{"id":47,"date":"2014-11-28T17:53:19","date_gmt":"2014-11-28T17:53:19","guid":{"rendered":"http:\/\/lab-dev.research.sickkids.ca\/brent-derry-lab\/?page_id=47"},"modified":"2024-09-13T17:54:29","modified_gmt":"2024-09-13T17:54:29","slug":"softwareandresources","status":"publish","type":"page","link":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/","title":{"rendered":"Software and Resources"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-overflow:visible;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;--awb-margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-menu-anchor Software\" id=\"software\"><\/div><div class=\"fusion-text fusion-text-1\"><h1>Software<\/h1>\n<\/div><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:2px;--awb-icon-size:13px;--awb-content-font-size:14.5px;--awb-icon-alignment:left;--awb-hover-color:#ffffff;--awb-border-color:#000000;--awb-background-color:#ffffff;--awb-divider-color:#e0dede;--awb-divider-hover-color:#e0dede;--awb-icon-color:#ffffff;--awb-title-color:#0046ad;--awb-content-color:#000000;--awb-icon-box-color:#000000;--awb-toggle-hover-accent-color:rgba(0,0,0,0.63);--awb-title-font-family:Arial, Helvetica, sans-serif;--awb-title-font-weight:700;--awb-title-font-style:normal;--awb-title-font-size:16px;--awb-title-letter-spacing:0px;--awb-title-line-height:1.88;--awb-content-font-family:Arial, Helvetica, sans-serif;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-boxed\" id=\"accordion-47-1\"><div class=\"fusion-panel panel-default panel-9981dccef8981787d fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_9981dccef8981787d\"><a aria-expanded=\"false\" aria-controls=\"9981dccef8981787d\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#9981dccef8981787d\" href=\"#9981dccef8981787d\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">ROPER<\/span><\/a><\/h4><\/div><div id=\"9981dccef8981787d\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_9981dccef8981787d\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Roper is a R package for differential expression analysis of RNA-Seq using robust profile likelihood method.<\/p>\n<p>The goal of roper is to accurately detect differentially expressed genes in the presence of unknown forms of additional variation that remains in the RNA-Seq read count.<\/p>\n<p>Access the package and get updates | <span style=\"text-decoration: underline\"><a href=\"https:\/\/github.com\/strug-hub\/roper\" target=\"_blank\" rel=\"noopener\">ROPER<\/a><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-7886ffd4733c8efbe fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_7886ffd4733c8efbe\"><a aria-expanded=\"false\" aria-controls=\"7886ffd4733c8efbe\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#7886ffd4733c8efbe\" href=\"#7886ffd4733c8efbe\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">ViKNGS: A C++ Variant Integrating Kit for Next Generation Sequencing<\/span><\/a><\/h4><\/div><div id=\"7886ffd4733c8efbe\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_7886ffd4733c8efbe\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><a href=\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png\"><img decoding=\"async\" class=\"alignnone size-medium wp-image-4258\" src=\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-300x121.png\" alt=\"vikngs logo\" width=\"300\" height=\"121\" srcset=\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-200x80.png 200w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-300x121.png 300w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-400x161.png 400w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-600x241.png 600w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-669x272.png 669w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-768x309.png 768w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-800x322.png 800w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-1024x412.png 1024w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-1200x483.png 1200w, https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png 1395w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>VikNGS is a freely available, user friendly C++ package that\u00a0uses the\u00a0<a href=\"http:\/\/www.tcag.ca\/tools\/RVS-R.html\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"text-decoration: underline\">RVS methodology<\/span><\/strong><\/a> to remove the bias in genetic association \u00a0due to differences in sequencing parameters \u00a0when combining external NGS data. VikNGS now enables RVS analysis that adjusts for covariates, conducts flexible power analyses and enables combination of NGS from multiple groups for both quantitative and binary trait analysis.