{"id":212,"date":"2020-04-29T16:30:29","date_gmt":"2020-04-29T16:30:29","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/taylor\/?page_id=212"},"modified":"2020-10-06T18:23:03","modified_gmt":"2020-10-06T18:23:03","slug":"discoveries","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/taylor\/discoveries\/","title":{"rendered":"Breakthroughs"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h1 style=\"text-align: center\"><strong>Major scientific discoveries in the Taylor lab<\/strong><\/h1>\n<p>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 a {\n  margin-right: ;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 {\n  min-width: 72px;\n  min-height: 72px;\n  font-size: 34px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:last-child {\n  margin-right: 0;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner {\n  margin: 0px;\n  min-width: 72px;\n  min-height: 72px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .dt-hover-icon {\n  line-height: 72px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:after,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:after {\n  min-width: 100%;\n  min-height: 100%;\n  padding: inherit;\n  border-radius: 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none;\n}\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon {\n  color: #282828;\n  background: none;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-font-icon,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-icon {\n  font-size: 34px;\n}<\/style><div class=\"dt-shortcode-icon-wrap dt-icon-center \"><span  class=\"anchor-link Defaults-diamond icon-1a400be133ff9d57bdf5d52cbde56d06 dt-shortcode-icon dt-icon-bg-on dt-icon-border-on dt-icon-hover-border-on dt-icon-hover-off dt-icon-hover-bg-on  \" ><span class=\"icon-inner\"><i class=\"dt-regular-icon soc-icon Defaults-diamond\"><\/i><i class=\"dt-hover-icon soc-icon Defaults-diamond\"><\/i><span class=\"screen-reader-text\"><\/span><\/span><\/span><\/div>[vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: center\"><b><span data-contrast=\"auto\">Discovery that medulloblastoma is a heterogeneous entity comprised of distinct diseases<\/span><\/b><span data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n<p style=\"text-align: center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20823417\/?from_term=Northcott+2011&amp;from_pos=2\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Northcott<\/span><span data-contrast=\"none\"> et al. <strong>Journal of\u00a0<\/strong><\/span><strong>Clinical\u00a0Oncology<\/strong><span data-contrast=\"none\">\u00a0<strong>2011<\/strong><\/span><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22134537\/?from_term=Taylor+MD++2012&amp;from_pos=2\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Taylor et al. <\/span><strong>Acta<\/strong><span data-contrast=\"none\"><strong> Neuropathologica\u00a02012<\/strong><\/span><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24493713\/?from_term=shih+D+2014&amp;from_pos=5\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Shih et al. <strong>Journal of\u00a0<\/strong><\/span><strong>Clinical\u00a0Oncology<\/strong><span data-contrast=\"none\">\u00a0<strong>2014<\/strong><\/span><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25605817\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Ramaswamy et al. <strong>Neuro-Oncology<\/strong> <strong>201<\/strong><\/span><strong>6<\/strong><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28609654\/?from_term=cavalli+cancer+cell+2017&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Cavalli<\/span><span data-contrast=\"none\"> et al. <strong>Cancer Cell<\/strong> <strong>2017<\/strong><\/span><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31043743\/?from_term=vladoiu+2019&amp;from_pos=1\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"none\">Vladoiu<\/span><span data-contrast=\"none\"> et al. <strong>Nature<\/strong> <strong>2019<\/strong><\/span><\/a><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p style=\"text-align: left\"><span data-contrast=\"auto\">We demonstrated, and it is accepted by the World Health Organization, that medulloblastoma (MB) comprises <\/span><span data-contrast=\"auto\">at least <\/span><span data-contrast=\"auto\">four distinct diseases, each with their own epidemiology, and response to therapy. Globally, clinical trials stratify patients based on this classification. Subgroup affiliation is now part of the standard of care for MB patients at SickKids and we have trained clinicians\/scientists around the globe to make this highly available. More <\/span><span data-contrast=\"auto\">recently we showed that the MB, are a disorder of early brain development, a finding which provides an explanation for the peak incidence in early childhood.