{"id":7,"date":"2020-04-23T17:05:02","date_gmt":"2020-04-23T17:05:02","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/taylor\/?page_id=7"},"modified":"2020-10-20T16:40:30","modified_gmt":"2020-10-20T16:40:30","slug":"home","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/taylor\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row type=&#8221;5&#8243;][vc_column][vc_empty_space height=&#8221;50px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h1><strong>Understanding the biology of brain tumours<\/strong><\/h1>\n<h5><q class=\"text-big shortcode-pullquote wf-cell align-right wf-1\"><p>The Taylor Lab <span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\">uses genetic tools to investigate how normal cells are turned into brain tumours. <\/span><\/span><span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\">G<\/span><\/span><span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\">enomic analyses <\/span><\/span><span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\">and genetic tools allow<\/span><\/span><span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\"> us to<\/span><\/span><span class=\"TextRun SCXW154357448 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW154357448 BCX4\"> create new models of medulloblastoma and ependymoma so that novel targeted therapies can be developed. This multi-layered approach using laboratory-driven scientific discovery and bioinformatics allows for rapid, clinically-important changes to brain tumour therapy. Our research helps to drastically improve the quality of life of paediatric patients.<\/span><\/span><span class=\"EOP SCXW154357448 BCX4\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<\/q><\/h5>\n<p>[\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;1&#8243; full_width=&#8221;stretch_row&#8221; bg_type=&#8221;bg_color&#8221; bg_color_value=&#8221;#282828&#8243;][vc_column][vc_empty_space][vc_column_text]<\/p>\n<h2 style=\"text-align: center\"><span style=\"color: #ffffff\"><strong>Selected publications<\/strong><\/span><\/h2>\n<p>[\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;]<div id=\"ult-carousel-199983942269e8ee34b21d5\" class=\"ult-carousel-wrapper   ult_horizontal\" data-gutter=\"15\" data-rtl=\"false\" ><div class=\"ult-carousel-256717670169e8ee34b2114 \" >[vc_single_image image=&#8221;643&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/32445698\/?from_term=taylor+md+and+cancer&amp;from_sort=date&amp;from_pos=1&#8243;][vc_single_image image=&#8221;278&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/32341580\/&#8221;][vc_single_image image=&#8221;276&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/31597162\/&#8221;][vc_single_image image=&#8221;273&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/31043743\/&#8221;][vc_single_image image=&#8221;274&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/29258295\/&#8221;][vc_single_image image=&#8221;277&#8243; img_size=&#8221;large&#8221; style=&#8221;vc_box_shadow_3d&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css_animation=&#8221;fadeIn&#8221; link=&#8221;https:\/\/pubmed.ncbi.nlm.nih.gov\/29474906\/&#8221;]<\/div><\/div>\t\t\t<script type=\"text\/javascript\">\n\t\t\t\tjQuery(document).ready(function ($) {\n\t\t\t\t\tif( typeof jQuery('.ult-carousel-256717670169e8ee34b2114').slick == \"function\"){\n\t\t\t\t\t\t$('.ult-carousel-256717670169e8ee34b2114').slick({dots: true,autoplaySpeed: \"5000\",speed: \"300\",infinite: true,arrows: true,nextArrow: '<button type=\"button\" role=\"button\" aria-label=\"Next\" style=\"color:#333333; font-size:20px;\" class=\"slick-next default\"><i class=\"ultsl-arrow-right4\"><\/i><\/button>',prevArrow: '<button type=\"button\" role=\"button\" aria-label=\"Previous\" style=\"color:#333333; font-size:20px;\" class=\"slick-prev default\"><i class=\"ultsl-arrow-left4\"><\/i><\/button>',slidesToScroll:6,slidesToShow:6,swipe: true,draggable: true,touchMove: true,pauseOnHover: true,pauseOnFocus: false,responsive: [\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 1026,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 6,\n\t\t\t\t\t\t\t\tslidesToScroll: 6,  \n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 1025,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 3,\n\t\t\t\t\t\t\t\tslidesToScroll: 3\n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t},\n\t\t\t\t\t\t\t{\n\t\t\t\t\t\t\t  breakpoint: 760,\n\t\t\t\t\t\t\t  settings: {\n\t\t\t\t\t\t\t\tslidesToShow: 2,\n\t\t\t\t\t\t\t\tslidesToScroll: 