Publications
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2024
Chin K, Jiang H, Steinberg BE, Goldenberg NM, Desjardins JF, Kabir G, Liu E, Vanama R, Baker AJ, Deschamps A, Simpson JA, Maynes JT, Vinogradov SA, Connelly KA, Mazer CD, Hare GMT. Bilateral nephrectomy impairs cardiovascular function and cerebral perfusion in a rat model of acute hemodilutional anemia. J Appl Physiol. 2024 May 1;136(5):1245-1259.
Wang DS, Ju L, Pinguelo AG, Kaneshwaran K, Haffey SC, Lecker I, Gohil H, Wheeler MB, Kaustov L, Ariza A, Yu M, Volchuk A, Steinberg BE, Goldenberg NM, Orser BA. Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs. Trans Res. 2024 May:267:39-53.
2023
Kayagaki N, Stowe IB, Alegre K, Deshpande I, Wu S, Lin Z, Kornfeld OS, Lee BL, Zhang J, Liu J, Suto E, Lee WP, Schneider K, Lin W, Seshasayee D, Bhangale T, Chalouni C, Johnson MC, Joshi P, Mossemann J, Zhao S, Ali D, Goldenberg NM, Sayed BA, Steinberg BE, Newton K, Webster JD, Kelly RL, Dixit VM. Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury. Nature 2023 Jun;618(7967):1072-1077.
Foley AE, Sulstarova S, Goldenberg NM. Assessment of HMGB1 Release During Experimentally Induced Pyroptosis. Methods Mol Biol. 2023:2641:189-202.
2022
Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE. Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. eLife 2022 Dec 5:11:e78609.
McVey MJ, Maishan M, Foley A, Turki R, Roach EJ, Deschler R, Weidenfeld S, Goldenberg NM, Khursigara CM, Kuebler WM. Pseudomonas aeruginosa membrane vesicles cause endothelial barrier failure and lung injury. Eur Resp J.
Foley A, Steinberg BE, Goldenberg NM. Inflammasome Activation in Pulmonary Arterial Hypertension. Front Med. 2022 Jan 13:8:826557.
2021
Gai N, Aoyama K, Faraoni D, Goldenberg NM, Levin DN, Mayne JT, McVey MJ, Munshey F, Siddiqui A, Switzer T, Steinberg BE.
General medical publications during COVID-19 show increased dissemination despite lower validation. PLoS One. 16(2):e0246427 (2021).
2020
McVey MJ, Steinberg BE, Goldenberg NM. Inflammasome activation in acute lung injury. Am J Physiol Lung Cell Mol Physiol 320(2):L165-L178 (2020).
Hu Y, Chi L, Kuebler WM, Goldenberg NM. Perivascular Inflammation in Pulmonary Arterial Hypertension. Cells 9(11):2338 (2020).
Ghaffari S, Jang E, Nabi FN, Sanwal R, Khosraviani N, Wang C, Steinberg BE, Goldenberg NM, Ikeda J, Lee WL. Endothelial HMGB1 is a critical regulator of LDL transcytosis via an SREBP2-SR-BI axis. Arterioscler Thromb Vasc Biol. Oct. (2020).
Hu Y, Chi L, Kuebler WM, Goldenberg NM. Perivascular Inflammation in Pulmonary Arterial Hypertension. Cells 9(11), 2338 (2020).
Volchuk A, Ye A, Chi L, Steinberg BE, Goldenberg NM. Indirect Regulation of HMGB1 Release By Gasdermin D. Nature Communications 11:4561 (2020).
Steinberg BE, Aoyama K, McVey M, Levin D, Siddiqui A, Munshey F, Goldenberg NM, Faraoni D, Maynes JT. Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis. Can J Anesth. Jul 27:1-10 (2020).
2019
Ali U, Goldenberg N, Foreman C, Crawford Lynn L, Honjo O, O’Leary J, Faraoni D. Association Between Cyanosis, Transfusion, and Thrombotic Complications in Neonates and Children Undergoing Cardiac Surgery. J Cardiothoracic Vasc Anesth. 2019 July 13.
Fergusson DA, Avey MT, Barron CC et al. Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature. PLoS One. 2019 May 23.
Goldenberg NM, Rabinovitch M, Steinberg BE. The inflammatory basis of pulmonary arterial hypertension: Clinical implications. Anesthesiology. 131(4)898-907 (2019).
Goldenberg NM, Hu Y, Hu X, Volchuk A, Zhao YD, Kucherenko MM, Knosalla C, de Perrot M, Tracey KJ, Al-Abed Y, Steinberg BE, Kuebler WM. Therapeutic targeting of high mobility group box-1 in pulmonary arterial hypertension. Am J Resp Crit Care Med. 199(12):1566-1569 (2019).
Goldenberg NM and Steinberg BE. Inflammation drives pulmonary arterial hypertension. Anesthesiology. 130(5):820-821 (2019).