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p>[\/vc_column_text][vc_separator style=&#8221;shadow&#8221; css_animation=&#8221;fadeInUp&#8221;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 a {\n  margin-right: ;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 {\n  min-width: 72px;\n  min-height: 72px;\n  font-size: 34px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:last-child {\n  margin-right: 0;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner {\n  margin: 0px;\n  min-width: 72px;\n  min-height: 72px;\n  border-radius: 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.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon {\n  color: #282828;\n  background: none;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-font-icon,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-icon {\n  font-size: 34px;\n}<\/style><div class=\"dt-shortcode-icon-wrap dt-icon-center \"><span  class=\"anchor-link Defaults-diamond icon-1a400be133ff9d57bdf5d52cbde56d06 dt-shortcode-icon dt-icon-bg-on dt-icon-border-on dt-icon-hover-border-on dt-icon-hover-off dt-icon-hover-bg-on  \" ><span class=\"icon-inner\"><i class=\"dt-regular-icon soc-icon Defaults-diamond\"><\/i><i class=\"dt-hover-icon soc-icon Defaults-diamond\"><\/i><span class=\"screen-reader-text\"><\/span><\/span><\/span><\/div>[vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: center\"><b><span data-contrast=\"auto\"> Discovery and delineation of the importance of epigenetic mechanisms in childhood brain tumours<\/span><\/b><\/h3>\n<p style=\"text-align: center\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23706743\/?from_single_result=PMID%3A+23706743&amp;expanded_search_query=PMID%3A+23706743\" target=\"_blank\" rel=\"noopener noreferrer\">Leprivier et al. <strong>Cell 2013<\/strong><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23184418\/?from_single_result=PMID%3A+23184418&amp;expanded_search_query=PMID%3A+23184418\" target=\"_blank\" rel=\"noopener noreferrer\">Dubuc et al. <strong>Acta Neuropathologica 2013<\/strong><\/a>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24553142\/?from_single_result=PMID%3A+24553142&amp;expanded_search_query=PMID%3A+24553142\" target=\"_blank\" rel=\"noopener noreferrer\">Mack et al. <strong>Nature 2014<\/strong><\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24847876\/?from_single_result=PMID%3A+24847876&amp;expanded_search_query=PMID%3A+24847876\" target=\"_blank\" rel=\"noopener noreferrer\">Hovestadt et al. <strong>Nature 2014<\/strong><\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29258295\/?from_single_result=PMID%3A+29258295&amp;expanded_search_query=PMID%3A+29258295\" target=\"_blank\" rel=\"noopener noreferrer\">Mack et al. Nature 2017<\/a><\/p>\n<p style=\"text-align: left\"><span data-contrast=\"auto\">Both medulloblastoma and ependymoma have a paucity of recurrent somatic mutations, particularly SNVs.\u00a0 Due to a lack of somatic genetic targets, alternatives must be found.\u00a0 We have shown in a number of publications that non-genetic, particularly epigenetic mechanisms (both DNA <\/span><span data-contrast=\"auto\">CpG<\/span><span data-contrast=\"auto\"> methylation and histone post-translational modifications) are important in medulloblastoma and ependymoma biology, and might serve as novel targets for rational therapy.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p>[\/vc_column_text][vc_separator style=&#8221;shadow&#8221; css_animation=&#8221;fadeInUp&#8221;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 a {\n  margin-right: 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.