2\n\t\t\t\t\t\t\t  }\n\t\t\t\t\t\t\t}\n\t\t\t\t\t\t],pauseOnDotsHover: true,customPaging: function(slider, i) {\n                   return '<i type=\"button\" style= \"color:#dbdbdb;\" class=\"ultsl-record\" data-role=\"none\"><\/i>';\n                },});\n\t\t\t\t\t}\n\t\t\t\t});\n\t\t\t<\/script>\n\t\t\t<div class=\"text-centered\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/michael.taylor.2\/bibliography\/public\/\" class=\"btn-shortcode dt-btn-m dt-btn default-btn-color default-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" target=\"_blank\" id=\"dt-btn-1\" rel=\"noopener\"><span>View all publications<\/span><\/a><\/div>[vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column css=&#8221;.vc_custom_1588278507019{background-color: #ffffff !important;}&#8221;][vc_empty_space height=&#8221;40px&#8221;]<div id=\"advanced-tabs-desc-wrap-1519\" class=\"ult_tabs \" style=\" \" data-tabsstyle=\"style1\"\n data-titlebg=\"#f7f7f7\" data-titlecolor=\"#282828\" data-fullheight=\"on\"\n data-titlehoverbg=\"#f2d653\" data-titlehovercolor=\"#282828\"\n data-rotatetabs=\"0\" data-responsivemode=\"Both\" data-animation=\"Fade\"\ndata-activetitle=\"#282828\" data-activeicon=\"\" data-activebg=\"#f2d653\"  data-respmode=\"Accordion\" data-respwidth=\"400\" data-scroll = \"on\" data-activeindex=\"1\"><ul id=advanced-tabs-wrap-9266 class=\"ult_tabmenu style1 Style_4\" style=\"color:transparent;border-bottom-color:transparent;border-bottom-width:0px;border-bottom-style:solid;border-bottom-width:0px;\"><li class=\"ult_tab_li ult_tab_style_4  \" data-iconcolor=\"#74777b\" data-iconhover=\"#ffffff\" style=\"background-color:#f7f7f7;border-color:transparent;border-width:0px;border-style:solid;border-top-left-radius:10px;\">\n\t\t\t\t\t<a href=\"#3c297a1e-e850-10\" id=\"3c297a1e-e850-10\" style=\"color:#282828;;  \" class=\"ult_a \">\n\t\t\t\t\t   <span class=\"ult_tab_main  Both \">\n\t\t\t\t\t    <span class=\"ult_tab_section\">\n\t\t\t\t\t  \t\t<span  data-ultimate-target='#advanced-tabs-wrap-9266 .ult-span-text'  data-responsive-json-new='{\"font-size\":\"desktop:25px;\",\"line-height\":\"\"}'  class=\"ult-span-text ult-responsive\" style=\"font-weight:bold;\">Medulloblastoma<\/span>\n\t\t\t\t\t\t   \t<span class=\"aio-icon none ult_tab_iconright\" style=\"color:#74777b;font-size:15px;\">\n\t\t\t\t\t\t   \t<i class=\"   ult_tab_icon\"  ><\/i>\n\t\t\t\t\t\t   <\/span>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t   <\/span>\n\n\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/li><li class=\"ult_tab_li ult_tab_style_4  \" data-iconcolor=\"#74777b\" data-iconhover=\"#ffffff\" style=\"background-color:#f7f7f7;border-color:transparent;border-width:0px;border-style:solid;border-top-right-radius:10px;\">\n\t\t\t\t\t<a href=\"#6a25b907-48c6-5\" id=\"6a25b907-48c6-5\" style=\"color:#282828;;  \" class=\"ult_a \">\n\t\t\t\t\t   <span class=\"ult_tab_main  Both \">\n\t\t\t\t\t    <span class=\"ult_tab_section\">\n\t\t\t\t\t  \t\t<span  data-ultimate-target='#advanced-tabs-wrap-9266 .ult-span-text'  data-responsive-json-new='{\"font-size\":\"desktop:25px;\",\"line-height\":\"\"}'  class=\"ult-span-text ult-responsive\" style=\"font-weight:bold;\">Ependymoma<\/span>\n\t\t\t\t\t\t   \t<span class=\"aio-icon none ult_tab_iconright\" style=\"color:#74777b;font-size:15px;\">\n\t\t\t\t\t\t   \t<i class=\"   ult_tab_icon\"  ><\/i>\n\t\t\t\t\t\t   <\/span>\n\t\t\t\t\t\t<\/span>\n\t\t\t\t\t   <\/span>\n\n\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/li><\/ul><div  data-ultimate-target='#advanced-tabs-desc-wrap-1519 .ult_tabcontent .ult_tab_min_contain  p'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' class=\"ult_tabcontent ult-responsive style1\" style=\"color:#74777b;\"><div class=\"ult_tab_min_contain \" >\n\t\t\t<div  class=\"ult_tabitemname\"  >\n\t\t\t\t[vc_row_inner][vc_column_inner width=&#8221;2\/6&#8243;][vc_empty_space height=&#8221;40px&#8221;][vc_single_image image=&#8221;467&#8243; img_size=&#8221;&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_3d&#8221; css_animation=&#8221;fadeIn&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;4\/6&#8243;][vc_empty_space height=&#8221;35px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h2><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Medulloblastoma research<\/span><\/span><\/h2>\n<p><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Brain tumours are the most common solid malignancies seen in childhood, and the most frequent cause of oncologic death in children. Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Current therapy of MB includes resection, radiation of the entire developing brain and spinal cord, and high dose cytotoxic chemotherapy, followed by autologous bone marrow transplant. <\/span><\/span><\/p>\n<p><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Five-year survival rates in population based studies approximate 60-70%. However, the majority of survivors are left with considerable disabilities including severely diminished IQ, neurological and language deficits, endocrine deficiencies, and the occurrence of secondary (radiation induced) cancers. Meeting one of our medulloblastoma survivors is quite sobering, and certainly conveys the urgency of our research to improve quality of life for our patients.<\/span><\/span><span class=\"EOP SCXW185888955 BCX4\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span>[\/vc_column_text]<a href=\"https:\/\/lab.research.sickkids.ca\/taylor\/medulloblastoma\/\" class=\"btn-shortcode dt-btn-s dt-btn default-btn-color default-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" id=\"dt-btn-13\"><span>Learn more about our medulloblastoma research<\/span><\/a>[\/vc_column_inner][\/vc_row_inner]\n\t\t\t<\/div>\n\t\t\t<div  class=\"ult_tabitemname\"  >\n\t\t\t\t[vc_row_inner][vc_column_inner width=&#8221;2\/6&#8243;][vc_empty_space height=&#8221;40px&#8221;][vc_single_image image=&#8221;466&#8243; img_size=&#8221;&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_3d&#8221; css_animation=&#8221;fadeIn&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;4\/6&#8243;][vc_empty_space height=&#8221;35px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h2><span data-contrast=\"auto\">Ependymoma research<\/span><\/h2>\n<p><span data-contrast=\"auto\">Ependymoma in infants is the third most common childhood brain tumour. Currently doctors treat children with ependymoma using surgery and radiation, but not chemotherapy as it has not been shown to extend survival despite numerous previous clinical trials. The specific ependymoma that we study Poster Fossa Type A (PFA) ependymoma is unique, because it is the only human cancer for which there are no genetic mutations that are found in all patients; we therefore have no targets for specific therapy using available drugs.<\/span><\/p>\n<p><span data-contrast=\"auto\">Changes other than genetic mutations can cause cancer, one of these is termed \u2018epigenetic\u2019 changes, these are basically post-it-notes that are placed on your DNA that tell your body to either \u2018read this\u2019 or \u2018don\u2019t read this\u2019. Fortunately, PFA-ependymoma has extensive epigenetic post-it-notes and patients with these changes have been shown to respond to DNA demethylation drugs and EZH2 inhibitors. In fact, we have exciting evidence of activity in children treated compassionately with a demethylation drug (<\/span><span data-contrast=\"auto\">Vidaza<\/span><span data-contrast=\"auto\">), that can remove the post-it-notes.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span>[\/vc_column_text]<a href=\"https:\/\/lab.research.sickkids.ca\/taylor\/research\/\" class=\"btn-shortcode dt-btn-s dt-btn default-btn-color default-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" id=\"dt-btn-15\"><span>Learn more about our ependymoma research<\/span><\/a>[\/vc_column_inner][\/vc_row_inner]\n\t\t\t<\/div><\/div><\/div><\/div><div class=\"ult_acord advanced-tabs-desc-wrap-1519\">\n   <div class=\"ult-tabto-accordion \" style=\"width:;\"\n    data-titlecolor=\"#282828\"  data-titlebg=\"#f7f7f7\"\n     data-titlehoverbg=\"#f2d653\" data-titlehovercolor=\"#282828\" data-animation=\"Fade\"\n     data-activetitle=\"#282828\" data-activeicon=\"\" data-activebg=\"#f2d653\" data-scroll = \"on\" data-activeindex=\"1\" >\n     <dl><dt class=\"\">\n        \t<a class=\"ult-tabto-actitle withBorder ult_a\" id=\"3c297a1e-e850-10\" style=\"color:#282828;;background-color:#f7f7f7;border-bottom-color:transparent;border-bottom-width:0px;border-bottom-style:solid;\" href=\"#3c297a1e-e850-10\">\n        \t\t<i class=\"accordion-icon\"><\/i>\n        \t\t\t<span class=\"ult_tab_main ult_ac_mainBoth\">\n\t\t\t\t\t   <span  data-ultimate-target='#advanced-tabs-wrap-9266 .ult-span-text'  data-responsive-json-new='{\"font-size\":\"desktop:25px;\",\"line-height\":\"\"}'  class=\"ult-span-text ult_acordian-text ult-responsive\" style=\"font-weight:bold;;color:inherit \" >Medulloblastoma<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t   <div class=\"aio-icon none \" style=\"color:#74777b;font-size:15px;\" data-iconcolor=\"#74777b\" data-iconhover=\"#ffffff\">\n\t\t\t\t\t   <i class=\"    ult_tab_icon\"  ><\/i>\n\t\t\t\t\t   <\/div>\n\t\t\t\t\t<\/a><\/dt>\n            \t\t<dd class=\"ult-tabto-accordionItem ult-tabto-accolapsed\">\n\t\t\t            <div class=\"ult-tabto-acontent\" style=\"color:#74777b;\">\n\t\t\t               [vc_row_inner][vc_column_inner width=&#8221;2\/6&#8243;][vc_empty_space height=&#8221;40px&#8221;][vc_single_image image=&#8221;467&#8243; img_size=&#8221;&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_3d&#8221; css_animation=&#8221;fadeIn&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;4\/6&#8243;][vc_empty_space height=&#8221;35px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h2><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Medulloblastoma research<\/span><\/span><\/h2>\n<p><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Brain tumours are the most common solid malignancies seen in childhood, and the most frequent cause of oncologic death in children. Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Current therapy of MB includes resection, radiation of the entire developing brain and spinal cord, and high dose cytotoxic chemotherapy, followed by autologous bone marrow transplant. <\/span><\/span><\/p>\n<p><span class=\"TextRun SCXW185888955 BCX4\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW185888955 BCX4\">Five-year survival rates in population based studies approximate 60-70%. However, the majority of survivors are left with considerable disabilities including severely diminished IQ, neurological and language deficits, endocrine deficiencies, and the occurrence of secondary (radiation induced) cancers. Meeting one of our medulloblastoma survivors is quite sobering, and certainly conveys the urgency of our research to improve quality of life for our patients.<\/span><\/span><span class=\"EOP SCXW185888955 BCX4\" data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span>[\/vc_column_text]<a href=\"https:\/\/lab.research.sickkids.ca\/taylor\/medulloblastoma\/\" class=\"btn-shortcode dt-btn-s dt-btn default-btn-color default-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" id=\"dt-btn-6\"><span>Learn more about our medulloblastoma research<\/span><\/a>[\/vc_column_inner][\/vc_row_inner]\n\t\t\t            <\/div>\n        \t<\/dd><dt class=\"\">\n        \t<a class=\"ult-tabto-actitle withBorder ult_a\" id=\"6a25b907-48c6-5\" style=\"color:#282828;;background-color:#f7f7f7;border-bottom-color:transparent;border-bottom-width:0px;border-bottom-style:solid;border-bottom-color:transparent;border-bottom-width:0px;border-bottom-style:solid;\" href=\"#6a25b907-48c6-5\">\n        \t\t<i class=\"accordion-icon\"><\/i>\n        \t\t\t<span class=\"ult_tab_main ult_ac_mainBoth\">\n\t\t\t\t\t   <span  data-ultimate-target='#advanced-tabs-wrap-9266 .ult-span-text'  data-responsive-json-new='{\"font-size\":\"desktop:25px;\",\"line-height\":\"\"}'  class=\"ult-span-text ult_acordian-text ult-responsive\" style=\"font-weight:bold;;color:inherit \" >Ependymoma<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t   <div class=\"aio-icon none \" style=\"color:#74777b;font-size:15px;\" data-iconcolor=\"#74777b\" data-iconhover=\"#ffffff\">\n\t\t\t\t\t   <i class=\"    ult_tab_icon\"  ><\/i>\n\t\t\t\t\t   <\/div>\n\t\t\t\t\t<\/a><\/dt>\n            \t\t<dd class=\"ult-tabto-accordionItem ult-tabto-accolapsed\">\n\t\t\t            <div class=\"ult-tabto-acontent\" style=\"color:#74777b;\">\n\t\t\t               [vc_row_inner][vc_column_inner width=&#8221;2\/6&#8243;][vc_empty_space height=&#8221;40px&#8221;][vc_single_image image=&#8221;466&#8243; img_size=&#8221;&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_shadow_3d&#8221; css_animation=&#8221;fadeIn&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;4\/6&#8243;][vc_empty_space height=&#8221;35px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h2><span data-contrast=\"auto\">Ependymoma research<\/span><\/h2>\n<p><span data-contrast=\"auto\">Ependymoma in infants is the third most common childhood brain tumour. Currently doctors treat children with ependymoma using surgery and radiation, but not chemotherapy as it has not been shown to extend survival despite numerous previous clinical trials. The specific ependymoma that we study Poster Fossa Type A (PFA) ependymoma is unique, because it is the only human cancer for which there are no genetic mutations that are found in all patients; we therefore have no targets for specific therapy using available drugs.