<\/p>\n<ul>\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/vikngsdocs.readthedocs.io\/en\/latest\/\" target=\"_blank\" rel=\"noopener\">Read the VikNGS Documentation<\/a> <\/span><\/li>\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/github.com\/ScottMastro\/vikNGS\" target=\"_blank\" rel=\"noopener\">View the source code<\/a><\/span><\/li>\n<\/ul>\n<p><b>Reference:<\/b><br \/>\nZeynep Baskurt, Scott Mastromatteo, Jiafen Gong and Lisa Strug<br \/>\n<b>VikNGS: A C++\u00a0<\/b><u><b>V<\/b><\/u><b>ariant\u00a0<\/b><u><b>I<\/b><\/u><b>ntegrating\u00a0<\/b><u><b>K<\/b><\/u><b>it for\u00a0<\/b><u><b>N<\/b><\/u><b>ext\u00a0<\/b><u><b>G<\/b><\/u><b>eneration\u00a0<\/b><u><b>S<\/b><\/u><b>equencing across\u00a0<\/b><b>Research studies for robust rare and common variant association analysis<\/b><\/p>\n<p>Derkach, A et al.<br \/>\n<span style=\"text-decoration: underline\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=24733292\" target=\"_blank\" rel=\"noopener\"><b>Association Analysis Using Next Generation Sequence Data from Publicly Available Control Groups: The Robust Variance Score Statistic.<\/b><\/a><\/span><br \/>\n<i>Bioinformatics<\/i>\u00a030 (15): 2179-2188 first published online April 14, 2014.\u00a0PMID:24733292<\/p>\n<p>Baskurt, Z et al.<br \/>\n<b><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31580400\" target=\"_blank\" rel=\"noopener\">VikNGS: A C++ Variant Integration Kit for Next Generation Sequencing Association Analysis<\/a><\/span>.<\/b><br \/>\n<i>Bioinformatics<\/i>\u00a0Advance publication date: 3 October 2019.\u00a0PMID:31580400<\/p>\n<ul>\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/github.com\/ScottMastro\/VikNGS\" target=\"_blank\" rel=\"noopener\">Access the package and get updates<\/a><\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-f1eed67d3ed7f46b1 fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_f1eed67d3ed7f46b1\"><a aria-expanded=\"false\" aria-controls=\"f1eed67d3ed7f46b1\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#f1eed67d3ed7f46b1\" href=\"#f1eed67d3ed7f46b1\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">RVS - Robust Variance Score<\/span><\/a><\/h4><\/div><div id=\"f1eed67d3ed7f46b1\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_f1eed67d3ed7f46b1\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>The robust variance score (RVS) is a novel likelihood-based method for genetic association with NGS data from external control groups. RVS substitutes genotype calls by their expected values given observed sequence data and implements a robust variance estimate for the score statistic.<\/p>\n<p><b>Reference:<\/b><br \/>\nDerkach, A et al.<br \/>\n<span style=\"text-decoration: underline\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=24733292\" target=\"_blank\" rel=\"noopener\"><b>Association Analysis Using Next Generation Sequence Data from Publicly Available Control Groups: The Robust Variance Score Statistic.<\/b><\/a><\/span><br \/>\n<i>Bioinformatics<\/i>\u00a030 (15): 2179-2188 first published online April 14, 2014.\u00a0PMID:24733292<\/p>\n<p><span style=\"text-decoration: underline\"><a href=\"https:\/\/github.com\/Struglab\/RVS\" target=\"_blank\" rel=\"noopener\">Download R package<\/a><\/span><\/p>\n<p>To install in R, simply run the following commands:<br \/>\ninstall.packages(\u201cdevtools\u201d)<br \/>\nlibrary(devtools)<br \/>\ninstall_github(\u2018Struglab\/RVS\u2019)<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-9de151e5ff00a7c08 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_9de151e5ff00a7c08\"><a aria-expanded=\"false\" aria-controls=\"9de151e5ff00a7c08\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#9de151e5ff00a7c08\" href=\"#9de151e5ff00a7c08\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Evian - Evidential Analysis of Genetic Association Data<\/span><\/a><\/h4><\/div><div id=\"9de151e5ff00a7c08\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_9de151e5ff00a7c08\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><b>Evi<\/b>dential\u00a0<b>An<\/b>alysis of Genetic Association Data.<\/p>\n<p>The evidential approach employs the Law of Likelihood, and uses the LR (likelihood ratio) rather than p-values to plan\/design, analyze, interpret and replicate genetic association studies. Here is a R package that implements the evidential approach to analyze genetic association SNP data.