{"id":9,"date":"2015-09-30T15:26:50","date_gmt":"2015-09-30T15:26:50","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/trimble\/?page_id=9"},"modified":"2024-12-30T19:49:19","modified_gmt":"2024-12-30T19:49:19","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/trimble\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<code class=\"rs-example-alias-1\">\n\t\t\t<!-- START Home REVOLUTION SLIDER 6.7.38 --><p class=\"rs-p-wp-fix\"><\/p>\n\t\t\t<rs-module-wrap id=\"rev_slider_1_1_wrapper\" data-source=\"gallery\" style=\"visibility:hidden;background:transparent;padding:0;margin:0px auto;margin-top:0;margin-bottom:0;\">\n\t\t\t\t<rs-module id=\"rev_slider_1_1\" style=\"\" data-version=\"6.7.38\">\n\t\t\t\t\t<rs-slides style=\"overflow: hidden; position: absolute;\">\n\t\t\t\t\t\t<rs-slide style=\"position: absolute;\" data-key=\"rs-5\" data-title=\"Slide\" 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data-height-mobile=\"10\" data-height-tab=\"10\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div>[vc_column_text]<\/p>\n<h2 style=\"text-align: center;\">Trimble Lab\u00a0 |\u00a0 Cell &amp; Systems Biology<\/h2>\n<p>[\/vc_column_text]<div class=\"ult-spacer spacer-69de4ed53a912\" data-id=\"69de4ed53a912\" data-height=\"10\" data-height-mobile=\"10\" data-height-tab=\"10\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div>[\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;]<section class=\"shortcode-teaser img-full frame-on\"><div class=\"layzr-bg shortcode-teaser-img\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 325 325&#039;%2F%3E\" width=\"325\" height=\"325\" alt=\"Photo of Dr. William Trimble\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/Bill_crop2.png 325w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/Bill_crop2.png\" \/><\/div><div class=\"shortcode-teaser-content text-big\"><p><a href=\"https:\/\/lab.research.sickkids.ca\/trimble\/people\/bill-trimble\/\">Dr. William Trimble<\/a><\/p>\n<p><span style=\"color: #000000;\">Canada Research Chair in Molecular Cell Biology<\/span><\/p>\n<p><span style=\"color: #000000;\">Senior Scientist \u2013 Cell &amp; Systems Biology<\/span><\/p>\n<p><span style=\"color: #000000;\">Professor \u2013 Department of Biochemistry,<\/span><br \/>\n<span style=\"color: #000000;\"> University of Toronto<\/span><\/p>\n<p><span style=\"color: #000000;\">416-813-6889<\/span><\/p>\n<p><a href=\"mailto:william.trimble@sickkids.ca\"><span style=\"color: #0000ff;\">william.trimble@sickkids.ca<\/span><\/a><\/p>\n<p><span style=\"color: #000000;\">\u00a0<\/span><\/p>\n<\/div><\/section>[\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<span style=\"color: #000000\">Using multidisciplinary approaches involving biochemistry, molecular and cell biology, the Trimble Lab&#8217;s\u00a0overarching aim is to investigate the mechanisms by which membranes and the cytoskeleton interact to control complex cellular processes. <\/span><\/p>\n<p><span style=\"color: #000000\">One area of focus involves the study of the septin family of cytoskeletal proteins and their roles as signaling platforms to control cellular activities such as cell division, cell migration and the development of cancer.<\/span><\/p>\n<p><span style=\"color: #000000\">A second area involves the study of membrane and cytoskeletal proteins implicated in the formation of the primary cilium, and their possible roles in cell and tissue polarity. <\/span><\/p>\n<p><span style=\"color: #000000\">Thirdly, we investigate how specific membrane proteins, such as the scavenger receptors CD36 and SR-B1, transport lipid into cells. <\/span><\/p>\n<p><span style=\"color: #000000\">Finally, we study the SNARE proteins that mediate membrane fusion and their regulators such as the AAA ATPase NSF, particularly in the context of neurotransmitter release.<\/span><\/p>\n<p><span style=\"color: #000000\">\u00a0<\/span>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243;]<section class=\"shortcode-teaser img-full frame-on\"><div class=\"layzr-bg shortcode-teaser-img\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 547 729&#039;%2F%3E\" width=\"547\" height=\"729\" alt=\"photo of Peter Gilgan Centre for Research and Learning\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2016\/10\/1016353-Wordpress-e1475515778805.jpg 547w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2016\/10\/1016353-Wordpress-e1475515778805.jpg\" \/><\/div><div class=\"shortcode-teaser-content text-big\"><p><span style=\"color: #000000\">Peter Gilgan Centre for Research and Learning<\/span><\/p>\n<p style=\"text-align: left\"><span style=\"color: #000000\">686 Bay Street<\/span><br \/>\n<span style=\"color: #000000\"> Toronto, ON<\/span><br \/>\n<span style=\"color: #000000\"> M5G 0A4<\/span><\/p>\n<\/div><\/section>[\/vc_column][\/vc_row][vc_row][vc_column]<div class=\"ult-spacer spacer-69de4ed53af8c\" data-id=\"69de4ed53af8c\" data-height=\"50\" data-height-mobile=\"50\" data-height-tab=\"50\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div><div class=\"hr-thin style-line\" style=\"width: 100%;border-top-width: 1px;\"><\/div>[\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/3&#8243;][vc_column_text]<span