{"id":30,"date":"2015-11-02T21:11:07","date_gmt":"2015-11-02T21:11:07","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/wheeler\/?page_id=30"},"modified":"2022-08-09T16:29:47","modified_gmt":"2022-08-09T20:29:47","slug":"research","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/wheeler\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1553273429788{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 25px !important;padding-right: 25px !important;padding-bottom: 25px !important;padding-left: 25px !important;background-color: #ffffff !important;}&#8221;]<\/p>\n<h1 style=\"text-align: left\"><\/h1>\n<h5><span style=\"color: #818a8f\">Brain regions are connected by axons in white matter tracts so that activity in one region affects all connected regions and behaviour and cognition emerge from these complex network interactions. Our research focuses on using brain-wide structural and functional imaging in patients and in animal models to examine brain connectivity and how changes in connectivity driven by development, learning and injury affect behaviour and cognition.\u00a0<\/span><\/h5>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;26px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1513113562921{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 10px !important;padding-right: 10px !important;padding-bottom: 10px !important;padding-left: 10px !important;}&#8221;]<\/p>\n<h2 style=\"text-align: center\"><span style=\"color: #007791\">THEMES OF OUR RESEARCH INCLUDE<\/span><\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;12px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-ddacc296fc18afbc5c6b8fdf1c815231.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-ddacc296fc18afbc5c6b8fdf1c815231.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-ddacc296fc18afbc5c6b8fdf1c815231 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-ddacc296fc18afbc5c6b8fdf1c815231 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-ddacc296fc18afbc5c6b8fdf1c815231 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/IMG_20141021_234010-300x300.jpg\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/IMG_20141021_234010-300x300.jpg 300w, https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/IMG_20141021_234010-600x600.jpg 600w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/wheeler\/research\/img_20141021_234010\/\" style=\"--ratio: 300 \/ 300;\" alt=\"A young child in a park walking towards trees\" \/><\/div><\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;.vc_custom_1553273567199{margin-top: 40px !important;margin-right: 1px !important;margin-bottom: 10px !important;margin-left: 1px !important;padding-top: 10px !important;padding-right: 10px !important;padding-bottom: 10px !important;padding-left: 10px !important;background-color: #ffffff !important;}&#8221;]<\/p>\n<h4 style=\"text-align: left\"><span style=\"color: #00afd8\">VULNERABLE PERIODS OF NEURODEVELOPMENT<\/span><\/h4>\n<p style=\"text-align: left\"><span style=\"color: #818a8f\">Injury to the\u00a0immature brain can impact neurodevelopmental processes that are undergoing maturation during this time, resulting in unique functional consequences. This research aims to identify how the timing of the injury relative to neurodevelopmental processes affects specific aspects of long-term outcome.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-44d338e1ec6f80836076f463879e3aff.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-44d338e1ec6f80836076f463879e3aff.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-44d338e1ec6f80836076f463879e3aff .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-44d338e1ec6f80836076f463879e3aff .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-44d338e1ec6f80836076f463879e3aff alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/Screen-Shot-2016-02-05-at-2.23.13-PM-e1454700573656-300x300.png\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/Screen-Shot-2016-02-05-at-2.23.13-PM-e1454700573656-300x300.png 300w, https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2015\/11\/Screen-Shot-2016-02-05-at-2.23.13-PM-e1454700573656-600x600.png 600w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/wheeler\/research\/screen-shot-2016-02-05-at-2-23-13-pm\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Tractography of four white matter tracts. Two frontal tracts, one cerebrospinal tract emerging from the spinal cord, and corpus clausal fibres displayed on the outline of a brain\" \/><\/div><\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;.vc_custom_1553273605100{margin-top: 30px !important;margin-right: 1px !important;margin-bottom: 10px !important;margin-left: 1px !important;padding-top: 10px !important;padding-right: 10px !important;padding-bottom: 10px !important;padding-left: 10px !important;background-color: #ffffff !important;}&#8221;]<\/p>\n<h4><span style=\"color: #00afd8\">CIRCUITS THAT SUPPORT COGNITION IN THE HEALTHY &amp; INJURED BRAIN<\/span><\/h4>\n<p><span style=\"color: #818a8f\">The healthy and injured brain may be able to support equivalent cognitive processes in unique ways. This research aims to identify brain networks that support cognitive processes and how they are different in the injured brain.<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1452705265829{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;border-left-width: 0px !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;}&#8221;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-7dc271ac5271dab04ec70b84da0517f2.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-7dc271ac5271dab04ec70b84da0517f2.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-7dc271ac5271dab04ec70b84da0517f2 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-7dc271ac5271dab04ec70b84da0517f2 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-7dc271ac5271dab04ec70b84da0517f2 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:500px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20437%20437&#39;%2F%3E\" data-src=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2016\/01\/Screen-Shot-2016-01-11-at-9.38.30-AM-e1452523221448.png\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/wheeler\/wp-content\/uploads\/sites\/18\/2016\/01\/Screen-Shot-2016-01-11-at-9.38.30-AM-e1452523221448.png 437w\" loading=\"eager\" sizes=\"(max-width: 437px) 100vw, 437px\" width=\"437\" height=\"437\"  data-dt-location=\"https:\/\/lab.research.sickkids.ca\/wheeler\/screen-shot-2016-01-11-at-9-38-30-am\/\" style=\"--ratio: 437 \/ 437;\" alt=\"An image of an MRI of a mouse brain\" \/><\/div><\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;.vc_custom_1553273649325{margin-top: 40px !important;margin-right: 1px !important;margin-bottom: 10px !important;margin-left: 1px !important;padding-top: 10px !important;padding-right: 10px !important;padding-bottom: 10px !important;padding-left: 10px !important;background-color: #ffffff !important;}&#8221;]<\/p>\n<h4><span style=\"color: #00afd8\">WHITE MATTER PLASTICITY<\/span><\/h4>\n<p><span style=\"color: #818a8f\">The majority of research on the brain&#8217;s ability to change (plasticity) is focused on synapses, the connection points between brain cells. Myelin, the fatty substance that insulates and supports axons is dynamic and can also modify brain networks. This research probes the role of white matter plasticity in recovery from injury as well as healthy brain function.<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1553273429788{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 25px !important;padding-right: 25px !important;padding-bottom: 25px !important;padding-left: 25px !important;background-color: #ffffff !important;}&#8221;] Brain regions are connected by axons in white matter tracts so that activity in one region affects all connected regions and behaviour and cognition emerge from these complex network interactions. Our research focuses on using&hellip;<\/p>\n","protected":false},"author":60,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-30","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Research - BRANCH Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/wheeler\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1553273429788{margin-top: 10px !important;margin-right: 10px !important;margin-bottom: 10px !important;margin-left: 10px !important;padding-top: 25px !important;padding-right: 25px !important;padding-bottom: 25px !important;padding-left: 25px !important;background-color: #ffffff !important;}&#8221;] Brain regions are connected by axons in white matter tracts so that activity in one region affects all connected regions and behaviour and cognition emerge from these complex network interactions. 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