Dr. Dae-Sung Kim – Postdoctoral Fellow, 2012-2015

Dae-Sung Kim received his PhD from Yonsei University, Seoul, Korea in 2009. During his PhD, he was interested in the neural induction mechanisms of vertebrates and the pluripotency of embryonic stem cells, and developed novel methods for neural/neuronal differentiation from human pluripotent stem cells which have been widely used by many research groups. With his speciality in developmental neuroscience, Kim joined the Ellis lab to establish efficient methods for cortical neuron differentiation from Rett syndrome patient-derived induced pluripotent stem cells. In the Ellis lab he worked on elucidating the pathophysiology of Rett syndrome and developing a drug screening platform.

Selected Publications:

Rodrigues D.C., D.-S. Kim, G. Yang, K. Zaslavsky, K.C.H. Ha, R.S.F. Mok, P.J. Ross, M. Zhao, A. Piekna, W. Wei, B.J. Blencowe, Q. Morris and J. Ellis. 2016. MECP2 is post-transcriptionally regulated during human neurodevelopment by combinatorial action of RNA-binding proteins and miRNAs. Cell Reports 17: 720-734.

Kim D.S, P.J. Ross, K. Zaslavsky and J. Ellis. 2014. Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD.  Frontiers in Cellular Neuroscience 8:109.

Kim DS, Lee DR, Kim HS, Yoo JE, Jung SJ, Lim BY, Jang J, Kang HC, You S, Hwang DY, Leem JW, Nam TS, Cho SR, Kim DW. (2012) Highly pure and expandable PSA-NCAM-positive neural precursors from human ESC and iPSC-derived neural rosettes.PLoS One. 7(7):e39715.

Kim DS, Jung SJ, Nam TS, Jeon YH, Lee DR, Lee JS, Leem JW, Kim DW.  (2010) Transplantation of GABAergic neurons from ESCs attenuates tactile hypersensitivity following spinal cord injury. Stem Cells. 28(11):2099-108.

Kang HC*, Kim DS*, Kim JY, Kim HS, Lim BY, Kim HD, Lee JS, Eun BL, Kim DW.  (2010)  Behavioral improvement after transplantation of neural precursors derived from embryonic stem cells into the globally ischemic brain of adolescent rats. Brain & Development.  32(8):658-68.

Kim DS, Lee JS, Leem JW, Huh YJ, Kim JY, Kim HS, Park IH, Daley GQ, Hwang DY, Kim DW.  (2010) Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity. Stem Cell Reviews and Reports. 6(2):270-81.

Kim DS, Kim JY, Kang M, Kang M, Cho MS, Kim DW. (2007) Derivation of functional dopamine neurons from embryonic stem cells. Cell Transplant. 16(2):117-23.