<\/span><\/p>\n<p><span data-contrast=\"auto\">Changes other than genetic mutations can cause cancer, one of these is termed \u2018epigenetic\u2019 changes, these are basically post-it-notes that are placed on your DNA that tell your body to either \u2018read this\u2019 or \u2018don\u2019t read this\u2019. Fortunately, PFA-ependymoma has extensive epigenetic post-it-notes and patients with these changes have been shown to respond to DNA demethylation drugs and EZH2 inhibitors. In fact, we have exciting evidence of activity in children treated compassionately with a demethylation drug (<\/span><span data-contrast=\"auto\">Vidaza<\/span><span data-contrast=\"auto\">), that can remove the post-it-notes.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span>[\/vc_column_text]<a href=\"https:\/\/lab.research.sickkids.ca\/taylor\/research\/\" class=\"btn-shortcode dt-btn-s dt-btn default-btn-color default-btn-hover-color default-btn-bg-color default-btn-bg-hover-color fadeIn animate-element animation-builder\" id=\"dt-btn-7\"><span>Learn more about our ependymoma research<\/span><\/a>[\/vc_column_inner][\/vc_row_inner]\n\t\t\t            <\/div>\n        \t<\/dd>\n    \t<\/dl>\n    <!--<div class=\"extraborder\" style=\"background-color:#f2d653\"><\/div>-->\n<\/div>\n\n<\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;5&#8243;][vc_column][vc_empty_space height=&#8221;50px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Understanding the biology of brain tumours [\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;1&#8243; full_width=&#8221;stretch_row&#8221; bg_type=&#8221;bg_color&#8221; bg_color_value=&#8221;#282828&#8243;][vc_column][vc_empty_space][vc_column_text] Selected publications [\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column css=&#8221;.vc_custom_1588278507019{background-color: #ffffff !important;}&#8221;][vc_empty_space height=&#8221;40px&#8221;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Home - Taylor Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/taylor\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Home\" \/>\n<meta property=\"og:description\" content=\"[vc_row type=&#8221;5&#8243;][vc_column][vc_empty_space height=&#8221;50px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Understanding the biology of brain tumours [\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;1&#8243; full_width=&#8221;stretch_row&#8221; bg_type=&#8221;bg_color&#8221; bg_color_value=&#8221;#282828&#8243;][vc_column][vc_empty_space][vc_column_text] Selected publications [\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column css=&#8221;.vc_custom_1588278507019{background-color: #ffffff !important;}&#8221;][vc_empty_space height=&#8221;40px&#8221;][\/vc_column][\/vc_row]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/taylor\/\" \/>\n<meta property=\"og:site_name\" content=\"Taylor Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-20T16:40:30+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/taylor\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/taylor\/\",\"name\":\"Home - Taylor Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/taylor\/#website\"},\"datePublished\":\"2020-04-23T17:05:02+00:00\",\"dateModified\":\"2020-10-20T16:40:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/taylor\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/taylor\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/taylor\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/taylor\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/taylor\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/taylor\/\",\"name\":\"Taylor Lab\",\"description\":\"The Brain Tumour Group\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/taylor\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Home - Taylor Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/taylor\/","og_locale":"en_US","og_type":"article","og_title":"Home","og_description":"[vc_row type=&#8221;5&#8243;][vc_column][vc_empty_space height=&#8221;50px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Understanding the biology of brain tumours [\/vc_column_text][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][\/vc_row][vc_row type=&#8221;1&#8243; 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