In the Strug lab, we develop novel statistical methodology to unravel the complex underpinnings of genetic disease. Our focus is on the identification of genetic modifiers in Mendelian disease such as Cystic Fibrosis, and on identifying genetic contributors to neurodevelopmental correlates of childhood onset Epilepsy. We aim to translate genetic findings to identify novel therapeutic targets, and to build diagnostic and predictive models for early intervention.<\/p>\n<\/div>
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Areas of Focus<\/h2><\/h2><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>![\"Genetic](\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/CF_research_banner_v4-1024x427-1-300x125.jpg\" "\\"Cystic")
<\/span><\/div><\/div><\/div><\/div><\/div>Genetic modification in cystic fibrosis<\/h3><\/h3><\/div><\/div><\/div><\/div><\/div><\/div><\/div>![\"Epilepsy](\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/epilepsy_banner3-1024x426-2-300x125.jpg\" "\\"Epilepsy")
<\/span><\/div><\/div><\/div><\/div><\/div>Epilepsy & neurodevelopment<\/h3><\/h3><\/div>
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Genetic modification in cystic fibrosis<\/h3><\/h3><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>Epilepsy & neurodevelopment<\/h3><\/h3><\/div>
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![\"Statistical](\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2021\/02\/igv_snapshot_mod2-1024x427-1-300x125.jpg\" "\\"Statistical")
<\/span><\/div><\/div>![\"Long-read](\"https:\/\/lab.research.sickkids.ca\/strug\/wp-content\/uploads\/sites\/30\/2025\/01\/20kbgraphbanner-1024x405.png\" "\\"20kbgraphbanner\\"")
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