On the fundamental research side, the Adeli Lab’s focus is on molecular and physiological mechanisms that control metabolic and cardiovascular health as well as disease, with a focus on lipid and lipoprotein metabolism. Our main aim is to elucidate the role of the gut-brain-liver axis in controlling lipid metabolism in healthy states and metabolic disease states, such as obesity, prediabetes, and type 2 diabetes.
The clinical side of the Adeli Lab carries out clinically-oriented studies in collaboration with a number of programs across SickKids and other hospitals in Canada. Our main focus is on the CALIPER program, with the goal of establishing a comprehensive database of paediatric reference intervals for laboratory biomarkers of health and disease.