{"id":6,"date":"2016-01-26T17:09:44","date_gmt":"2016-01-26T17:09:44","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/zani\/?page_id=6"},"modified":"2021-07-09T16:14:22","modified_gmt":"2021-07-09T16:14:22","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/zani\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1331.2px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1 fusion-animated\" data-animationType=\"fadeInDown\" data-animationDuration=\"1.0\" data-animationOffset=\"top-into-view\"><h1 class=\"fusion-responsive-typography-calculated\" style=\"line-height: 1.67;\" data-fontsize=\"34\" data-lineheight=\"56.78px\"><strong>Research in the Zani Lab<\/strong><\/h1>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-2 fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"top-into-view\"><p style=\"text-align: left; font-size: 20px; color: #000000;\" data-fusion-font=\"true\">Our mission is to use extracellular vesicles as therapeutic and diagnostic tools for fetal, neonatal, and paediatric conditions.<\/p>\n<p style=\"text-align: left;\">Extracellular vesicles (EVs) are highly stable membrane-bound nanoparticles that are released by all cells and mediate intercellular communication. They are powerful tools, as they carry bioactive cargo in the form of genetic material (RNA and DNA), proteins, and lipids.<\/p>\n<\/div><div class=\"fusion-text fusion-text-3 fusion-animated\" data-animationType=\"fadeInUp\" data-animationDuration=\"1.0\" data-animationOffset=\"top-into-view\"><h2 style=\"color: #de4561;\" data-fusion-font=\"true\"><span style=\"color: #000000;\">Extracellular vesicles for therapy<\/span><\/h2>\n<p>The Zani Lab is investigating EVs as therapeutic agents for a birth defect, Congenital Diaphragmatic Hernia.<\/p>\n<h2 style=\"color: #de4561;\"><span style=\"color: #000000;\">Extracellular vesicles as biomarkers<\/span><\/h2>\n<p data-fontsize=\"16\" data-lineheight=\"25.6px\">We are also interested in testing cargos that EVs carry from their cells of origin as a diagnostic tool for clinical conditions.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-4\"><p style=\"font-size: 20px; color: #000000;\" data-fontsize=\"24\" data-lineheight=\"40.08px\" data-fusion-font=\"true\">Watch our video describing the first use of exosomes as fetal therapy using animal models and human lung cells:<\/p>\n<\/div><div class=\"fusion-video fusion-youtube\" style=\"--awb-max-width:600px;--awb-max-height:360px;--awb-align-self:center;--awb-width:100%;\"><div class=\"video-shortcode\"><div class=\"fluid-width-video-wrapper\" style=\"padding-top:60%;\" ><iframe title=\"YouTube video player 1\" src=\"https:\/\/www.youtube.com\/embed\/0PU0jgbSMKY?wmode=transparent&autoplay=0\" width=\"600\" height=\"360\" allowfullscreen allow=\"autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture;\"><\/iframe><\/div><\/div><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;flex-grow:2;margin-top:15px;margin-bottom:15px;width:100%;\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Zani Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/zani\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/zani\/\" \/>\n<meta property=\"og:site_name\" content=\"Zani Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-09T16:14:22+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/zani\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/zani\/\",\"name\":\"Home - 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