Selected publications<\/strong><\/h1>\n\n- Modeling CF Patient-Specific Responses to CFTR Modulators Using Human Induced Pluripotent Stem Cells. <\/a><\/strong>Kanagarajah KR, Wu MJM, Lam T, Quach H, Salih R, Antonio K, Moraes TJ, Ratjen F, Bear CE, Wong AP.<\/span>Am J Respir Crit Care Med. 2025 Jun 23. doi: 10.1164\/rccm.202502-0467RL. Online ahead of print.<\/span>PMID:<\/span>\u00a0<\/span>40548910<\/span>\u00a0<\/span>No abstract available.<\/span><\/div><\/div><\/div><\/div><\/em>Il-6 knockout reduces doxorubicin-induced toxicity in the developing mouse brain. <\/strong><\/a>Yeung J, Quach H, Wong AP, Wheeler AL, Weksberg R, Guger SL, Schachar RJ, Ito S, Hitzler J, Nieman BJ. Brain Behav Immun. 2025 Jun 28;129:609-619. doi: 10.1016\/j.bbi.2025.06.034. Online ahead of print. PMID: 40588079 <\/div><\/div><\/div><\/div><\/em><\/li>\n
- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.<\/strong><\/a> Quach H, Farrell S, Wu MJM, Kanagarajah KR, Leung JWH, Xu X, Kallurkar P, Turinsky AL, Bear CE, Ratjen F, Kalish B, Goyal S, Moraes, TJ, Wong AP. <\/span>Nat Commun. 2024 Jul 13;15(1):5898.<\/div><\/div><\/div><\/div><\/em><\/li>\n
- Collagen Tubular Airway-on-Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics.<\/a><\/strong> Gao W, Kanagarajah KR, Graham E, Soon K, Veres T, Moraes TJ, Bear CE, Veldhuizen RA, Wong AP, G\u00fcnther A. Small. 2024 Mar 3:e2309270.
\n<\/div><\/div><\/div><\/div><\/em><\/li>\n- Tunable In Situ Synthesis of Ultra-Thin Extracellular Matrix-Derived Membranes.<\/a> <\/strong>Newton J, Song Y, Park S, Kanagarajah K, Wong AP, Young EWK. (2024). Advanced Health Materials. 2024 Apr 8:e2401158.
\n<\/span><\/div><\/div><\/div><\/div><\/em><\/b><\/li>\n- \nTargeting Protein Homeostasis with Small Molecules as a Strategy for the Development of Pan-Coronavirus Antiviral Therapies<\/a>.<\/strong> Mao YQ, Jahanshahi S, Malty R, Van Ommen DAJ, Wan Y, Chuang S, Pavlova V, Ahmed C, Dahal S, Lin F, Mangos M, Nurtanto J, Song Y, Been T, Christie-Holmes N, Gray-Owen SD, Babu M, Wong AP, Batey RA, Attisano L, Cochrane A, and Houry WA. (2024). NPJ Communications Biology. 7(1): 1460.<\/div>\n<\/div><\/div><\/div><\/div><\/em><\/div>\n<\/li>\n
- \nA cell-based optimized approach for rapid and efficient gene-editing of human pluripotent stem cells.<\/a><\/strong> Cuevas-Ocana S, Yang JY, Aushev M, Schlossmacher G, Bear CE, Perkins ND, Rossant J, Wong AP, Gray MA. Int J Mol ^<\/span><\/span>Sci. 2023 Jun 17;24(12):10266.
\n<\/div><\/div><\/div><\/div>\n<\/em><\/div>\n<\/li>\n- A novel method for detection of A Cas9 gRNAs using a fluorophore-labeled DNA oligo.<\/a> <\/strong>Bandara RA, Zhou ZP, Chen RZ, Duan R, Davidson A, Wong AP, Hu J. (2025). <\/span>Accepted Genes & Diseases. <\/span><\/div><\/div><\/div><\/div><\/em>
\n<\/span><\/li>\n- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity. <\/a><\/b>Quach HT*, Farrell S*, Kanagarajah KR, Wu M, Xu X, Kallurkar P, Turinsky A, Bear C, Ratjen F, Goyal S, <\/span>Mores TJ, Wong AP. (2023). bioRxiv 2023.10.27.564403 *Equal contribution
\n<\/div><\/div><\/div><\/div><\/em><\/span><\/span><\/b><\/li>\n- Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.<\/a><\/b> Ngan SY, Quach HT, Laselva O, Huang EN, Mangos M, Xia S, Bear CE, Wong AP (2022). Current Protocols<\/i>, 2(1), e341
\n<\/div><\/div><\/div><\/div><\/em><\/li>\n- A developmental role of CFTR in cystic fibrosis lung disease pathogenesis<\/strong><\/a>. Huang EN*, Quach HT*, Lee J, Dierolf JG, Moraes TJ, Wong AP. Frontiers in Cell and Developmental Biology<\/em>. (2021). Oct 11;9:742891.*<\/b>Equal contribution <\/div><\/div><\/div><\/div><\/em><\/li>\n
- Gene therapy for cystic fibrosis: New tools for precision medicine<\/strong><\/a>. <\/span>Lee J, Cho A*, Huang EN*, Xu Y, Quach HT, Hu J, <\/span>Wong AP<\/span>. <\/span>Journal of Translational Medicine<\/em>. (2021). Oct 30;19(1):452. <\/div><\/div><\/div><\/div><\/em><\/i><\/span><\/li>\n