<\/p>\n<p><b>Reference:<\/b><br \/>\nStrug, L.J et al.\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=24733292\" target=\"_blank\" rel=\"noopener\"><b>A pure likelihood approach to the analysis of genetic association data: an alternative to Bayesian and frequentist analysis.<\/b><\/a><\/span><br \/>\nEJHG. Epub Apr 28, 2010.\u00a0PMID: 20424645<\/p>\n<h4 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"13\" data-lineheight=\"20.02px\"><strong>R package<\/strong><\/h4>\n<p>version 1.0.0 (Mar 19, 2010):\u00a0<span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.0.0\/evian_1.0.tar.gz\" target=\"_blank\" rel=\"noopener\">evian_1.0.tar.gz<\/a>.<\/span><br \/>\nversion 1.0.1 (Apr 13, 2010):\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.0.1\/evian_1.0.1.tar.gz\" target=\"_blank\" rel=\"noopener\">evian_1.0.1.tar.gz<\/a>.\u00a0<\/span><i>(w\/robust, mle inversion fix, 2df plot title fix)<\/i><br \/>\nversion 1.0.2 (Apr 15, 2010):\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.0.2\/evian_1.0.2.tar.gz\" target=\"_blank\" rel=\"noopener\">evian_1.0.2.tar.gz<\/a>.<\/span>\u00a0<i>(robust example in vignette\/demo, listterms length fix, as.vector() for char covariates fix)<\/i><br \/>\nversion 1.1.0 (May 6, 2010):\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.1.0\/evian_1.1.0.tar.gz\">evian_1.1.0.tar.gz<\/a>.<\/span>\u00a0<i>(with linear regression functions). Online Documentation.<\/i><br \/>\nversion 1.1.0 (May 17, 2010):\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.1.0\/evian_1.1.0.zip\" target=\"_blank\" rel=\"noopener\">evian_1.1.0.zip<\/a>.<\/span>\u00a0<i>(<b>For windows<\/b>).<\/i><i>\u00a0<\/i><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/evian\/version_1.1.0\/evian.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline\">Online Documentation<\/span><\/a>.<i><br \/>\n<\/i>version 2.0.0 (Mar. 30, 2018):\u00a0<span style=\"text-decoration: underline\"><a href=\"https:\/\/cran.r-project.org\/package=evian\" target=\"_blank\" rel=\"noopener\">evian_2.0.0.tar.gz<\/a><\/span>\u00a0available on CRAN.\u00a0<em>(<strong>NEW<\/strong>\u00a0with parallel processing ability with support for Mac, Windows and Linux)<\/em>.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-98cd47db387b1671c fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_98cd47db387b1671c\"><a aria-expanded=\"false\" aria-controls=\"98cd47db387b1671c\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#98cd47db387b1671c\" href=\"#98cd47db387b1671c\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">maxLRc - Rare Variant Prioritization<\/span><\/a><\/h4><\/div><div id=\"98cd47db387b1671c\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_98cd47db387b1671c\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><b>Reference:<\/b><br \/>\nWeili Li, Sara Dobbins, Ian Tomlinson, Richard Houlston, Deb Pal, Lisa Strug.<br \/>\n<b><span style=\"text-decoration: underline\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25659987\" target=\"_blank\" rel=\"noopener\">Prioritizing Rare Variants with Conditional Likelihood Ratios<\/a><\/span>.<\/b>\u00a0<i>Human Heredity<\/i>\u00a02015. PMID:\u00a025659987<\/p>\n<h4 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"13\" data-lineheight=\"20.02px\"><strong>R code<\/strong><\/h4>\n<ol class=\"decimal\">\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/maxLRc\/maxLRc-calculation.R\" target=\"_blank\" rel=\"noopener\">R script<\/a><\/span><\/li>\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/maxLRc\/data-50inds-30vars.txt\" target=\"_blank\" rel=\"noopener\">Example dataset<\/a><\/span><\/li>\n<\/ol>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-913c094c22fe0ee1a fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_913c094c22fe0ee1a\"><a aria-expanded=\"false\" aria-controls=\"913c094c22fe0ee1a\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#913c094c22fe0ee1a\" href=\"#913c094c22fe0ee1a\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">JLS - Joint Location Scale Testing<\/span><\/a><\/h4><\/div><div id=\"913c094c22fe0ee1a\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_913c094c22fe0ee1a\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><span style=\"text-decoration: underline\"><a href=\"http:\/\/www.utstat.toronto.edu\/sun\/Software\/JLS\/index.html\" target=\"_blank\" rel=\"noopener\">Learn more about JLS and download the software.