The Tabori Laboratory
The Tabori Laboratory is a highly translational group, fusing clinical expertise with ambitious laboratory and bioinformatics-based projects to drive discoveries in paediatric oncology.
One of our key areas of focus is the paediatric cancer predisposition disorder known as Replication Repair Deficiency (RRD) for which we run a large, international consortium and biobank holding thousands of tissue samples. RRD is a rare, but devastating disorder whereby affected individuals develop multiple malignancies in childhood. Our research utilizes both animal and human-based models such as stem cells and organoids to investigate and better understand CMMRD, leading to advances in surveillance, diagnosis, management and treatment of affected individuals.
Our lab also studies the mechanisms that control tumour progression and resistance to therapy. We focus on tumours that have low and high grade components such as paediatric low grade gliomas (PLGG) and neuroblastoma. Using these models we work to understand how tumours stop progressing, and expand our knowledge of the specific pathways that controls this unique behaviour. Specifically we have shown that replicative and oncogene induced senescence may be the most important prognostic and predictive factors in some paediatric glial neoplasms.
Our program has expertise in the following:
- Cancer genomics
- Novel diagnostic tools for cancer and germline testing
- Transgenic and PDX mouse models
- Human models such as organoids and IPC
- Translating big data into guidelines, novel therapies, and clinical trials