- Modelling lung cell development using human pluripotent stem cells.<\/a> <\/span><\/strong>Ngan SY*, Quach HT*, Dierolf JG, Laselva O, Lee J, Huang EN, Mangos M, Xia S, <\/span>Wong AP<\/span>. <\/span>(2021). bioRxiv<\/em> 2021.07.16.452691 *Equal contribution <\/div><\/div><\/div><\/div><\/em><\/i><\/span><\/li>\n
- A new platform for high-throughput therapy testing on iPSC-derived, lung progenitor cells from Cystic Fibrosis Patients.<\/a><\/strong> Stem Cell Reports. <\/span>Jiang JX, Wellhauser L, Laselva O, Utkina I, Bozoky Z, Gunawardena T, Ngan SY, Xia S, Eckford P, Ratjen F, Moraes TJ, Parkinson J, <\/span>Wong AP<\/span> and Bear CE. <\/span>(2021).<\/span> Stem Cell Reports.<\/em> 2021 Oct 12. <\/div><\/div><\/div><\/div><\/em><\/i><\/span><\/li>\n
- Conversion of human and mouse fibroblasts into lung-like epithelial cells.<\/a><\/strong> Wong AP, Shojaie S, Liang Q, Xia S, Di Paola M, Ahmadi S, Bilodeau C, Garner J, Post M, Duchesneau P, Waddell TK, Bear CE, Nagy A, Rossant J. Sci Rep<\/span><\/em>. 2019 Jun 21;9(1):9027.<\/div><\/div><\/div><\/div><\/em><\/li>\n
- The CF Canada-SickKids Program in Individual CF Therapy: A Resource for the <\/strong>Advancement of Personalized Medicine in CF.<\/strong><\/a> Eckford PW, McCormack J, Munsie L, He G, Stanojevic S, Pereira S, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang J, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. Journal of Cystic Fibrosis 2018 Apr 20 <\/em>S1569-1993(18)30086-9.<\/div><\/div><\/div><\/div><\/em><\/li>\n
- Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia<\/a>. <\/strong>Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski S, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. NPJ Genom Med. <\/em>2017 Apr 14;2:12.
<\/div>
<\/div><\/div>
<\/div><\/em>Il-6 knockout reduces doxorubicin-induced toxicity in the developing mouse brain. <\/strong><\/a>Yeung J, Quach H, Wong AP, Wheeler AL, Weksberg R, Guger SL, Schachar RJ, Ito S, Hitzler J, Nieman BJ. Brain Behav Immun. 2025 Jun 28;129:609-619. doi: 10.1016\/j.bbi.2025.06.034. Online ahead of print. PMID: 40588079
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.<\/strong><\/a> Quach H, Farrell S, Wu MJM, Kanagarajah KR, Leung JWH, Xu X, Kallurkar P, Turinsky AL, Bear CE, Ratjen F, Kalish B, Goyal S, Moraes, TJ, Wong AP. <\/span>Nat Commun. 2024 Jul 13;15(1):5898.
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- Collagen Tubular Airway-on-Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics.<\/a><\/strong> Gao W, Kanagarajah KR, Graham E, Soon K, Veres T, Moraes TJ, Bear CE, Veldhuizen RA, Wong AP, G\u00fcnther A. Small. 2024 Mar 3:e2309270.
\n
\n
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- Tunable In Situ Synthesis of Ultra-Thin Extracellular Matrix-Derived Membranes.<\/a> <\/strong>Newton J, Song Y, Park S, Kanagarajah K, Wong AP, Young EWK. (2024). Advanced Health Materials. 2024 Apr 8:e2401158.
\n<\/span>
\n<\/span>
<\/div>
<\/div><\/div>
<\/div><\/em><\/b><\/li>\n- \n
Targeting Protein Homeostasis with Small Molecules as a Strategy for the Development of Pan-Coronavirus Antiviral Therapies<\/a>.<\/strong> Mao YQ, Jahanshahi S, Malty R, Van Ommen DAJ, Wan Y, Chuang S, Pavlova V, Ahmed C, Dahal S, Lin F, Mangos M, Nurtanto J, Song Y, Been T, Christie-Holmes N, Gray-Owen SD, Babu M, Wong AP, Batey RA, Attisano L, Cochrane A, and Houry WA. (2024). NPJ Communications Biology. 7(1): 1460.<\/div>\n
<\/div>
<\/div><\/div>
<\/div><\/em><\/div>\n<\/li>\n- \n
A cell-based optimized approach for rapid and efficient gene-editing of human pluripotent stem cells.<\/a><\/strong> Cuevas-Ocana S, Yang JY, Aushev M, Schlossmacher G, Bear CE, Perkins ND, Rossant J, Wong AP, Gray MA. Int J Mol ^<\/span><\/span>Sci. 2023 Jun 17;24(12):10266.