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon {\n  color: #282828;\n  background: none;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-font-icon,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-icon {\n  font-size: 34px;\n}<\/style><div class=\"dt-shortcode-icon-wrap dt-icon-center \"><span  class=\"anchor-link Defaults-diamond icon-1a400be133ff9d57bdf5d52cbde56d06 dt-shortcode-icon dt-icon-bg-on dt-icon-border-on dt-icon-hover-border-on dt-icon-hover-off dt-icon-hover-bg-on  \" ><span class=\"icon-inner\"><i class=\"dt-regular-icon soc-icon Defaults-diamond\"><\/i><i class=\"dt-hover-icon soc-icon Defaults-diamond\"><\/i><span class=\"screen-reader-text\"><\/span><\/span><\/span><\/div>[vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: center\"><b><span data-contrast=\"auto\">Discovery of molecular distinct subgroups of ependymoma brain tumors from different parts of the central nervous system that are biologically distinct, likely arise from radia<\/span><\/b><b><span data-contrast=\"auto\">l glial cell progenitor cells<\/span><\/b><\/h3>\n<p style=\"text-align: center\"><span data-contrast=\"auto\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16226707\/?from_single_result=PMID%3A+16226707&amp;expanded_search_query=PMID%3A+16226707\" target=\"_blank\" rel=\"noopener noreferrer\">Taylor et al. <strong>Cancer Cell 2005<\/strong><\/a>, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20639864\/?from_single_result=PMID%3A+20639864&amp;expanded_search_query=PMID%3A+20639864\" target=\"_blank\" rel=\"noopener noreferrer\">Johnson et al.\u00a0<strong>Nature 2010<\/strong><\/a><span data-contrast=\"auto\"><strong>,<\/strong>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21840481\/?from_single_result=PMID%3A+21840481&amp;expanded_search_query=PMID%3A+21840481\" target=\"_blank\" rel=\"noopener noreferrer\">Witt et al. <strong>Cancer Cell 2011<\/strong><\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25957288\/?from_single_result=PMID%3A+25957288&amp;expanded_search_query=PMID%3A+25957288\" target=\"_blank\" rel=\"noopener noreferrer\">Mack et al. <strong>Clinical Cancer Research 2015<\/strong><\/a>\u00a0<\/span><\/p>\n<p style=\"text-align: left\"><span data-contrast=\"auto\">Ependymoma can arise at all levels of the nervous system, and was thought to arise from post-mitotic cells of the ependymal.\u00a0 We have shown that in fact, ependymomas arise from radial glial cells (CNS progenitors), and that there are several distinct molecular subgroups of ependymoma with widely variant biology and outcomes.\u00a0 The next round of clinical trials for ependymoma are all accounting for these molecular subgroups.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p>[\/vc_column_text][vc_separator style=&#8221;shadow&#8221; css_animation=&#8221;fadeInUp&#8221;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 a {\n  margin-right: ;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 {\n  min-width: 72px;\n  min-height: 72px;\n  font-size: 34px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:last-child {\n  margin-right: 0;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner {\n  margin: 0px;\n  min-width: 72px;\n  min-height: 72px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .dt-hover-icon {\n  line-height: 72px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:after,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:after {\n  min-width: 100%;\n  min-height: 100%;\n  padding: inherit;\n  border-radius: inherit;\n}\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-bg-on .icon-inner:before,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-bg-on .icon-inner:before {\n  background: #f2d653;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-border-on:before {\n  border-width: 2px;\n  border-style: solid;\n  border-color: #f2d653;\n}\n.dt-icon-border-dashed.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-border-on:before {\n  border-style: dashed;\n}\n.dt-icon-border-dotted.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-border-on:before {\n  border-style: dotted;\n}\n.dt-icon-border-double.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-border-on:before {\n  border-style: double;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-border-on:after {\n  border-width: 2px;\n  border-style: solid;\n  border-color: ;\n}\n.dt-icon-border-dashed.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-border-on:after {\n  border-style: dashed;\n}\n.dt-icon-border-dotted.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-border-on:after {\n  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.