style=\"color: #000000\">Contact us:<\/span><\/p>\n<p><strong><span style=\"color: #000000\">Rashna Irani<\/span><\/strong><\/p>\n<p><span style=\"color: #000000\">Administrative Coordinator<br \/>\n<\/span><\/p>\n<p><span style=\"color: #000000\">SickKids Research Institute<\/span><\/p>\n<p><span style=\"color: #000000\">Peter Gilgan Centre for Research and Learning<\/span><\/p>\n<p><span style=\"color: #000000\">686 Bay Street, Room 19.9800<\/span><\/p>\n<p><span style=\"color: #000000\">Toronto, ON M5G 0A4<br \/>\n<\/span><\/p>\n<p><span style=\"color: #000000\">Phone: 416-813-5727<\/span><\/p>\n<p><a href=\"mailto:rashna.irani@sickkids.ca\"><span style=\"color: #0000ff\">rashna.irani@sickkids.ca<\/span><\/a>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][vc_column_text]&nbsp;<\/p>\n<p><span style=\"color: #000000\">Our Funding Partners<\/span>[\/vc_column_text]<div class=\"ult-spacer spacer-69de4ed53afb4\" data-id=\"69de4ed53afb4\" data-height=\"6\" data-height-mobile=\"6\" data-height-tab=\"6\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div><section class=\"shortcode-teaser img-full\"><div class=\"shortcode-teaser-img\"><a class=\"layzr-bg rollover\" href=\"http:\/\/www.cihr-irsc.gc.ca\/e\/193.html\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 381 238&#039;%2F%3E\" width=\"381\" height=\"238\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CIHR-IRSC-Logo.jpg 381w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CIHR-IRSC-Logo.jpg\" \/><\/a><\/div><div class=\"shortcode-teaser-content text-big\"><\/div><\/section>[\/vc_column][vc_column width=&#8221;1\/6&#8243;]<div class=\"ult-spacer spacer-69de4ed53b1ef\" data-id=\"69de4ed53b1ef\" data-height=\"100\" data-height-mobile=\"100\" data-height-tab=\"100\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div><section class=\"shortcode-teaser img-full\"><div class=\"shortcode-teaser-img\"><a class=\"layzr-bg rollover\" href=\"http:\/\/www.innovation.ca\/\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 800 500&#039;%2F%3E\" width=\"800\" height=\"500\" alt=\"logo for Canadian Foundation for Innovation\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CFI_3.png 800w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CFI_3.png\" \/><\/a><\/div><div class=\"shortcode-teaser-content text-big\"><\/div><\/section>[\/vc_column][vc_column width=&#8221;1\/6&#8243;]<div class=\"ult-spacer spacer-69de4ed53b41e\" data-id=\"69de4ed53b41e\" data-height=\"100\" data-height-mobile=\"100\" data-height-tab=\"100\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div><section class=\"shortcode-teaser img-full\"><div class=\"shortcode-teaser-img\"><a class=\"layzr-bg rollover\" href=\"http:\/\/www.nserc-crsng.gc.ca\/index_eng.asp\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 400 250&#039;%2F%3E\" width=\"400\" height=\"250\" alt=\"logo for The Natural Sciences and Engineering Research\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/NSERC_2.png 400w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/NSERC_2.png\" \/><\/a><\/div><div class=\"shortcode-teaser-content text-big\"><\/div><\/section>[\/vc_column][vc_column width=&#8221;1\/6&#8243;]<div class=\"ult-spacer spacer-69de4ed53b650\" data-id=\"69de4ed53b650\" data-height=\"100\" data-height-mobile=\"100\" data-height-tab=\"100\" data-height-tab-portrait=\"\" data-height-mobile-landscape=\"\" style=\"clear:both;display:block;\"><\/div><section class=\"shortcode-teaser img-full\"><div class=\"shortcode-teaser-img\"><a class=\"layzr-bg rollover\" href=\"http:\/\/www.chairs-chaires.gc.ca\/home-accueil-eng.aspx\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 400 250&#039;%2F%3E\" width=\"400\" height=\"250\" alt=\"logo for Canada Research Chairs\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CRC_2.png 400w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/CRC_2.png\" \/><\/a><\/div><div class=\"shortcode-teaser-content text-big\"><\/div><\/section>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text] Trimble Lab\u00a0 |\u00a0 Cell &amp; Systems Biology [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Using multidisciplinary approaches involving biochemistry, molecular and cell biology, the Trimble Lab&#8217;s\u00a0overarching aim is to investigate the mechanisms by which membranes and the cytoskeleton interact to control complex cellular processes. One area of focus involves the study of the septin family of cytoskeletal proteins and&hellip;<\/p>\n","protected":false},"author":47,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Trimble Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/trimble\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text] Trimble Lab\u00a0 |\u00a0 Cell &amp; Systems Biology [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]Using multidisciplinary approaches involving biochemistry, molecular and cell biology, the Trimble Lab&#8217;s\u00a0overarching aim is to investigate the mechanisms by which membranes and the cytoskeleton interact to control complex cellular processes. 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