Co-Principal Investigators: Natoshia Cunningham, Ph.D. and Andrea Knight, MD, MSCE  Funded by: United States Department of Defense  Study Goals: To examine the effect of TEACH on psychological/functional outcomes and disease-related outcomes in youth with cSLE in real-world rheumatology settings versus medical TAU at post assessment (after 8 weeks). To determine longitudinal trajectories (over 1 year) of depressive [...]

Principal Investigator: Andrea Knight, MD, MSCE  Co-Principal Investigators: Ekemini Ogbu, MD, MSc, FAAP    Funded by: Department of Defense  Study Goals: To determine the longitudinal outcome of Neuropsychiatric SLE (NPSLE) and the trajectories of cognitive functions in pediatric SLE patients. To compare the longitudinal outcomes of children without NPSLE, including disease activity damage index, medication [...]

Principal Investigator: Andrea Knight, MD, MSCE  Co-Principal Investigator: Shirley Tse, MD, FRCPC  Funded by: SPARCC  Study Goals: To identify MH symptoms and needs for youth with JSpA, and to evaluate the feasibility of MH screening.  Description: This mixed-method study aims to identify MH symptoms and needs for youth with JSpA while also evaluating the feasibility [...]

Co-Principal Investigators: Andrea Knight, MD, MSCE and Roberta Berard, MD, FRCPC, MSc  Additional Investigators: Michelle Batthish, MD, MSc and Karen Bax, C. Psychology  Funded by: Brain Canada & Cassie and Friends Foundation    Study Goals: To evaluate the effectiveness of a live-online mindfulness-based family intervention program, (M3©) for children with JIA and their caregiver(s).  Description: [...]

Co-Principal Investigators: Busi Zapparoli, Ph.D., C.Psych and Andrea Knight, MD, MSCE  Funded by: Garry Hurvitz Centre for Brain and Mental Health (GH CBMH), Early Career Scientist Health Outcomes Catalyst Grant  Study Goals: To develop and assess preliminary feasibility and acceptability of an intervention strategy tailored to address specific brain health needs of children and youth with cSLE. To assess the Teen Online Problem [...]

Principal Investigator: Andrea Knight, MD, MSCE  Co-Principal Investigator: Michelle Batthish, MD  Funded by: Canadian Institution of Health Research (CIHR)  Study Goals: To perform an environmental scan of current mental health care practices, patient, family, and healthcare provider experiences, and gaps in pediatric rheumatology, followed by the development of a nationally prioritized research agenda to guide future work.  Description: This study aims [...]

Co-Principal Investigators: Andrea Knight, MD, MSCE and Polly Livermore, PhD  Funded by: Unfunded  Study Goals: To investigate the support needs of caregivers of children with rheumatological conditions and how these could be improved upon. To understand and compare similarities and differences between UK and Canadian families.    Description: This study will conduct 5 virtual focus [...]

Principal Investigator: Andrea Knight, MD, MSCE  Funded by: Cure JM, Lupus Research Alliance and US Department of Defense  Study Goals: To characterize cognitive and psychiatric function in children with JM, compared to patients with cSLE and healthy controls. To characterize neuroimaging metrics in children with JM, compared to patients with cSLE and healthy controls.  Description: This [...]

Principal investigator: Andrea Knight, MD, MSCEFunded by: United States of America Department of Defense Lupus Research ProgramStudy Goals: To quantify the effect of Childhood-onset Systemic Lupus Erythematosus (cSLE) on brain structure, function and development. To determine the association of neuroimaging measures with cognitive test performance in cSLE. To determine the relative contribution of cSLE disease-related [...]

Principal Investigator: Andrea Knight, MD, MSCE Co-Principal Investigator: Ashley Danguecan, PhD Funded by: Centre for Brain and Mental Health Study Goals: To better understand the cognitive and mental health comorbidities in Childhood-onset Systemic Lupus Erythematosus (cSLE), perceived barriers to treatment, as well as the contribution of social disadvantage to cognitive, mental health and disease [...]