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon {\n  color: #282828;\n  background: none;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-font-icon,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-icon {\n  font-size: 34px;\n}<\/style><div class=\"dt-shortcode-icon-wrap dt-icon-center \"><span  class=\"anchor-link Defaults-diamond icon-1a400be133ff9d57bdf5d52cbde56d06 dt-shortcode-icon dt-icon-bg-on dt-icon-border-on dt-icon-hover-border-on dt-icon-hover-off dt-icon-hover-bg-on  \" ><span class=\"icon-inner\"><i class=\"dt-regular-icon soc-icon Defaults-diamond\"><\/i><i class=\"dt-hover-icon soc-icon Defaults-diamond\"><\/i><span class=\"screen-reader-text\"><\/span><\/span><\/span><\/div>[vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: center\"><b><span data-contrast=\"auto\">Discovery of clinically significant heterogeneity in metastatic and recurrent medulloblastoma<\/span><\/b><\/h3>\n<p style=\"text-align: center\"><span data-contrast=\"auto\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22343890\/?from_single_result=PMID%3A+22343890&amp;expanded_search_query=PMID%3A+22343890\" target=\"_blank\" rel=\"noopener noreferrer\">Wu et al. <strong>Nature 2012<\/strong><\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24140199\/?from_single_result=PMID%3A+24140199&amp;expanded_search_query=PMID%3A+24140199\" target=\"_blank\" rel=\"noopener noreferrer\">Ramaswamy et al. <strong>Lancet Oncology 2013<\/strong><\/a>, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25689980\/?from_single_result=PMID%3A+25689980&amp;expanded_search_query=PMID%3A+25689980\" target=\"_blank\" rel=\"noopener noreferrer\">Wang et al. <strong>Acta Neuropathologica 2015<\/strong><\/a><span data-contrast=\"auto\">, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26760213\/?from_single_result=PMID%3A+26760213&amp;expanded_search_query=PMID%3A+26760213\" target=\"_blank\" rel=\"noopener noreferrer\">Garzia et al. <strong>Nature 2016<\/strong><\/a><span data-contrast=\"auto\">, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28394352\/?from_single_result=PMID%3A+28394352&amp;expanded_search_query=PMID%3A+28394352\" target=\"_blank\" rel=\"noopener noreferrer\">Morrissy et al. <strong>Nature Genetics 2017<\/strong><\/a><\/span><\/p>\n<p style=\"text-align: left\"><span data-contrast=\"auto\">Current <\/span><i><span data-contrast=\"auto\">modus operandi<\/span><\/i><span data-contrast=\"auto\"> are to discover and validate novel targets for therapy on untreated primary tumours, and then to take novel agents to clinical trials and test them on patients with highly treated, recurrent, metastatic disease.\u00a0 This approach is doomed to failure, as we have shown that children die from metastases rather than the primary tumour, that metastases are vastly different from the primary tumour, and that recurrent disease has undergone extensive clonal divergence from the untreated primary tumour.\u00a0 These findings necessitate re-biopsy at recurrence for targeted therapy, and considering temporal and spatial heterogeneity when studying medulloblastoma to develop novel therapies.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p>[\/vc_column_text][vc_separator style=&#8221;shadow&#8221; css_animation=&#8221;fadeInUp&#8221;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 a {\n  margin-right: ;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 {\n  min-width: 72px;\n  min-height: 72px;\n  font-size: 34px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:last-child {\n  margin-right: 0;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner {\n  margin: 0px;\n  min-width: 72px;\n  min-height: 72px;\n  border-radius: 50px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .dt-hover-icon {\n  line-height: 72px;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06:after,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:before,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .icon-inner:after {\n  min-width: 100%;\n  min-height: 100%;\n  padding: inherit;\n  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none;\n}\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-on:not(:hover) .soc-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-font-icon,\n#page .