\n
\n
<\/div>
<\/div><\/div>
<\/div>\n<\/em><\/div>\n<\/li>\n- A novel method for detection of A Cas9 gRNAs using a fluorophore-labeled DNA oligo.<\/a> <\/strong>Bandara RA, Zhou ZP, Chen RZ, Duan R, Davidson A, Wong AP, Hu J. (2025). <\/span>Accepted Genes & Diseases. <\/span>
<\/div>
<\/div><\/div>
<\/div><\/em>
\n<\/span><\/li>\n- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity. <\/a><\/b>Quach HT*, Farrell S*, Kanagarajah KR, Wu M, Xu X, Kallurkar P, Turinsky A, Bear C, Ratjen F, Goyal S, <\/span>Mores TJ, Wong AP. (2023). bioRxiv 2023.10.27.564403 *Equal contribution
\n
\n<\/span><\/li>\n
\n
<\/div>
<\/div><\/div>
<\/div><\/em><\/span><\/span><\/b><\/li>\n- Stage-Specific Generation of Human Pluripotent Stem Cell Derived Lung Models to Measure CFTR Function.<\/a><\/b> Ngan SY, Quach HT, Laselva O, Huang EN, Mangos M, Xia S, Bear CE, Wong AP (2022). Current Protocols<\/i>, 2(1), e341
\n
\n
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- A developmental role of CFTR in cystic fibrosis lung disease pathogenesis<\/strong><\/a>. Huang EN*, Quach HT*, Lee J, Dierolf JG, Moraes TJ, Wong AP. Frontiers in Cell and Developmental Biology<\/em>. (2021). Oct 11;9:742891.*<\/b>Equal contribution
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- Gene therapy for cystic fibrosis: New tools for precision medicine<\/strong><\/a>. <\/span>Lee J, Cho A*, Huang EN*, Xu Y, Quach HT, Hu J, <\/span>Wong AP<\/span>. <\/span>Journal of Translational Medicine<\/em>. (2021). Oct 30;19(1):452.
<\/div>
<\/div><\/div>
<\/div><\/em><\/i><\/span><\/li>\n- Modelling lung cell development using human pluripotent stem cells.<\/a> <\/span><\/strong>Ngan SY*, Quach HT*, Dierolf JG, Laselva O, Lee J, Huang EN, Mangos M, Xia S, <\/span>Wong AP<\/span>. <\/span>(2021). bioRxiv<\/em> 2021.07.16.452691 *Equal contribution
<\/div>
<\/div><\/div>
<\/div><\/em><\/i><\/span><\/li>\n- A new platform for high-throughput therapy testing on iPSC-derived, lung progenitor cells from Cystic Fibrosis Patients.<\/a><\/strong> Stem Cell Reports. <\/span>Jiang JX, Wellhauser L, Laselva O, Utkina I, Bozoky Z, Gunawardena T, Ngan SY, Xia S, Eckford P, Ratjen F, Moraes TJ, Parkinson J, <\/span>Wong AP<\/span> and Bear CE. <\/span>(2021).<\/span> Stem Cell Reports.<\/em> 2021 Oct 12.
<\/div>
<\/div><\/div>
<\/div><\/em><\/i><\/span><\/li>\n- Conversion of human and mouse fibroblasts into lung-like epithelial cells.<\/a><\/strong> Wong AP, Shojaie S, Liang Q, Xia S, Di Paola M, Ahmadi S, Bilodeau C, Garner J, Post M, Duchesneau P, Waddell TK, Bear CE, Nagy A, Rossant J. Sci Rep<\/span><\/em>. 2019 Jun 21;9(1):9027.
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- The CF Canada-SickKids Program in Individual CF Therapy: A Resource for the <\/strong>Advancement of Personalized Medicine in CF.<\/strong><\/a> Eckford PW, McCormack J, Munsie L, He G, Stanojevic S, Pereira S, Ho K, Avolio J, Bartlett C, Yang JY, Wong AP, Wellhauser L, Huan LJ, Jiang J, Ouyang H, Du K, Klingel M, Kyriakopoulou L, Gonska T, Moraes TJ, Strug LJ, Rossant J, Ratjen F, Bear CE. Journal of Cystic Fibrosis 2018 Apr 20 <\/em>S1569-1993(18)30086-9.
<\/div>
<\/div><\/div>
<\/div><\/em><\/li>\n- Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia<\/a>. <\/strong>Ahmadi S, Bozoky Z, Di Paola M, Xia S, Li C, Wong AP, Wellhauser L, Molinski S, Ip W, Ouyang H, Avolio J, Forman-Kay JD, Ratjen F, Hirota JA, Rommens J, Rossant J, Gonska T, Moraes TJ, Bear CE. NPJ Genom Med. <\/em>2017 Apr 14;2:12.