<\/a><\/span><\/p>\n<p>Reference:\u00a0<span style=\"text-decoration: underline\"><a href=\"http:\/\/www.cell.com\/ajhg\/abstract\/S0002-9297%2815%2900201-3\" target=\"_blank\" rel=\"noopener\">Soave et al. 2015 AJHG 1:125-138<\/a><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-6705b8131d1c88077 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_6705b8131d1c88077\"><a aria-expanded=\"false\" aria-controls=\"6705b8131d1c88077\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#6705b8131d1c88077\" href=\"#6705b8131d1c88077\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Composite Likelihood for genetic association<\/span><\/a><\/h4><\/div><div id=\"6705b8131d1c88077\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_6705b8131d1c88077\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>R-codes and Sample data \u00a0for \u2018The analysis of correlated binary data in genetic association studies: direct inference using the composite likelihood ratio\u2019<br \/>\ncan be downloaded below.<\/p>\n<ul>\n<li><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/Zeynep_paper\/sample_dataset.txt\" target=\"_blank\" rel=\"no opener noopener noreferrer\">Sample data used by R code<\/a><\/span><\/li>\n<li><span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/Zeynep_paper\/sample_functions.R\" target=\"_blank\" rel=\"noopener\">R functions called by R code<\/a><\/span><\/li>\n<li><span style=\"text-decoration: underline\"><a href=\"http:\/\/cfpercentile.research.sickkids.ca\/Zeynep_paper\/sample_Rcode.R\" target=\"_blank\" rel=\"noopener\">main R code<\/a><\/span><\/li>\n<\/ul>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-9a782e3e7f9d978b2 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_9a782e3e7f9d978b2\"><a aria-expanded=\"false\" aria-controls=\"9a782e3e7f9d978b2\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#9a782e3e7f9d978b2\" href=\"#9a782e3e7f9d978b2\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Simple Sum<\/span><\/a><\/h4><\/div><div id=\"9a782e3e7f9d978b2\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_9a782e3e7f9d978b2\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Here is the <span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/SimpleSum\/Simple_Sum_Rscript.R\" target=\"_blank\" rel=\"noopener\">R script used for the Simple Sum method<\/a><\/span> in PLoS Genetics 2018.<\/p>\n<p>Our <span style=\"text-decoration: underline\"><a href=\"https:\/\/locusfocus.research.sickkids.ca\/\" target=\"_blank\" rel=\"noopener\">our web tool, Locus Focus,<\/a> <\/span>may be accessed to apply the Simple Sum method to GWAS summary statistics.\u00a0<span style=\"text-decoration: underline\"><a href=\"https:\/\/locusfocus.readthedocs.io\/\" target=\"_blank\" rel=\"noopener\">Full documentation for the Simple Sum tool<\/a><\/span> is also available.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-c8ce53936528f4c5c fusion-toggle-no-divider fusion-toggle-boxed-mode\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_c8ce53936528f4c5c\"><a aria-expanded=\"false\" aria-controls=\"c8ce53936528f4c5c\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-1\" data-target=\"#c8ce53936528f4c5c\" href=\"#c8ce53936528f4c5c\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">LocusFocus<\/span><\/a><\/h4><\/div><div id=\"c8ce53936528f4c5c\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_c8ce53936528f4c5c\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p><a class=\"reference external\" href=\"https:\/\/locusfocus.research.sickkids.ca\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline\">LocusFocus<\/span><\/a>\u00a0is a web application to facilitate the exploration of a GWAS signal at a particular locus of the genome and its degree of colocalization with any SNP-level association data (e.g. expression quantitative trait loci for genes within +\/- 1Mbp in the relevant GTEx tissues selected).<\/p>\n<p>When paired with GTEx data, the aim is to annotate a GWAS (or region-based association) to the most probable gene(s) and tissue(s) that may be driving the observed GWAS signal.<\/p>\n<p>In addition, users may upload other datasets to test colocalization with. For example, other phenotypic associations (i.e. PheWAS) may be uploaded for assessing pleiotropy, or eQTL data from other sources to obtain a formal colocalization test and visualization of the data.