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon,\n#phantom .dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06.dt-icon-hover-off .soc-icon {\n  color: #282828;\n  background: none;\n}\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-font-icon,\n.dt-shortcode-icon.icon-1a400be133ff9d57bdf5d52cbde56d06 .soc-icon {\n  font-size: 34px;\n}<\/style><div class=\"dt-shortcode-icon-wrap dt-icon-center \"><span  class=\"anchor-link Defaults-diamond icon-1a400be133ff9d57bdf5d52cbde56d06 dt-shortcode-icon dt-icon-bg-on dt-icon-border-on dt-icon-hover-border-on dt-icon-hover-off dt-icon-hover-bg-on  \" ><span class=\"icon-inner\"><i class=\"dt-regular-icon soc-icon Defaults-diamond\"><\/i><i class=\"dt-hover-icon soc-icon Defaults-diamond\"><\/i><span class=\"screen-reader-text\"><\/span><\/span><\/span><\/div>[vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;]<\/p>\n<h3 style=\"text-align: center\"><b><span data-contrast=\"auto\">Discovery of novel medulloblastoma oncogenes and t<\/span><\/b><b><span data-contrast=\"auto\">umour<\/span><\/b><b><span data-contrast=\"auto\"> suppressor genes<\/span><\/b><\/h3>\n<p style=\"text-align: center\"><span data-contrast=\"auto\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12068298\/?from_single_result=PMID%3A+12068298&amp;expanded_search_query=PMID%3A+12068298\" target=\"_blank\" rel=\"noopener noreferrer\">Taylor et al. <strong>Nature Genetics 2002<\/strong><\/a>,<\/span>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12068298\/?from_single_result=PMID%3A+12068298&amp;expanded_search_query=PMID%3A+12068298\" target=\"_blank\" rel=\"noopener noreferrer\"><span data-contrast=\"auto\">Northcott<\/span><\/a><span data-contrast=\"auto\"> et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19270706\/?from_term=northcott+P+2009&amp;from_pos=5\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Nature Genetics 2009<\/strong><\/a>, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12068298\/?from_single_result=PMID%3A+12068298&amp;expanded_search_query=PMID%3A+12068298\" target=\"_blank\" rel=\"noopener noreferrer\">Northcott et al.\u00a0<strong>Nature 2012<\/strong><\/a><span data-contrast=\"auto\">, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12068298\/?from_single_result=PMID%3A+12068298&amp;expanded_search_query=PMID%3A+12068298\" target=\"_blank\" rel=\"noopener noreferrer\">Huang et al. <strong>Nature Neuroscience 2015<\/strong><\/a><\/span><\/p>\n<p style=\"text-align: left\"><span data-contrast=\"auto\">We have described and characterized a number of somatic and germline mutations that are drivers in subgroups of medulloblastoma.\u00a0 These driver events are useful for modeling the disease, and as targets for rational therapy.<\/span><span data-ccp-props=\"{&quot;335551550&quot;:6,&quot;335551620&quot;:6}\">\u00a0<\/span><\/p>\n<p>[\/vc_column_text][vc_separator style=&#8221;shadow&#8221; css_animation=&#8221;fadeInUp&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;] Major scientific discoveries in the Taylor lab [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Discovery that medulloblastoma is a heterogeneous entity comprised of distinct diseases\u00a0 Northcott et al. Journal of\u00a0Clinical\u00a0Oncology\u00a02011, Taylor et al. Acta Neuropathologica\u00a02012, Shih et al. Journal of\u00a0Clinical\u00a0Oncology\u00a02014, Ramaswamy et al. Neuro-Oncology 2016, Cavalli et al. Cancer Cell 2017, Vladoiu et&hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-212","page","type-page","status-publish","hentry","description-off"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Breakthroughs - Taylor Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/taylor\/discoveries\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breakthroughs\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;1\/6&#8243;][vc_empty_space height=&#8221;50px&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css_animation=&#8221;fadeIn&#8221;] Major scientific discoveries in the Taylor lab [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space height=&#8221;20px&#8221;][vc_column_text css_animation=&#8221;fadeIn&#8221;] Discovery that medulloblastoma is a heterogeneous entity comprised of distinct diseases\u00a0 Northcott et al. Journal of\u00a0Clinical\u00a0Oncology\u00a02011, Taylor et al. Acta Neuropathologica\u00a02012, Shih et al. Journal of\u00a0Clinical\u00a0Oncology\u00a02014, Ramaswamy et al. Neuro-Oncology 2016, Cavalli et al. 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