2515-29. Collaborator Integrin cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling . Calderwood, DA, Fujioka, Y, de Pereda, JM, Garcia-Alvarez, B, Nakamoto, T, Margolis, B, McGlade, CJ , Liddington, RC and MH Ginsberg. (2003). Proc. Natl. Acad. Sci. USA. 100:2272-2277. Collaborator Structural Basis for Specific Binding of the Gads SH3 Domain to an RxxK Motif-Containing SLP-76 Peptide . A Novel Mode of Peptide Recognition. Liu, Q., Berry, D ., Nash P., Pawson, T., McGlade, CJ ., Li, S-C. (2003) Molecular Cell. 11:471-481. Collaborator Involvement of numb in vertebrate retinal development: Evidence for multiple roles of numb in neural differentiation and maturation . Dooley CM, James J, McGlade C.J ., Ahmad I. (2003) J Neurobiol. 54:313-325 Collaborator Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform . Loreto, M.P. , McGlade, C.J. (2003) , SLAP-2-v. Oncogene. 22: 266-273. Senior Responsible Author T cell receptor ligation induces the formation of signaling assemblies whose composition is dynamically regulated . Bunnell, S., Hong, D., Kardon, J., Yamazaki, T., McGlade, C.J ., Barr, V., and Samelson, L. (2002) . J. Cell. Biol. 158:1263-1275. Collaborator A novel, high affinity SH3-binding motif confers specificity for the interaction between Gads and SLP-76 in T-cell signaling . Berry, D.M ., Nash, P., Liu, S. K-W ., Pawson, T., and McGlade, C.J . (2002) Curr Biol. 12:1336-1340. Senior Responsible Author PI 3’ Kinase and MEK1/2 Differentially Regulate Expression of Vascular Endothelial Growth Factor in Human Malignant Astrocytoma Cell Lines . Woods, S.A ., McGlade, C.J ., Guha, A. (2002) Neuro-oncol. 4:( 4) 242-252. Co-Principle Author Functional cooperation between c-Cbl and Src-like adaptor protein SLAP-2 in the negative regulation of TCR signaling . Loreto, M.P., Berry, D.M. and McGlade, C.J . (2002) Mol. Cell. Biol., 22:4241-4255. Senior Responsible Author The gamma-secretase-generated intracellular domain of b-amyloid precursor protein binds to Numb and inhibits Notch signaling . Roncarati, R., Sestan, N., Scheinfeld, M.H., Berechid, B.E., Lopez, P.A., Meucci, O., McGlade, C.J . Rakic, P., and D’Adamio, L. (2002) Proc. Natl. Acad. Sci. 99:7107-7102. Collaborator Attenuation of leptin action and regulation of obesity by PTP1B . Cheng. A., Uetani, N., Simoncic, P.D ., Chaubet, V.P., Lee-Loy, A., McGlade, C.J ., Kennedy, B.P., and Tremblay, M.L. (2002) Dev. Cell 2:497- 503. Collaborator Transgenic expression of Numb in the thymus inhibits Notch signalling but does not alter T cell fate specification . French M.B. , Koch U. McGill M.A., Dho S.E. , Guidos C.J., and C.J. McGlade . (2002) J. Immunol. 68:3173-80. Senior Responsible Author Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis . Pellikka, M, Tanentzapf,G, Pinto, M, Smith, CA , McGlade, CJ , Ready, DF, and Tepass, U (2002) Nature 416:143-149. Collaborator The T-cell Protein Tyrosine Phosphatase is a negative regulator of Janus Family Kinases 1 and 3 . Simoncic, D.P ., Barber, D.L., Tremblay, M.L. and C.J. McGlade . (2002) Curr. Biol. 19:446-53. Senior Responsible Author LNX functions as a RING-type E3 that targets the cell fate determinant Numb for ubiquitin-dependent degradation . Nie, J., McGill, M.A., Dermer, M., Dho, S.E., Wolting, C.D ., and C.J McGlade . (2002) EMBO J, 21: 93-102. Senior Responsible Author The role of Gads in hematopoietic cell signalling . Oncogene, Liu, S. K.-W., Berry, D.M. , and McGlade, C.J . (2001) 20:6284-6290. Senior Responsible Author Neuralized functions as an E3 ubiquitin ligase during Drosophila developmentDermer, M. , Zhou, L., Commisso, C. McGlade, C.J ., Boulianne, G.L. (2001). Curr. Biol. 11:1675-1679. Collaborator HACS1 encodes a novel SH3-SAM adaptor differentially expressed in normal and malignant hematopoietic cells . Claudio, J.O., Zhu, Y.X. Benn, S.J., Shukla, H. , McGlade, C.J ., Falcioni, N. Stewart, A.K. (2001) Oncogene 20:5373-5377. Collaborator Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor. Berry, D.M., Benn, S.J ., Cheng, A., McGlade, C.J . (2001) Oncogene. 