<\/p>\n<p>The\u00a0<span style=\"text-decoration: underline\"><a class=\"reference external\" href=\"https:\/\/doi.org\/10.1371\/journal.pgen.1008007\" target=\"_blank\" rel=\"noopener\">Simple Sum method<\/a>\u00a0<\/span>is used for assessing the degree of colocalization of any two given datasets. When applied to GTEx, LocusFocus presents the degree of colocalization of genes nearby the GWAS association for all the tissues selected in an interactive heatmap plot.<\/p>\n<p>COLOC2 colocalization testing is also available, and more colocalization methods may be made available in future version releases.<\/p>\n<p>For more information, checkout the <span style=\"text-decoration: underline\"><a href=\"https:\/\/locusfocus.readthedocs.io\/en\/latest\/\" target=\"_blank\" rel=\"noopener\">documentation page for LocusFocus<\/a><\/span>.<\/p>\n<p><a href=\"https:\/\/locusfocus.research.sickkids.ca\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline\">Link to the LocusFocus web application<\/span><\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1331.2px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-menu-anchor\" id=\"resources\"><\/div><div class=\"fusion-text fusion-text-2\"><h1>Resources<\/h1>\n<\/div><div class=\"accordian fusion-accordian\" style=\"--awb-border-size:2px;--awb-icon-size:13px;--awb-content-font-size:14.5px;--awb-icon-alignment:left;--awb-hover-color:#ffffff;--awb-border-color:#000000;--awb-background-color:#ffffff;--awb-divider-color:#e0dede;--awb-divider-hover-color:#e0dede;--awb-icon-color:#ffffff;--awb-title-color:#0046ad;--awb-content-color:#000000;--awb-icon-box-color:#000000;--awb-toggle-hover-accent-color:rgba(0,0,0,0.63);--awb-title-font-family:Arial, Helvetica, sans-serif;--awb-title-font-weight:700;--awb-title-font-style:normal;--awb-title-font-size:16px;--awb-title-letter-spacing:0px;--awb-title-line-height:1.88;--awb-content-font-family:Arial, Helvetica, sans-serif;--awb-content-font-style:normal;--awb-content-font-weight:400;\"><div class=\"panel-group fusion-toggle-icon-boxed\" id=\"accordion-47-2\"><div class=\"fusion-panel panel-default panel-33b833430514a6b21 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_33b833430514a6b21\"><a aria-expanded=\"false\" aria-controls=\"33b833430514a6b21\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#33b833430514a6b21\" href=\"#33b833430514a6b21\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Nature Genetics 2012<\/span><\/a><\/h4><\/div><div id=\"33b833430514a6b21\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_33b833430514a6b21\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Summary statistics from the <span style=\"text-decoration: underline\"><a href=\"https:\/\/www.nature.com\/articles\/ng.2221\" target=\"_blank\" rel=\"noopener\">Genome-wide association study of Meconium Ileus from the International CF Gene Modifier Consortium<\/a><\/span> in <em>Nature Genetics\u00a0<\/em>2012 can be downloaded below.<\/p>\n<p><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS1_imputation_results\/README.txt\" target=\"_blank\" rel=\"noopener\">README<\/a><\/span><br \/>\n<span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS1_imputation_results\/GWAS1_MI_imputation_results_gee.txt.gz\" target=\"_blank\" rel=\"noopener\">GWAS1 Summary Statistics<\/a><\/span>\u00a0(indexed with tabix)<\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-7a61eb64a15d61ebf fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_7a61eb64a15d61ebf\"><a aria-expanded=\"false\" aria-controls=\"7a61eb64a15d61ebf\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#7a61eb64a15d61ebf\" href=\"#7a61eb64a15d61ebf\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Nature Communication 2015<\/span><\/a><\/h4><\/div><div id=\"7a61eb64a15d61ebf\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_7a61eb64a15d61ebf\"><div class=\"panel-body toggle-content fusion-clearfix\">Summary statistics from the <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26417704\" target=\"_blank\" rel=\"noopener\">meta-Genome-wide association study of the International CF Gene Modifier Consortium<\/a> in <em>Nature Communication<\/em><span style=\"text-decoration: underline\">,<\/span> 2015\u00a0can be downloaded below.