{"id":244,"date":"2015-11-03T23:35:42","date_gmt":"2015-11-03T23:35:42","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/trimble\/?page_id=244"},"modified":"2015-11-10T01:13:31","modified_gmt":"2015-11-10T01:13:31","slug":"snare-mediated-membrane-fusion","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/trimble\/research-2-2\/snare-mediated-membrane-fusion\/","title":{"rendered":"SNARE Proteins"},"content":{"rendered":"<p><a class=\"dt-single-image\" href=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/10\/Primary-hippocampal-neurons.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-87 alignleft\" src=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/10\/Primary-hippocampal-neurons.jpg\" alt=\"Primary hippocampal neurons\" width=\"240\" height=\"240\" srcset=\"https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/10\/Primary-hippocampal-neurons.jpg 240w, https:\/\/lab.research.sickkids.ca\/trimble\/wp-content\/uploads\/sites\/37\/2015\/10\/Primary-hippocampal-neurons-150x150.jpg 150w\" sizes=\"auto, (max-width: 240px) 100vw, 240px\" \/><\/a><span style=\"color: #000000\">We have a longstanding interest in understanding the mechanisms controlling membrane fusion by the SNARE proteins and their regulation. In particular, recent work has focused on the AAA ATPase NSF which functions as a helicase to unwind the SNARE complex. Future directions will involve characterizing the role of APT hydrolysis in NSF helicase activity and the development of novel methods to monitor protein conformational changes.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We have a longstanding interest in understanding the mechanisms controlling membrane fusion by the SNARE proteins and their regulation. In particular, recent work has focused on the AAA ATPase NSF which functions as a helicase to unwind the SNARE complex. Future directions will involve characterizing the role of APT hydrolysis in NSF helicase activity and&hellip;<\/p>\n","protected":false},"author":46,"featured_media":0,"parent":159,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-244","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>SNARE Proteins - Trimble Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/trimble\/research-2-2\/snare-mediated-membrane-fusion\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SNARE Proteins\" \/>\n<meta property=\"og:description\" content=\"We have a longstanding interest in understanding the mechanisms controlling membrane fusion by the SNARE proteins and their regulation. 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