Our Research

Welcome to the Costain Lab! Our Lab uses advanced genetic technologies to facilitate diagnosis and discovery in children with suspected undiagnosed genetic diseases. Priority research populations include children with unexplained medical complexity and severe neurological impairment, and children with genetic or unexplained epilepsy. We are also pioneering new approaches for classifying and interpreting rare genetic variation.

Selected Publications

For a complete list of Costain Lab publications, please visit PubMed.

Funders

Our research would not be possible without the generous support of our funders!

Meet Our Team

Dr. Gregory Costain

Dr. Gregory Costain, MD, PhD

Dr. Costain is a physician-scientist who specializes in the diagnosis of rare genetic conditions in children. He joined the Division of Clinical and Metabolic Genetics at SickKids as a staff physician in 2020 after completing his residency training at the University of Toronto.

He runs the specialized Genetics of Epilepsy and severe Neurological Impairment Clinic (GENIC) at SickKids. He is also a Scientist-Track Investigator in the Genetics and Genome Biology program at SickKids Research Institute, and Assistant Professor at the University of Toronto.

His research program is focused on understanding the causes and consequences of rare variation in the human genome. His lab uses genome sequencing to discover new disease genes and genotype-phenotype associations, in a setting of an undiagnosed paediatric disease program.

Staff

Nicole Liang

Nicole Liang
Genetic Counsellor

Meet Nicole

Madeline Campbell
Clinical Research Project Coordinator

Meet Madeline
Initials D and H

Denese Henry
Administrative Assistant

Meet Denese

Students

Bushra Haque

Bushra Haque

Meet Bushra
Ali Amail

Ali Almail

Meet Ali
Jade Zhang

Jade Zhang

Meet Jade
Amy Pan

Amy Pan

Meet Amy

Alumni

Tayyaba Khan

Tayyaba Khan
Clinical Research Project Coordinator

Meet Tayyaba
Alyssa Joynt

Alyssa Joynt

Meet Alyssa
Wendy Wu

Wendy Wu

Meet Wendy
Meredith Curtis

Meredith Curtis

Meet Meredith

Collaborators

Anna Szuto

Anna Szuto
Genetic Counsellor

Meet Anna

Contact Us

To contact the Costain Lab, fill out the form below!

PGCRL building entrance photo

Address

The Costain Lab
Genetics and Genome Biology Program
SickKids Research Institute
686 Bay Street
Toronto, ON, Canada
M5G 0A4