<\/p>\n<p><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS_Summary_Public\/gwas.public.README\" target=\"_blank\" rel=\"noopener noreferrer\">README<\/a><\/span><br \/>\n<span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS_Summary_Public\/gwas.public.txt.gz\" target=\"_blank\" rel=\"noopener\">GWAS Summary Statistics<\/a><\/span><\/p>\n<p>A covariance matrix for the association region around <em>MUC4<\/em> and corresponding SNP list:<br \/>\n<a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS_Summary_Public\/ld_matrix_chr3_195560_195935Kbp.tar.gz\">MUC4 covariance matrix<\/a><\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-7c4cd4c533a561d0e fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_7c4cd4c533a561d0e\"><a aria-expanded=\"false\" aria-controls=\"7c4cd4c533a561d0e\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#7c4cd4c533a561d0e\" href=\"#7c4cd4c533a561d0e\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">Canadian FEV1 CF-Specific Percentiles<\/span><\/a><\/h4><\/div><div id=\"7c4cd4c533a561d0e\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_7c4cd4c533a561d0e\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Here is the webtool for<span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/\" target=\"_blank\" rel=\"noopener\"> Canadian FEV1 CF-Specific Percentiles.<\/a><\/span><\/p>\n<p><span style=\"text-decoration: underline\"><a href=\"https:\/\/thorax.bmj.com\/content\/73\/5\/446\" target=\"_blank\" rel=\"noopener\">Additional publication.<\/a><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-e93261eb9289deea7 fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_e93261eb9289deea7\"><a aria-expanded=\"false\" aria-controls=\"e93261eb9289deea7\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#e93261eb9289deea7\" href=\"#e93261eb9289deea7\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">MI GWAS 2019<\/span><\/a><\/h4><\/div><div id=\"e93261eb9289deea7\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_e93261eb9289deea7\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Summary statistics from the\u00a0<span style=\"text-decoration: underline\"><a href=\"https:\/\/urldefense.proofpoint.com\/v2\/url?u=https-3A__journals.plos.org_plosgenetics_article-3Fid-3D10.1371_journal.pgen.1008007&amp;d=DwMGaQ&amp;c=Sj806OTFwmuG2UO1EEDr-2uZRzm2EPz39TfVBG2Km-o&amp;r=94QS7fYXI94_qI9tWdeV9blVzqAPXUl8Sy1leDSDFYc&amp;m=iaHSJu6cvoSkSyMD2AValrnFyMAIsa24-VgzUHMuFD0&amp;s=EXTdmCkF-UmVNCU1GAK2YqCvCiABHWxceA20fz3KfHg&amp;e=\">GWAS of Meconium Ileus (2019)<\/a><\/span>\u00a0from the International CF Gene Modifier Consortium can be downloaded below.<\/p>\n<p><span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS_MI2_Summary_Public\/MI_GWAS_Summary_Stats_PLoS_Genet.tsv.gz\">GWAS Summary Statistics<\/a><\/span>\u00a0(indexed with tabix)<br \/>\n<span style=\"text-decoration: underline\"><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/GWAS_MI2_Summary_Public\/README.txt\">README<\/a><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-aa330cf9ab7abb5ec fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_aa330cf9ab7abb5ec\"><a aria-expanded=\"false\" aria-controls=\"aa330cf9ab7abb5ec\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#aa330cf9ab7abb5ec\" href=\"#aa330cf9ab7abb5ec\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">BIOJUME 2022<\/span><\/a><\/h4><\/div><div id=\"aa330cf9ab7abb5ec\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_aa330cf9ab7abb5ec\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Summary statistics from for the BIOJUME GWAS on BIS can be downloaded below.<\/p>\n<p><a href=\"https:\/\/cfpercentile.research.sickkids.ca\/BIOJUME\/BIS_GWAS_glm_eur_unrelset_dosage_topmed.txt.gz\">GWAS Summary Statistics<\/a> (indexed with tabix)<br \/>\n<a href=\"https:\/\/cfpercentile.research.sickkids.ca\/BIOJUME\/README.txt\">README<\/a><\/p>\n<\/div><\/div><\/div><div class=\"fusion-panel panel-default panel-98713f612f15f0a0a fusion-toggle-no-divider fusion-toggle-boxed-mode\" style=\"--awb-title-color:#0046ad;--awb-content-color:#000000;\"><div class=\"panel-heading\"><h4 class=\"panel-title toggle\" id=\"toggle_98713f612f15f0a0a\"><a aria-expanded=\"false\" aria-controls=\"98713f612f15f0a0a\" role=\"button\" data-toggle=\"collapse\" data-parent=\"#accordion-47-2\" data-target=\"#98713f612f15f0a0a\" href=\"#98713f612f15f0a0a\"><span class=\"fusion-toggle-icon-wrapper\" aria-hidden=\"true\"><i class=\"fa-fusion-box active-icon awb-icon-minus\" aria-hidden=\"true\"><\/i><i class=\"fa-fusion-box inactive-icon awb-icon-plus\" aria-hidden=\"true\"><\/i><\/span><span class=\"fusion-toggle-heading\">PsA GWAS, European Respiratory Journal 2024<\/span><\/a><\/h4><\/div><div id=\"98713f612f15f0a0a\" class=\"panel-collapse collapse \" aria-labelledby=\"toggle_98713f612f15f0a0a\"><div class=\"panel-body toggle-content fusion-clearfix\">\n<p>Summary statistics from the GWAS of PsA (2024) from the Canadian CF Gene Modifier Consortium can be downloaded below.