2018
Sugiyama MG, Raheel H, Mintsopoulos V, Goldenberg NM, et al. Lung ultrasound and microbubbles enhance aminoglycoside efficacy in the lung in E. coli-induced pneumonia and ARDS. Am J Resp Crit Care Med. 198(3):404-408. (2018).
Hu Y, Zabini D, Gu W, Breitling S, Goldenberg NM, Kabir G, Connelly K, Kuebler WM. The role of the human immune system in chronic hypoxic pulmonary hypertension. Am J Resp Crit Care Med. 198(4):528-531 (2018).
2017
Breitling S, Zhang H, Zabini D, Hu Y, Hoffmann J, Goldenberg NM, Buelow R, Kuebler WM. The mast cell – B-cell axis in lung vascular remodeling and pulmonary hypertension. Am J Physiol – Lung. 312(5):L710-L721 (2017)
2016
Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL. Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): A cohort study. CMAJ Open. 4(3):E444-E447 (2016)
Kuebler WM, Wittenberg C, Lee WL, Reppien E, Goldenberg NM, Lindner K, Gao Y, Winoto-Morbach S, Drab M, Mühlfeld C, Dombrowsky H, Ochs M, Schütze S, Uhlig S. Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase. Am J Physiol – Lung. 310(8):L720-L732 (2016)
Yin J, Michalick L, Tang CT, Tabuchi A, Goldenberg NM, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles-Kursar G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke W, Kuppe H, Kuebler WM. Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury. Am J Resp Cell Mol Biol. 54(3):370-83 (2016).
Steinberg BE, Goldenberg NM, Fairn GD, Kuebler WM, Slutsky AS, Lee WL. Is basic science disappearing from medicine? The decline of biomedical research in the medical literature. FASEB J. 30(2):515-528 (2016)
2015
Breitling S, Ravindran K, Goldenberg NM, Kuebler WM. The Pathophysiology of Pulmonary Hypertension in Left Heart Disease. Am J Physiol – Lung. 309(9):L924-41 (2015).
Steinberg BE, Goldenberg NM, Laffey JG. Extracorporeal membrane oxygenation for blastomycosis-related severe ARDS: a new indication as a rescue therapy? Can J Anesth. Apr. 16 (2015).
Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction. Proc Nat Acad Sci. 112(13):E1614-23 (2015).
Goldenberg NM, Steinberg BE, Wijeysundera D, Kavanagh BP. In Reply. Anesthesiology. 122(2):473 (2015).
Goldenberg NM, Wang L, Ranke H, Tabuchi A, Liedtke W, Kuebler WM. TRPV4 is required for hypoxic pulmonary vasoconstriction. Anesthesiology 122(6):1338-48 (2015).
Goldenberg NM, Ravindran K, Kuebler WM. TRPV4: Physiological role and therapeutic potential in respiratory diseases. Naunyn Schmiedeberg Arch Pharmacol. 388(4):421 (2015).
Goldenberg NM and Kuebler WM. Endothelial Cell Regulation of Pulmonary Vascular Tone, Inflammation, and Coagulation. Comprehensive Physiology.5(2):532 (2015).
2014-
Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL. Is Nosocomial Infection Really the Major Cause of Death in Sepsis? Crit Care. 18(5):540 (2014).
Goldenberg NM, Steinberg BE, Wijeysundera D, Kavanagh BP. Lung Protective Ventilation in the Operating Room: Time to Implement? Anesthesiology. 121(1):184-8 (2014).
Goldenberg NM, Hare GM. From the Journal archives: Understanding the mechanism(s) regulating hypoxic pulmonary vasoconstriction: how an early study has led to novel translational approaches. Can J Anesth. 62(2):195-9 (2014).
Steinberg BE, Goldenberg NM, Lee WL. Do viral infections mimic bacterial sepsis? The role of microvascular permeability: A review of mechanisms and methods. Antiviral Research 93(1):2-15 (2012).
Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL. Broken Barriers: A New Take On Sepsis Pathogenesis. Sci. Transl. Med. 3, 86ps22 (2011).
Goldenberg NM, Steinberg BE. Surface Charge: A key determinant of protein localization and function. Cancer Res. 70(4):1277-80 (2010).
Goldenberg NM, Silverman M. Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia. Am J Physiol Cell Physiol. 297(4):C1053-8 (2009).
Plant PJ, Correa J, Goldenberg N, Bain J, Batt J. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase NEDD4. Biochem J. 419(1):57-63 (2009).
Goldenberg NM, Grinstein S, Silverman M. Golgi-bound Rab34 is a novel member of the secretory pathway. Mol Biol Cell. 8(12):4762-4771 (2007).
Ailenberg M, Goldenberg NM, Silverman M. Description of a PCR-based technique for DNA splicing and mutagenesis by producing 5’ overhangs with run through stop DNA synthesis utilizing Ara-C. BMC Biotechnol. 5:23 (2005).