{"id":272,"date":"2017-05-24T20:08:43","date_gmt":"2017-05-24T20:08:43","guid":{"rendered":"https:\/\/lab.research.sickkids.ca\/task\/?page_id=272"},"modified":"2026-04-01T18:36:20","modified_gmt":"2026-04-01T18:36:20","slug":"themes","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/task\/themes\/","title":{"rendered":"Themes"},"content":{"rendered":"

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<\/span>Our Research Themes<\/span><\/div><\/div>[vc_empty_space][vc_empty_space][\/vc_column][vc_column width=”1\/6″][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/6″][\/vc_column][vc_column width=”2\/3″ css=”.vc_custom_1523374150120{margin-top: -30px !important;}”][vc_tta_accordion style=”modern” spacing=”3″ c_icon=”chevron” active_section=”0″ collapsible_all=”true”][vc_tta_section title=”Genomics” tab_id=”1681153904769-e21ef038-772f”][vc_column_text css=””]Genomics<\/span> and precision medicine are being increasingly integrated into clinical practice. These technologies may lead to better diagnostic accuracy, earlier referral to appropriate treatment interventions and a better treatment response based on targeted use of drugs and other interventions. However, new generations of sequencing technologies are costly and can produce additional findings that result in further downstream healthcare costs. It is not yet clear whether such technologies are cost-effective or where they should be positioned in a diagnostic pathway to maximize value for money. TASK force members are working to generate evidence regarding economic value, including social and ethical considerations to inform implementation.<\/p>\n

Table of contents<\/strong><\/p>\n

    \n
  1. Cost and cost-effectiveness of whole genome sequencing in paediatric cardiac conditions<\/a><\/li>\n
  2. Cost and cost-effectiveness of alternative genome-based diagnostic strategies <\/a><\/li>\n
  3. The clinical and personal utility of genomic testing<\/a><\/li>\n
  4. Cascade genetic testing<\/a><\/li>\n
  5. Genome sequencing policy research<\/a><\/li>\n
  6. A cost-effectiveness analysis of maternal genotyping to guide treatment for postpartum pain and avert infant adverse events<\/a><\/li>\n
  7. Cost-effectiveness analysis of thiopurine methyltransferase genotype testing<\/a><\/li>\n
  8. Genetic counselling<\/a><\/li>\n
  9. Other<\/a><\/li>\n<\/ol>\n

    Cost and cost-effectiveness of whole genome sequencing in paediatric cardiac conditions<\/h3>\n

    Prospective study led by Drs. Wendy Ungar and Robin Hayeems on clinical utility and cost-effectiveness of whole genome sequencing for children with cardiomyopathy. In progress.<\/p>\n