<\/p>\n<p><a href=\"https:\/\/github.com\/strug-hub\/gwas_psa\">Summary Statistics and README<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":252,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-47","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.0 (Yoast SEO v27.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Software and Resources - Strug Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Software and Resources\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/\" \/>\n<meta property=\"og:site_name\" content=\"Strug Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-13T17:54:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1395\" \/>\n\t<meta property=\"og:image:height\" content=\"561\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"13 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/\",\"url\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/\",\"name\":\"Software and Resources - Strug Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-300x121.png\",\"datePublished\":\"2014-11-28T17:53:19+00:00\",\"dateModified\":\"2024-09-13T17:54:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage\",\"url\":\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png\",\"contentUrl\":\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png\",\"width\":1395,\"height\":561,\"caption\":\"vikngs logo\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lab.research.sickkids.ca\/strug\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Software and Resources\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lab.research.sickkids.ca\/strug\/#website\",\"url\":\"https:\/\/lab.research.sickkids.ca\/strug\/\",\"name\":\"Strug Lab\",\"description\":\"Genome Data Science\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lab.research.sickkids.ca\/strug\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Software and Resources - Strug Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/","og_locale":"en_US","og_type":"article","og_title":"Software and Resources","og_url":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/","og_site_name":"Strug Lab","article_modified_time":"2024-09-13T17:54:29+00:00","og_image":[{"width":1395,"height":561,"url":"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"13 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/","url":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/","name":"Software and Resources - Strug Lab","isPartOf":{"@id":"https:\/\/lab.research.sickkids.ca\/strug\/#website"},"primaryImageOfPage":{"@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage"},"image":{"@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage"},"thumbnailUrl":"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs-300x121.png","datePublished":"2014-11-28T17:53:19+00:00","dateModified":"2024-09-13T17:54:29+00:00","breadcrumb":{"@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#primaryimage","url":"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png","contentUrl":"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/Vikngs.png","width":1395,"height":561,"caption":"vikngs logo"},{"@type":"BreadcrumbList","@id":"https:\/\/lab.research.sickkids.ca\/strug\/softwareandresources\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lab.research.sickkids.ca\/strug\/"},{"@type":"ListItem","position":2,"name":"Software and Resources"}]},{"@type":"WebSite","@id":"https:\/\/lab.research.sickkids.ca\/strug\/#website","url":"https:\/\/lab.research.sickkids.ca\/strug\/","name":"Strug Lab","description":"Genome Data Science","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lab.research.sickkids.ca\/strug\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/pages\/47","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/users\/252"}],"replies":[{"embeddable":true,"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/comments?post=47"}],"version-history":[{"count":11,"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/pages\/47\/revisions"}],"predecessor-version":[{"id":4915,"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/pages\/47\/revisions\/4915"}],"wp:attachment":[{"href":"https:\/\/lab.research.sickkids.ca\/strug\/wp-json\/wp\/v2\/media?parent=47"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}