Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration.
Khazaei S, Chen CCL, Andrade AF, Kabir N, Azarafshar P, Morcos SM, França JA, Lopes M, Lund PJ, Danieau G, Worme S, Adnani L, Nzirorera N, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ, Bryant L, Hébert S, Tong B, Sihota TS, Faury D, Puligandla E, Jawhar W, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam B, Gomes CC, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K, Cocanougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI, Kleinman CL, Garzia L, Jabado N.
Cell (2023) 186(6):1162-1178.e20. doi: 10.1016/j.cell.2023.02.023. PMID: 36931244
CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing.
Kerschbamer E, Arnoldi M, Tripathi T, Pellegrini M, Maturi S, Erdin S, Salviato E, Di Leva F, Sebestyén E, Dassi E, Zarantonello G, Benelli M, Campos E, Basson MA, Gusella JF, Gustincich S, Piazza S, Demichelis F, Talkowski ME, Ferrari F, Biagioli M.
Nucleic Acids Res (2022) 50(22):12809-12828. doi: 10.1093/nar/gkac1134. PMID: 36537238
The in vivo Interaction Landscape of Histones H3.1 and H3.3.
Siddaway R, Milos S, Coyaud É, Yun HY, Morcos SM, Pajovic S, Campos EI, Raught B, Hawkins C.
Mol Cell Proteomics. 2022 Oct;21(10):100411. doi: 10.1016/j.mcpro.2022.100411. PMID: 36089195
Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma.
Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio SG, Vadivel Anguraj AK, Lubanszky E, Yun HY, Portante A, Carette S, Zhang C, Moran MF, Raught B, Campos EI, Hawkins C.
Acta Neuropathol (2022) 144(5):1027-1048. doi: 10.1007/s00401-022-02489-2. PMID: 36070144
Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
McQuaid ME, Ahmed K, Tran S, Rousseau J, Shaheen R, Kernohan KD, Yuki KE, Grover P, Dreseris ES, Ahmed S, Dupuis L, Stimec J, Shago M, Al-Hassnan ZN, Tremblay R, Maass PG, Wilson MD, Grunebaum E, Boycott KM, Boisvert FM, Maddirevula S, Faqeih EA, Almanjomi F, Khan ZU, Alkuraya FS, Campeau PM*, Kannu P*, Campos EI*, Wurtele H*.
JCI Insight (2022) 7(10):e155648. doi: 10.1172/jci.insight.155648. PMID: 35603789
ATRX proximal protein associations boast roles beyond histone deposition.
Scott WA, Dhanji EZ, Dyakov BJA, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras AC, Campos EI.
PLOS Genet (2021) 17(11):e1009909. doi: 10.1371/journal.pgen.1009909. PMID: 34780483
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.
Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC, Taipale M.
Mol Cell (2021) 81(12):2549-2565.e8. doi: 10.1016/j.molcel.2021.04.012. PMID: 33957083
Interactions With Histone H3 & Tools to Study Them.
Scott WA, Campos EI.
Front Cell Dev Biol (2020) doi: 10.3389/fcell.2020.00701. PMID: 32850821
The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.
Tracey LJ, Brooke-Bisschop T, Jansen PWTC, Campos EI, Vermeulen M, Justice MJ.
Mol Cancer Res (2019) 17(7):1468-1479. doi: 10.1158/1541-7786.MCR-18-1327. PMID: 31015254
H3-H4 Histone Chaperone Pathways.
Grover P, Asa JS, Campos EI.
Annu Rev Genet (2018) 52:109-130. doi: 10.1146/annurev-genet-120417-031547. PMID: 30183406
A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. Ho TH, Sitz J, Shen Q, Leblanc-Lacroix A, Campos EI, Borozan I, Marcon E, Greenblatt J, Fradet-Turcotte A, Jin DY, Frappier L.
J Virol (2018) 92(14):e00262-18. doi: 10.1128/JVI.00262-18. PMID: 29743367