20:1203-1211. Senior Responsible Author Requirement for the SLP-76 adaptor Gads in T cell development . Yoder, J., Pham, C., Matsubayashi, Y., Liu, S.K ., McGlade, C.J ., and A. Cheng. (2001) Science 291:1987-1991. Co-Principle Author Apical, lateral and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis . Tanentzapf, G., Smith, C. , McGlade, C.J . and U. Tepass. (2000). J. Cell Biol. 151:891-904 Collaborator Interaction of LAT with multiple adapter proteins in platelets activated by the GPVI selective ligand, convulxin . Asazuma, N., J. I. Wilde, O. Berlanga, M. Leduc, A. Leo, E. Schweighoffer, V. Tybulewicz, C. Bon, S.K. Liu , C.J. McGlade , B. Schraven and S. P. Watson. (2000). J Biol Chem. 275:33427-33434 Collaborator The Hematopoietic specific adaptor protein Gads is implicated in coupling HPK1 to the T-cell receptor . Liu, S.K., Smith, C.A. , Kiefer, F. and C.J.McGlade . (2000). J. Imm. 165:1417-1426. Senior Responsible Author The association of Grb2, Gads and PLC-g with phosphorylated LAT tyrosine residues: the effect of tyrosine mutations on TCR-mediated signalling . Zhang, W., Trible, R.P., Zhu, M., Liu, S.K., McGlade, C.J ., and L.E. Samelson. (2000) J. Biol. Chem. 275:23355-23361. Collaborator Differential expression and subcellular localization of mammalian Numb protein isoforms . Dho, S.E., French M.B., Woods S.A. , and J.McGlade. (1999). J. Biol. Chem. 274: 33097-33104. Senior Responsible Author Cloning and characterization of mPAL, a unique Shc binding protein expressed in proliferating cells . Schmandt, R, Liu, S.K., and C.J. McGlade (1999). Oncogene 18:1867-1880. Senior Responsible Author The hematopoietic-specific adaptor protein, Gads functions in T cell receptor signaling through interactions with SLP-76 and LAT. Liu S. K. , N. Fang, D. Bouchard , G. A. Koretzky, and C. J. McGlade (1999). Curr. Biol. 9: 78-88. Senior Responsible Author Gads is a novel SH2 and SH3 domain containing adaptor protein that binds to tyrosine phosphorylated Shc . Liu, S.K. and C.J. McGlade . (1998). Oncogene 17:3073-3082. Senior Responsible Author Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity . Li, S.-C., C. Zwahlen, S.J.F. Vincent, C.J. McGlade , L.E. Kay, T. Pawson, and J.D. Forman-Kay. (1998) Nature Structure 5:1075-1083. Collaborator The mNumb PTB(PI) Domain: Characterization of Binding Specificity and Identification of a Numb Binding Protein . Dho, S., Jacob, S., French, M., C., Wolting , Rohrschneider, L., and C.J. McGlade .(1998) (1998) J. Biol. Chem. 273:9179-9187. Senior Responsible Author Cloning and chromosomal localization of TIC, a new member of the bHLH/PAS family of transcription factors . Wolting, C. and C.J. McGlade .(1998). Mammalian Genome. 9:463-468. Senior Responsible Author Requirement of phospholipase Cg , the tyrosine phosphorylation of SYP, the adapter proteins Shc and Nck for PDGF- induced DNA synthesis: evidence for the existence of Ras dependent and Ras-independent pathways . Roche, S., J. McGlade , M. Jones, G.P. Gish, T. Pawson and S.A. Courtneidge. (1996) EMBO J. 15:4940-4948. Collaborator Mammalian NUMB is a novel signaling adapter protein that specifies neuronal cell fates . Verdi, J., R. Schmandt , A. Bashirullah, S. Jacob , R. Salvino, C. Craig, H. Lipshitz, and C.J. McGlade . (1996). Curr. Biol. 6:1134-1145. Senior Responsible Author Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein. Garrity, Y. Rao, I. Salecker, J. McGlade , T. Pawson, and S.L. Zipursky. (1996). Cell 85:639-650. Collaborator NEDD4 WW domains bind to the proline rich regions in the ß and g subunits of the epithelial sodium channel (ENaC) deleted in Liddle’s syndrome . Staub, O., S. Dho, P. Henry, J. Correa, T. Ishikawa, J. McGlade , and D. Rotin. (1996) EMBO J. 15:2371-2380. Collaborator Phosphotyrosine Independent binding of SHC to the NPLH Sequence of MPTP-PEST: Evidence for extended PTB/PI Domain Recognition Specificity . Charest, A., J. Wagner, S. Jacob, C.J. McGlade , and M.L. Tremblay. (1996) J. Biol. Chem. 271:8424-8429. Co-Principle Author A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase . Lai, K-M. V., J.P. Olivier, G.D. Gish, M. Henkemeyer, J. McGlade , and T. Pawson. (1995) Mol. Cell. Biol. 9:4810-4819. Collaborator Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins . Salcini, A.E., J. McGlade , G. Pelicci, I. Nicoletti, T. Pawson and P.G. Pelicci. (1994) Oncogene. 