{"id":248,"date":"2015-11-03T23:42:47","date_gmt":"2015-11-03T23:42:47","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/trimble\/?page_id=248"},"modified":"2015-11-10T01:12:53","modified_gmt":"2015-11-10T01:12:53","slug":"lipid-transport-via-scavenger-receptors","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/trimble\/research-2-2\/lipid-transport-via-scavenger-receptors\/","title":{"rendered":"Scavenger Receptors"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<section class=\"shortcode-teaser img-full frame-on\"><div class=\"layzr-bg shortcode-teaser-img\"><img loading=\"lazy\" decoding=\"async\" class=\"lazy-load\" src=\"data:image\/svg+xml;charset=utf-8,%3Csvg xmlns%3D&#039;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#039; viewBox%3D&#039;0 0 240 240&#039;%2F%3E\" width=\"240\" height=\"240\" alt=\"CGI showing scavenger receptor (transparent) and tunnel in yellow\" data-srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/Lipid-Transport2.png 240w\" data-src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/11\/Lipid-Transport2.png\" \/><\/div><div class=\"shortcode-teaser-content text-big\"><p><span style=\"color: #000000\">Space-filling model of SR-B1 with cholesterol molecules (orange) traversing the hydrophobic tunnel (yellow) directly into the plasma membrane (white). Graphic image courtesy of Christopher Collins.<\/span><\/p>\n<\/div><\/section>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]<span style=\"color: #000000\">The SCARB family of scavenger receptors (CD36, SR-B1 and LIMP II) are broadly expressed proteins that serve as receptors for a number of ligands including the lipoproteins HDL and LDL. These lipoproteins control the homeostatic balance of cholesterol levels in the body and their proper function is important for protection against atherosclerosis. By determining the crystal structure of the SCARB receptors we and our collaborators showed that they contain a hydrophobic tunnel through which cholesterol can directly transit from the lipoprotein to the plasma membrane. Future studies will involve further characterization of this novel mode of lipid transport, and determination of the relative contributions of endocytosis and direct transport in cholesterol homeostasis.<\/span>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]The SCARB family of scavenger receptors (CD36, SR-B1 and LIMP II) are broadly expressed proteins that serve as receptors for a number of ligands including the lipoproteins HDL and LDL. These lipoproteins control the homeostatic balance of cholesterol levels in the body and their proper function is important for protection against atherosclerosis. By&hellip;<\/p>\n","protected":false},"author":46,"featured_media":0,"parent":159,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-248","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Scavenger Receptors - Trimble Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/trimble\/research-2-2\/lipid-transport-via-scavenger-receptors\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scavenger Receptors\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]The SCARB family of scavenger receptors (CD36, SR-B1 and LIMP II) are broadly expressed proteins that serve as receptors for a number of ligands including the lipoproteins HDL and LDL. These lipoproteins control the homeostatic balance of cholesterol levels in the body and their proper function is important for protection against atherosclerosis. 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These lipoproteins control the homeostatic balance of cholesterol levels in the body and their proper function is important for protection against atherosclerosis. 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