9:2827-2836. Co-Principle Author Analysis of the role of Shc and Grb-2 proteins in signal transduction by the v-ErbB protein . Meyer, S., K. LaBudda, J. McGlade , M.J. Hayman. (1994) Mol. Cell. Biol. 14:3253-3262. Collaborator Direct interaction between Shc and the PDGFb-receptor . Yokote, K., S. Mori, K. Hansen, J. McGlade , T. Pawson, C.-H. Heldin, and L. Claesson-Welsh. (1994) J. Biol. Chem. 269:15337-15343. Collaborator Specific motifs recognized by the SH2 domains of csk, 3BP2, fes/fps, Grb-2, SHPTP1, SHC, Syk and vav . Songyang, Z., S.E. Shoelson, J. McGlade , P.Olivier, T. Pawson, R.X. Bustelo, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R.A. Feldman, and L.C. Cantley. (1994) Mol. Cell Biol. 14: 2777-2785. Collaborator Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase . Crowe, A., J. McGlade , T. Pawson, and M. J. Hayman.(1994) Oncogene.9:537-544. Collaborator Immunolocaliation of the Nuk receptor tyrosine kinase suggests a role in segmental patterning of the brain and axonogenesis . Henkemeyer, M., L.E.M. Marengere, J. McGlade , J. P. Olivier, R. A. Conlon, D. Holmyard, K. Letwin, and T. Pawson. (1994) Oncogene.9: 1001-1014. Co-Principle Author Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways . Pawson, T., P. Olivier, M. Rozakis-Adcock, J. McGlade , and M. Henkemeyer. (1993) Phil. Trans. R. Soc. London B 340: 279-285. Co-Principle Author The amino-terminal region of GAP regulates cytoskeletal structure and cell adhesion . McGlade, C. J., B. Brunkhorst, G. Mbamalu, D. Anderson, J. Settleman, S. Dedhar, M. Rozakis-Adcock, L.B. Chen and T. Pawson. (1993) EMBO J. 12:3073-3081. Principle Author Shc products are substrates of erbB-2 kinase . Segatto, O., G. Pelicci, S. Giuli, G. Degiesi, P.P. Di Fiore, J. McGlade , T. Pawson, and P.G. Pelicci. (1993) Oncogene, 8:2105-2112. Collaborator Epidermal growth factor stimulates the tyrosine phosphorylation of SHC in the mouse . Ruff-Jamison, S., J. McGlade , K. Chen, T. Pawson, and S.Cohen. (1993) J. Biol. Chem . 268:7610-7612. Collaborator Insulin-induced phosphorylation of the 46 and 52 kDa Shc proteins . Pronk, G.J., J. McGlade , T. Pawson, and J.L. Bos. (1993) J. Biol. Chem. 268:5748-5753. Collaborator Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Rozakis-Adcock, M., J. McGlade , G. Mbamalu, G. Pelicci, R. Daly, W. Li, A. Batzer, P.G. Pelicci, J. Schlessinger, and T. Pawson. (1992) Nature 360:689-692. Co-Principle Author Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases . McGlade, J. , A. Cheng, G, Pelicci, P.G. Pelicci, and T. Pawson. (1992) Proc. Natl. Acad. Sci. USA. 89:8869-8873. Principle Author A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signalling . Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade , F. Cavallo, G. Forni, I. Nicoletti, T. Pawson and P.G. Pelicci. (1992) Cell 70:93-104. Co-Principle Author SH2 domains of the p85a subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors . McGlade, C.J ., C. Ellis, M. Reedijk, D. Anderson, G. Mbamalu, A.D. Reith, G. Panayotou, P. End, A. Bernstein, A. Kazlauskas, M.D. Waterfield, and T. Pawson. (1992) Mol. and Cell. Biol. 12:991-997. Principle Author Individual adenovirus E1B proteins induce transformation independently but by additive pathways . McClorey, W, C.J. McGlade , D. Takayesu, P.E. Branton. (1991) J. Gen. Virol. 72:1467-1471. Co-Principle Author Mapping of a phosphorylation site in the 176R (19kDa) early region 1B protein of human adenovirus type 5 . McGlade, C.J ., M.L. Tremblay, and P.E. Branton. (1989) Virology 163:119-127. Principle Author Identification of the phosphorylation sites in early region 1A proteins of adenovirus type 5 by amino acid sequencing of peptide fragments . Tremblay, M.L., C.J. McGlade , G. Gerber, and P.E. Branton. (1988) J. Biol. Chem. 263:6375-6383. Collaborator Acylation of the 176R (19-kilodalton) early region 1B protein of human adenovirus type 5 . McGlade, C.J ., M.L. Tremblay, S-P. Yee, R. Ross, and P.E. Branton. (1987) J. Virol. 61:3227-3234. Principle Author Go to Top 
